An antisense oligonucleotide on the mouse Shaker-like potassium channel Kv1.1 gene prevents antinociception induced by morphine and baclofen

Journal of Pharmacology and Experimental Therapeutics

Volumn 281, Issue 2, 1997, Pages 941-949

  Galeotti, Nicoletta ^a   Ghelardini, Carla ^a   Papucci, Laura ^a   Capaccioli, Sergio ^a   Quattrone, Alessandro ^a   Bartolini, Alessandro ^a,b  

^a UNIVERSITY OF FLORENCE   (Italy)

^b Department of Pharmacology ^*  (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID B RECEPTOR; ANTISENSE OLIGONUCLEOTIDE; BACLOFEN; GUANINE NUCLEOTIDE BINDING PROTEIN; MORPHINE; POTASSIUM CHANNEL;

ANALGESIA; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; DROSOPHILA; GENE EXPRESSION; MEMBRANE POTENTIAL; MOUSE; NEUROTRANSMISSION; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE DIAGNOSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ANALYSIS;

ANALGESICS; ANIMALS; BACLOFEN; BEHAVIOR, ANIMAL; DRUG DESIGN; GENE EXPRESSION REGULATION; KV1.1 POTASSIUM CHANNEL; MALE; MICE; MORPHINE; OLIGONUCLEOTIDES, ANTISENSE; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED;

EID: 0031000269     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (64)

