The DARPP-32/protein phosphatase-1 cascade: A model for signal integration

Brain Research Reviews

Volumn 26, Issue 2-3, 1998, Pages 274-284

  Greengard, Paul ^a   Nairn, Angus C ^a   Girault, Jean Antoine ^b   Ouimet, Charles C ^c   Snyder, Gretchen L ^a   Fisone, Gilberto ^d   Allen, Patrick B ^a   Fienberg, Allen ^a   Nishi, Akinori ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

^b INSERM   (France)

^c FLORIDA STATE UNIVERSITY   (United States)

^d KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHOPROTEIN PHOSPHATASE 1;

ANIMAL TISSUE; CONFERENCE PAPER; INFORMATION PROCESSING; MONKEY; NERVE CONDUCTION; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION;

ANIMALS; BRAIN; DOPAMINE AND CAMP-REGULATED PHOSPHOPROTEIN 32; HUMANS; ION CHANNELS; NERVE TISSUE PROTEINS; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHOPROTEINS; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

EID: 0032078547     PISSN: 01650173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-0173(97)00057-X     Document Type: Conference Paper

References (64)

1. Allen P.B., Ouimet C.C., Greengard P. Spinophilin, A novel protein phosphatase 1 binding protein localized to dendritic spines. Proc. Natl. Acad. Sci. USA. 94:1997;9956-9961.
2. Anderson K.D., Reiner A. Immunohistochemical localization of DARPP-32 in striatal projection neurons and striatal interneurons: Implications for the localization of D1-like dopamine receptors on different types of striatal neurons. Brain Res. 568:1991;235-243.
3. +-ATPase activity in renal tubule cells. Proc. Natl. Acad. Sci. USA. 88:1991;2798-2801.
4. +-ATPase inhibits the activity of the enzyme. Proc. Natl. Acad. Sci. USA. 88:1991;11359-11362.
5. 2 dopamine receptor synergism. Nature. 347:1990;386-388.
6. Blank T., Nijholt I., Teichert U., Kugler H., Behrsing H., Fienberg A., Greengard P., Spiess J. The phosphoprotein DARPP-32 mediates cAMP-dependent potentiation of striatal NMDA responses. Proc. Natl. Acad. Sci. USA. 94:1997;14859-14864.
7. Bredt D.S., Snyder S.H. Nitric oxide, a novel neuronal messenger. Neuron. 8:1992;3-11.
8. Calabresi P., Mercuri N., Stanzione P., Stefani A., Bernardi G. Intracellular studies on the dopamine-induced firing inhibition of neostriatal neurons in vitro: Evidence for D1 receptor involvement. Neuroscience. 20:1987;757-777.
9. Cepeda C., Buchwald N.A., Levine M.S. Neuromodulatory actions of dopamine in the neostriatum are dependent on the excitatory amino acid subtypes activated. Proc. Natl. Acad. Sci. USA. 90:1993;9576-9580.
10. 2+ block of NMDA-receptor channels as a mechanism of modulation. Nature. 356:1992;521-523.
11. Clark D., White F.J. D1 dopamine receptor - the search for a function: A critical evaluation of the D1/D2 dopmaine classification and its functional implications. Synapse. 1:1997;347-388.
12. Colwell C.S., Levine M.S. Excitatory synaptic transmission in neostriatal neurons: Regulation by cyclic AMP-dependent mechanisms. J. Neurosci. 15:1995;1704-1713.
13. Cserr H. Physiology of the choroid plexus. Physiol. Rev. 51:1971;273-311.
14. Da Cruz e Silva E.F., Fox C.A., Ouimet C.C., Gustafson E., Watson S.J., Greengard P. Differential expression of protein phosphatase 1 isoforms in mammalian brain. J. Neurosci. 15:1995;3375-3389.
