Effect of ventilator flow rate on respiratory timing in normal humans

American Journal of Respiratory and Critical Care Medicine

Volumn 159, Issue 3, 1999, Pages 710-719

  Fernandez, Rafael ^a   Mendez, Manuel ^a   Younes, Magdy ^a,b  

^a UNIVERSITY OF MANITOBA   (Canada)

^b HEALTH SCIENCES CENTRE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AIRWAY DYNAMICS; AIRWAY PRESSURE; AIRWAY RESISTANCE; ARTICLE; BREATHING MUSCLE; BREATHING RATE; ELECTROMYOGRAPHY; EXPIRATORY FLOW; EXPIRATORY FLOW RATE; FEMALE; HUMAN; HUMAN EXPERIMENT; INSPIRATORY CAPACITY; LUNG FUNCTION; MALE; NORMAL HUMAN; PEAK EXPIRATORY FLOW; PRIORITY JOURNAL; RESPIRATORY AIRFLOW;

EID: 0032987048     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.159.3.9709090     Document Type: Article

References (40)

1. 1. Puddy, A., and M. Younes. 1992. Effect of inspiratory flow rate on respiratory motor output in normal humans. Am. Rev. Respir. Dis. 146: 787-789.
2. 2. Georgopoulos, D., I. Mitrouska, Z. Bshouty, N. R. Anthonisen, and M. Younes. 1996. Effects of NREM sleep on the response of respiratory output to varying inspiratory flow. Am. J. Respir. Crit. Care Med. 153: 1624-1630.
3. 3. Georgopoulos, D., I. Mitrouska, Z. Bshouty, K. Webster, N. R. Anthonisen, and M. Younes. 1996. Effects of breathing route, temperature and volume of inspired gas and airway anesthesia on the response of respiratory output to varying inspiratory flow. Am. J. Respir. Crit. Care Med. 153:168-175.
4. 4. Tobert, D. G., P. M. Simon, R. W. Stroetz, and R. D. Hubmayr. 1997. The determinants of respiratory rate during mechanical ventilation. Am. J. Respir. Crit. Care Med. 155:485-492.
5. 5. Corne, S., D. Gillespie, D. Roberts, and M. Younes. 1997. Effect of inspiratory flow rate on respiratory rate in intubated ventilated patients. Am. J. Respir. Crit. Care Med. 156:304-308.
6. 6. Pretcher, G. C., S. B. Nelson, and R. D. Hubmayr. 1990. The ventilatory recruitment threshold for carbon dioxide. Am. Rev. Respir. Dis. 141: 758-764.
7. 7. Mead, J., and E. Agostoni. 1964. Dynamics of breathing. In W. O. Fenn and H. Rahn, editors. Handbook of Physiology: Respiration, Sect. 3, Vol. 1. American Physiology Society, Washington, DC. 411-427.
8. 8. Younes, M. 1992. Proportional assist ventilation: a new approach to ventilatory support: theory. Am. Rev. Respir. Dis. 145:114-120.
9. 9. Simon, P. M., J. D. Skatrud, M. S. Badr, D. M. Griffin, C. Iber, and J. A. Dempsey. 1991. Role of airway mechanoreceptors in the inhibition of inspiration during mechanical ventilation in humans. Am. Rev. Respir. Dis. 144:1033-1041.
10. 10. Agostoni, E., and J. Mead. 1964. Statics of the respiratory system. In W. O. Fenn and H. H. Rahn, editors. Handbook of Physiology: Respiration, Sect. 3, Vol. 1: American Physiological Society. Washington, DC. 387-409.
11. 11. Horner, R. L., J. A. Innes, K. Murphy, and A. Guz. 1991. Evidence for reflex upper airway dilator muscle activation by sudden negative airway pressure in man. J. Physiol. (Lond.) 436:15-29.
12. 12. Younes, M., R. Sanii, W. Patrick, S. Marantz, and K. Webster. 1994. An approach to the study of upper airway function in humans. J. Appl. Physiol. 77:1383-1392.
13. 13. Widdicombe, J. G. 1986. Reflexes from the upper respiratory tract. In N. S. Cherniack and J. G. Widdicombe, editors. Handbook of Physiology: The Respiratory System, Vol. 2. American Physiological Society, Bethesda, MD. 363-394.
14. 14. Jammes, Y. 1995. Functional role of respiratory muscle reflexes. In C. Roussos, editor. The Thorax: Lung Biology in Health and Disease, Vol. 85, Chap. 31. Marcel Dekker, New York. 933-952.
15. 15. Shannon, R. 1986. Reflexes from respiratory muscles and costovertebral joints. In N. S. Cherniack and J. G. Widdicombe, editors. Handbook of Physiology: The Respiratory System, Vol. 2. American Physiological Society, Bethesda, MD. 431-448.
16. 16. Duron, B. 1981. Intercostal and diaphragmatic muscle endings and afferents. In T. F. Hornbein, editor. Lung Biology in Health and Disease, Vol. 17. Marcel Dekker, New York. 473-540.
