Identification of P-glycoprotein at the membrane of mast cell secretory granules. An immunofluorescence and protein A-gold electron microscopical investigation

Histochemical Journal

Volumn 29, Issue 3, 1997, Pages 193-198

  Crivellato, Enrico ^a   Travan, Luciana ^a   Candussio, Luigi ^b   Klugmann, Fiora Bartoli ^b   Decorti, Giuliana ^b  

^a UNIVERSITY OF UDINE   (Italy)

^b UNIVERSITY OF TRIESTE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEIN P;

ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; HUMAN CELL; IMMUNOELECTRON MICROSCOPY; IMMUNOFLUORESCENCE; MAST CELL; NONHUMAN; PRIORITY JOURNAL; RAT; SECRETORY GRANULE;

ANIMALS; CELL MEMBRANE; CYTOPLASMIC GRANULES; EXOCYTOSIS; FLUORESCENT ANTIBODY TECHNIQUE, DIRECT; IMMUNOHISTOCHEMISTRY; MALE; MAST CELLS; MICROSCOPY, IMMUNOELECTRON; P-GLYCOPROTEIN; P-METHOXY-N-METHYLPHENETHYLAMINE; PERITONEUM; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0030982076     PISSN: 00182214     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1026445724699     Document Type: Article

References (24)

1. ARCECI, R.J., CROOP, J.M., HORWITZ, S.B. & HOUSMAN, D. (1988) The gene encoding multidrug resistance is induced and expressed at high levels during pregnancy in the secretory epithelium of the uterus. Proc. Natl. Acad. Sci. USA 85, 4350-4.
2. BECKER, K.F., ALLMEIER, H. & HOLTZ, V. (1992) New mechanisms of hormone secretion: MDR-like gene products as extrusion pumps for hormones. Horm. Metab. Res. 24, 210-4.
3. CHAUDHARY, P.M. & RONNISON, J.B. (1991) Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells. Cell 66, 85-94.
4. CHEN, C.J., CHIN, J.E., UEDA, K., CLARK, D.P., PASTAN, I., GOTTESMAN, M.M. & RONINSON, I.B. (1986) Internal duplication and homology with bacterial transport proteins in the mdr-1 (P-glycoprotein) gene from multidrug-resistant human cells. Cell 47, 381-9.
5. CORDON-CARDO, C., O'BRIEN, J.P., BOCCIA, J., CASALS, D., BERTINO, J.R. & MELAMED, M.R. (1990) Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues. J. Histochem. Cytochem. 38, 1277-87.
6. ENDICOTT, J.A. & LING, V. (1989) The biochemistry of P-glycoprotein mediated multidrug resistance. Annu. Rev. Biochem. 58, 137-71.
7. EZEAMUZIE, J.C. & ASSEM, E.S.K. (1990) Inhibition of histamine release from human lung and rat peritoneal mast cells by cyclosporin A. Agents Actions 30, 110-3.
8. GALLI, S.J. (1993) New concepts about the mast cell. N. Engl. J. Med. 328, 257-65.
9. GOTTESMAN, M.M. & PASTAN, I. (1988) The multidrug transporter, a double-edged sword. J. Biol. Chem. 263, 12163-6.
10. GUPTA, S. & AGGARWAL, S. (1995) Role of P-glycoprotein in the secretion of basic fibroblast growth factor. J. Allergy Clin. Immunol. 95, 345.
11. GUPTA, S. & GOLLAPUDI, S. (1993) P-glycoprotein (MDR 1 gene product) in cells of the immune system: its possible physiologic role in ageing and human immunodeficiency virus-1 (HIV-1) infection. J. Clin. Immunol. 13, 289-301.
12. GUPTA, S., KIM, C.H., TSURUO, T. & GOLLAPUDI, S. (1992) Preferential expression of multidrug resistance gene 1 product (P-glycoprotein), a functionally active efflux pump, in human CD8+ T cells. A role in cytotoxic effector function. J. Clin. Immunol. 12, 451-8.
13. KRISHAN, A., SAUERTEIG, A. & STEIN, J.H. (1991) Comparison of three commercially available antibodies for flow cytometric monitoring of P-glycoprotein expression in tumor cells. Cytometry 12, 731-42.
14. METCALFE, D.D., KALINER, M. & DONLON, M.A. (1981) The mast cell. CRC Crit. Rev. Immunol. 3, 23-74.
15. SCHEPER, R.J., BULTE, J.W., BRAKKEE, J.G., QUAK, J.J., VAN DER SCHOOT, E., BALM, A.J., MEIJER, C.J., BROXTERMAN, H.J., KUIPER, C.M., LANKELMA, J. & PINEDO, H.M. (1988) Monoclonal antibody JSB-1 detects a highly conserved epitope on the P-glycoprotein associated multi-drug resistance. Int. J. Cancer 42, 389-94.
16. SLOT, J.W. & GEUZE, H.J. (1981) Sizing of protein A-colloidal gold probes for immunoelectron microscopy. J. Cell. Biol. 90, 533-6.
17. SUGAWARA, I., KATAOKA, I., MORISHITA, Y., HAMADA, H., TSURUO, T., ITOYAMA, S. & MORI, S. (1988) Tissue distribution of P-glycoprotein encoded by a multidrug-resistant gene as revealed by a monoclonal antibody, MRK 16. Cancer Res. 48, 1926-9.
18. THIEBAUT, F., TSURUO, T., HAMADA, H., GOTTESMAN, M.M., PASTAN, I. & WILLINGHAM, M.C. (1987) Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues. Proc. Natl. Acad. Sci. USA 84, 7735-8.
19. THIEBAUT, F., TSURUO, T., HAMADA, H., GOTTESMAN, M.M., PASTAN, I. & WILLINGHAM, M.C. (1989) Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein. J. Histochem. Cytochem. 37, 159-64.
20. VAN DER BLIEK, A.M., KOOIMAN, P.M., SCHNEIDER, C. & BORST, P. (1988) Sequence of mdr3 cDNA encoding a human P-glycoprotein. Gene 71, 401-11.
21. WASSERMAN, S.I. & MARQUARDT, D. (1986) The utility of mouse cultured mast cells in the analysis of biochemical regulation, mediator generation, and drug effects. In Mast Cell Differentiation and Heterogenity (edited by BEFUS, A.D., BIENENSTOCK, J. & DENBURG, J.A.), pp. 323-9. New York: Raven Press.
22. WEIN, D. & GUPTA, S. (1996) Expression of P-glycoprotein, encoded by MDR 1 gene, a metabolically active efflux pump in murine mast cells. Cancer Lett. 101, 241-6.
23. WILLINGHAM, M.C., RICHERT, N.D., CORNWELL, M.M., TSURUO, T., HAMADA, H., GOTTESMAN, M.M. & PASTAN, I. (1987) Immunocytochemical localization of P170 at the plasma membrane of multidrug-resistant human cells. J. Histochem. Cytochem. 35, 1451-6.
24. YOUNG, P.R. & KRASNEY, P.A. (1992) Stimulation of interleukin 1β secretion in monkey kidney cells by coexpression of the mammalian P-glycoprotein MDR 1. In Pathophysiology and Pharmacology of Cytokines (edited by GHEZZI, P. & MANTOVANI, A.), pp. 21-7. Biomedical Press.