The determinants of respiratory rate during mechanical ventilation

American Journal of Respiratory and Critical Care Medicine

Volumn 155, Issue 2, 1997, Pages 485-492

  Tobert, Daren G ^a   Simon, Peggy M ^a   Stroetz, Randolph W ^a   Hubmayr, Rolf D ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; ARTIFICIAL VENTILATION; BREATHING RATE; CARBON DIOXIDE MEASUREMENT; FEEDBACK SYSTEM; FEMALE; HUMAN; HUMAN EXPERIMENT; HYPOCAPNIA; INSPIRATORY CAPACITY; MALE; NONREM SLEEP; NORMAL HUMAN; PRIORITY JOURNAL; WAKEFULNESS;

EID: 0031044957     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.155.2.9032183     Document Type: Article

References (43)

1. 2 in the hypocapnic range in awake humans. J. Appl. Physiol. 79:2058-2068.
2. Puddy, A., W. Patrick, K. Webster, and M. Younes. 1996. Respiratory control during volume-cycled ventilation in normal humans. J. Appl. Physiol 80:1749-1758.
3. Tobert, D. G., P. M. Simon, W. M. Wies, R. W. Stroetz, and R. D. Hubmayr. 1994. Interdependence of tidal volume, flow, carbon dioxide tension, and respiratory rate in awake mechanically ventilated humans (abstract). Am. J. Respir. Crit. Care Med. 149:A290.
4. Hubmayr, R. D. 1994. Setting the ventilator. In M. J. Tobin, editor. Principles and Practice of Mechanical Ventilation. McGraw-Hill, New York. 191-206.
5. Guz, A., M. I. M. Noble, D. Trenchard, H. L. Cochrane, and A. R. Makey. 1964. Studies on the vagus nerves in man: their role in respiratory and circulatory control. Clin. Sci. 27:293-304.
6. Polacheck, J., R. Strong, J. Arens, C. Davies, I. Metcalf, and M. Younes. 1980. Phasic vagal influence on inspiratory motor output in anesthetized human subjects. J. Appl. Physiol. 49:609-619.
7. Iber, C., P. Simon, J. B. Skatrud, M. W. Mahowald, and J. A. Dempsey. 1995. The Breuer-Hering reflex in humans: effects of pulmonary denervation and hypocapnia. Am. J. Respir. Crit. Care Med. 152: 217-224.
8. Lofaso, F., D. Isabey, H. Lorino, A. Harf, and P. Scheid. 1992. Respiratory response to positive and negative inspiratory pressure in humans. Respir. Physiol. 89:75-88.
9. Camacho, J. R., M. A. Reinoso, G. A. Farkas, D. R. Gracey, R. W. Stroetz, and R. D. Hubmayr. 1994. Entrainment of inspiratory activity to a mechanical ventilator in sleeping humans (abstract). Am. J. Respir. Crit. Care Med. 149:A17.
10. 2 during positive inspiratory pressure in humans. J. Appl. Physiol. 77:876-882.
11. Hamilton, R. D., A. J. Winning, R. L. Horner, and A. Guz. 1988. The effect of lung inflation on breathing in man during wakefulness and sleep. Respir. Physiol. 73:145-154.
12. Skatrud, J. B., and J. A. Dempsey. 1983. Interaction of sleep state and chemical stimuli in sustaining rhythmic ventilation. J. Appl. Physiol. 55:813-822.
13. Datta, A. K., S. A. Shea, R. L. Horner, and A. Guz. 1991. The influence of induced hypocapnia and sleep on the endogenous respiratory rhythm in humans. J. Physiol. 440:17-33.
14. Georgopoulos, D., I. Mitruska, Z. Bshouty, N. R. Anthonisen, and M. Younes. 1996. Effect of non-REM sleep on the response of respiratory output to varying inspiratory flow. Am. J. Respir. Crit. Care Med. 153:1624-1630.
15. Puddy, A., and M. Younes. 1992. Effect of inspiratory flow rate on respiratory output in normal subjects. Am. Rev. Respir. Dis. 146: 787-789.
16. Breuer, J. 1868. Die selbststeurung der atmung durch den nervus vagus. S. B. Math. Naturwiss. Cl. Akad. Wiss. Wien 58:909-937.
17. Widdicombe, J. G. 1961. Respiratory reflexes in man and other mammalian species. Clin. Sci. 21:163-170.
18. Bartlett, D., Jr., and W. M. St. John. 1979. Adaptation of pulmonary stretch receptors in different mammalian species. Respir. Physiol. 37:303-312.
19. Younes, M., P. Vaillancourt, and J. Milic-Emili. 1974. Interaction between chemical factors and duration of apnea following lung inflation. J. Appl. Physiol. 36:190-201.
20. Gautier, H., M. Bonora, and J. H. Gaudy. 1981. Breuer-Hering reflex and breathing pattern in anesthetized humans and cats. J. Appl. Physiol. 51:1162-1168.
