μ- and δ-opioid receptor agonists inhibit DARPP-32 phosphorylation in distinct populations of striatal projection neurons

European Journal of Neuroscience

Volumn 11, Issue 6, 1999, Pages 2182-2186

  Lindskog, Maria ^a   Svenningsson, Per ^a   Fredholm, Bertil ^a   Greengard, Paul ^b   Fisone, Gilberto ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b ROCKEFELLER UNIVERSITY   (United States)

Author keywords

Adenosine A(2A) receptor; DAMGO; Dopamine D1 receptor; DPDPE; Rat

Indexed keywords

3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE; ADENOSINE A2A RECEPTOR; CYCLIC AMP; DELTA OPIATE RECEPTOR AGONIST; DOPAMINE 1 RECEPTOR; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; ENKEPHALIN[2,5 DEXTRO PENICILLAMINE]; MU OPIATE RECEPTOR AGONIST; PHOSPHOPROTEIN DARPP 32;

ANIMAL TISSUE; ARTICLE; CORPUS STRIATUM; MALE; NERVE CELL; NIGRONEOSTRIATAL SYSTEM; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT;

8-BROMO CYCLIC ADENOSINE MONOPHOSPHATE; ANIMALS; CORPUS STRIATUM; DOPAMINE AND CAMP-REGULATED PHOSPHOPROTEIN 32; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; ENKEPHALIN, D-PENICILLAMINE (2,5)-; ENKEPHALINS; MALE; N-METHYLASPARTATE; NERVE TISSUE PROTEINS; NEURONS; PHOSPHOPROTEINS; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, MU;

EID: 0033005506     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.1999.00597.x     Document Type: Article

References (27)

