Mechanisms of in vivo antineuroblastoma activity of human natural IgM

European Journal of Cancer

Volumn 33, Issue 12, 1997, Pages 1942-1948

  Ollert, M W ^a   David, K ^a   Vollmert, C ^a   Juhl, H ^b   Erttmann, R ^c   Bredehorst, R ^a   Vogel, C W ^a  

^a UNIVERSITY OF HAMBURG   (Germany)

^b UNIVERSITY OF KIEL   (Germany)

^c UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

Apoptosis; Immunotherapy; Natural antibodies; Neuroblastoma; Tumour antigen

Indexed keywords

IMMUNOGLOBULIN M; TUMOR ANTIGEN; CANCER ANTIBODY;

ANTIGEN EXPRESSION; ANTIGEN RECOGNITION; APOPTOSIS; COMPLEMENT ACTIVATION; CONFERENCE PAPER; CYTOTOXIC T LYMPHOCYTE; GRANULOCYTE; HUMAN; HUMAN CELL; IMMUNOTHERAPY; KERATINOCYTE; NEUROBLASTOMA; NEUTROPHIL; PRIORITY JOURNAL; ADULT; ANIMAL; ARTICLE; CELL CULTURE; CELLULAR IMMUNITY; CYTOTOXICITY TEST; DISEASE COURSE; FEMALE; IMMUNOLOGY; MALE; NUDE RAT; PATHOLOGY; RAT; XENOGRAFT;

ADULT; ANIMALS; ANTIBODIES, NEOPLASM; ANTIGENS, NEOPLASM; COMPLEMENT ACTIVATION; CYTOTOXICITY TESTS, IMMUNOLOGIC; DISEASE PROGRESSION; FEMALE; HUMANS; IMMUNITY, CELLULAR; IMMUNOGLOBULIN M; MALE; NEUROBLASTOMA; NEUTROPHILS; RATS; RATS, NUDE; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED;

EID: 0031283005     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-8049(97)00285-2     Document Type: Conference Paper

References (11)

1. Pinkerton CR. Neuroblastoma in the 1990s. A clinical perspective. In Schwab M, Tonini GP, Bénard J, eds. Human Neuroblastoma. Recent Advances in Clinical and Genetic Analysis. Chur, Switzerland, Harwood Academic Publishers, 1993, 3-10.
2. Philip T, Pinkerton R. Neuroblastoma. In Magrath J, ed. New Directions in Cancer Treatment. Heidelberg, Germany, Springer Verlag, 1989, 605-611.
3. Ollert MW, David K, Schmitt C, et al. Normal human serum contains a natural IgM antibody cytotoxic for human neuroblastoma cells. Proc Natl Acad Sci USA 1996, 93, 4498-4503.
4. Erttmann R, Schmitt C, Ollert MW, David K, Bredehorst R, Vogel C-W. Naturally occuring humoral cytotoxicity against neuroblastoma (NB) cells in healthy persons and NB patients. Pediatr Hematol Oncol 1996, 13, 545-548.
5. David K, Ollert MW, Juhl H, et al. Growth arrest of solid human neuroblastoma xenografts in nude rats by natural IgM from healthy humans. Nature Med 1996, 2, 686-689.
6. Mujoo K, Kipps TJ, Yang HM, et al. Functional properties and effect on growth suppression of human neuroblastoma tumours by isotype switch variants of monoclonal antiganglioside GD2 antibody 14.18. Cancer Res 1989, 49, 2857-2861.
7. Gavrieli Y., Sherman Y., BenSasson S. A. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol. 119:1992;493-501.
8. Laemmli U. K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 227:1970;680-685.
9. Sylvestre D. L., Ravetch J. V. Fc receptors initiate the Arthus reaction: redefining the inflammatory cascade. Science. 265:1994;1095-1098.
10. Bruchelt G, Handgretinger R, Kimmig A, et al. Effect of granulocytes on human neuroblastoma cells measured by chemiluminescence and chromium-51 release assay. J Biolumin Chemilumin 1989, 3, 93-96.
11. Savill J., Fadok V., Henson P., Haslett C. Phagocyte recognition of cells undergoing apoptosis. Immunol Today. 14:1993;131-136.