17. 17. Younes, M., and J. Remmers. 1981. Control of tidal volume and respiratory frequency. In T. Hornbein, editor. Control of Breathing: Lung Biology in Health and Disease, Vol. 17, Part 1. Marcel Dekker, New York. 617-667.
18. 18. Younes, M., and D. Georgopoulos. 1998. Control of breathing relevant to mechanical ventilation. In J. Marini and A. Slutsky, editors. Physiological Basis of Ventilatory Support: Lung Biology in Health and Disease, Vol. 118, Ch. 1. Marcel Dekker, New York. 1-74.
19. 19. Coleridge, H. M., and J. C. G. Coleridge. 1986. Reflexes evoked from tracheobronchial tree and lungs. In N. S. Cherniack and J. G. Widdicomebe, editors. Handbook of Physiology: The Respiratory System, Vol. 2. American Physiological Society, Bethesda, MD. 394-430.
20. 20. Sant'Ambrogio, G. 1982. Information arising from the tracheobronchial tree of mammals. Physiol. Rev. 62:531-569.
21. 21. Younes, M., and M. Youssef. 1978. Effect of five human anesthetics on respiratory control in cats. J. Appl. Physiol. 44:596-606.
22. 22. Remmers, J. E. 1970. Inhibition of inspiratory activity by intercostal muscle afferents. Respir. Physiol. 10:358-383.
23. 23. Clark, F. J., and C. von Euler. 1972. On the regulation of depth and rate of breathing. J. Physiol. (Lond.) 222:267-295.
24. 24. Grunstein, M. M., M. Younes, and J. Milic-Emili. 1973. Control of tidal volume and respiratory frequency in anesthetized cats. J. Appl. Physiol. 35:463-476.
25. 25. Pack, A. I., and R. G. Delaney. 1983. Response of pulmonary rapidly adapting receptors during lung inflation. J. Appl. Physiol. 55:955-963.
26. 26. Bartoli, A., E. Bystrzycka, A. Guz, S. K. Jain, M. I. M. Noble, and D. W. Trenchard. 1973. Studies of pulmonary vagal control of central respiratory rhythm in the absence of breathing movements. J. Appl. Physiol. 230:449-465.
27. 27. Grunstein, M., I. Wyszogrodski, and J. Milic-Emili. 1975. Regulation of frequency and depth of breathing during expiratory threshold loading in cats. J. Appl. Physiol. 38:869-874.
28. 28. Younes, M., and J. Polacheck. 1985. Central adaptation to inspiratory inhibitory, expiratory prolonging vagal input. J. Appl. Physiol. 59:1072-1084.
29. 29. Baker, J. P., Jr., J. E. Remmers, and M. K. Younes. 1979. Graded inspiratory inhibition: specific effects of flow rate. J. Appl. Physiol. 46: 669-674.
30. 30. Younes, M., J. Baker, and J. E. Remmers. 1987. Temporal changes in effectiveness of an inspiratory inhibitory pontine stimulus. J. Appl. Physiol. 62:1502-1512.
31. 31. Puddy, A., W. Patrick, K. Webster, and M. Younes. 1996. Control of breathing during volume-cycled ventilation in normal humans. J. Appl. Physiol. 80:1749-1758.
32. 32. Amato, M. B. P., C. S. V. Barbas, J. Bonassa, P. H. N. Saldiva, W. A. Zin, and C. R. R. de Carvalho. 1992. Volume-assured pressure support ventilation (VAPSV). Chest 102:1225-1234.
33. 33. Nava, S., C. Bruschi, F. Rubini, A. Palo, G. Iotti, and A. Braschi. 1995. Respiratory response to inspiratory effort during pressure support ventilation in COPD patients. Intensive Care Med. 21:871-879.
34. 34. Yamada, Y., M. Shigeta, K. Suwa, and K. Hanaoka. 1994. Respiratory muscle pressure analysis in pressure-support ventilation. J. Appl. Physiol. 77:2237-2243.
35. 35. Marini, J. J., R. M. Rodriguez, and V. Lamb. 1986. The inspiratory workload of patient-initiated mechanical ventilation. Am. Rev. Respir. Dis. 134:902-909.
36. 36. Ward, M. E., C. Corbeil, W. Gibbons, S. Newman, and P. T. Macklem. 1988. Optimization of respiratory muscle relaxation during mechanical ventilation. Anesthesiology 69:29-34.
37. 37. Bellemare, F., and A. Grassino. 1982. Effect of pressure and timing of contraction on human diaphragm fatigue. J. Appl. Physiol. 53:1190-1195.
38. 38. Bunburaphong, T., H. Imanaka, M. Nishimura, D. Hess, and R. M. Kacmarek. 1997. Performance characteristics of bilevel pressure ventilators. Chest 111:1050-1060.
39. 39. Hirsch, C., R. M. Kacmarek, and K. Stanek. 1991. Work of breathing during CPAP and PSV imposed by the new generation mechanical ventilators: a lung model study. Respir. Care 36:815-828.
40. 40. Younes, M. 1993. Patient-ventilator interaction with pressure-assisted modalities of ventilatory support. Semin. Respir. Med. 14:229-322.