15. Dawson V.L., Dawson T.M., Wamsley J.K. Muscarinic and dopaminergic receptor subtypes on striatal cholinergic interneurons. Brain. Res. Bull. 23:1990;903-912.
16. Desdouits F., Cheetham J.J., Huang H.-B., Kwon Y.-G., Da Cruz e Silva E.F., Denefle P., Ehrlich M.E., Nairn A.C., Greengard P., Girault J.-A. Mechanism of inhibition of protein phosphatase 1 by DARPP-32: Studies with recombinant DARPP-32 and synthetic peptides. Biochem. Biophys. Res. Commun. 206:1995;652-658.
17. Desdouits F., Cohen D., Nairn A.C., Greengard P., Girault J.-A. Phosphorylation of DARPP-32, a dopamine- and cAMP-regulated phosphoprotein, by casein kinase I in vitro and in vivo. J. Biol. Chem. 270:1995;8772-8778.
18. Desdouits F., Siciliano J.C., Greengard P., Girault J.-A. Dopamine- and cAMP-regulated phosphoprotein DARPP-32: Phosphorylation of Ser-137 by casein kinase I inhibits dephosphorylation of Thr-34 by calcineurin. Proc. Natl. Acad. Sci. USA. 92:1995;2682-2685.
19. F. Desdouits, J.C. Siciliano, A.C. Nairn, P. Greengard, J.-A. Girault, Dephosphorylation of DARPP-32 Ser-137 in vitro and in striatonigral neurons by protein phosphatase 2C, Biochem. J. (1998) in press.
20. +-ATPase in the choroid plexus. Regulation by serotonin/protein kinase C pathway. J. Biol. Chem. 270:1995;2427-2430.
21. Freund T.F., Powell J.F., Smith A.D. Tyrosine hydroxylase immunoreactive boutons in synaptic contact with identified striatonigral neurons with particular reference to dendritic spines. Neuroscience. 13:1997;1189-1215.
22. Gerfen C.R., Engber L.C., Mahan L.C., Susel Z., Chase T.N., Mosma Jr., Sibley D.R. D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons. Science. 250:1990;1429-1432.
23. Girault J., Hemmings H.C. Jr., Williams K.R., Nairn A.C., Greengard P. Phosphorylation of DARPP-32, a dopamine- and cAMP-regulated phosphoprotein, by casein kinase II. J. Biol. Chem. 264:1989;21748-21759.
24. Girault J., Shalaby I.A., Rosen N.L., Greengard P. Regulation by cAMP and vasoactive intestinal peptide of phosphorylation of specific proteins in striatal cells in culture. Proc. Natl. Acad. Sci. USA. 85:1988;7790-7794.
25. Girault J.-A., Hemmings H.C. Jr., Zorn S.H., Gustafson E.L., Greengard P. Characterization in mammalian brain of a DARPP-32 serine kinase identical to casein kinase II. J. Neurochem. 55:1990;1772-1783.
26. Goldberg J., Huang H.B., Kwon Y.G., Greengard P., Nairn A.C., Kuriyan J. Three-dimensional structure of the catalytic subunit of protein serine/threonine phosphatase-1. Nature. 376:1995;745-753.
27. Goto S., Matsukado Y., Mihara Y., Inoue N., Miyamoto E. The distribution of calcineurin in rat brain by light and electron microscopic immunohistochemistry and enzyme-immunoassay. Brain Res. 397:1986;161-172.
28. Gross S.D., Hoffman D.P., Fisette P.L., Baas P., Anderson R.A. A phosphatidylinositol 4,5bisphosphatesensitive casein kinase I alpha associates with synaptic vesicles and phosphorylates a subset of vesicle proteins. J. Cell Biol. 130:1995;711-724.
29. Halpain S., Girault J., Greengard P. NMDA receptor activation induces dephosphorylation of DARPP-32 in rat striatal slices. Nature. 343:1990;369-372.
30. Hemmings H.C. Jr., Greengard P., Tung H.Y., Cohen P. DARPP-32, a dopamine-regulated neuronal phosphoprotein, is a potent inhibitor of protein phosphatase-1. Nature. 310:1984;503-505.
