Synthesis of carbon-14 labelled 2-amino-9-(3-hydroxymethyl-4-isopropoxycarbonyloxybut-1-yl)purine (SK 1875), a potential prodrug of penciclovir

Journal of Labelled Compounds and Radiopharmaceuticals

Volumn 42, Issue 6, 1999, Pages 597-604

  Kim, Dae Kee ^a   Lee, Junwon ^a   Kim, Youngseok ^a   Lee, Namkyu ^a   Kim, Young Woo ^a   Chang, Kieyoung ^a   Kim, Jae Sun ^a   Lee, Kiseung ^a   Kim, Key H ^a  

^a SK Chemicals   (South Korea)

Author keywords

2 Amino 9 (3 hydroxy 14C methyl 4 isopropoxycarbonyloxybut 1 yl)purine; Antiviral agent; Radiosynthesis; SK 1875 14C

Indexed keywords

2-AMINO-9-(3-HYDROXY[14C]METHYL-4-ISOPROPOXYCARBONYLOXYBUT-1-YL)PURINE; CARBON 14; DIETHYL MALONATES; PENCICLOVIR; PRODRUGS; RADIOCHEMICAL PURITY; RADIOCHEMICAL YIELD; RADIOSYNTHESIS; SK 1875 [14C]; STEP SEQUENCES;

ANTIVIRAL AGENTS;

CARBON 14; MALONIC ACID; PENCICLOVIR; PRODRUG; PURINE DERIVATIVE; SK 1875; UNCLASSIFIED DRUG;

ARTICLE; HUMAN; RADIOCHEMISTRY; SYNTHESIS;

EID: 0032994667     PISSN: 03624803     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1099-1344(199906)42:6<597::aid-jlcr220>3.0.co;2-#     Document Type: Article

References (20)

1. Harnden, M. R., Jarvest, R. L., Bacon, T. H., and Boyd, M. R. - J. Med. Chem. 30: 1636 (1987).
2. Boyd, M. R., Bacon, T. H., Sutton, D., and Cole, M. - Antimicrob. Agents Chemother. 31: 1238 (1987).
3. Boyd, M. R., Bacon, T. H., and Sutton, D. - Antimicrob. Agents Chemother. 32: 358 (1988).
4. Sutton, D., and Boyd, M. R. - Antimicrob. Agents Chemother. 37: 642 (1993).
5. Korba, B. E., and Boyd, M. R. - Antimicrob. Agents Chemother. 40: 1282 (1996).
6. Jacobson, M. A., de Miranda, P., Cederberg, D. M., Burnett, T., Cobb, E., Brodie, H. R., and Mills, J. - Antimicrob. Agents Chemother. 31: 1251 (1987).
7. Boyd, M. R., Safrin, S., and Kern, E. R. - Antiviral Chem. Chemother. 4 (Suppl. 1): 3 (1993).
8. Bacon, T. H., and Schinazi, R. F. - Antiviral Chem. Chemother. 4 (Suppl. 1): 25 (1993).
9. de Miranda, P., Krasny, H. C., Page, D. A., and Elion, G. B. - J. Pharmacol. Exp. Ther. 219: 309 (1981).
10. Jacobson, M. A., de Miranda, P., Cederberg, D. M., Burnette, T., Cobb, E., Brodie, H, R., and Mills, J. - Antimicrob. Agents Chemother. 31: 1251 (1987).
11. Larsson, A., Stenberg, K.. Ericson, A.-C., Haglund, U., Yisak, W.-A., Johansson, N. G., Öberg, B., and Datema, R. - Antimicrob. Agents Chemother. 30: 598 (1986).
12. Harnden, M. R., Jarvest, R. L., Boyd, M. R., Sutton, D., and Vere Hodge, R. A. - J. Med. Chem. 32: 1738 (1989).
13. Vere Hodge, R. A., Sutton, D., Boyd, M. R., Harnden, M. R., and Jarvest, R. L. -Antimicrob. Agents Chemother. 33: 1765 (1989).
14. Pue, M. A., and Benet, L. Z. - Antiviral Chem. Chemother. 4 (Suppl. 1): 47 (1993).
15. Tsiquaye, K. N., Slomka, M. J., and Maung, M. - J. Med. Virol. 42: 306 (1994).
16. Krüger, M., Tillmann, H. L, Trautwein, C., Bode, U., Oldhafer, K., Böker, K. H. W., Pichlmayr, R., and Manns, M. P. - In Proceedings of the American Association for the Study of Liver Disease: 45th Annual Meeting p. 134 (1994).
17. Böker, K. H. W., Ringe, B., Krüger, M., Pichlmayr, R., and Manns, M. P. -Transplantation 57: 1706 (1994).
18. Main, J., Brown, J. L., Karayiannis, P., Georgiou, P., Boyd, M., Prince, W., and Thomas H. - J. Hepatol. 21 (Suppl. 1): S32 (1994).
19. Kim, D.-K., Lee, N., Im, G.-J., Kim, Y.-W., Chang, K., Kim, H.-T., Cho, Y.-B., Choi, W.-S., Jung, I., and Kim, K. H. - Bioorg. Med. Chem. Lett. 6: 1849 (1996).
20. Kim, D.-K, Lee, N., Kim, Y.-W., Chang, K., Kim, J.-S., Im, G.-J., Choi, W.-S., Jung, I.. Kim, T.-S., Hwang, Y.-Y., Min, D.-S., Um, K. A., Choi, Y.-B., and Kim, K. H. - J. Med. Chem. 41: 3435 (1998).