Simultaneous loss of E-cadherin and catenins in invasive lobular breast cancer and lobular carcinoma in situ

Journal of Pathology

Volumn 183, Issue 4, 1997, Pages 404-411

  De Leeuw, Wiljo J F ^a   Berx, Geert ^b   Vos, Carla B J ^a   Peterse, Johannes L ^c   Van De Vijver, Marc J ^a,c   Litvinov, Sergey ^a   Van Roy, Frans ^b   Cornelisse, Cees J ^a   Cleton Jansen, Anne Marie ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b GHENT UNIVERSITY   (Belgium)

^c ANTONI VAN LEEUWENHOEK HOSPITAL   (Netherlands)

Author keywords

Adhesion; Breast; Catenin; E cadherin; Expression; Lobular carcinoma; Mutation

Indexed keywords

UVOMORULIN;

ARTICLE; BREAST CANCER; CARCINOGENESIS; CELL ADHESION; CYTOSKELETON; DNA DETERMINATION; FRAMESHIFT MUTATION; GENE ACTIVATION; GENE DELETION; GENE INSERTION; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN TISSUE; PRIORITY JOURNAL;

ALPHA CATENIN; BETA CATENIN; BREAST NEOPLASMS; CADHERINS; CARCINOMA IN SITU; CARCINOMA, DUCTAL, BREAST; CARCINOMA, LOBULAR; CYTOSKELETAL PROTEINS; DESMOPLAKINS; DNA MUTATIONAL ANALYSIS; FEMALE; GAMMA CATENIN; HUMANS; NEOPLASM INVASIVENESS; TRANS-ACTIVATORS;

EID: 0030726101     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9896(199712)183:4<404::AID-PATH1148>3.0.CO;2-9     Document Type: Article

References (55)

