Normal development of preimplantation mouse embryos deficient in gap junctional coupling

Journal of Cell Science

Volumn 110, Issue 15, 1997, Pages 1751-1758

  De Sousa, Paul A ^a   Juneja, Subhash C ^b   Caveney, Stanley ^a   Houghton, Franchesca D ^a   Davies, Tyler C ^c   Reaume, Andrew G ^d   Rossant, Janet ^c   Kidder, Gerald M ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c MOUNT SINAI HOSPITAL   (Canada)

^d CEPHALON INC   (United States)

Author keywords

Confocal microscopy; Connexin43; Connexin45; Gap junction; Gene targeting; Immunogold labeling; Intercellular coupling; Mouse; Preimplantation development

Indexed keywords

6 CARBOXYFLUORESCEIN; CONNEXIN 43; GAP JUNCTION PROTEIN;

ANIMAL TISSUE; ARTICLE; BLASTOCYST; CELL JUNCTION; CONTROLLED STUDY; ELECTRON MICROSCOPY; EMBRYO; EMBRYO DEVELOPMENT; GENE MUTATION; HOMOZYGOTE; IMMUNOFLUORESCENCE MICROSCOPY; IMMUNOGOLD STAINING; MEMBRANE PERMEABILITY; MORULA; MOUSE; MULTIGENE FAMILY; NONHUMAN; PREIMPLANTATION EMBRYO; PRIORITY JOURNAL; PROTEIN ASSEMBLY;

ANIMALS; BLASTOCYST; CELL COMMUNICATION; CONNEXIN 43; CONNEXINS; FLUORESCEINS; FLUORESCENT DYES; GAP JUNCTIONS; HOMOZYGOTE; MICE; MICE, INBRED C57BL; MICROSCOPY, CONFOCAL; MICROSCOPY, FLUORESCENCE; MORULA; MUTATION;

ANIMALIA; RODENTIA;

