Contribution of ogt-encoded alkyltransferase to resistance to chloroethylnitrosoureas in nucleotide excision repair-deficient Escherichia coli

Carcinogenesis

Volumn 17, Issue 8, 1996, Pages 1609-1614

  Abril, Nieves ^a   Ferrezuelo, Francisco ^a   Prieto Alamo, María José ^a   Rafferty, Joseph A ^b   Margison, Geoffrey P ^b   Pueyo, Carmen ^a  

^a UNIVERSITY OF CÓRDOBA   (Spain)

^b CHRISTIE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATING AGENT; BACTERIAL ENZYME; CARMUSTINE; CHLOROETHYLNITROSOUREA; LOMUSTINE;

ARTICLE; BACTERIUM MUTANT; CELL PROTECTION; CONTROLLED STUDY; ENZYME DEFICIENCY; ESCHERICHIA COLI; EXCISION REPAIR; GENE AMPLIFICATION; GENE FUNCTION; MUTAGENIC ACTIVITY; MUTATION RATE; NONHUMAN; PRIORITY JOURNAL;

EID: 0029760025     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/17.8.1609     Document Type: Article

References (46)

1. International Agency for Research on Cancer (1986) Carcinogenicity of Alkylating Cytostatic Drugs. IARC Scientific Publication no. 78, IARC, Lyon, France.
2. International Agency for Research on Cancer (1987) Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Vols 1-42. IARC Monographs on the Evaluation of Carcinogenic Risk to Humans, Suppl. 7, IARC, Lyon, France, pp. 150-152.
3. Heflich, R.H. (1991) Chemical mutagens. In Li, A.P. and Heflich, R.H. (eds), Genetic Toxicology. CRC Press, Boca Ratón, FL.
4. Ludlum, D.B. (1990) DNA alkylation by the haloethylnitrosoureas: nature of modifications produced and their enzymatic repair or removal. Mutat. Res., 233, 117-126.
5. Erickson, L.C., Laurent, G., Sharkey, N.A. and Kohn, K.W. (1980) DNA cross-linking and monoadduct repair in nitrosourea-treated tumor cells. Nature, 288, 727-729.
6. 6-alkylguanine-DNA alkyltransferase. Cancer Res., 46, 3353-3357.
7. 6-alkylguanine-DNA alkyltransferase complexed with BCNU-treated, synthetic oligonucleotide. Nucleic Acids Res., 17, 6581-6590.
8. 6-alkylguanine function. Nucleic Acids Res., 18, 3961-3966.
9. 6-alkylguanine-DNA-alkyltransferase gene of E.coli. Nucleic Acids Res., 15, 9177-9193.
10. 6-methylguanine in adapted Escherichia coli. Proc. Natl Acad. Sci. USA, 12, 6017-6020.
11. McCarthy, T.V., Karran, P. and Lindahl, T. (1984) Inducible repair of O-alkylated DNA pyrymidines in Escherichia coli. EMBO J., 3, 545-550.
12. Teo, I., Sedgwick, B., Demble, B., Li, B. and Lindahl, T. (1984) Induction of resistance to alkylating agents in E.coli: the ada gene product serves both as a regulatory protein and as an enzyme for repair of mutagenic damage. EMBO J., 3, 2151-2157.
13. Samson, L. and Cairns, J. (1977) A new pathway for DNA repair in Escherichia coli. Nature, 267, 281-282.
14. Rebeck, G.W., Coons, S., Carroll, P. and Samson, L. (1988) A second DNA methyltransferase repair enzyme in Escherichia coli. Proc. Natl Acad. Sci. USA, 85, 3039-3043.
15. Potter, P.M., Kleibl, K., Cawkwell, L. and Margison, G.P. (1989) Expression of the ogt gene in wild-type and ada mutants of E.coli. Nucleic Acids Res., 17, 8047-8060.
16. Rebeck, G.W., Smith, C.M., Goad, D.L. and Samson, L. (1989) Characterization of the major DNA repair methyltransferase activity in unadapted Escherichia coli and identification of a similar activity in Salmonella typhimurium. J. Bacteriol., 171, 4563-4568.
17. 4-methylthymine in dodecadeoxyribonucleotides. Nucleic Acids Res., 17, 8475-8484.
18. Abril, N., Roldán-Arjona, T., Prieto-Alamo, M-J., van Zeeland, A.A. and Pueyo, C. (1992) Mutagenesis and DNA repair for alkylation damages in Escherichia coli K-12. Environ. Mol. Mutagen., 19, 288-296.
19. Abril, N., Hera, C., Alejandre, E., Rafferty, J.A., Margison, G.P. and Pueyo, C. (1994) Effect of ogt expression on mutation induction by methyl-, ethyl-and propylmethanesulphonate in Escherichia coli K-12 strains. Mol. Gen. Genet., 242, 744-748.