1. 3H]-[D-Pen2,D-Pen5]enkephalin as a highly selective ligand for the delta-binding site. Br. J. Pharmacol., 84, 927-932.
2. Fienberg, A.A., Hiroi, N., Mermelsten, P., Song, W.-J., Snyder, G.L., Nishi, A., Cheramy, A., O'Callaghan, J.P., Miller, D.B., Cole, D.G., Corbett, R., Haile, C.N., Cooper, D.C., Onn, S.P., Grace, A.A., Ouimet, C.C., White, F.J., Hyman, S.E., Surmeier, D.J., Girault, J.A., Nestler, E.J. & Greengard, P. (1998) DARPP-32: regulator of the efficacy of dopaminergic neurotransmission. Science, 281, 838-842.
3. Fink, J.S., Weaver, D.R., Rivkees, S.A., Peterfreund, R.A., Pollack, A.E., Adler, E.M. & Reppert, S.M. (1992) Molecular cloning of the rat A2 adenosine receptor: selective co-expression with D2 dopamine receptor in rat striatum. Mol. Brain Res., 14, 186-195.
4. Georges, F., Stinus, L., Bloch, B. & Le Moine, C. (1999) Chronic morphine exposure and spontaneous withdrawal are associated with modifications of dopamine receptor and neuropeptide gene expression in the rat striatum. Eur. J. Neurosci., 11, 481-490.
5. Gerfen, C.R. (1992) The neostriatal mosaic: multiple levels of compartmental organization in the basal ganglia. Annu. Rev. Neurosci., 15, 285-320.
6. 2 dopamine receptors-regulated gene expression of striatonigral and striatopallidal neurons. Science, 250, 1429-1432.
7. Greengard, P., Nairn, A.C., Girault, J.-A., Ouimet, C.C., Snyder, G.L., Fisone, G., Allen, P.B., Fienberg, A. & Nishi, A. (1998) The DARPP-32/protein phosphatase-1 cascade: a model for signal integration. Brain Res. Rev., 26, 274-284.
8. Guttenberg, N.D., Klop, H., Minami, M., Satoh, M. & Voorn, P. (1996) Co-localization of μ opioid receptor is greater with dynorphin than enkephalin in rat striatum. Neuroreport, 7, 2119-2124.
9. Halpain, S., Girault, J.-A. & Greengard, P. (1990) NMDA receptor activation induces dephosphorylation of DARPP-32 in rat striatal slices. Nature, 343, 369-372.
10. Heijna, M.H., Hogenboom, F., Portoghese, P.S., Mulder, A.H. & Schoffelmeer, A.N.M. (1989) Mu- and delta-opioid receptor-mediated inhibition of adenylate cyclase activity stimulated by released endogenous dopamine in rat neostriatal slices; demonstration of potent delta-agonist activity of bremazocine. J. Pharmacol. Exp. Ther., 249, 864-868.
11. Hemmings, J.H.C., Greengard, P., Tung, H.Y.L. & Cohen, P. (1984) DARPP-32, a dopamine-regulated neuronal phosphoprotein, is a potent inhibitor of protein phosphatase-1. Nature, 310, 503-505.
12. Hersh, S.M., Ciliax, B.J., Gutekunst, C.A., Rees, H.D., Heilman, C.J., Yung, K.K.L., Bolam, J.P., Ince, E., Yi, H. & Levey, A.I. (1995) Electron microscopic analysis of Dl and D2 dopamine receptor proteins in the dorsal striatum and their synaptic relationships with motor corticostriatal afferents. J. Neurosci., 15, 5222-5237.
13. 1 dopamine receptor in a subset of DARPP-32-containing neurons in rat caudate-putamen. Neuroscience, 78, 977-983.
14. Le Moine, C., Kieffer, B., Gaveriaux-Ruff, C., Befort, K. & Bloch, B. (1994) Delta-opioid receptor gene expression in the mouse forebrain: localization in cholinergic neurons of the striatum. Neuroscience, 62, 635-640.
15. Mansour, A., Khachaturian, H., Lewis, M.E., Akil, H. & Watson, S.J. (1988) Anatomy of CNS opioid receptors. Trends Neurosci., 11, 308-314.
16. 2-opioid agonists in rat caudate putamen. J. Neurochem., 65, 125-133.
17. Ouimet, C.C., Miller, P.E., Hemmings, H.C., Walaas, S.I. & Greengard, P. (1984) DARPP-32, a dopamine- and adenosine 3': 5'-monophosphate-regulated phosphoprotein enriched in dopamine-innervated brain regions. III. Immunocytochemical localization. J. Neurosci., 4, 111-124.
18. Schiffman, S.N. & Vanderhaeghen, J.-J. (1993) Adenosine A2 receptors regulate the gene expression of striatopallidal and striatonigral neurons. J. Neurosci., 13, 1080-1087.
19. Schoffelmeer, A.N.M., Hogenboom, F. & Mulder, A.H. (1987) Inhibition of dopamine-sensitive adenylate cyclase by opioids: possible involvement of physically associated μ- and 5-opioid receptors. Naunyn Schmiedebergs Arch. Pharmacol., 335, 278-284.
20. Snyder, G.L., Girault, J.-A., Chen, J., Czernik, A.J., Kebabian, J.W., Nathanson, J.A. & Greengard, P. (1992) Phosphorylation of DARPP-32 and inhibitor-1 in rat choroid plexus: regulation by factors other than dopamine. J. Neurosci., 12, 3071-3083.
21. Svenningsson, P., Le Moine, C., Kuli, B.,-Sunahara, R., Bloch, B. & Fredholm, B.B. (1997) Cellular expression of adenosine A2A receptors mRNA in the rat central nervous system with special reference to dopamine innervated areas. Neuroscience, 80, 1171-1185.
22. 1 receptors stimulates cyclic AMP-dependent phosphorylation of DARPP-32 in distinct populations of striatal projection neurons. Neuroscience, 84, 223-228.
23. Towbin, H., Staehelin, T. & Gordon, J. (1979) Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl Acad. Sci. U.S.A., 76, 4350-4354.
24. Van Vliet, B.J., Mulder, A.H. & Schoffelmeer, A.M. (1990) Mu-opioid receptors mediate the inhibitory effect of opioids on dopamine-sensitive adenylate cyclase in primary culture of rat neostriatal neurons. J. Neurochem., 55, 1274-1280.
25. Walaas, S.I. & Greengard, P. (1984) DARPP-32, a dopamine- and adenosine 3': 5'-monophosphate-regulated phosphoprotein enriched in dopamineinnervated brain regions. I. Regional and cellular distribution in rat brain. J. Neurosci., 4, 84-98.
26. Yeadon, M. & Kitchen, I. (1988) Comparative binding of μ and δ selective ligands in whole brain and pons/medulla homogenates from rat: affinity profiles of fentanyl derivatives. Eur. J. Pharmacol., 27, 345-348.
27. Zhang, L., Yu, Y., Mackin, S., Weight, F., Uhl, G.R. & Wang, J.B. (1996) Differential μ opiate receptor phosphorylation and desensitization induced by agonists and phorbol esters. J. Biol. Chem., 271, 11449-11454.