31. Hemmings H.C. Jr., Nairn A.C., Elliott J.I., Greengard P. Phosphorylation, dephosphorylation and inhibitory activity of synthetic peptide analogs of DARPP-32, an inhibitor of protein phosphatase-1. J. Biol. Chem. 265:1990;20369-20376.
32. Hemmings H.C. Jr., Nairn A.C., Greengard P. DARPP-32 a dopamine- and cyclic AMP-regulated neuronal phosphoprotein. 2. Comparison of the kinetics of phosphorylation of DARPP-32 and phosphatase inhibitor 1. J. Biol. Chem. 259:1984;14491-14497.
33. Hemmings H.C. Jr., Williams K.R., Konigsberg W.H., Greengard P. DARPP-32, a dopamine- and adenosine 3′:5′-monophosphate-regulated neuronal phosphoprotein. I. Amino acid sequence around the phosphorylated threonine. J. Biol. Chem. 259:1984;14486-14490.
34. Huang H.B., Horiuchi A., Goldberg J., Greengard P., Nairn A.C. Site-directed mutagenesis of amino acid residues of protein phosphatase 1 involved in catalysis and inhibitor binding. Proc. Natl. Acad. Sci. USA. 94:1997;3530-3535.
35. Hubbard M.J., Cohen P. On target with a new mechanism for the regulation of protein phosphorylation. Trends Biochem. Sci. 18:1993;172-177.
36. Ito M., Matsui T., Tanigucki T., Tsukamoto T., Murayama T., Arima N. Functional characterization of a human brain cholecystokinin-B receptor. J. Biol. Chem. 268:1993;18300-18305.
37. Kemp J.M., Powell T.P.S. The structure of the caudate nucleus of the cat: Light and electron microscopy. Philos. Trans. R. Soc. Lond. [Biol]. 263:1971;383-401.
38. King M.M., Huang C.Y., Chock P.B., Nairn A.C., Hemmings H.C. Jr., Chan K.F., Greengard P. Mammalian brain phosphoproteins as substrates for calcineurin. J. Biol. Chem. 259:1984;8080-8083.
39. Kwon Y.G., Huang H.B., Desdouits F., Girault J.A., Greengard P., Nairn A.C. Characterization of the interaction between DARPP-32 and protein phosphatase 1 (PP-1): DARPP-32 peptides antagonize the interaction of PP-1 with binding proteins. Proc. Natl. Acad. Sci. USA. 94:1997;3536-3541.
40. LeMoine C., Normand E., Bloch B. Phenotypical characterization of the rat striatal neurons expressing the D1 dopamine receptor gene. Proc. Natl. Acad. Sci. USA. 88:1991;4205-4209.
41. LeMoine C., Normand E., Guitteny A.F., Fonque B., Teoule R., Bloch B. Dopamine receptor gene expression by enkephalin neurons in rat forebrain. Proc. Natl. Acad. Sci. USA. 87:1990;230-234.
42. Li M., West J.W., Lai Y., Scheuer T., Catterall W.A. Functional modulation of brain sodium channels by cAMP-dependent phosphorylation. Neuron. 8:1992;1151-1159.
43. Li M., West J.W., Numann R., Murphy B.J., Scheuer T., Catterall W.A. Convergent regulation of sodium channels by protein kinase C and cAMP-dependent protein kinase. Science. 261:1993;1439-1442.
44. + channel subunit by cAMP-dependent protein kinase and phosphoprotein phosphatases. J. Biol. Chem. 268:1997;27355-27362.
45. Nishi A., Snyder G.L., Greengard P. Bidirectional regulation of DARPP-32 phosphorylation by dopamine. J. Neurosci. 17:1997;8147-8155.
46. Ouimet C.C., Da Cruz e Silva E.F., Greengard P. The α and gamma1 isoforms of protein phosphatase 1 are highly and specifically concentrated in dendritic spines. Proc. Natl. Acad. Sci. USA. 92:1995;3396-3400.
47. Ouimet C.C., Greengard P. Distribution of DARPP-32 in the basal ganglia. J. Neurocytol. 19:1990;39-52.
48. Ouimet C.C., Miller P.E., Hemmings H.C. Jr., Walaas S.I., Greengard P. DARPP-32, a dopamine and adenosine 3′:5′-monophosphate regulated phosphoprotein enriched in dopamine-innervated brain regions. III. Immunocytochemical localization. J. Neurosci. 4:1984;111-124.
