Functional inactivation of p53 by HPV-E6 transformation is associated with a reduced expression of radiation-induced potentially lethal damage

International Journal of Radiation Biology

Volumn 75, Issue 3, 1999, Pages 285-291

  Schwartz, J L ^a   Rasey, J ^a   Wiens, L ^a   Jordan, R ^a   Russell, K J ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53;

ARTICLE; CELL CYCLE G1 PHASE; CELL DEATH; CELL KILLING; CELL SURVIVAL; HUMAN; HUMAN CELL; MEDIATOR RELEASE; PRIORITY JOURNAL; RADIATION EXPOSURE; RADIATION INJURY; RADIOSENSITIVITY; TUMOR CELL LINE; VIRUS INACTIVATION; VIRUS TRANSFORMATION; WART VIRUS;

HUMAN PAPILLOMAVIRUS TYPES;

EID: 0032992771     PISSN: 09553002     EISSN: None     Source Type: Journal    
DOI: 10.1080/095530099140465     Document Type: Article

References (27)

1. BRACHMAN, D. G., BECKETT, M., GRAVES, D., HARAF, D., VOKES, E. and WEICHSELBAUM, R. R., 1993, p53 mutation does not correlate with radiosensitivity in 24 head and neck cancer cell lines. Cancer Research, 53, 3667-3669.
2. BRISTOW, R. G., BENCHIMOL, S. and HILL, R. P., 1996, The p53 gene as a modifier of intrinsic radiosensitivity: implications for radiotherapy. Radiotherapy and Oncology, 40, 197-223.
3. CLARKE, A. R., PURDIE, C. A., HARRISON, D. J., MORRIS, R. G., BIRD, C. C., HOOPER, M. L. and WYLLIE, A. H., 1993, Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature, 362, 849-852.
4. CORNFORTH, M. N. and BEDFORD, J. S., 1987, A quantitative comparison of potentially lethal damage repair and the rejoining of interphase chromosome breaks in low passage normal human fibroblasts. Radiation Research, 111, 385-405.
5. 1 arrest and long-term induction of Cip 1 in normal human fibroblasts. Genes and Development, 8, 2540-2551.
6. GADBOIS, D. M., BRADBURY, E. M. and LEHNERT, B. E., 1997, Control of radiation-induced G1 arrest by cell-substratum interactions. Cancer Research, 57, 1151-1156.
7. GORCZYCA, W., 1993, Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase and nick translation assays. Cancer Research, 53, 1-7.
8. GUICHARD, M., WEICHSELBAUM, R. R., LITTLE, J. B. and MALAISE, E. P., 1984, Potentially lethal damage repair as a possible determinant of human tumour radiosensitivity. Radiotherapy and Oncology, 1, 263-269.
9. HENDRY, J. H., CAI, W. B., ROBERTS, S. A. and POTTEN, C. S., 1997, p53 deficiency sensitizes clonogenic cells to irradiation in the large but not the small intestine. Radiation Research, 148, 254-259.
10. HUANG, H., LI, C-Y. and LITTLE, J.B., 1996, Abrogation of p53 function by transfection of HPV16 E6 gene does not enhance resistance of human tumour cells to ionizing radiation. International Journal of Radiation Biology, 70, 151-160.
11. ILIAKIS, G., 1988, Radiation-induced potentially lethal damage: DNA lesions susceptible to fixation. International Journal of Radiation Biology, 53, 541-584.
12. KASTAN, M. B., ONYEKEWERE, D., SIDRANSKY, D. and VOLGELSTEIN, B., 1991, Participation of p53 protein in the cellular response to DNA damage. Cancer Research, 51, 6304-6311.
13. KESSIS, T. D., SLEBOS, R. J., NELSON, W. G., KASTAN, M. B., PLUNKETT, B. S., HAN, S. M., LORINES, T., HEDRICK, L. and CHO, K. R., 1993, Human papillomavirus 16 E6 expression disrupts the p53-mediated cellular response to DNA damage. Proceedings of the National Academy of Sciences, USA, 90, 3988-3992.
14. KUERBITZ, S. J., PLUNKETT, B. S., WALSH, W. V. and KASTAN, M. B., 1992, Wild-type p53 is a cell cycle checkpoint determinant following irradiation. Proceedings of the National Academy of Sciences, USA, 89, 7491-7495.
15. LEE, J. M. and BERNSTEIN, A., 1993, p53 mutations increase resistance to ionizing radiation. Proceedings of the National Academy of Sciences, USA, 90, 5742-5746.
16. LINKE, S. P., CLARKIN, K. C. and WAHL, G. M., 1997, p53 mediates permanent arrest over multiple cell cycles in response to γ-irradiation. Cancer Research, 57, 1171-1179.
17. LOWE, S. W., SCHMITT, E. M., SMITH, S. W., OSBORNE, B. A. and JACKS, T., 1993, p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature, 362, 847-849.
18. NELSON W. G. and KASTAN, M. B., 1994. DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways. Molecular and Cell Biology, 14, 1815-1823.
19. NIGRO, J. M., ALDAPE, K. D., HESS, S. M. and TLSTY, T. D., 1997, Cellular adhesion regulates p53 protein levels in primary human keratinocytes, Cancer Research, 57, 3635-3639.
20. 1 checkpoint-competent cells. Cancer Research, 55, 1639-1642.
21. SCHWARTZ, J. L., JORDAN, R., SEDITA, B. A., SWENNINGSON, M. J., BANÁTH, J. P. and OLIVE, P. L., 1995, Different sensitivity to cell killing and chromosome mutation induction by gamma rays in two human lymphoblastoid cell lines derived from a single donor: Possible role of apoptosis. Mutagenesis, 10, 227-233.
22. TERASIMA, R. and TOLMACH, L. J., 1963, X-ray sensitivity and DNA synthesis in synchronous populations of HeLa cells. Science, 140, 490-492.
23. TSANG, N.-M., NAGASAWA, H., LI, C.-Y. and LITTLE, J. B., 1995, Abrogation of p53 function by transfection of HPV16 E6 gene enhances the resistance of human fibroblasts to ionizing radiation. Oncogene, 10, 2403-2408.
24. WEICHSELBAUM, R. R. and BECKETT, M. A., 1987, The maximum recovery potential of human tumor cells may predict clinical outcome in radiotherapy. International Journal of Radiation Oncology, Biology, and Physics, 13, 709-713.
25. WEICHSELBAUM, R. R., DAHLBERG, W., LITTLE, J. B., ERVIN, T. J., MILLER, D., HELLMAN, S. and REINWALD, J. G., 1984, Cellular x-ray repair parameters of early passage squamous cell carcinoma cell lines derived from patients with known responses to radiotherapy. British Journal of Cancer, 49, 595-601.
26. WERNESS, B. A., LEVINE, A. J. and HOWLEY, P. M., 1990, Association of human papillomavirus types 16 and 18 E6 proteins with p53. Science, 248, 76-79.
27. YOUNT, G. L., HAAS-KIGAN, D. A., VIDAIR, C. A., HAAS, M., DEWEY, W. C. and ISRAEL, M. A., 1996, Cell cycle synchrony unmasks the influence of p53 function on radiosensitivity of human glioblastoma cells. Cancer Research, 56, 500-506.