Chemistry of opium alkaloids. Part 44: Synthesis and opioid receptor binding profile of substituted ethenoisomorphinans and ethenomorphinans

Bioorganic and Medicinal Chemistry

Volumn 7, Issue 3, 1999, Pages 529-541

  Maat, Leendert ^a   Woudenberg, Richard H ^a,b   Meuzelaar, Gerrit J ^a   Linders, Joannes T M ^a,c  

^a DELFT UNIVERSITY OF TECHNOLOGY   (Netherlands)

^b AKZO NOBEL CENTRAL RESEARCH   (Netherlands)

^c NV ORGANON   (Netherlands)

Author keywords

Alkaloids; Analgesics; Diels Alder reactions; Morphinan 6,8 dienes; NMR; Receptors; Thebaine analogues

Indexed keywords

BREMAZOCINE; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; ENKEPHALIN[2,5 DEXTRO PENICILLAMINE]; ETORPHINE; MORPHINAN DERIVATIVE; MORPHINE; N METHYL N [7 (1 PYRROLIDINYL) 1 OXASPIRO[4.5]DEC 8 YL]BENZENEACETAMIDE; OPIATE RECEPTOR; RECEPTOR SUBTYPE;

ANIMAL TISSUE; ARTICLE; BRAIN HOMOGENATE; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; CRYSTALLIZATION; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; GUINEA PIG; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RECEPTOR AFFINITY;

ANIMALS; BRAIN; GUINEA PIGS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MOLECULAR STRUCTURE; MORPHINANS; PROTEIN BINDING; RECEPTORS, OPIOID;

EID: 0032979698     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(98)00267-3     Document Type: Article

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