1. 2-adrenoceptor-induced hyperpolarization of locus coeruleus neurones in brain slices: Reversal by cyclic adenosine 3′:5′-monophosphate analogues. J. Neurosci. 5: 2359-2364, 1985.
2. ASHCROFT, F. M.: Adenosine 5′-triphosphate-sensitive potassium channels. Annu. Rev. Neurosci. 11: 97-118, 1989.
3. BLAGOSKLONNY, M. V. AND NECKERS, L. M.: Oligonucleotides protect cells from the cytotoxicity of several anti-cancer chemotherapeutic drugs. Anti-Cancer Drugs 5: 437-442, 1994.
4. BOSMA, M. M., ALLEN, M. L., MARTIN, T. M. AND TEMPEL, B. L.: PKA-dependent regulation of mKv1.1, a mouse Shaker-like potassium channel gene, when expressed in CHO cells. J. Neurosci. 13: 5242-5250, 1993.
5. BROWN, A. M. AND BIRNBAUMER, L.: Ionic channels and their regulation by G protein subunits. Annu. Rev. Physiol. 52: 197-213, 1990.
6. BROWN, D. A.: G-proteins and potassium currents in neurones. Annu. Rev. Physiol. 52: 215-242, 1990.
7. CAPACCIOLI, S., D. I. PASQUALE, G., MINI, E., MAZZEI, T. AND QUATTRONE, A.: Cationic lipids improve antisense oligonucleotide uptake and prevent degradation in cultured cells and in human serum. Biochem. Biophys. Res. Commun. 107: 818-825, 1993.
8. CATTERALL, W. A.: Structure and function of voltage-sensitive ion channels. Science 242: 50-61, 1988.
9. CHANDY, K. G., WILLIAMS, C. B., SPENCER, R. H., AGUILAR, B. A., GHANSHANI, S., TEMPEL, B. L. AND GUTMAN, G. A.: A family of three mouse potassium channel genes with intronless coding regions. Science 247: 973-975, 1990.
10. CHERUBINI, E. AND NORTH, R. A.: μ and κ opioids inhibit transmitter release by different mechanism. Proc. Natl. Acad. Sci. U.S.A. 82: 1860-1863, 1985.
11. CHOU, Q., RUSSELL, M., BIRCH, D. E., RAYMOND, J. AND BLOCH, W.: Prevention of pre-PCR mis-priming and primer dimerization improves low-copy-number amplifications. Nucleic Acids Res. 20: 1717-1723, 1992.
12. CHRISTIE, M. J., ADELMAN, J. P., DOUGLASS, J. AND NORTH, R. A.: Expression of a cloned rat brain potassium channel in Xenopus oocytes. Science 244: 221-224, 1989.
13. COOK, N. S. AND QUAST, U.: Potassium channel pharmacology. In Potassium Channels: Structure, Classification, Function and Therapeutic Potential. ed. by N. S. Cook, pp. 181-255, Ellis Horwood Limited, Chichester, 1990.
14. DUNWIDDIE, T. V. AND SU, M. T.: Pertussis toxin pretreatment antagonizes the actions of mu- and delta-opiate agonists in hippocampal slices. Neurosci. Lett. 95: 329-334, 1988.
15. + current in voltage-clamped CA3 pyramidal cells in hippocampal cultures. Proc. Natl. Acad. Sci. U.S.A. 82: 1558-1562, 1985.
16. GALEOTTI, N., GHELARDINI, C. AND BARTOLINI, A.: Effect of pertussis toxin on morphine, diphenhydramine, baclofen, clomipramine and physostigmine antinociception. Eur. J. Pharmacol. 308: 125-133, 1996.
17. GAO, W.-Y., HAN, F.-S., STORM, C., EGAN, W. AND CHEN, Y.-C.: Phosphorothioate oligonucleotides are inhibitors of human DNA polymerases and RNase H: Implications for antisense technology. Mol. Pharmacol. 41: 223-229, 1992.
18. + current by isoprenaline in bull-frog atrial myocytes. J. Physiol. 415: 233-249, 1989.
19. GOODCHILD, J.: Inhibition of gene expression by oligonucleotides. In Oligodeoxynucleotides, Antisense Inhibitors of Gene Expression, ed. by J. Cohen, pp.53-77, Macmillan, London, 1989.
20. + channels, types Kv1.1, 1.2, 1.3, 1.5 and 3.1, stably expressed in mammalian cell lines. J. Pharmacol. Exp. Ther. 45: 1227-1234, 1994.
21. HALEY, T. J. AND MCCORMICK, W. G.: Pharmacological effects produced by intracerebral injection of drugs in the conscious mouse. Br. J. Pharmacol. Chemother. 12: 12-15, 1957.
22. + channels in the central nervous system. In Potassium Channels: Structure, Classification, Function and Therapeutic Potential, ed. by N. S. Cook, pp. 348-381, Ellis Horwood Limited, Chichester, 1990.
