Transport of doxorubicin in mast cell granules and the effect of the calcium antagonist verapamil

Anticancer Research

Volumn 19, Issue 2 A, 1999, Pages 1101-1108

  Candussio, Luigi ^a   Decorti, Giuliana ^a   Crivellato, Enrico ^b   Rosati, Anna Maria ^a   Traversa, Ugo ^a   Klugmann, Fiora Bartoli ^a  

^a UNIVERSITY OF TRIESTE   (Italy)

^b UNIVERSITY OF UDINE   (Italy)

Author keywords

Doxorubicin; Granule remnants; Mast cell granules; Mast cells; P glycoprotein; Verapamil

Indexed keywords

CALCIUM ANTAGONIST; DOXORUBICIN; GLYCOPROTEIN P; HISTAMINE; N ETHYLMALEIMIDE; OUABAIN; PROTEOGLYCAN; SODIUM AZIDE; VANADATE SODIUM; VERAPAMIL; VINBLASTINE;

ANIMAL CELL; ARTICLE; CELL GRANULE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG ACCUMULATION; DRUG TRANSPORT; EXOCYTOSIS; HISTAMINE RELEASE; IMMUNOBLOTTING; MAST CELL; NONHUMAN; PERITONEUM MAST CELL; PRIORITY JOURNAL; RAT; TEMPERATURE DEPENDENCE;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; BIOLOGICAL TRANSPORT; CALCIUM CHANNEL BLOCKERS; CYTOPLASMIC GRANULES; DOXORUBICIN; MAST CELLS; MICROSCOPY, FLUORESCENCE; P-GLYCOPROTEIN; RATS; RATS, WISTAR; VERAPAMIL;

