How pre-existing, germline-derived antibodies and complement may help induce a primary immune response to nonself

Scandinavian Journal of Immunology

Volumn 49, Issue 3, 1999, Pages 224-228

  Lutz, Hans U ^a  

^a ETH ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY PRODUCTION; ANTIGEN ANTIBODY COMPLEX; ANTIGEN PRESENTATION; ANTIGEN RECOGNITION; COMPLEMENT DEPOSITION; GERM LINE; HUMAN; PRIMARY IMMUNE RESPONSE; PRIORITY JOURNAL; REVIEW;

ANIMALS; ANTIBODY AFFINITY; ANTIBODY DIVERSITY; ANTIBODY FORMATION; B-LYMPHOCYTES; COMPLEMENT C3B; COMPLEMENT SYSTEM PROTEINS; EPITOPES; HUMANS; IMMUNITY, NATURAL; MODELS, BIOLOGICAL;

EID: 0032986830     PISSN: 03009475     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3083.1999.00494.x     Document Type: Review

References (49)

1. 1 Pepys MB. Role of complement in the induction of antibody production in vivo. J Exp Med 1974;140:126.
2. 2 O'Neil KM, Ochs HD, Heller SR, Cork LC, Morris JM, Winkelstein JA. Role of C3 in humoral immunity. Defective antibody production in C3-deficient dogs. J Immunol 1988;140:1939-45.
3. 3 Gustavsson S, Kinoshita T, Heyman B. Antibodies to murine complement receptor 1 and 2 can inhibit the antibody response in vivo without inhibiting T helper cell induction. J Immunol 1995;154:6524-8.
4. 4 Fehr T, Bachmann MF, Bluethmann H, Kikutani H, Hengartner H, Zinkernagel RM. T-independent activation of B cells by vesicular stomatitis virus: no evidence for the need of a second signal. Cell Immunol 1996;168:184-92.
5. 5 Krych M, Atkinson JP, Holers VM. Complement receptors. Curr Opin Immunol 1992;4:8-13.
6. 6 Liszewski MK, Farries TC, Lublin DM, Rooney IA, Atkinson JP. Control of the complement system. Adv Immunol 1996;61:201-83.
7. 7 Law SKA, Dodds AW. The internal thioester and the covalent binding properties of the complement proteins C3 and C4. Protein Sci 1997;6:263-74.
8. 8 Tedder TF, Zhou L-J, Engel P. The CD19/CD21 signal transduction complex of B lymphocytes. Immunol Today 1994;15:437-42.
9. 9 Carter RH, Fearon DT. CD19: lowering the threshold for antigen receptor stimulation of B lymphocytes. Science 1992;256:105-7.
10. 10 Dempsey PW, Allison MED, Akkaraju S, Goodnow CC, Fearon DT. C3d of complement as a molecular adjuvant: bridging innate and acquired immunity. Science 1996;271:348-50.
11. 11 Jacquier-Sarlin MR, Gabert FM, Williers M-B, Colomb MG. Modulation of antigen processing and presentation by covalently linked complement C3b fragment. Immunology 1995;84:164-70.
12. 12 Thornton BP, Vetvicka V, Ross GD. Function of C3 in humoral response: iC3b/C3dg bound to an immune complex generated with natural antibody and a primary antigen promotes antigen uptake and the expression of co-stimulatory molecules by all B cells, but only stimulates immunoglobulin synthesis by antigen-specific B cells. Clin Exp Immunol 1996;104:531-7.
13. 13 Thornton BP, Vetvicka V, Ross GD. Natural antibody and complement-mediated antigen processing and presentation by B lymphocytes. J Immunol 1994;152:1727-37.
14. 14 Gadd KJ, Reid KBM. The binding of complement component C3 to antibody-antigen aggregates after activation of the alternative pathway in human serum. Biochem J 1981;195:471-80.
15. 15 Sahu A, Pangburn MK. Covalent attachment of human complement C3 to IgG. Identification of the amino acid residue involved in ester linkage formation. J Biol Chem 1994;269:28997-9002.
16. 16 Taylor RP, Wright EL, Pocanic F. Quantitative analyses of C3b capture and immune adherence of IgM antibody dsDNA immune complexes. J Immunol 1989;143:3626-31.
17. 17 Jacobs RJ, Reichlin M. Generation of low M.W., C3-bearing immunoglobulin in human serum. J Immunol 1983;130:2775-81.
18. 18 Lutz HU, Stammler P, Fasler S. Preferential formation of C3b-IgG complexes in vitro and in vivo from nascent C3b and naturally occurring anti-band 3 antibodies. J Biol Chem 1993;268:17418-26.
19. 19 Kulics J, Rajnavölgyi E, Füst G, Gergely J. Interaction of C3 and C3b with immunoglobulin G. Mol Immunol 1983;20:805-10.
20. 20 Lutz HU, Nater M, Stammler P. Naturally occurring anti-band 3 antibodies have a unique affinity for C3. Immunology 1993;80:191-6.
21. 21 Basta M, Fries LF, Frank MM. High doses of intravenous Ig inhibit in vitro uptake of C4 fragments onto sensitized erythrocytes. Blood 1991;77:376-80.
22. n-IgG complexes. Blood 1996;88:184-93.
23. 23 Basta M, Dalakas MC. High-dose intravenous immunoglobulin exerts its beneficial effect in patients with dermatomyositis by blocking endomysial deposition of activated complement fragments. J Clin Invest 1994;94:1729-35.
