Characterization of a bioengineered chimeric Na+-nucleoside transporter

Molecular Pharmacology

Volumn 55, Issue 2, 1999, Pages 234-240

  Wang, Juan ^a   Giacomini, Kathleen M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE; CARRIER PROTEIN; CYTIDINE; GUANINE; INOSINE; PURINE NUCLEOSIDE; PYRIMIDINE NUCLEOSIDE; THYMIDINE; URIDINE;

ARTICLE; BINDING SITE; BIOENGINEERING; CHIMERA; NUCLEOSIDE TRANSPORT; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN STRUCTURE; SODIUM TRANSPORT;

EID: 0032981168     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.55.2.234     Document Type: Article

References (19)

1. Belt JA, Marina NM, Phelps DA and Crawford CR (1993) Nucleoside transport in normal and neoplastic cells. Adv Enzyme Regul 33:235-252.
2. Caas CE (1995) Nucleoside transport, in Drug Transport in Antimicrobial and Anticancer Chemotherapy (Georgopapadakou NH ed) pp 403-451, Marcel Dekker, New York.
3. +-nucleoside cotransporter. J Biol Chem 270:13596-599.
4. Craig JE, Zhang Y and Gallagher MP (1994) Cloning of the nupC gene of Escherichia coli encoding a nucleoside transport system, and identification of an adjacent insertion element, IS 186. Mol Microbiol 11:1159-1168.
5. +-nucleoside cotransport system (N2) in Xenopus laevis oocytes. Pflugers Arch 427:381-383.
6. Griffith DA and Jarvis SM (1996) Nucleoside and nucleobase transport systems of mammalian cells. Biochim Biophys Acta 1286:153-181.
7. +-dependent nucleoside transport systems of rat intestine in isolated oocytes of Xenopus laevis. Demonstration that rat jejunum expresses the purine-selective system N1 (cif) and a second, novel system N3 having broad specificity for purine and pyrimidine nucleosides. J Biol Chem 268:20613-20619.
8. Huang QQ, Yao SY, Ritzel MW, Paterson AR, Cass CE and Young JD (1994) Cloning and functional expression of a complementary DNA encoding a mammalian nucleoside transport protein. J Biol Chem 269:17757-17760.
9. +/nucleoside cotransport activity in Xenopus laevis oocytes. Biochem Biophys Res Commun 225:106-11.
10. +-nucleoside cotransporter (hCNT1). Am J Physiol 272:C707-C714.
11. Schaner ME, Wang J, Zevin S, Gerstin KM and Giacomini KM (1997) Transient expression of a purine-selective nucleoside transporter (SPNTint) in a human cell line (HeLa). Pharm Res 14:1316-1321.
12. +-dependent nucleoside transporters. J Biol Chem 272:28845-28845.
13. +-dependent nucleoside transporters. Pharm Res 14:1524-1532.
14. +-dependent purine nucleoside transporter from human kidney: cloning and functional characterization. Am J Physiol 273:F1058-F1065.
15. Wu X, Gutierrez MM and Giacomini KM (1994) Further characterization of the sodium-dependent nucleoside transporter (N3) in choroid plexus from rabbit. Biochim Biophys Acta 1191:190-196.
16. Wu X, Yuan G, Brett CM, Hui AC and Giacomini KM (1992) Sodium-dependent nucleoside transport in choroid plexus from rabbit. Evidence for a single transporter for purine and pyrimidine nudeosides. J Biol Chem 267:8813-8818.
17. Yao SY, Cass CE and Young JD (1996a) Transport of the antiviral nucleoside analogs 3′-azido-3′-deoxythymidine and 2′,3′-dideoxycytidine by a recombinant nucleoside transporter (rCNT) expressed in Xenopus laevis oocytes. Mol Pharmacol 50:388-393.
18. Yao SY, Ng AM, Ritzel MW, Gati WP, Cass CE and Young JD (1996b) Transport of adenosine by recombinant purine- and pyrimidine-selective sodium/nucleoside cotransporterg from rat jejunum expressed in Xenopus laevis oocytes. Mol Pharmacol 50:1529-1535.
19. Zhang L, Dresser MJ, Gray AT, Yost SC, Terashita S and Giacomini KM (1997) Cloning and functional expression of a human liver organic cation transporter. Mol Pharmacol 51:913-921.