Amino acid changes affecting the activity of pneumolysin alter the behaviour of pneumococci in pneumonia

Microbial Pathogenesis

Volumn 24, Issue 3, 1998, Pages 167-174

  Alexander, Janet E ^a   Berry, Anne M ^b   Paton, James C ^b   Rubins, Jeffrey B ^c   Andrew, Peter W ^a   Mitchell, Timothy J ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b WOMEN S AND CHILDREN S HOSPITAL   (Australia)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Pneumolysin; Pneumonia; Streptococcus pneumoniae

Indexed keywords

PNEUMOLYSIN;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COMPLEMENT ACTIVATION; CONTROLLED STUDY; CYTOTOXICITY; FEMALE; HEMOLYSIS; MOUSE; MUTANT; NONHUMAN; PATHOGENESIS; PNEUMONIA; POINT MUTATION; PRIORITY JOURNAL; STREPTOCOCCUS PNEUMONIAE; VIRULENCE;

ANIMALIA; POSIBACTERIA; STREPTOCOCCUS PNEUMONIAE;

EID: 0031885031     PISSN: 08824010     EISSN: None     Source Type: Journal    
DOI: 10.1006/mpat.1997.0185     Document Type: Article

References (15)

1. Canvin JR, Marvin AP, Sivakumaran M. et al. The role of pneumolysin and autolysin in the pathology of pneumonia and septicaemia in mice infected with a type 2 pneumococcus. J Infect Dis 1995; 172: 119-23.
2. Rubins J, Charboneau D, Paton JC, Mitchell TJ, Andrew PW, Janoff EN. Dual function of pneumolysin in the early pathogenesis of murine pneumococcal pneumonia. J Clin Invest 1994; 95: 142-50.
3. Mitchell TJ, Andrew PW, Boulnois GJ, Lee C-J, Lock RA, Paton JC. Molecular studies of pneumolysin as an aid to vaccine design. Zbl Bakt 1992; 23: 429-38.
4. Mitchell TJ, Andrew PW, Saunders FK, Smith AN, Boulnois GJ. Complement activation and antibody binding by pneumolysin via a region homologous to a human acute phase protein. Molec Micro 1991; 5: 1883-8.
5. Toumanen E, Tomasz A, Hengstler B, Zak O. Induction of pulmonary inflammation by components of the pneumococcal cell surface. Am Rev Resp Dis 1987; 135: 869-74.
6. Friedland IR, Paris MM, Hickey S. et al. The limited role of pneumolysin in the pathogenesis of pneumococcal meningitis. J Infect Dis 1995; 172: 805-9.
7. Comis SD, Osborne MP, Stephen J. et al. Cytotoxic effects on hair cells of guinea pig cochlea produced by pneumolysin, the thiol activated toxin of Streptococcus pneumoniae. Acta Otolaryngol 1993; 113: 152-9.
8. Benton KA, Everson MP, Briles DE. A pneumolysin negative mutant of Streptococcus pneumoniae causes chronic bacteremia rather than acute sepsis in mice. Infect Immun 1995; 63: 448-55.
9. Rubins J, Charboneau D, Fashing C. et al. Distinct roles for pneumolysin's cytotoxic and complement activities in the pathogenesis of pneumococcal pneumonia. Amer J Resp Crit Care Med 1996; 153: 1339-46.
10. Berry AM, Alexander JE, Mitchell TJ, Andrew PW, Hansman D, Paton JC. Effect of defined point mutations in the pneumolysin gene on the virulence of Streptococcus pneumoniae. Infect Immun 1995; 63: 1969-74.
11. Alexander JE, Lock RA, Peeters CCAM, et al. Immunization of mice with pneumolysin toxoid confers a significant degree of protection against at least nine serotypes of Streptococcus pneumoniae. Infect Immun 1994; 62: 5683-8.
12. Berry AM, Yother J, Briles DE, Hansman D, Paton JC. Reduced virulence of a defined pneumolysin-negative mutant of Streptococcus pneumoniae. Infect Immun 1989; 57: 2037-42.
13. Johnson MK. Properties of purified pneumolysin. FEMS Lett 1972; 2: 243-5.
14. Jalonen E, Paton JC, Koskela M, Kerttula Y, Leinonen M. Measurement of antibody responses to pneumolysin - a promising method for the etiological diagnosis of pneumococcal pneumonia. J Infect Dis 1989; 19: 127-34.
15. Hill J, Andrew PW, Mitchell TJ. Amino acids in pneumolysin important for hemolytic activity identified by random mutagenesis. Infect Immun 1994; 62: 757-8.