Loss of heterozygosity of APC and DCC tumor suppressor genes in human sporadic colon cancer

Journal of Molecular Medicine

Volumn 77, Issue 3, 1999, Pages 316-321

  Šturlan, Sanda ^a,c   Kapitanović, Sanja ^a   Kovačević, Duje ^d   Lukač, Josip ^d   Spaventi, Šime ^c   Spaventi, Radan ^e   Pavelić, Krešimir ^a,b  

^a RUDER BO KOVI INSTITUTE   (Croatia)

^b National Cancer Research Program

^c CROATIAN ACADEMY OF SCIENCES AND ARTS   (Croatia)

^d SESTRE MILOSRDNICE UNIVERSITY HOSPITAL   (Croatia)

^e PLIVA Research Institute Ltd   (Croatia)

Author keywords

APC; Colon cancer; DCC; Loss of heterozygosity; Tumor suppressor genes

Indexed keywords

ARTICLE; CELL HETEROGENEITY; COLON CANCER; COLON CARCINOGENESIS; GENE LOCUS; HUMAN; HUMAN TISSUE; POLYMERASE CHAIN REACTION; TUMOR SUPPRESSOR GENE;

EID: 0033003578     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001090050357     Document Type: Article

References (23)

1. Fearon ER (1992) Genetic alterations underlaying colorectal tumorigenesis. Cancer Surv 12:119-136
2. Iacopetta B, DiGrandi S, Dix B, Haig C, Soong R, House A (1994) Loss of heterozygosity of tumor suppressor gene loci in human colorectal carcinoma. Eur J Cancer 30A:664-670
3. Boland CR, Sato J, Appelman HD, Bresalier RS, Feinberg AP (1995) Microallelotyping defines the sequence and tempo of allelic losses at tumor suppressor gene loci during colorectal cancer progression. Nat Med 1:902-909
4. Miyaki M, Tanaka K, Kikuchi-Yanoshita R, Muraoka M, Konishi M (1995) Familial polyposis: recent advances. Crit Rev Oncol Hematol 19:1-31
5. Ookawa K, Sakamoto M, Hirohashi S, Yoshida Y, Sugimura T, Terada M, Yokota J (1993) Concordant p53 and DCC alterations and allelic losses on chromosomes 13q and 14q associated with liver metastases of colorectal carcinoma. Int J Cancer 53:382-387
6. Spaventi R, Pećur L, Pavelić K, Pavelić ZP, Spaventi Š, Stambrook PJ (1994) Human tumor bank in Croatia: a possible model for a small bank as part of future European tumor bank network. Eur J Cancer 30A:419
7. Herak Bosnar M, Pavelić K, Hrašćan R, Zeljko , Krhen I, Mareković Z, Kriěanac Š, Pavelić J (1997) Loss of heterozygosity of the nm23-H1 gene in human renal cell carcinomas. J Cancer Res Clin Oncol 123:485-488
8. Miyaki M, Konishi M, Kikuchi-Yanoshita R, Enomoto M, Igari T, Tanaka K, Muraoka M, Takahashi H, Amada Y, Fukayama M, Maeda Y, Iwama T, Mishima Y, Mori T, Koike M (1994) Characteristics of somatic mutation of the adenomatous polyposis coli gene in colorectal tumors. Cancer Res 54:3011-3020
9. Cho J-H, Noguchi M, Ochiai A, Hirohashi S (1996) Loss of heterozygosity of multiple tumor suppressor genes in human gastric cancers by polymerase chain reaction. Lab Invest 74:835-841
10. Gao X, Zacharek A, Grignon D, Liu H, Sakr W, Porter AT, Chen YQ, Honn KV (1995) High frequency of loss of expression and allelic deletion of the APC and MCC genes in human prostate cancer. Int J Oncol 6:111-117
11. Boynton RF, Blount PL, Yin J, Brown VL, Huang Y, Tong Y, McDaniel T, Newkirk C, Resau JH, Raskind WH, Haggitt RC, Reid BJ, Meltzer SJ (1992) Loss of heterozygosity involving the APC and MCC genetic loci occurs in the majority of human esophageal cancers. Proc Natl Acad Sci USA 89:3385-3388
12. Greenwald BD, Harpaz N, Yin J, Huang Y, Tong Y, Brown VL, McDaniel T, Newkirk C, Resau JH, Meltzer SJ (1992) Loss of heterozygosity affecting the p53, Rb and MCC/APC tumor suppressor gene loci in dysplastic and cancerous ulcerative colitis. Cancer Res 52:741-745
13. Kraus C, Ballhausen WG (1992) Two intragenic polymorphism of the APC-gene detected by PCR and enzymatic digestion. Hum Genet 88:705-706
14. Sjolander A, Birgauder R, Kivela A, Beckman G (1995) p53 polymorphism and haplotypes in different ethnic group. Hum Hered 45:144-149
15. Thiagalingam S, Lengauer C, Leach FS, Schutte M, Hahn SA, Overhauser J, Wilson JKV, Markowitz S, Hamilton SR, Kern SE, Kinzler KW, Vogelstein B (1996) Evaluation of candidate tumor suppressor genes on chromosome 18 in colorectal cancers. Nat Genet 13:343-346
16. Cropp CS, Lidereau R, Campbell G, Champene MH, Callahan R (1990) Loss of heterozygosity on chromosomes 17 and 18 in breast carcinoma: two additional regions identified. Proc Natl Acad Sci USA 87:7737-7741
17. Uchino S, Tsuda H, Noguchi M, Yokota J, Terada M, Sation T, Kobayashi M, Sugimura T, Hirahashi S (1992) Frequent loss of expression and loss of heterozygosity at the DCC locus in gastric cancer. Cancer Res 52:3099-3102
18. Hohne MW, Halatsch M-E, Kahl GF, Weinel RJ (1992) Frequent loss of expression of the potential tumor suppressor gene DCC in ductal pancreatic adenocarcinoma. Cancer Res 52:2616-2619
19. Scheck AC, Coons SW (1993) Expression of the tumor suppressor gene DCC in human gliomas. Cancer Res 53:5605-5609
20. Porfiri E, Secher-Walker LM, Hoffbrand AV, Hancock JF (1993) DCC tumor suppressor gene is inactivated in hematologic malignancies showing monosomy 18. Blood 81:2696-2701
21. Jen J, Kim H, Piantadosi S, Liu Z-F, Levitt RC, Sistonen P, Kinzler KW, Vogelstein B, Hamilton SR (1994) Allelic loss of chromosome 18q and prognosis in colorectal cancer. N Engl J Med 331:213-221
22. Lothe RA (1997) Microsatellite instability in human solid tumors. Mol Med Today 3:61-68
23. Powell SM, Zilz N, Beazer-Barclay Y, Bryan TM, Hamilton SR, Thibodeau SN, Vogelstein B, Kinzler KW (1992) APC mutations occur early during colorectal tumorigenesis. Nature 359:235-237