Uptake of tetracycline by aortic aneurysm wall and its effect on inflammation and proteolysis

British Journal of Surgery

Volumn 86, Issue 6, 1999, Pages 771-775

  Franklin, I J ^a   Harley, S L ^a   Greenhalgh, R M ^a   Powell, J T ^a,a  

^a CHARING CROSS HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROXYPROLINE; INTERLEUKIN 6; MATRIX METALLOPROTEINASE; TETRACYCLINE;

ABDOMINAL AORTA ANEURYSM; ANESTHESIA INDUCTION; AORTA WALL; ARTERY CLAMP; ARTICLE; BIOPSY; CLINICAL ARTICLE; COLORIMETRY; CULTURE MEDIUM; DRUG BLOOD LEVEL; DRUG UPTAKE; EXPLANT; HUMAN; HUMAN TISSUE; IMMUNOASSAY; INFLAMMATION; INTRAVENOUS DRUG ADMINISTRATION; MICROBIOLOGY; PRIORITY JOURNAL; PROTEIN DEGRADATION; THROMBUS;

AORTIC ANEURYSM, ABDOMINAL; AORTITIS; CHEMOKINE CCL2; COLLAGEN; COLLAGENASES; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; INFLAMMATION; MATRIX METALLOPROTEINASE 9; PROTEIN SYNTHESIS INHIBITORS; TETRACYCLINE;

EID: 0033011647     PISSN: 00071323     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2168.1999.01137.x     Document Type: Article

References (22)

1. Ryan ME, Greenwald RA, Golub LM. Potential of tetracylines to modify cartilage breakdown in osteoarthritis. Curr Opin Rheumatol 1996; 8: 238-17.
2. Vernillo AT, Ramamurthy NS, Golub LM, Rifkin BR. The nonantimicrobial properties of tetracycline for the treatment of periodontal disease. Curr Opin Periodontal 1994; 111-18.
3. Thompson RW, Holmes DR, Merterns RA, Liao S, Botney MD, Mecham RP et al. Production and localization of 92-kilodalton gelatinase in abdominal aortic aneurysms. An elastolytic metalloproteinase expressed by aneurysm-infiltrating macrophages. J Clin Invest 1995; 96: 318-26.
4. Freestone T, Turner RJ, Coady A, Higman DJ, Greenhalgh RM, Powell JT. Inflammation and matrix metalloproteinases in the enlarging aortic aneurysm. Arterioscler Thromb Vasc Biol 1995; 15: 1145-51.
5. McMillan WD, Tamarina NA, Cipollone M, Johnson DA, Parker MA, Pearce WH. Size matters: the relationship between MMP-9 expression and aortic diameter. Circulation 1997; 96: 2228-32.
6. Shah PK. Inflammation, metalloproteinases, and increased proteolysis: an emerging pathophysiological paradigm in aortic aneurysm. Circulation 1997; 96: 2115-17 (Editorial).
7. Petrinec D, Liao S, Holmes DR, Reilly JM, Parks WC, Thompson RW. Doxycycline inhibition of aneurysmal degeneration in an elastase-induced rat model of abdominal aortic aneurysm: preservation of aortic elastin associated with suppressed production of 92 kD gelatinase. J Vasc Surg 1996; 23: 336-46.
8. Boyle JR, McDermott E, Crowther M, Wills AD, Bell PR, Thompson MM. Doxycycline inhibits elastin degradation and reduces metalloproteinase activity in a model of aneurysmal disease. J Vasc Surg 1998; 27: 354-61.
9. Farrell W, Williams JD. Tetracyclines. In: Reeves DS, Phillips I, Williams JD, Wise R, eds. Laboratory Methods in Antimicrobial Chemotherapy. Edinburgh: Churchill Livingstone, 1978: 237-238
10. Wilson DM, Lever M, Brosnan EA, Stilwell A. A simplified tetracycline assay. Clin Chim Acta 1972; 36: 260-1.
11. Franklin IJ, Walton LJ, Greenhalgh RM, Powell JT. The influence of indomethacin on the metabolism and cytokine secretion of human aneurysmal aorta. Eur J Vasc Endovasc Surg 1999 (in press).
12. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976; 72: 248-56.
13. Harley SL. Fibrinogen as an inflammatory mediator at saphenous vein endothelium. PhD Thesis, University of London, London, 1998.
14. Vine N, Powell JT. Metalloproteinases in degenerative aortic disease. Clin Sci 1991; 81: 233-9.
15. Murphy-Chutorian D, Kosek J, Mok W, Quay S, Huestis W, Mehigan J et al. Selective absorption of ultraviolet laser energy by human atherosclerotic plaque treated with tetracycline. Am J Cardiol 1985; 55: 1293-7.
16. Lauhio A, Salo T, Ding Y, Konttinen YT, Nordstrom D, Tschesche H et al. In vivo inhibition of human neutrophil collagenase (MMP-8) activity during long-term combination therapy of doxycycline and non-steroidal anti-inflammatory drugs (NSAID) in acute reactive arthritis. Clin Exp Immunol 1994; 98: 21-8.
17. Tyagi SC, Kumar SG, Alla SR, Reddy HK, Voelker DJ, Janicki JS. Extracellular matrix regulation of metalloproteinase and antiproteinase in human heart fibroblast cells. J Cell Physiol 1996; 167: 137-47.
18. Smith GNJr, Brandt KD, Mickler EA, Hasty KA. Inhibition of recombinant human neutrophil collagenase by doxycycline is pH dependent. J Rheumatol 1997; 24: 1769-73.
19. Amin AA, Attur MG, Thakker GD, Patel PD, Vyas PR, Patel RN et al. A novel mechanism of action of tetracyclines: effects on nitric oxide synthases. Proc Natl Acad Sci USA 1996; 93: 14014-19.
20. Ong G, Thomas BJ, Mansfield AO, Davidson BR, Taylor-Robinson D. Detection and widespread distribution of Chlamydia pneumoniae in the vascular system and its possible implications. J Clin Pathol 1996; 49: 102-6.
21. Juvonen J, Juvonen T, Laurila A, Alakarppa M, Lounatmaa K, Surcel HM et al. Demonstration of Chlamydia pneumoniae in the walls of abdominal aortic aneurysms. J Vasc Surg 1997; 25: 499-505.
22. Gibbs RGJ, Carey N, Davies AH. Chlamydia pneumoniae and vascular disease. Br J Surg 1998; 85: 1191-7.