EID: 0030820607     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Barron, D. J., Valdimarsson, G., Paul, D. L. and Kidder, G. M. (1989). Connexin32, a gap junction protein, is a persistent oogenetic product through preimplantation development of the mouse. Dev. Genet. 10, 318-323.
2. Beblo, D. A., Wang, H.-Z., Beyer, E. C., Westphale, E. M. and Veenstra, R. D. (1995). Unique conductance, gating, and selective permeability properties of gap junction channels formed by connexin40. Circ. Res. 77, 813-822.
3. Becker, D. L., Evans, W. H., Green, C. R. and Warner, A. (1995). Functional analysis of amino acid sequences in connexin43 involved in intercellular communication through gap junctions. J. Cell Sci. 108, 1455-1467.
4. Beyer, E. C., Kistler, J., Paul, D. L. and Goodenough, D. L. (1989). Antisera directed against connexin43 peptides react with a 43-kD protein localized to gap junctions in myocardium and other tissues. J. Cell Biol. 108, 595-605.
5. Bevilacqua, A., Loch-Caruso, R. and Erickson, R. P. (1989). Abnormal development and dye coupling produced by antisense RNA to gap junction protein in mouse preimplantation embryos. Proc. Nat. Acad. Sci. USA 86, 5444-5448.
6. Bruzzone, R., White, T. W. and Paul, D. L. (1996). Connections with connexins: the molecular basis of direct intercellular signalling. Eur. J. Biochem. 238, 1-27.
7. Dahl, E., Manthey, D., Chen, Y., Schwarz, H.-J., Chang, Y. S., Lalley, P. A., Nicholson, B. J. and Willecke, K. (1996). Molecular cloning and functional expression of mouse connexin-30, a gap junction gene highly expressed in adult brain and skin. J. Biol. Chem. 271, 17903-17910.
8. Dahl, E., Winterhager, E., Reuss, B., Traub, O., Butterweck, A. and Willecke, K. (1996). Expression of the gap junction proteins connexin31 and connexin43 correlates with communication compartments in extraembryonic tissues and in the gastrulating mouse embryo, respectively. J. Cell Sci. 109, 191-197.
9. Davies, T. C., Barr, K. J., Jones, D. H., Zhu, D. and Kidder, G. M. (1996). Multiple members of the connexin gene family participate in preimplantation development of the mouse. Dev. Genet. 18, 234-243.
10. De Sousa, P. A., Valdimarsson, G., Nicholson, B. J. and Kidder, G. M. (1993). Connexin trafficking and the control of gap junction assembly in mouse preimplantation embryos. Development 117, 1355-1367.
11. Elfgang, C., Eckert, R., Lichtenberg-Fraté, H., Butterweck, A., Traub, O., Klein, R. A., Hülser, D. F. and Willecke, K. (1995). Specific permeability and selective formation of gap junction channels in connexin-transfected HeLa cells. J. Cell Biol. 129, 805-817.
12. Grümmer, R., Reuss, B. and Winterhager, E. (1996). Expression pattern of different gap junction connexins is related to embryo implantation. Int. J. Dev. Biol. 40, 361-367.
13. Jiang, J. X. and Goodenough, D. A. (1996). Heteromeric connexons in lens gap junction channels. Proc. Nat. Acad. Sci. USA 93, 1287-1291.
14. Kalimi, G. H. and Lo, C. W. (1988). Communication compartments in the gastrulating mouse embryo. J. Cell Biol. 107, 241-255.
15. Kalimi, G. H. and Lo, C. W. (1989). Gap junctional communication in the extraembryonic tissues of the gastrulating mouse embryo. J. Cell Biol. 109, 3015-3026.
16. Kanter, H. L., Saffitz, J. E. and Beyer, E. H. (1992). Cardiac myocytes express multiple gap junction proteins. Circ. Res. 70, 438-444.
17. Kidder, G. M. (1987). Intercellular communication during mouse embryogenesis. In The Mammalian Preimplantation Embryo: Regulation of Growth and Differentiation In Vitro (ed. B. Bavister), pp. 43-64. New York: Plenum Press.
18. Kidder, G. M., Barron, D. J. and Olmsted, J. B. (1988). Contribution of midbody channels to embryogenesis in the mouse: analysis by immunofluorescence. Roux's Arch. Dev. Biol. 197, 110-114.
19. Konig, N. and Zampighi, G. A. (1995). Purification of bovine lens cell-to-cell channels composed of connexin44 and connexin50. J. Cell Sci. 108, 3091-3098.
20. Koval, M., Geist, S. T., Westphale, E. M., Kemendy, A. E., Civitelli, R., Beyer, E. C. and Steinberg, T. H. (1995). Transfected connexin45 alters gap junction permeability in cells expressing endogenous connexin43. J. Cell Biol. 130, 987-995.
21. Laing, J. G., Westphale, E. M., Engelmann, G. L. and Beyer, E. H. (1994). Characterization of the gap junction protein, connexin45. J. Membr. Biol. 139, 31-40.
22. Laird, D. W. and Revel, J.-P. (1990). Biochemical and immunochemical analysis of the arrangement of connexin43 in rat heart gap junction membranes. J. Cell Sci. 97, 109-117.
23. Lee, S., Gilula, N. B. and Warner, A. E. (1987). Gap junctional communication and compaction during preimplantation stages of mouse development. Cell 51, 851-860.
24. Milks, L. C., Kumar, N. M., Houghten, R., Unwin, N. and Gilula, N. B. (1988). Topology of the 32-kd liver gap junction protein determined by site-directed antibody localizations. EMBO J. 7, 2967-2975.
25. Reaume, A., De Sousa, P. A., Kulkarni, S., Langille, B. L., Zhu, D., Davies, T. C., Juneja, S. C., Kidder, G. M. and Rossant, J. (1995). Cardiac malformation in neonatal mice lacking connexin43. Science 267, 1831-1834.
26. Risek, B., Guthrie, S., Kumar, N. B. and Gilula, N. B. (1990). Modulation of gap junction transcript and protein expression during pregnancy in the rat. J. Cell Biol. 110, 269-282.
27. Safranyos, R. G. A. and Caveney, S. (1985). Rate of diffusion of fluorescent molecules through cell-to-cell membrane channels. J. Cell Biol. 100, 736-747.
28. Spindle, A. (1980). An improved culture medium for mouse blastocysts. In Vitro 16, 669-674.
29. 2-connexin (connexin-26) can form heteromeric hemichannels. J. Biol. Chem. 270, 6768-6772.
30. Steinberg, T. H., Civitelli, R., Geist, S. T., Robertson, A. J., Hick, E., Veenstra, R. D., Wang, H.-Z., Warlow, P. M., Westphale, E. M., Laing, J. G. and Beyer, E. C. (1994). Connexin43 and connexin45 form gap junctions with different molecular permeabilities in osteoblastic cells. EMBO J. 13, 744-750.
31. Valdimarsson, G., De Sousa, P. A., Beyer, E. C., Paul, D. L. and Kidder, G. M. (1991). Zygotic expression of the connexin43 gene supplies subunits for gap junction assembly during mouse preimplantation development. Mol. Reprod. Dev. 30, 18-26.
32. Valdimarsson, G., De Sousa, P. A. and Kidder, G. M. (1993). Coexpression of gap junction proteins in the cumulus-oocyte complex. Mol. Reprod. Dev. 36, 7-15.
33. Valdimarsson, G. and Kidder, G. M. (1995). Temporal control of gap junction assembly in preimplantation mouse embryos. J. Cell Sci. 108, 1715-1722.
34. Veenstra, R. D., Wang, H.-Z., Beblo, D. A., Chilton, M. G., Harris, A. L., Beyer, E. C. and Brink, P. R. (1995). Selectivity of connexin-specific gap junctions does not correlate with channel conductance. Circ. Res. 77, 1156-1165.
35. Veenstra, R. D., Wang, H.-Z., Beyer, E. C. and Brink, P. R. (1994). Selective dye and ionic permeability of gap junction channels formed by connexin45. Circ. Res. 75, 483-490.
36. White, T. W., Paul, D. L., Goodenough, D. A. and Bruzzone, R. (1995). Functional analysis of selective interactions among rodent connexins. Mol. Biol. Cell 6, 459-470.