1. Takeichi M. Morphogenetic roles of classic cadherins. Curr Opin Cell Biol 1995; 7: 619-627.
2. Nelson W. Regulation of cell adhesion and development of epithelial cell surface polarity. Curr Top Membranes 1994; 41: 123-142.
3. Gumbiner B. Cell adhesion: the molecular basis of tissue architecture and morphogenesis. Cell 1996; 84: 345-357.
4. Cowen P. Unravelling the cytoplasmatic interaction of the cadherin super-family. Proc Natl Acad Sci USA 1994; 91: 10759-10761.
5. Shapiro L, Fannon A, Kwong P, et al. Structural basis of cell-cell adhesion by cadherins. Nature 1995; 374: 327-337.
6. Jou J-S, Stewart DB, Stappert J, Nelson WJ, Marrs JA. Genetic and biochemical dissection of protein linkage in the cadherin catenin complex. Proc Natl Acad Sci USA 1995; 92: 5067-5071.
7. Rimm DL, Koslov ER, Kebriael P, Cianci CD, Morrows JS. αl(E)-catenin is an actin-binding and bundling protein mediating the attachment of F-actin to the membrane adhesion complex. Proc Natl Acad Sci USA 1995; 92: 8813-8817.
8. Knudson K, Solar A, Johnson K, Wheelock M. Interaction of α-actinin with the cadherin/catenin cell-cell adhesion complex via α-catenin. J Cell Biol 1995; 130: 1-11.
9. Bracke ME, Van Roy FM, Mareel MM. The E-cadherin/catenin complex in invasion and metastasis. Curr Top Microbiol Immunol 1996; 213/I: 123-161.
10. Birchmeier W, Behrens J. Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness. Biochim Biophys Acta 1994; 1198: 11-26.
11. Takeichi M. Cadherins in cancer: implications for invasion and metastasis. Curr Opin Cell Biol 1993; 5: 806-811.
12. Behrens J. Cell contacts, differentiation, and invasiveness of epithelial cells. Invasion Metastasis 1994; 14: 61-70.
13. Frixen U, Behrens J, Sachs M, et al. E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells. J Cell Biol 1991; 113: 173-185.
14. Vleminckx K, Vakaet L, Mareel M, Fiers W, Van Roy F. Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role. Cell 1991; 66: 107-119.
15. Risinger J, Berchuk A, Kohler M, Boyd J. Mutations in the E-cadherin gene in human gynaecologic cancers. Nature Genet 1994; 7: 98-102.
16. Becker K, Atkinson M, Reich U, et al. E-cadherin gene mutations provide clues to diffuse type gastric carcinomas. Cancer Res 1994; 54: 3845-3852.
17. Schipper J, Frixen U, Behrens J, Unger A, Jahnke K, Birchmeier W. E-cadherin expression in squamous cell carcinomas of head and neck: inverse correlation with tumor differentiation and lymph node metastasis. Cancer Res 1991; 51: 6328-6337.
18. Umbas R, Schalken J, Aalders T, et al. Expression of the cellular adhesion molecule E-cadherin is reduced or absent in high-grade prostate cancer. Cancer Res 1992; 52: 5104-5109.
19. Shiozaki H, Tahara H, Oka H, et al. Expression of immunoreactive E-cadherin adhesion molecules in human cancers. Am J Pathol 1991; 139: 17-23.
20. Mareel M, Bracke M, Van Roy F. Invasion promotor versus invasion suppressor molecules: the paradigm of E-cadherin. Mol Biol Rep 1994; 19: 45-67.
21. Rimm D, Sinard J, Morrow J. Reduced α-catenin and E-cadherin expression in breast cancer. Lab Invest 1995; 5: 506-512.
22. Berg J, Hutter R. Breast cancer. Cancer 1995; 75: 257-269.
23. Gamallo C, Palacios J, Suarez A, et al. Correlation of E-cadherin expression with differentiation grade and histological type in breast carcinoma. Am J Pathol 1993; 142: 987-993.
24. Moll R, Mitze M, Frixen U, Birchmeier W. Differential loss of E-cadherin expression in infiltrating ductal and lobular breast carcinomas. Am J Pathol 1993; 143: 1731-1742.
25. Rasbridge S, Gillett C, Sampson S, Walsh F, Millis R. Epithelial (E-) and placental (P-) cadherin cell adhesion molecule expression in breast carcinoma. J Pathol 1993; 169: 245-250.
26. Graff J, Herman J, Lapidus R, et al. E-cadherin expression is silenced by DNA hypermethylation in breast and prostate carcinomas. Cancer Res 1995; 55: 5195-5199.
27. Yoshiura K, Kanai Y, Ochiai A, Shimoyama Y, Sugimura T, Hirohashi S. Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomas. Proc Natl Acad Sci USA 1995; 92: 7416-7419.
28. Berx G, Cleton-Jansen A-M, Nollet F, et al. E-cadherin is a tumour/invasion suppressor gene mutated in human lobular breast cancer. EMBO J 1995; 14: 6107-6115.
29. Berx G, Cleton-Jansen A-M, Strumane K, et al. E-cadherin is inactivated in a majority of invasive human lobular breast cancers by truncation mutations throughout its extracellular domain. Oncogene 1996; 13: 1919-1925.
30. Shimoyama Y, Nagafuchi A, Fujita S, et al. Cadherin dysfunction in human cancer cell lines: possible involvement of loss of α-catenin expression in reduced cell-cell adhesiveness. Cancer Res 1992; 52: 5770-5774.