23. HEPLER, J. R. AND GILMAN, A. G.: G proteins. Trends Biochem. Sci., 17: 383-387, 1992
24. HILLE, B.: Modulation of ion-channel function by G-protein-coupled receptors. Trends Neurosci. 17: 531-536, 1994.
25. HOPKINS, W. F. AND TEMPEL, B. L.: Members of a mouse subfamily of genes encoding voltage-gated potassium channel subunits form heteromultimers when co-expressed in Xenopus oocytes. Soc. Neurosci. Abstr. 18: 1093, 1992.
26. + conductance in guinea-pig hippocampal pyramidal cells maintained in vitro. Br. J. Pharmacol. 84: 833-841, 1985.
27. JAN, L. Y. AND JAN, Y. N.: Voltage-sensitive ion channels. Cell 56: 13-25, 1989.
28. + channels gated by voltage and ions. Annu. Rev. Physiol. 46: 485-495, 1984.
29. NARITA, M., SUZUKI, T., MISAWA, M., NAGASE, H., NABESHIMA, A., ASHIZAWA, T., OZAWA, H. SAITO, T. AND TAKAHATA, N.: Role of central ATP-sensitive potassium channels in the analgesic effect and spinal noradrenaline turnover-enhancing effect of intracerebroventricularly injected morphine in mice. Brain Res. 596: 209-214, 1992.
30. NG, S. Y., GUNNING, P., EDDY, R., PONTE, P., LEAVITT, J., SHOWS, T. AND KEDES, L.: Evolution of the functional human β-actin gene and its multipseudogene family: conservation of non-coding regions and chromosomal dispersion of pseudogenes. Mol. Cell Biol. 5: 2720-2732, 1985.
31. NORTH, R. A. AND WILLIAMS, J. T.: On the potassium conductance increased by opioids in rat locus coeruleus neurones. J. Physiol. 364: 265-280, 1985.
32. O'CALLAGHAN, J. P. AND HOLTZMAN, S. G.: Quantification of the analgesic activity of narcotic antagonists by a modified hot-plate procedure. J. Pharmacol. Exp. Ther. 192: 497-505, 1975.
33. B and k-opioid receptor agonists. Br. J. Pharmacol. 110: 1049-1054, 1993.
34. B, mu and kappa opioid receptors. J. Pharmacol. Exp. Ther. 276: 1136-1142, 1996.
35. + channel-acting drugs. Br. J. Pharmacol. 144: 1296-1302, 1995.
36. + channel with conserved delayed-rectifier properties. J. Neurosci. 11: 869-880, 1991.
37. PARENTI, M., TIRONE, F., GIAGNONI, G., PECORA, N. AND PAROLARO, D.: Pertussis toxin inhibits the antinociceptive action of morphine in the rat. Eur. J. Pharmacol. 124: 357-359, 1986.
38. QUATTRONE, A., FIBBI, G., PUCCI, M., ANICHINI, E., CAPACCIOLI, S. AND DEL ROSSO, M.: Reversion of the invasive phenotype of transformed human fibroblasts by antimessenger oligonucleotide inhibiting the urokinase receptor gene expression. Cancer Res. 55: 91-95, 1995a.
39. QUATTRONE, A., PAPUCCI, L., MORGANTI, L., CORONNELLO, M., MINI, E., MAZZEI, T. COLONNA, F. P., GARBESI, A. AND CAPACCIOLI, S.: Inhibition of MDR1 gene expression by antimessenger oligonucleotides lowers multiple drug resistance in neoplastic cells. Oncol. Res. 6: 311-320, 1994a.
40. QUATTRONE, A., PAPUCCI, L., SANTINI, V., SCHIAVONE, N., NOFERINI, D., CALASTRETTI, A., COPRENI, E., MORELLI, S., ROSSI FERRINI, P. L., NICOLIN, A. AND CAPACCIOLI, S.: Quantitation of bcl-2 oncogene expression in cultured follicular lymphoma and primary leukemia B-cells by a highly sensitive RT-PCR method. Haematologica 80: 495-504, 1995b.
41. QUATTRONE, A., PAPUCCI, L., SCHIAVONE, N., MINI, E. AND CAPACCIOLI, S.: Intra-cellular enhancement of intact antisense oligonucleotide steady-state levels by cationic lipids. Anti-Cancer Drug Design 9: 549-553, 1994b.
42. RAFFA, R. B. AND MARTINEZ, R. P.: The 'glibenclamide shift' of centrally acting antinociceptive agents in mice. Brain Res. 677: 277-282, 1995.
43. ROANE, D. S. AND BOYD, N. E.: Reduction of food intake and morphine analgesia by central glibenclamide. Pharmacol. Biochem. Behav. 46: 205-207, 1993.
44. ROBERTSON, B. AND OWEN, D. G.: Pharmacology of a cloned potassium channel from mouse brain (MK-1) expressed in CHO cells: effects of blockers and an 'inactivation peptide.' Br. J. Pharmacol. 109: 725-735, 1993.
