Irradiation of singly and doubly transduced murine neuroblastoma cells expressing B7-1 and producing interferon-gamma reduces their capacity to induce systemic immunity

Cancer Gene Therapy

Volumn 3, Issue 2, 1996, Pages 75-82

  Katsanis, Emmanuel ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

B7 1; Interferon gamma; Irradiation; Major histocompatibility complex class i; Neuroblastoma

Indexed keywords

B7 ANTIGEN; GAMMA INTERFERON;

ANIMAL; ARTICLE; BIOSYNTHESIS; CD4 CD8 RATIO; CELL CULTURE; CELLULAR IMMUNITY; EXPERIMENTAL NEOPLASM; FEMALE; GENETIC TRANSDUCTION; IMMUNOLOGY; MAJOR HISTOCOMPATIBILITY COMPLEX; METABOLISM; MOUSE; NEUROBLASTOMA; RADIATION EXPOSURE; RADIATION RESPONSE; SECRETION; SURVIVAL RATE; UPREGULATION;

ANIMALS; ANTIGENS, CD80; CD4-CD8 RATIO; DOSE-RESPONSE RELATIONSHIP, RADIATION; FEMALE; IMMUNITY, CELLULAR; INTERFERON TYPE II; MAJOR HISTOCOMPATIBILITY COMPLEX; MICE; NEOPLASMS, EXPERIMENTAL; NEUROBLASTOMA; SURVIVAL RATE; TRANSDUCTION, GENETIC; TUMOR CELLS, CULTURED; UP-REGULATION;

EID: 0030101636     PISSN: 09291903     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (4)

1. Lampson LA, Fisher CA, Whelan JP. Striking paucity of HLA-A, B, C and beta 2-microglobuIin on human neuroblastoma cell lines. J Immunol. 1983;130:2471-2478.
2. Main EK, Lampson LA, Hart MK, Kornbluth J, Wilson DB. Human neuroblastoma cell lines are susceptible to lysis by natural killer cells but not by cytotoxic T lymphocytes. J Immunol. 1985;135:242-246.
3. Zier KS, Pierson GR, Brown V. Susceptibility of human neuroblastoma cell lines to cytotoxic T lymphocyte-mediated lysis. J Neuroimmunol 1990;28:153-160.
4. Restifo NP, Spiess PJ, Karp SE, Mule JJ, Rosenberg SA. A nonimmunogenic sarcoma transduced with the cDNA for interferon gamma elicits CD8+ T cells against the wild-type tumor: correlation with antigen presentation capability. J Exp Med. 1992;175:1423-1431.