Interleukin-10 inhibits burst-forming unit-erythroid growth by suppression of endogenous granulocyte-macrophage colony-stimulating factor production from T cells

Experimental Hematology

Volumn 27, Issue 2, 1999, Pages 217-223

  Oehler, Leopold ^a   Kollars, Marietta ^a   Bohle, Barbara ^b   Berer, Andrea ^a   Reiter, Elisabeth ^a   Lechner, Klaus ^a   Geissler, Klaus ^a  

^a Division of Hematology   (Austria)

^b UNIVERSITY OF VIENNA   (Austria)

Author keywords

Burst forming unit erythroid; Granulocyte macrophage colony stimulating factor; Interleukin 10; T lymphocytes

Indexed keywords

GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; NEUTRALIZING ANTIBODY; RECOMBINANT ERYTHROPOIETIN; RECOMBINANT GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; RECOMBINANT INTERLEUKIN 10; RECOMBINANT INTERLEUKIN 3; RECOMBINANT STEM CELL FACTOR;

ARTICLE; BURST FORMING UNIT E; CELL PROLIFERATION; CONTROLLED STUDY; DOSE RESPONSE; ERYTHROPOIESIS; GROWTH INHIBITION; HUMAN; HUMAN CELL; MONONUCLEAR CELL; PRIORITY JOURNAL; T LYMPHOCYTE;

CELLS, CULTURED; ERYTHROID PROGENITOR CELLS; ERYTHROPOIESIS; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; INTERLEUKIN-10; LYMPHOCYTE DEPLETION; RECOMBINANT PROTEINS; T-LYMPHOCYTES;

EID: 0033001214     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0301-472X(98)00049-6     Document Type: Article

References (46)

