YAP1 confers resistance to the fatty acid synthase inhibitor cerulenin through the transporter Flr1p in Saccharomyces cerevisiae

Molecular and General Genetics

Volumn 261, Issue 2, 1999, Pages 346-353

  Oskouian, B ^a   Saba, J D ^a  

^a CHILDREN S HOSPITAL OAKLAND RESEARCH INSTITUTE   (United States)

Author keywords

(Cer(R)); Cerulenin resistance; FLR1; YAP1; YCF1; Yeast

Indexed keywords

ABC TRANSPORTER; ALCOHOL DEHYDROGENASE; CERULENIN; FATTY ACID SYNTHASE; GLUTATHIONE REDUCTASE;

ARTICLE; GENE OVEREXPRESSION; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE;

ANTIBIOTICS, ANTIFUNGAL; ATP-BINDING CASSETTE TRANSPORTERS; CARRIER PROTEINS; CERULENIN; DNA-BINDING PROTEINS; DRUG RESISTANCE, MICROBIAL; ENZYME INHIBITORS; FATTY ACID SYNTHETASE COMPLEX; FUNGAL PROTEINS; MEMBRANE TRANSPORT PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TRANSCRIPTION FACTORS;

EUKARYOTA; SACCHAROMYCES CEREVISIAE;

EID: 0032996479     PISSN: 00268925     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004380050975     Document Type: Article

References (40)