20. 6-methylguanine DNA repair methyltransferase. J. Bacteriol., 173, 2068-2076.
21. 6-alkylguanine-DNA-alkyltransferase: comparative sequence and structural properties. Mol. Carcinogen., 5, 161-169.
22. 4-alkylthimines in human cells. J. Biol. Chem., 269, 25521-25528.
23. 6-alkylguanine-DNA alkyltransferase-proficient and -deficient strains. Mol. Carcinogen., 14, 233-239.
24. Vidal, A., Abril, N. and Pueyo, C. (1995) DNA repair by Ogt alkyltransferase influences EMS mutational specificity. Carcinogenesis, 16, 817-821.
25. Abril, N., Luque-Romero, F.L., Prieto-Alamo, M.J., Margison, G.P. and Pueyo, C. (1995) ogt alkyltransferase enhances dibromoalkane mutagenicity in excision repair-deficient Escherichia coli K-12. Mol. Carcinogen., 12, 110-117.
26. Yanisch-Perron, C., Vieira, J. and Messing, J. (1985) Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors. Gene, 33, 103-119.
27. Hanna, Z., Fregeau, C., Prefontaine, G. and Brousseau, R. (1984) Construction of a family of expression plasmid vectors. Gene, 30, 247-250.
28. 6-methylguanine DNA repair methyltransferase. J. Bacteriol., 173, 2068-2076.
29. Mackay, W.J., Han, S. and Samson, L.D. (1994) DNA alkylation repair limits spontaneous base substitution mutations in Escherichia coli. J. Bacteriol., 176, 3224-3230.
30. 6-alkylguanine-DNA-alkyltransferase gene, molecular analysis of expression in rat liver. Carcinogenesis, 12, 727-733.
31. Curtis, R. (1981) Gene transfer. In Gerhardt, P. (ed.), Manual of Methods for General Bacteriology. American Society for Microbiology, Washington, DC.
32. Davis, R.W., Botstein, D. and Roth, J.R. (1980) A Manual for Genetic Engineering. Advanced Bacterial Genetics. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, pp. 201-206.
33. Pueyo, C. and Ruiz-Rubio, M. (1984) The L-arabinose resistance test with Salmonella typhimurium. In de Serres, F.J. (ed.), Chemical Mutagens: Principles and Methods for their Detection. Plenum Press, New York, NY, Vol. 9, pp. 89-109.
34. Abril, N. and Pueyo, C. (1990) Mutagenesis in E.coli lacking catalase. Environ. Mol. Mutagen., 15, 184-189.
35. Hera, C. and Pueyo, C. (1992) Conditions for the optimal use of the L-arabinose-resistance mutagenesis test with Salmonella typhimurium. Mutagenesis, 1, 267-273.
36. Kacinski, B.M., Rupp, W.D. and Ludlum, D.B. (1985) Repair of haloethylnitrosourea-induced DNA damage in mutant and adapted bacteria. Cancer Res., 45, 6471-6474.
37. Fram, R.J., Sullivan, J. and Marinus, M.G. (1986) Mutagenesis and repair of DNA damage caused by nitrogen mustard, N,N′-bis(2-chloroethyl)-N-nitrosourea (BCNU), streptozotocin, and mitomycin C in E.coli. Mutat. Res., 166, 229-242.
38. Takahashi, K., Kohda, K., Oh-hara, T., Sekiguchi, M. and Kawazoe, Y. (1988) Structural requirement for the induction of the adaptive response in Escherichia coli among N-(substituted alkyl)-N-nitrosoureas. Mutat. Res., 202, 193-201.
39. Foster, P.L. and Eisenstadt, E. (1985) Induction of transversion mutations in Escherichia coli by N-methyl-N′-nitro-N-nitrosoguanidine is SOS dependent. J. Bacteriol., 163, 213-220.
40. 6-alkylguanine alkyltransferase reduces the toxic effects of alkylating agents. Carcinogenesis, 7, 2081-2084.
41. 6-ethylguanine in DNA. Nucleic Acids Res., 22, 1613-1619.
42. Margison, G.P., Cooper, D.P. and Potter, P.M. (1990) The E.coli ogt gene. Mutat. Res., 233, 15-21.
43. Samson, L. (1992) The suicidal DNA repair methyltransferases of microbes. Mol. Microbiol., 6, 825-831.
44. Inga, A., Iannone, R., Campomenosi, P., Molina, F., Menichini, P., Abbondandolo, A. and Fronza, G. (1995) Mutational fingerprint induced by the antineoplastic drug chloroethyl-cyclohexyl-nitrosourea in mammalian cells. Cancer Res., 55, 4658-4663.
45. 6-alkylguanine-DNA alkyltransferase gene ogt reduces the toxicity of alkylnitrosoureas. Br. J. Cancer, 67, 1196-1202.
46. 6-benzylguanine. Biochem. J., 298, 231-235.