1. Nathan D.G., Sytkowski A. Editorial retrospective. Erythropoietin and the regulation of erythropoiesis. N Engl J Med. 308:1983;520.
2. de Haan G., Dontje B., Nijhof W. Concepts of hemopoietic cell amplification. Synergy, redundancy, and pleiotropy of cytokines affecting the regulation of erythropoiesis. Leuk Lymphoma. 22:1996;385.
3. Sonoda Y., Yang Y.-C., Wong G.G., Clark S.C., Ogawa M. Erythroid burst-promoting activity of purified recombinant human GM-CSF and interleukin-3. studies with anti-GM-CSF and anti-IL-3 sera and studies in serum-free cultures Blood. 72:1988;1381.
4. Migliaccio A.R., Bruno M., Migliaccio G. Evidence for direct action of human biosynthetic (recombinant) GM-CSF on erythroid progenitors in serum-free culture. Blood. 70:1987;1867.
5. Migliaccio G., Migliaccio A.R., Adamson J.W. In vitro differentiation of human granulocyte/macrophage and erythroid progenitors. comparative analysis of the influence of recombinant human erythropoietin, G-CSF, GM-CSF, and IL-3 in serum-supplemented and serum-deprived cultures Blood. 72:1988;248.
6. Platzer E., Rubin B.Y., Lu L., Welte K., Broxmeyer H.E., Moore M.A.S. OKT3 monoclonal antibody induces production of colony-stimulating factor(s) for granulocytes and macrophages in cultures of human T lymphocytes and adherent cells. J Immunol. 134:1985;265.
7. Fibbe W.E., van Damme J., Billiau A., Voogt P.J., Duinkerken N., Kluck P.M.C., Falkenburg J.H.F. Interleukin-1 (22-K factor) induces release of granulocyte-macrophage colony-stimulating activity from human mononuclear phagocytes. Blood. 68:1986;1316.
8. Mosmann T.R., Cherwinski H., Bond M.W., Giedlin M.A., Coffman R.L. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol. 136:1986;2348.
9. Oster W., Lindemann A., Mertelsmann R., Herrmann F. Production of macrophage-, granulocyte-, granulocyte-macrophage- and multi-colony-stimulating factor by peripheral blood cells. Eur J Immunol. 19:1989;543.
10. Broxmeyer H.E., Lu L., Platzer E., Feit C., Juliano L., Rubin B.Y. Comparative analysis of the influences of human gamma, alpha, and beta interferons on human multipotential (CFU-GEMM), erythroid (BFU-E), and granulocyte-macrophage (CFU-GM) progenitor cells. J Immunol. 131:1983;1300.
11. Wang C.Q., Udupa K.B., Lipschitz D.A. Interferon-gamma exerts its negative regulatory effect primarily on the earliest stages of murine erythroid progenitor cell development. J Cell Physiol. 162:1995;134.
12. Tracy K.J., Wie H., Manoque K.R., Fong J., Hesse D.G., Nguyen H.T., Kuo G.C., Beutler B., Cotran R.S., Cerami A., Lowry S.F. Cachectin/tumor necrosis factor induces cachexia, anemia, and inflammation. J Exp Med. 167:1988;1211.
13. Schooley J.C., Kullgren B., Allison A.C. Inhibition by interleukin-1 of the action of erythropoietin on erythroid precursors and its possible role in the pathogenesis of hypoplastic anemias. Br J Haematol. 67:1987;11.
14. Zoumbos N.C., Djeu J.Y., Young N.S. Interferon is the suppressor of hematopoiesis generated by stimulated lymphocytes. J Immunol. 133:1984;769.
15. Iscove N.N., Sieber F. Erythroid progenitors in mouse bone marrow detected by macroscopic colony formation in culture. Exp Hematol. 3:1975;32.
16. Fauser A.A., Messner H.A. Fetal hemoglobin in mixed hemopoietic colonies (CFU-GEMM), erythroid bursts (BFU-E) and erythroid colonies (CFU-E). assessment by radioimmune assay and immunofluorescence Blood. 54:1979;1384.
17. Emerson S.G., Thomas S., Ferrara J.L., Greenstein J.L. Developmental regulation of erythropoiesis by hematopoietic growth factors. analysis on populations of BFU-E from bone marrow, peripheral blood, and fetal liver Blood. 74:1989;49.
18. Valtieri M., Gabbianelli M., Pelosi E., Bassano E., Petti S., Russo G., Testa U., Peschle C. Erythropoietin alone induces erythroid burst formation by human embryonic but not adult BFU-E in unicellular serum-free culture. Blood. 74:1989;460.
19. De Waal Malefyt R., Abrams J., Bennet B., Figdor C., deVries J. IL-10 inhibits cytokine synthesis by human monocytes. an autoregulatory role of IL-10 produced by monocytes J Exp Med. 174:1991;1209.
20. Gazzinelli R.T., Oswald I.P., James S.L., Sher A. IL-10 inhibits parasite killing and nitrogen oxide production by INF-gamma activated macrophages. J Immunol. 149:1992;4048.
21. Fiorentino D.F., Bond M.W., Mosmann T.R. Two types of mouse helper T cells IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J Exp Med. 170:1989;2081.