21. Graves, C., L. Glass, D. Laporta, R. Meloche, and A. Grassino. 1986. Respiratory phase locking during mechanical ventilation in anesthetized human subjects. Am. J. Physiol. 250:R902-R909.
22. Chow, C. M., L. Xi, C. A. Smith, K. W. Saupe, and J. A. Dempsey. 1994. A volume-dependent apneic threshold during NREM sleep in the dog. J. Appl. Physiol. 76:2315-2325.
23. Leevers, A. M., S. Manchanda, J. L. Murty, P. M. Simon, and J. A. Dempsey. 1994. The effects of tidal volume during normocapnic mechanical ventilation (MV) on the apnea following termination of MV (abstract). Am. J. Respir. Crit. Care Med. 149:A17.
24. Leevers, A. M., P. M. Simon, and J. A. Dempsey. 1994. Apnea after normocapnic mechanical ventilation during NREM sleep. J. Appl. Physiol 77:2079-2085.
25. Rajagopalan, N., P. M. Simon, P. C. Gay, R. W. Stroetz, and R. D. Hubmayr. 1996. Effects of nasal BiPAP on breathing in normal sleeping humans (abstract). Am. J. Respir. Crit. Care Med. 153:A371.
26. Stroetz, R. W., P. M. Simon, and R. D. Hubmayr. 1996. Effect of lung disease on the relationship between ventilator tidal volume and respiratory timing (abstract). Am. J. Respir. Crit. Care Med. 153:A379.
27. Bolser, D. C., B. G. Lindsey, and R. Shannon. 1987. Medullary inspiratory activity: Influence of intercostal tendon organs and muscle spindle endings. J. Appl. Physiol. 62:1046-1056.
28. Speck, D. G. 1987. Supraspinal involvement in the phrenic-to-phrenic inhibitory reflex. Brain Res. 414:169-172.
29. Mathew, O. P., Y. K. Abu-Osba, and B. T. Thach. 1982. Influence of upper airway pressure changes on respiratory frequency. Respir. Physiol. 49:223-233.
30. Easton, P. A., C. Jadue, M. E. Arnup, R. C. Meatherall, and N. R. Anthonisen. 1985. Effects of upper or lower airway anesthesia on hypercapnic ventilation in humans. J. Appl. Physiol. 59:1090-1097.
31. McBride, B., and W. A. Whitelaw. 1981. A physiological stimulus to upper airway receptors in humans. J. Appl. Physiol. 51:1189-1197.
32. Wies, W. M., P. M. Simon, D. G. Tobert, R. W. Storetz, and R. D. Hubmayr. 1994. Entrainment pattern of inspiratory activity in awake human subjects during controlled mechanical ventilation (abstract). Chest 106:69S.
33. Dempsey, J. A., and J. B. Skatrud. 1986. A sleep-induced apneic threshold and its consequences. Am. Rev. Respir. Dis. 133:1163-1170.
34. 2 and in arterial pH. In A. P. Fishman, N. S. Cherniack, J. G. Widdicombe, and S. R. Geiger, editors. Handbook of Physiology, Section 3: The Respiratory System, Volume II. Control of Breathing, Part 2: Physiological and Pathophysiolgical Integration. Waverly Press, Baltimore. 475-528.
35. Prechter, G. C., S. B. Nelson, and R. D. Hubmayr. 1990. The ventilatory recruitment threshold for carbon dioxide. Am. Rev. Respir. Dis. 141:758-764.
36. Simon, P. M., J. B. Skatrud, M. S. Badr, D. M. Griffin, C. Iber, and J. A. Dempsey. 1991. Role of airway mechanoreceptors in the inhibition of inspiration during mechanical ventilation in humans. Am. Rev. Respir. Dis. 144:1033-1041.
37. Henke, K. G., A. Arias, J. B. Skatrud, and J. A. Dempsey. 1988. Inhibition if inspiratory muscle activity during sleep. Chemical and nonchemical influences. Am. Rev. Respir. Dis. 138:8-15.
38. 2 responsiveness: A study of the unloaded respiratory pump in humans. Am. Rev. Respir. Dis. 144: 1125-1129.
39. Simon, P. M., J. A. Dempsey, D. M. Landry, and J. B. Skatrud. 1993. Effect of sleep on respiratory muscle activity during mechanical ventilation. Am. Rev. Respir. Dis. 147:32-37.
40. Morrell, M. J., S. A. Shea, L. Adams, and A. Guz. 1993. Effect of inspiratory support upon breathing in humans during wakefulness and sleep. Respir. Physiol. 93:57-70.
41. Bouverot, P., J. P. Crance, and P. Dejours. 1970. Factors influencing the intensity of the Breuer-Hering inspiration-inhibiting reflex. Respir. Physiol. 8:376-384.
42. Marini, J. J., J. S. Capps, and B. H. Culver. 1985. The inspiratory work of breathing during assisted mechanical ventilation. Chest 87:612-618.
43. Pack, A. I., R. G. Delaney, and A. P. Fishman. 1981. Augmentation of phrenic neural activity by increased rate of lung inflation. J. Appl. Physiol. 50:149-161.