24. 24 Fearon DT, Locksley RM. The instructive role of innate immunity in the acquired immune response. Science 1996;272:50-4.
25. 25 Lu J. Collectins: collectors of microorganisms for the innate immune system. Bioessays 1997;19:509-18.
26. 26 Super M, Levinsky RJ, Turner MW. The level of mannan-binding protein regulates the binding of complement-derived opsonins to mannan and zymosan at low serum concentrations. Clin Exp Immunol 1990;79:144-50.
27. 27 Lassiter HA, Tanner JE, Miller RD. Inefficient bacteriolysis of Escherichia coli by serum from human neonates. J Infect Dis 1992;165:290-8.
28. 28 Zhang MX, Lupan DM, Kozel TR. Mannan-specific immunoglobulin G antibodies in normal human serum mediate classical pathway initiation of C3 binding to Candida albicans. Infect Immun 1997;65:3822-7.
29. 29 Ollert MW, David K, Vollmert C et al. Mechanisms of in vivo antineuroblastoma activity of human natural IgM. Eur J Cancer 1997;33:1942-8.
30. 30 Lutz HU, Pfister M, Hornig R. Tissue homeostatic role of naturally occurring anti-band 3 antibodies. Cell Mol Biol 1996;42:995-1005.
31. 31 Vuist WMJ, Van Schaik IN, Van Lint M, Brand A. The growth arresting effect of human immunoglobulin for intravenous use is mediated by antibodies recognizing membrane glycolipids. J Clin Immunol 1997;17:301-10.
32. 32 Hurez V, Kazatchkine MD, Vassilev T et al. Pooled normal human polyspecific IgM contains neutralizing anti-idiotypes to IgG autoantibodies of autoimmune patients and protects from experimental autoimmune disease. Blood 1997;90:4004-13.
33. 33 Rodman TC, To SE, Sullivan JJ, Winston R. Innate natural antibodies. Primary roles indicated by specific epitopes. Hum Immunol 1997;55:87-95.
34. H families. J Immunol 1989;142:4054-61.
35. 35 Avrameas S. Natural autoantibodies - from horror autotoxicus to gnothi seauton. Immunol Today 1991;12:154-9.
36. 36 Tew JG, Wu J, Qin D, Helm S, Burton GF, Szakal AK. Follicular dendritic cells and presentation of antigen and costimulatory signals to B cells. Immunol Rev 1997;156:39-52.
37. 37 Hathcock KS, Hodes RJ. Role of the CD28-B7 costimulatory pathways in T cell-dependent B cell responses. Adv Immunol 1996;62:131-66.
38. 38 Terness P, Opelz G. Regulation of antibody response by an IgG-anti-Ig autoantibody occurring during alloimmunization. I. A few IgG molecules inactivate one B cell. Transplant 1992;54:88-91.
39. 39 Terness P, Berteli A, Süsal C, Opelz G. Regulation of antibody response by an IgG-anti-Ig autoantibody occurring during alloimmunization. II. Selective inactivation of antigen receptor-occupied B cells. Transplant 1992;54:92-6.
40. 40 Birdsall HH, Rossen RD. Regulation of antibody release by naturally occurring anti-immunoglobulins in cultures of pokeweed mitogen-stimulated human peripheral blood lymphocytes. J Immunol 1984;133:1257-64.
41. 2 autoantibody. Proc Natl Acad Sci USA 1997;94:1902-7.
42. 42 Stewart JJ, Agosto H, Litwin S et al. A solution to the rheumatoid factor paradox - pathologic rheumatoid factors can be tolerized by competition with natural rheumatoid factors. J Immunol 1997;159:1728-38.
43. 43 Jefferis R. Rheumatoid factors, B cells and immunoglobulin genes. Br Med Bull 1995;51:312-31.
44. 44 Lutz HU, Bussolino F, Flepp R et al. Naturally occurring anti-band 3 antibodies and complement together mediate phagocytosis of oxidatively stressed human red blood cells. Proc Natl Acad Sci USA 1987;84:7368-72.
45. 45 Liatsis M, Kanariou M, Petridou E et al. Serum immunoglobulin G subclasses in healthy infants and children in Greece. Eur J Epidemiol 1997;13:151-5.
46. 46 Lacroix-Desmazes S, Mouthon L, Coutinho A, Kazatchkine MD. Analysis of the natural human IgG antibody repertoire: life-long stability of reactivities towards self antigens contrasts with age-dependent diversification of reactivities against bacterial antigens. Eur J Immunol 1995;25:2598-604.
47. 47 Heyman B, Pilström L, Shulman MJ. Complement activation is required for IgM-mediated enhancement of the antibody response. J Exp Med 1988;167:1999-2004.
48. 48 Cunningham-Rundles C, Feng ZK, Zhou Z, Woods KR. Relationship between naturally occurring human antibodies to casein and autologous antiidiotypic antibodies - implications for the network theory. J Clin Immunol 1991;11:279-90.
49. 2 antibody recognizes a conformational IgG1 hinge epitope. J Immunol 1995;154:6446-52.