22. Taga K., Mostowski H., Tosato G. Human interleukin-10 can directly inhibits T cell growth. Blood. 81:1993;2964.
23. Buelens C., Willems F., Delvaux A., Pierard G., Delville J.P., Velu T., Goldman M. Interleukin-10 differentially regulates B7-1 (CD80) and B7-2 (CD86) expression on human peripheral blood dendritic cells. Eur J Immunol. 25:1995;2668.
24. Wang P., Wu P., Anthes J.C., Siegel M.I., Egan R.W., Billah M.M. Interleukin-10 inhibits interleukin-8 production in human neutrophils. Blood. 83:1994;2678.
25. Oehler L., Foedinger M., Koeller M., Kollars M., Reiter E., Bohle B., Skoupy S., Fritsch G., Lechner K., Geissler K. Interleukin-10 inhibits spontaneous colony-forming unit-granulocyte-macrophage growth from human peripheral blood mononuclear cells by suppression of endogenous granulocyte-macrophage colony-stimulating factor release. Blood. 89:1997;1147.
26. Geissler K. Current status of clinical development of interleukin-10. Curr Opin Hematol. 3:1996;203.
27. Miltenyi S., Müller W., Weichel W., Radbruch A. High gradient magnetic cell separation with MACS. Cytometry. 11:1990;231.
28. Wang C.Q., Udupa K.B., Lipschitz D.A. The role of macrophages in the regulation of erythroid colony growth in vitro. Blood. 80:1992;1702.
29. Torok-Storb B., Martin P.J., Hansen J.A. Regulation of in vitro erythropoiesis by normal T cells. evidence for two T cell subsets with opposing function Blood. 58:1981;171.
30. Lipton J.M., Nathan D.G. Cell-cell interaction in in vitro erythropoiesis. Blood Cells. 6:1980;645.
31. Wang C.Q., Udupa K.B., Lipschitz D. Evidence suggesting a stimulatory role for interleukin-10 in erythropoiesis in vitro. J Cell Physiol. 166:1996;305.
32. + stem cells Exp Hematol. 22:1994;136.
33. Metcalf D., Nicola N.A. The regulatory factors controlling murine erythropoiesis in vitro. Prog Clin Biol Res. 148:1984;93.
34. Geissler K., Oehler L., Foedinger M., Virgolini I., Leimer M., Kabrna E., Kollars M., Skoupy S., Bohle B., Rogy M., Lechner K. Interleukin-10 inhibits growth and granulocyte/macrophage colony-stimulating factor production in chronic myelomonocytic leukemia cells. J Exp Med. 184:1996;1377.
35. Chernoff A.E., Granowitz E.V., Shapiro L., Vannier E., Lonnemann G., Angel G.B., Kennedy J.S., Rabson A.R., Wolff S.M., Dinarello C.A. A randomized, controlled trial of IL-10 in humans. J Immunol. 154:1995;5492.
36. Fuchs A.C., Granowitz E.V., Shapiro L., Vannier E., Lonnemann G., Angel J.B., Kennedy J.S., Rabson A.R., Radwanski E., Affrime M.B., Cutler D.L., Grint P.C.et al. Clinical, hematologic, and immunologic effects of IL-10 in humans. J Clin Immunol. 16:1996;291.
37. Van Deventer S.J., Elson C.O., Fedorak R.N. Multiple doses of intravenous interleukin 10 in steroid-refractory Crohn's disease. Crohn's disease study group. Gastroenterology. 113:1997;383.
38. Baer A.N., Dessyspris E.N., Goldwasser E., Krantz S.B. Blunted erythropoietin response to anemia in rheumatoid arthritis. Br J Haematol. 66:1987;559.
39. Cartwright GE. The anemia of chronic disorders. Semin Hematol 3:351.
40. Faquin W.C., Schneider T.J., Goldberg M.A. Regulation of erythropoietin production by inflammatory cytokines. Possible role in the pathogenesis of anemia of chronic disease. Blood. 79:1992;1987.
41. Dainiak N., Hardin J., Floyd V., Callahan M., Hoffmann R. Humoral suppression of erythropoiesis in systemic lupus erythematosus. Am J Med. 69:1980;537.
42. Means R.T. Jr., Krantz S.B. Progress in understanding the pathogenesis of the anemia of chronic disease. Blood. 80:1992;1639.
43. Kucharzik T., Stoll R., Lugering N., Domschke W. Circulating antiinflammatory cytokine IL-10 in patients with inflammatory bowel disease (IBD). Clin Exp Immunol. 100:1995;452.
44. Cush J.J., Splawski J.B., Thomas R., McFarlin J.E., Schulze-Koops H., Davis L.S., Fujita K., Lipsky P.E. Elevated interleukin-10 levels in patients with rheumatoid arthritis. Arthritis Rheum. 38:1995;96.
45. al Janadi M., al Dalaan A., al Balla S., al Humaidi M., Raziuddin S. Interleukin-10 (IL-10) secretion in systemic lupus erythematosus and rheumatoid arthritis. IL-10-dependent CD4 + CD45RO + T cell-B cell antibody synthesis J Clin Immunol. 16:1996;198.
46. Stasi R., Zinzani L., Galieni P., Lauta V.M., Damasio E., Dispensa E., Dammacco F., Venditti A., Del Poeta G., Cantonetti M. Clinical implications of cytokine and soluble receptor measurements in patients with newly-diagnosed aggressive non-HodgkinÄs lymphoma. Eur J Haematol. 54:1995;9.