EID: 0032997111     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Bosch I and Croop J: P-glycoprotein multidrug resistance and cancer. Biochim Biophys Acta 1288: F37-F54, 1996.
2. Fojo AT, Ueda K, Slamon DJ, Poplack DG, Gottesman MM and Pastan I: Expression of a multidrug-resistance gene in human tumors and tissues. Proc Natl Acad Sci 84: 265-269, 1987.
3. Trezise AE, Romano PR, Gill DR, Hayd SC, Sepulveda FV, Buchwald M and Higgins CF: The multidrug resistance and cystic fibrosis gene have complementary patterns of epithelial expression. EMBO J 11: 4291-4303, 1992.
4. Georges E, Bradley G, Gariepy J and Ling V: Detection of P-glycoprotein isoforms by gene specific monoclonal antibodies. Proc Natl Acad Sci 87: 152-156, 1990.
5. Cordon-Cardo C, O'Brien JP, Boccia J, Casals D, Bertino JR and Melamed MR: Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues. J Histochem Cytochem 38: 1277-1287, 1990.
6. van der Valk P, van Kalken CK, Ketelaars H, Broxterman HJ, Scheffer G, Kuiper CM, Tsuruo T, Lankelma J, Meijer CJ, Pinedo H and Scheper R: Distribution of multi-drug resistance associated P-glycoprotein in normal and neoplastic human tissues. Analysis with 3 monoclonal antibodies recognising different epitopes of the P-glycoprotein molecule. Ann Oncol 1: 56-64, 1990.
7. Arceci RJ, Croop JM, Horwitz SB and Housman D: The gene encoding multidrug resistance is induced and expressed at high levels during pregnancy in secretory epithelium of the uterus. Proc Natl Acad Sci 85: 4350-4354, 1988.
8. Axiotis CA, Guarch R, Merino MJ, Laporte N and Neumann RD: P-glycoprotein expression is increased in human secretory and gestational endometrium. Lab Invest 65: 577-581, 1991.
9. Bradley G, Georges E and Ling V: Sex-dependent and independent expression of the P-glycoprotein isoforms in Chinese-hamster. J Cell Physiol 145: 398-408, 1990.
10. Cordon-Cardo C, O'Brien JP, Casals D, Rittman-Grauer L, Biedler JL, Melamed MR and Bertino JR: Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood brain barrier sites. Prot Natl Acad Sci 86: 695-698, 1989.
11. Chaudhary PM and Roninson IB: Expression and activity of P-glycoprotein, a multidrug efflux pump in human hematopoietic stem cells. Cell 66: 85-94, 1991.
12. Chaudhary PM, Mechetner EB and Roninson IB: Expression and activity of the multidrug resistance P-glycoprotein in human peripheral blood lymphocytes. Blood 80: 2735-2739, 1992.
13. Drach D, Zhao S, Drach J, Mahadevia R, Gattringer C, Huber H and Andreeff M: Subpopulations of normal peripheral blood and bone-marrow cells express a functional multidrug resistant phenotype. Blood 80: 2729-2734, 1992.
14. Decorti G, Bartoli Klugmann F, Candussio L, Furlani A, Scarcia V and Baldini L: Uptake of adriamycin by rat and mouse mast cells and correlation with histamine release. Cancer Res 49: 1921-1926, 1989.
15. Decorti G, Bartoli Klugmann F, Candussio L and Baldini L: Characterisation of histamine secretion induced by anthracyclines in rat peritoneal mast cells. Biochem Pharmacol 35: 1939-1942, 1986.
16. Klugmann FB, Decorti G, Candussio L, Grill V, Mallardi F and Baldini L: Inhibitors of adriamycin-induced histamine release in vitro limit adriamycin cardiotoxicity in vivo. Br J Cancer 54: 743-748, 1986.
17. Gupta S, Kim CH, Tsuruo T and Gollapudi S: Preferential expression of multidrug resistance gene 1 product (P-glycoprotein), a functionally active efflux pump, in human CD8+ T cells. A role in cytotoxic effector function. J Clin Immunol 12: 451-458, 1992.
18. Wein D and Gupta S: Expression of P-glycoprotein encoded by MDR-1 gene, a metabolically active efflux pump in murine mast cells. Cancer Lett 101: 241-246, 1996.
19. Crivellato E, Candussio L, Decorti G, Bartoli Klugmann F and Baldini L: Adriamycin binds to the matrix of secretory granules during mast cell exocytosis. Histochem J 29: 193-198, 1997.
20. Lagunoff D and Rickard A: Methods for the study of rat peritoneal mast cell secretion. In: In vitro methods for studying secretion. The secretory process. (Poisner AM and Trifarò JM, eds), Elsevier Science Publishers BV, Amsterdam, 1987, pp.13-28.
21. Kruger PG, Lagunoff D and Wan H: Isolation of rat mast cell granules with intact membranes. Exp Cell Res 129: 83-93, 1980.
22. Kokkonen JO and Kovanen PT: Low density lipoprotein binding to mast cell granules. Demonstration of binding of apolipoprotein B to heparin proteoglycan of exocytosed granules. Biochem J 241: 583-589, 1987.
23. Shore PA, Burkhalter A and Cohn VH: A method for the fluorometric assay of histamine in tissues. J Pharmacol Exp Ther 127: 182-186, 1959.
24. Bachur NR, Moore AL, Bernstein JG and Liu A: Tissue distribution and disposition of daunomycin (NSC-82151) in mice: fluorometric and isotopic methods. Cancer Chemother Rep 54: 89-94, 1970.
25. Lowry OH, Rosenbrough NJ, Fark AL and Randell LJ: Protein measurement with the Folin phenol reagent. J Biol Chem 193: 265-275, 1951.
26. Laemmli UK: Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685, 1970.
27. Greenberger LM, Williams SS, Georges E, Ling V and Horwitz SB: Electrophoretic analysis of P-glycoproteins produced by mouse J774.2 and Chinese hamster ovary multidrug-resistant cells. J Natl Cancer Inst 80: 49-53, 1988.
28. Otter T, Stephen MK and Witman GB: A two-step procedure for efficient electrotransfer of both high-molecular-weight (greater than 400,000) and low molecular-weight (less than 20,000) proteins. Anal Biochem 162: 370-377, 1987.
29. Barrand MA and Twentyman PR: Differential recognition of mdr1a and mdr1b gene products in multidrug resistant mouse tumour cell lines by different monoclonal antibodies. Br J Cancer 65: 239-245, 1992.
30. Decorti G, Candussio L, Bartoli Klugmann F, Strohmayer A, Mucci MP, Mosco A, Baldini L: Adriamycin-induced histamine release from heart tissue in vitro. Cancer Chemother Pharmacol 40: 363-366, 1997.
31. Merry S, Courtney ER, Fetherson CA, Kaye SB and Freshney I: Circumvention of drug resistance in human non-small cell lung cancer in vitro by verapamil. Br J Cancer 56: 401-405, 1987.
32. Cornwell MM, Pastan I and Gottesman MM: Certain calcium channel blockers bind specifically to multidrug resistance human KB carcinoma membrane vesicles and inhibit drug binding to P-glycoprotein. J Biol Chem 262: 2166-2170, 1987.
33. Suzuki T, Mori K and Uchida M: Inhibition by calcium antagonists of histamine release and calcium influx of rat mast cells: difference between induction of histamine release by concanavalin A and compound 48/80. Eur J Pharmacol 85: 155-161, 1982.
34. Decorti G, Peloso I, Favarin D, Bartoli Klugmann F, Candussio L, Crivellato E, Mallardi F and Baldini L: Handling of doxorubicin by the LLC-PK1 kidney epithelial cell line. J Pharmacol Exp Ther 286: 525-530, 1998.
35. Urbatsch IL, Al-Shawi MK and Senior AE: Characterization of the ATPase activity of purified Chinese hamster P-glycoprotein. Biochemistry 33: 7069-7076, 1994.
36. McLaren KM and Pepper DS: The immunoelectronmicroscopic localization of human platelet factor 4 in tissue mast cells. Histochem J 15: 795-800, 1983.
37. Decorti G, Candussio L, Bartoli Klugmann F and Baldini L: Binding of aminoglycoside antibiotics by degranulating mast cells. Chemotherapy 43: 36-42, 1997.
38. Aoyama T, Horioka M and Nagamitus S: Macromolecular complex of drugs. 1. Doxorubicin-heparin complex. Chem Pharm Bull (Tokyo) 35: 808-813, 1987.
39. Cofrancesco E, Vigo A and Pogliani E: Anti heparin activity of Adriamycin. Thromb Res 18: 743-746, 1980.
40. Foa P, Cofrancesco E, Lombardi L, Colombi M, Pogliani EM and Polli EE: Non interference by heparin with the cytostatic effect of adriamycin: an in vitro study on a human promyelocytic leukemia cell line. Br J Cancer 48: 735-738, 1983.
41. Kawai K, Kusano I, Ido M, Sakurai M, Shiraishi T and Yatani R: Identification of a P-glycoprotein-related protein (mini-P-glycoprotein) which is overexpressed in multidrug resistant cells. Biochem Biophys Res Commun 198: 804-810, 1994.
42. Heike Y and Tsuruo T: Antibodies in the study of multiple drug resistance. Cytotechnology 12: 91-107, 1993.