31. Kawanishi J, Kato J, Sasaki K, Fujii S, Watanabe N, Niitsu Y. Loss of E-cadherin-dependent cell-cell adhesion due to mutation of the β-catenin gene in a human cancer cell line, HCS-39. Mol Cell Biol 1995; 15: 1175-1181.
32. Oyama T, Kanai Y, Ochiai A, et al. A truncated β-catenin disrupts the interaction between E-cadherin and α-catenin: a cause of loss of intercellular adhesiveness in human cancer cell lines. Cancer Res 1994; 54: 6282-6287.
33. Oda T, Kanai Y, Shimoyama Y, Nagafuchi A, Tsukita S, Hirohashi S. Cloning of the human α-catenin cDNA and its aberrant mRNA in a human cancer cell line. Biochem Biophys Res Commun 1993; 193: 897-904.
34. Morton R, Ewing C, Nagafuchi A, Tsukita S, Isaacs W. Reduction of E-cadherin levels and deletion of the α-catenin gene in human prostate cancer cells. Cancer Res 1993; 53: 3585-4520.
35. Matsuura K, Kawanishi J, Fujii S, et al. Altered expression of E-cadherin in gastric cancer tissues and carcinomatous fluid. Br J Cancer 1992; 66: 1122-1130.
36. Takayama T, Shiozaki H, Shibamoto S, et al. β-Catenin expression in human cancers. Am J Pathol 1996; 148: 39-46.
37. Takayama T, Shiozaki H, Inoue M, et al. Expression of E-cadherin and α-catenin molecules in human breast cancer tissues and association with clinicopathological features. Int J Oncol 1994; 5: 775-780.
38. Kadowaki T, Shiozaki H, Inoue M, et al. E-cadherin and α-catenin expression in human esophageal cancer. Cancer Res 1994; 54: 291-296.
39. Matsui S, Shiozaki H, Inoue M, et al. Immunohistochemical evaluation of α-catenin expression in human gastric cancer. Virchows Arch 1994; 424: 375-381.
40. Shiozaki H, Iihara K, Oka H, et al. Immunohistochemical detection of α-catenin expression in human cancers. Am J Pathol 1994; 14: 667-674.
41. Candidus S, Bischoff P, Becker K-F, Hofler H. No evidence for mutations in the α-catenin and β-catenin genes in human gastric and breast carcinomas. Cancer Res 1996; 56: 49-52.
42. Hazelbach H, van de Broek L, van Dorst E, Offerhaus G, Fleuren G, Hoogendoorn P. Immunostaining of chain-specific keratins on formalin-fixed, paraffin-embedded tissues: a comparison of various antigen retrieval systems using microwave heating and proteolytic pretreatment. J Histochem Cytochem 1995; 43: 429-437.
43. Rosen PP, Oberman HA. Atlas of Tumour Pathology, Tumours of the Mammary Gland. Washington, DC: AFIP.
44. Hinck L, Nathke IS, Papkoff J, Nelson WJ. Dynamics of cadherin/catenin complex formation: novel protein interactions and pathways of complex assembly. J Cell Biol 1994; 125: 1327-1340.
45. Nathke IS, Hinck L, Swedlow JR, Papkoff J, Nelson WJ. Defining interactions and distribution of cadherin and catenin complexes in polarized epithelial cells. J Cell Biol 1994; 125: 1341-1352.
46. Nagafushi A, Ishihara S, Tsukita S. The roles of catenins in the cadherin-mediated cell adhesion: functional analysis of E-cadherin-α-catenin fusion molecules. J Cell Biol 1994; 127: 235-245.
47. Kanai Y, Oda T, Tsuda H, Ochiai A, Hirohashi S. Point mutations of the E-cadherin gene in invasive lobular carcinoma of the breast. Jpn J Cancer Res 1994; 85: 1035-1039.
48. Forrest S, Cotton R, Landegren U, Southern E. How to find all these mutations. Nature Genet 1995; 10: 375-376.
49. Sanson B, White P, Vincent J-P. Uncoupling cadherin-based adhesion from wingless signalling in Drosophila. Nature 1996; 383: 627-630.
50. Korman N, Russel W, Eyre M, Klaus-Kovtun V, Stanley J. Demonstration of an adherens-junction molecule (plakoglobin) in the autoantigens of pemphigus foliaceous and pemphigus vulgaris. N Engl J Med 1989; 321: 631-635.
51. Simcha I, Geiger B, Yehuda-Levenberg S, Solomon D, Ben-Ze'ev A. Suppression of tumorigenicity by plakoglobin: an augmenting effect of N-cadherin. J Cell Biol 1996; 133: 199-209.
52. Gumbiner BM. Proteins associated with the cytoplasmic surface of adhesion molecules. Neuron 1993; 11: 551-564.
53. Hashizume R, Koizumi H, Ihara A, Ohta T, Uchikoshi T. Expression of β-catenin in normal breast tissue and breast carcinoma: a comparative study with epithelial cadherin and α-catenin. Histopathology 1996; 29: 139-146.
54. Daniels C, Strickland P, Friedmann Y. Expression and functional role of E- and P-cadherin in mouse mammary ductal morphogenesis and growth. Dev Biol 1995; 169: 511-519.
55. Bussemakers MJ, Van-Bokhoven A, Mees SG, Kemler R, Schalken JA. Molecular cloning and characterization of the human E-cadherin cDNA. Mol Biol Rep 1993; 17: 123-128.