Loss of heterozygosity of the nm23-H1 gene in human renal cell carcinomas

Journal of Cancer Research and Clinical Oncology

Volumn 123, Issue 9, 1997, Pages 485-488

  Bosnar, Maja Herak ^a   Pavelić, Krešimir ^a   Hrašćan, Reno ^a   Zeljko, Žarko ^b   Krhen, Ivan ^c   Mareković, Zvonimir ^c   Križanac, Šimun ^c   Pavelić, Jasminka ^a  

^a RUDER BO KOVI INSTITUTE   (Croatia)

^b University of Zagreb   (Croatia)

^c UNIVERSITY OF ZAGREB   (Croatia)

Author keywords

LOH; Nm23 H1; Renal cell carcinoma

Indexed keywords

ARTICLE; CANCER GENETICS; GENE LOSS; HETEROZYGOSITY LOSS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KIDNEY CARCINOMA; MALIGNANT TRANSFORMATION; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION;

EID: 0030801366     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01192202     Document Type: Article

References (22)

1. Bugert P, Kovacs G (1996) Molecular differential diagnosis of renal cell carcinomas by microsatellite analysis. Am J Pathol 149:2081-2088
2. Florenes VA, Aamdal S, Myklebost O, Maelandsmo GM, Bruland OS, Fodstad O (1992) Levels of nm23 messenger RNA in metastatic malignant melanomas: inverse correlation to disease progression. Cancer Res 52:6088-6091
3. Fuhrman SA, Lasky LC, Limas C (1982) Prognostic significance of morphologic parameter in renal cell carcinoma. Am J Surg Pathol 6:665-668
4. Haut M, Steeg PS, Willson JKW, Markowitz SD (1991) Induction of nm13 gene expression in human colonic neoplasm and equal expression in colon tumors of high and low metastatic potential. J Natl Cancer Inst 83:712-716
5. Hiasa Y, Konishi N, Tao M, Matsuda H, Tsumatani K, Nakamura Y, Kitahori Y, Ozono S, Hirao Y, Okajima E (1996) Different expression of nm23-H1 and nm23-H2 protein with proliferative activities in various sizes of human renal cell carcinoma. Oncology 53:79-87
6. Higashiyama M, Doi O, Yokouchi H, Kodama K, Nakamori S, Tateishi R, Kimura N (1992) Immunohistochemical analysis of mn23 gene product/NDP kinase expression in pulmonary adenocarcinoma: lack of prognostic value. Br J Cancer 66:533-536
7. Hughson MD, Meloni A, Dougherty S, Silva FG, Sandberg AA (1996) Analysis of 3p allelic loss in papillary and nonpapillary renal cell carcinomas correlation with tumor karyotypes. Cancer Genet Cytogenet 87:133-139
8. Ishikawa J, Xu H-J, Hu S-X, Yandell DW, Maeda S, Kamidono S, Benedict WF, Takahashi R (1991) Inactivation of the retinoblastoma gene in human bladder and renal cell carcinomas. Cancer Res 51:5736-5743
9. Jeffreys AJ, Wilson V, Thein LS (1985) Hypervariable "minisatellite" regions in human DNA. Nature 314:67-73
10. Leone A, McBride OW, Weston A, Wang MG, Anglard P, Cropp CS, Goepel JR, Lidereau R (1991) Somatic allelic deletion of nm23 in human cancer. Cancer Res 51:2490-2493
11. Pavelić J, Gall-Trošelj K, Hlavka V, Pavelić ZP, Gluckman JL, Stambrook PJ, Pavelić K (1994) nm23-H1 protein in oligodendrogliomas. Int J Oncol 4:1399-1403
12. Pavelić K, Pavelić ZP, Denton D, Reising J, Khalily M, Preisler HD (1990) Immunohistochemical detection of c-myc oncoprotein in paraffin embedded tissue. J Exp Pathol 5:143-153
13. Pavelić K, Pavelić ZP, Preisler HD (1991) c-myc detection in bone marrow biopsies. Leukemia Res 15:1075-1078
14. Peterson RO (1992) Urologic pathology. Lippincott, Philadelphia
15. Sambrook J, Fritsch EF, Maniatis T (1989) Molecular cloning. A laboratory manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
16. Steeg PS, Bevilacqua G, Kopper L, Thorgeirsson UP, Talmadge JE, Liotta LA, Sobel ME (1988) Evidence for a novel gene associated with low tumor metastatic potential. J Natl Cancer Inst 80:200-204
17. Strohmeyer TG, Slamon DJ (1994) Proto-oncogenes and tumor suppressor genes in human urological malignancies. J Urol 151:1479-1497
18. Thrash-Bingham CA, Greenberg RE, Howard S, Bruzel A, Bremer M, Goll A, Salazar H, Freed JJ, Tartof KD (1995) Comprehensive allelotyping of human renal cell carcinomas using microsatellite DNA probes. Proc Natl Acad Sci USA 92:2854-2858
19. Uchida T, Wada C, Wang C, Egawa S, Ohtani H, Koshiba K (1994) Genomic instability of microsatellite repeats and mutations of H-, K- and N-ras, and p53 genes in renal cell carcinoma. Cancer Res 54:3682-3685
20. Walther MM, Anglard P, Gnarra J, Pozzatti R, Venzon D, De La Rosa A, McDonald NJ, Steeg PS, Linehan WM (1995) Expression of nm23 in cell lines derived from patients with metastatic renal cell carcinoma. J Urol 154:278-282
21. Wang L, Patel U, Ghosh L, Chen HC, Banerjee S (1993) Mutation in the nm23 gene is associated with metastasis in colorectal cancer. Cancer Res 53:717-720
22. Yamakawa K, Morita R, Takahashi E, Hori T, Ishikawa J, Nakamura Y (1991) A detailed deletion mapping of the short arm of chromosome 3 in sporadic renal cell carcinoma. Cancer Res 51:4707-4711