1. Alarco AM, Balan I, Talibi D, Mainville N, Raymond M (1997) AP1-mediated multidrug resistance in Saccharomyces cerevisiae requires FLR1 encoding a transporter of the major facilitator superfamily. J Biol Chem 272:19304-19313
2. Bossier P, Fernandes L, Rocha D, Rodrigues-Pousada C (1993) Overexpression of YAP2, coding for a new yAP protein, and YAP1 in Saccharomyces cerevisiae alleviates growth inhibition caused by 1,10-phenanthroline. J Biol Chem 268:23640-23645
3. DeRisi JL, Iyer VR, Brown PO (1997) Exploring the metabolic and genetic control of gene expression on a genomic scale. Science 278:680-686
4. Duronio RJ, Knoll LJ, Gordon JI (1992) Isolation of a Saccharomyces cerevisiae long-chain fatty acyl:CoA synthase gene (FAA). J Cell Biol 117:515-529
5. Giaever GN, Shoemaker DD, Davis RW (1998) Heterozygous yeast strains reveal haploinsufficiencies in the presence of drugs: a genomic method for drug target identification. Abstract, Yeast Genetics and Molecular Biology Meeting, College Park, Md.
6. Gömpel-Klein P, Brendel M (1990) Allelism of SNQ1 and ATR1, genes of the yeast Saccharomyces cerevisiae required for controlling sensitivity to 4-nitroquinolone-N-oxide and aminotriazole. Curr Genet 18:93-96
7. Gömpel-Klein P, Mack M, Brendel M (1989) Molecular characterization of the two genes SNQ and SFA that confer hyper-resistance to 4-nitroquinolone-N-oxide and formaldehyde in Saccharomyces cerevisiae. Curr Genet 16:65-74
8. Gounalaki N, Thireos G (1994) Yaplp, a yeast transcriptional activator that mediates multidrug resistance, regulates the metabolic stress response. EMBO J 13:4036-4041
9. Grey M, Brendel M (1994) Overexpression of the SNQ3/YAP1 gene confers hyper-resistance to nitrosoguanidine in Saccharomyces cerevisiae via a glutathione-independent mechanism. Curr Genet 25:469-471
10. Heitman J, Rao NM, Hiestand PC, Hall M (1991) FK 506-binding protein proline rotamase is a target for the immunosuppressive agent FK 506 in Saccharomyces cerevisiae. Proc Natl Acad Sci USA 88:1948-1952
11. Hirata D, Yano K, Miyakawa T (1994) Saccharomyces cerevisiae YDR1, which encodes a member of the ATP-binding (ABC) superfamily, is required for multidrug resistance. Curr Genet 26:285-294
12. Hussain M, Lenard J (1991) Characterization of PDR4, a Saccharomyces cerevisiae gene that confers pleiotropic drug resistance in high-copy number: identity with YAP1, encoding a transcriptional activator. Gene 101:149-152
13. Inokoshi J, Tomoda H, Hashimoto H, Watanabe A, Takeshima H, Omura S (1994) Cerulenin-resistant mutants of Saccharomyces cerevisiae with an altered fatty acid synthase gene. Mol Gen Genet 244:90-96
14. Ito H, Fukuda Y, Murata K, Kimura A (1983) Transformation of intact yeast cells treated with alkali cations. J. Bacteriol 153:163-168
15. Johnson DR, Knoll LJ, Levin DE, Gordon JI (1994a) Saccharomyces cerevisiae contains four fatty acid activation (FAA) genes: an assessment of their role in regulating protein N-myristoylation and cellular lipid metabolism. J Cell Biol 127:751-762
16. Johnson DR, Knoll LJ, Rowley N, Gordon JI (1994b) Genetic analysis of the role of Saccharomyces cerevisiae acyl CoA synthase genes in regulating protein N-myristoylation. J Biol Chem 269:18037-18046
17. Kanazawa S, Driscoll M, Struhl K (1988) ATR1, a Saccharomyces cerevisiae gene encoding a transmembrane protein required for aminotriazole resistance. Mol Cell Biol 8:664-673
18. Kuge S, Jones N (1994) YAP1-dependent activation of TRX2 is essential for the response of Saccharomyces cerevisiae to oxidative stress by hydroperoxides. EMBO J 13:655-664
19. Kuhajda FP, Jenner K, Wood FD, Hennigar RA, Jacobs LB, Dick JD, Pasternack GR (1994) Fatty acid synthesis: a potential selective target for antineoplastic therapy. Proc Natl Acad Sci USA 91:6379-6383
20. Li ZS, Szczypa M, Lu YP, Thiele DJ, Rea PA (1996) The yeast cadmium factor protein (YCF1) is a vacuolar gluthatione S-conjugate pump. J Biol Chem 271:6509-6517
21. Li ZS, Lu YP, Zhen RG, Szczypa M, Thiele DJ, Rea PA (1997) A new pathway for vacuolar cadmium sequestration in Saccharomyces cerevisiae: YCF1-catalyzed transport of bis(glutathionato)cadmium. Proc Natl Acad Sci USA 94:42-47
22. McElhaney-Feser GE, Cihlar RL (1995) Basis of cerulenin resistance of two strains of Candida albicans. Microbiology 141:1553-1558
23. Miyahara K, Hirata D, Miyakawa T (1996) yAP-1 and yAP-2-mediated, heat shock-induced transcriptional activation of the multidrug resistance ABC transporter genes in Saccharomyces cerevisiae. Curr Genet 29:103-105
24. Moye-Rowley WS, Harshman KD, Parker CS (1988) YAP1 encodes a yeast homolog of mammalian transcription factor AP-1. Cold Spring Harb Symp Quant Biol 53:711-717
25. Moye-Rowley WS, Harshman KD, Parker CS (1989) Yeast YAP1 encodes a novel form of the jun family of transcriptional activator proteins. Genes Dev 3:283-292
26. Mumberg D, Muller R, Funk M (1995) Yeast vectors for the controlled expression of heterologous proteins in different genetic backgrounds. Gene 156:119-122
27. Omura S (1976) The antibiotic cerulenin, a novel tool for biochemistry as an inhibitor of fatty acid synthase. Bacteriol Rev 40:681-697
28. Pizer ES, Jackisch C, Wood FD, Pasternack GR, Davidson NE, Kuhajda FP (1996a) Inhibition of fatty acid synthesis induces programmed cell death in human breast cancer cells. Cancer Res 56:2745-2747
29. Pizer ES, Wood FD, Heine HS, Romantsev FE, Pasternack GR, Kuhajda FP (1996b) Inhibition of fatty acid synthesis delays disease progression in a xenograft model of ovarian cancer. Cancer Res 56:1189-1193
30. Pizer ES, Wood FD, Pasternack GR, Kuhajda F (1996c) Fatty acid synthase (FAS): a target for cytotoxic antimetabolites in HL60 promyelocytic leukemia cells. Cancer Res 56:745-751
31. Saermark T, Kleinschmidt A, Wulff AM, Andreassen, H, Magee A, Erfle V (1991) Characterization of N-myristoyl transferase inhibitors and their effect on HIV release. AIDS 5:951-958
32. Saitoh S, Takahashi K, Nabeshima J, Yamashita Y, Nakeseko Y, Hirata A, Yanagida M (1996) Aberrant mitosis in fission yeast mutants defective in fatty acid synthetase and acetyl CoA carboxylase. J Cell Biol 134:949-961
33. Sanger F, Nicklen S, Coulson AR (1977) DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci USA 74:5463-5467
34. Sanglard D, Ischer F, Monod M, Bille J (1996) Susceptibilities of Candida albicans multidrug transporter mutants to various antifungal agents and other metabolic inhibitors. Antimicrob Agents Chemother 40:2300-2305
35. Schnell N, Entian KD (1991) Identification and characterization of a Saccharomyces cerevisiae gene (PAR1) conferring resistance to iron chelators. Eur J Biochem 200:487-493
36. Sikorski RS, Hieter P (1989) A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 122:19-27
37. Stephen DW, Rivers SL, Jamieson DJ (1995) The role of the YAP1 and YAP2 genes in the regulation of the adaptive oxidative stress responses of Saccharomyces cerevisiae. Mol Microbiol 16:415-423
38. Wemmie JA, Szczpka MS, Thiele DJ, Moye-Rowley WS (1994a) Cadmium tolerance mediated by the yeast AP-1 protein requires the presence of an ATP-binding cassette transporter-encoding gene, YCF1. J Biol Chem 269:32592-32597
39. Wemmie JA, Wu AL, Harshman KD, Parker CS, Moye-Rowley WS (1994b) Transcriptional activation mediated by the yeast AP-1 protein is required for normal cadmium tolerance. J Biol Chem 269:14690-14697
40. Wendler F, Bergler H, Prutej K, Jungwirth H, Zisser G, Kuchler K, Hogenauer G (1997) Diazaborine resistance in the yeast Saccharomyces cerevisiae reveals a link between YAP1 and the pleiotropic drug resistance genes PDR1 and PDR3. J Biol Chem 272:27091-27098