49. +-activated adenosine triphosphatase and cerobrospinal fliud formation. Neurosurgery. 17:1985;768-772.
50. Rossie S., Catterall W.A. Cyclic-AMP-dependent phosphorylation of voltage-sensitive sodium channels in primary cultures of rat brain neurons. J. Biol. Chem. 262:1987;12735-12744.
51. Schiffmann S.N., Lledo P.-M., Desdouits F., Greengard P., Vanderhaegen J.J., Vincent J.-D., Girault J.-A. Activation of DARPP-32, an inhibitor of protein phosphatase 1, modulates the voltage-gated sodium current in striatal neurons. Society for Neuroscience Meeting. 21:1995;1143.
52. 1 receptor modulates the voltage-gated sodium current in rat striatal neurones through a protein kinase A. J. Physiol. (Lond.). 483:1995;95-107.
53. Shields S.M., Ingebritsen T.S., Kelly P.T. Identification of protein phosphatase 1 in synaptic junctions: dephosphorylation of endogenous calmodulin-dependent kinase II and synapse-enriched phosphoproteins. J. Neurosci. 5:1985;3414-3422.
54. Snyder G.L., Fienberg A., Dulubova I., Nairn A.C., Greengard P. Dopamine-mediated phosphorylation of NMDA-R1 in the rat nucleus accumbens. Society for Neuroscience Meeting. 22:1996;380.
55. Snyder G.L., Fisone G., Greengard P. Phosphorylation of DARPP-32 is regulated by GABA in rat striatum and substantia nigra. J. Neurochem. 63:1994;1766-1771.
56. Snyder G.L., Fisone G., Morino P., Gundersen V., Ottersen O.P., Hökfelt T., Greengard P. Regulation by the neuropeptide cholecystokinin (CCK-8S) of protein phosphorylation in the neostriatum. Proc. Natl. Acad. Sci. USA. 90:1993;11277-11281.
57. Snyder G.L., Girault J.-A., Chen J.Y.C., Czernik A.J., Kebabian J.W., Nathanson J.A., Greengard P. Phosphorylation of DARPP-32 and protein phosphatase inhibitor-1: Regulation by factors other than dopamine. J. Neurosci. 12:1992;3071-3083.
58. Somogyi P., Bolam J.P., Smith A.D. Monosynaptic cortical input and local axon collaterals of identified striatonigral neurons. A light and electron microscopic study using the Golgi-peroxidase transport-degeneration procedure. J. Comp. Neurol. 195:1981;567-584.
59. 1 dopaminergic protein kinase/phosphatase cascade in rat neostriatal neurons. Neuron. 14:1995;385-397.
60. Surmeier D.J., Song W.J., Yan Z. Coordinated expression of dopamine receptors in neostriatal medium spiny neurons. J. Neurosci. 16:1996;6579-6591.
61. P. Svenningsson, M. Lindskog, F. Rognoni, B.B. Fredholm, P. Greengard, G. Fisone, Activation of adenosine A2A nand dopamine d1 receptors stimulates cyclic AMP-dependent phosphorylation of DARPP-32 in distinct populations of striatal projection neurons, Neuroscience, (1998) in press.
62. Tsou K., Snyder G.L., Greengard P. Nitric oxide/cGMP pathway stimulates phosphorylation of DARPP-32, a dopamine- and cAMP-regulated phosphoprotein, in the substantia nigra. Proc. Natl. Acad. Sci. USA. 90:1993;3462-3465.
63. Walaas S.I., Greengard P. DARPP-32, a dopamine- and adenosine 3′:5′-monophosphate-regulated phosphoprotein enriched in dopamine-innervated brain regions. I. Regional and cellular distribution in the rat brain. J. Neurosci. 4:1984;84-98.
64. 1 dopamine receptor in a subset of DARPP-32-containing neurons in rat caudate-putamen. Neuroscience. 78:1997;977-983.