Intracellular interferon-gamma (IFN-γ) production in normal children and children with atopic dermatitis

Clinical and Experimental Immunology

Volumn 115, Issue 3, 1999, Pages 377-382

  Campbell, D E ^b   Fryga, A S ^a   Bol, S ^a   Kemp, A S ^a  

^a ROYAL CHILDREN'S HOSPITAL   (Australia)

^b NONE

Author keywords

Atopic dermatitis; Children; Interferon gamma; Intracellular

Indexed keywords

GAMMA INTERFERON; STAPHYLOCOCCUS ENTEROTOXIN B;

ARTICLE; ATOPIC DERMATITIS; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; HELPER CELL; HUMAN; HUMAN CELL; INTERFERON PRODUCTION; LEUKOCYTE ACTIVATION; LEUKOCYTE COUNT; MONONUCLEAR CELL; NATURAL KILLER CELL; NONHUMAN; PATHOPHYSIOLOGY; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN SYNTHESIS INHIBITION; STAPHYLOCOCCUS AUREUS; T LYMPHOCYTE SUBPOPULATION;

CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; DERMATITIS, ATOPIC; ENTEROTOXINS; HUMANS; INFANT; INFANT, NEWBORN; INTERFERON TYPE II; INTRACELLULAR FLUID; LEUKOCYTES, MONONUCLEAR; STAPHYLOCOCCUS AUREUS; T-LYMPHOCYTE SUBSETS;

EID: 0032991043     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.1999.00814.x     Document Type: Article

References (26)

1. Tang ML, Kemp AS, Thorburn J, Hill DJ. Reduced interferon-gamma secretion in neonates and subsequent atopy. Lancet 1994; 344:983-5.
2. Warner JA, Miles EA, Jones AC, Quint DJ, Colwell BM, Warner JO. Is deficiency of interferon gamma production by allergen triggered cord blood cells a predictor of atopic eczema? Clin Exp Allergy 1994; 24:423-30.
3. Jujo K, Renz H, Abe J, Gelfand EW, Leung DY. Decreased interferon gamma and increased interleukin-4 production in atopic dermatitis promotes IgE synthesis. J Allergy Clin Immunol 1992; 90:323-31.
4. Reinhold U, Wehrmann W, Kukel S, Kreysel HW. Evidence that defective interferon-gamma production in atopic dermatitis patients is due to intrinsic abnormalities. Clin Exp Immunol 1990; 79:374-9.
5. Tang M, Kemp A, Varigos G. IL4 and interferon-gamma production in children with atopic disease. Clin Exp Immunol 1993; 92:120-4.
6. Katagiri K, Itami S, Hatano Y, Takayasu S. Increased levels of IL-13 mRNA, but not IL-4 mRNA, are found in vivo in peripheral blood mononuclear cells (PBMC) of patients with atopic dermatitis. Clin Exp Immunol 1997; 108:289-94.
7. Jung T, Lack G, Schauer U et al. Decreased frequency of interferon-gamma- and interleukin-2-producing cells in patients with atopic diseases measured at the single cell level. J Allergy Clin Immunol 1995; 96:515-27.
8. Nakazawa M, Sugi N, Kawaguchi H, Ishii N, Nakajima H, Minami M. Predominance of type 2 cytokine-producing CD4+ and CD8+ cells in patients with atopic dermatitis. J Allergy Clin Immunol 1997;99:673-82.
9. Frenkel L, Bryson YJ. Ontogeny of phytohemagglutinin-induced gamma interferon by leukocytes of healthy infants and children: evidence for decreased production in infants younger than 2 months of age. J Pediatr 1987; 111:97-100.
10. Tang ML, Varigos G, Kemp AS. Reduced interferon-gamma (IFN-gamma) secretion with increased IFN-gamma mRNA expression in alopic dermatitis: evidence for a post-transcriptional defect. Clin Exp Immumol 1994; 97:483-90.
11. Hagiwara E, Abbasi F, Ishigatsubo Y, Klinnan D. Phenotype and frequency of cells secreting IL-2, IL-4, IL-6, IL-10, INF and TNF-alpha in human peripheral blood. Cytokine 1995;7:815-22.
12. Prussin C, Metcalfe D. Detection of intracytoplasmic cytokine using flow cytometry and directly conjugated anti-cytokine antibodies. J Immunol Methods 1995; 188:117-28.
13. Jung T, Schauer U, Heusser C, Neumann C, Rieger C. Detection of intracellular cytokines by flow cytometry. J Immunol Methods 1993; 159:197-207.
14. Fujiwara T, Oda K, Yokota S, Takatsuki A, Ikehara Y. Brefeldin A causes disassembly of the Golgi complex and accumulation of secretory proteins in the endoplasmic reticulum. J Biol Chem 1988; 263:18545-52.
15. Leung DY, Harbeck R, Bina P et al. Presence of IgE antibodies to staphylococcal exotoxins on the skin of patients with atopic dermatitis. Evidence for a new group of allergens. J Clin Invest 1993;92:1374-80.
16. Strange P, Skov L, Lisby S, Nielsen PL, Baadsgaard O. Staphylococcal enterotoxin B applied on intact normal and intact atopic skin induces dermatitis. Arch Dermatol 1996; 132:27-33.
17. Hoeger PH, Lenz W, Boutonnier A, Foumier JM. Staphylococcal skin colonization in children with atopic dermatitis: prevalence, persislence, and transmission of toxigenic and nontoxigenic strains. J Infect Dis 1992:165:1064-8.
18. Campbell DE, Kemp AS. Proliferation and production of interferon-gamma and IL-4 in response to Staphylococcus aureus and Staphylococcal superantigen in childhood atopic dermatitis. Clin Exp Immunol 1997; 107:392-7.
19. Hanifin JM, Rajka G. Diagnostic features of atupic dermatitis. Acta Derm Venereol (Suppl) 1980; 92:44-47.
20. Hanifin JM. Standardized grading of subjects for clinical research studies in atopic dermatitis: workshop report. Acta Dermato Venereol (Suppl) 1989; 144:28-30.
21. Leyden JJ, Marples RR, Kligman AM. Staphylccoccus aureus in the lesions of atopic dermatitis. Br J Dermatol 1974; 90:525-30.
22. McFadden JP, Noble WC, Camp RD. Superantigenic exotoxin-secreting potential of staphylococci isolated from atopic eczematous skin. Br J Dermatol 1993; 128:631-2.
23. Ferry B, Anlrobus P, Huzicka I, Farrell A, Lane A, Chapel H. Intracellular cytokine expression in whole blood preparations from normals and patients with atopic dermatitis. Clin Exp Immunol 1997; 110:410-7.
24. D'Orazio J, Burke GW, Stein-Streilein J. Staphylococcal enterotoxin B activates purified NK cells to secrete IFN- gamma but requires T lymphocytes to augment NK cytotoxicity. J Immunol 1995. 154:1014-23.
25. Hardy KJ, Manger B, Newton M, et al. Molecular events involved in regulating human interferon-gamma gene expression during T cell activation. J Immunol 1987; 138:2353-8.
26. Leung DY, Bahn AK, Schneeberger EE, Geha RS. Characterization of the mononuclear cell infiltrate in atopic dermatitis using monoclonal antibodies. J Allergy Clin Immunol 1983; 72:47-50.