45. RUDY, B.: Diversity and ubiquity of potassium channels. Neuroscience 25: 729-749, 1988.
46. SCHICK, B. P., ERAS, J. L. AND MINTZ, P. L.: Phosphorothioate oligonucleotides cause degradation of secretory but not intracellular serglycin proteoglycan core protein in a sequence-independent manner in human megacaryocytic tumor cells. Antisense Res. Dev. 5: 59-65, 1995.
47. SHARMA, S. K., NIRENBERG, M. AND KLEE, W. A.: Morphine receptors as regulators of adenylate cyclase activity. Proc. Natl. Acad. Sci. U.S.A. 72: 590-594, 1975.
48. + current in human T lymphocytes. J. Membr. Biol. 117: 263-274, 1990.
49. STEIN, C. A. AND CHENG, Y.-C.: Antisense oligonucleotides as therapeutic agents. Is the bullet really magic? Science 261: 1004-1011, 1993.
50. STEPHENS, G. J., GARRATT, J. C., ROBERTSON, B. AND OWEN, D. G.: On the mechanism of 4-aminopyridine action on the cloned mouse brain potassium channel mKv1.1. J. Physiol. 477: 187-196, 1994.
51. STEVENS, D. R., GALLAGHER, J. P. AND SHINNICK-GALLAGHER, P.: Further studies on the action of baclofen on neurons of the dorsolateral septal nucleus of the rat, in vitro. Brain Res. 358: 360-363, 1985.
52. STOREY, A., OATES, D., BANKS, L., CRAWFORD, L. AND CROOK, T.: Antisense phosphorothioate oligonucleotides have both specific and non-specific effects on cells containing human papillomavirus type 16. Nucleic Acids Res. 19: 4109-4114, 1991.
53. STÜHMER, W., RUPPERSBERG, J. P., SCHRÖTER, K. H., SAKMANN, B., STOCKER, M., GIESE, K. P., PERSCHKE, A., BAUMANN, A. AND PONGS, O.: Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain. EMBO J. 8: 3235-3244, 1989.
54. SWANSON, R., MARSHALL, J. SMITH, J. S., WILLIAMS, J. B., BOYLE, M. B., FOLANDER, K., LUNEAU, C. J., ANTANAVAGE, J., OLIVA, C., BUHROW, S. A., BENNET, C., STEIN, R. B. AND KACZMAREK, L. K.: Cloning and expression of cDNA and genomic clones encoding three delayed rectifier potassium channels in rat brain. Neuron 4: 929-939, 1990.
55. TEMPEL, B. L., JAN, Y. N. AND YAN, L. Y.: Cloning of a probable potassium channel gene from the mouse brain. Nature 332: 837-839, 1988.
56. VAUGHT, J., PELLEY, K., COSTA, L. G., SETHER, P. AND ENNA, S. J.: A comparison of the antinociceptive responses to GABA-receptor agonists THIP and baclofen. Neuropharmacology 24: 211-16, 1985.
57. VERGONI, A. V., SCARANO, A. AND BERTOLINI, A.: Pinacidil potentiates morphine analgesia. Life Sci. 50: PL135-PL138, 1992.
58. WAHLESTEDT, C.: Antisense oligonucleotide strategies in neuropharmacology. Trends Pharmacol. Sci. 15: 42-46, 1994.
59. WANG, H., KUNKEL, D. D., SCHWARTZKROIN, P. A. AND TEMPEL, B. L.: Localization of Kv1.1 and Kv1.2, two K channel proteins, to synaptic terminals, somata, and dendrites in the mouse brain. J. Neurosci. 14: 4588-4599, 1994.
60. WANG, Y.-Y. AND AGHAJANIAN, G. K.: GTPγS restores the ability of morphine to hyperpolarize rat locus coeruleus neurones after blockade by pertussis toxin. Brain Res. 436: 396-401, 1987.
61. WELCH, S. P. AND DUNLOW, L. D.: Antinociceptive activity of intrathecally administered potassium channel openers and opioid agonists: A common mechanism of action? J. Pharmacol. Exp. Ther. 267: 390-399, 1993.
62. WHITESELL, L., GESELOWITZ, D., CHAVANY, C., FAHMY, B., WALBRIDGE, S., ALGER, J. AND NECKERS, L. M.: Stability, clearance, and disposition of intraventricularly administered oligodeoxynucleotides: Implications for therapeutic application within the central nervous system. Proc. Natl. Acad. Sci. U.S.A. 90: 4665-4669, 1993.
63. WILD, K. D., VANDERAH, T., MOSBERG, H. I. AND PORRECA, F.: Opioid δ receptor subtypes are associated with different potassium channels. Eur. J. Pharmacol. 193: 135-136, 1991.
64. WILLIAMS, J. T., NORTH, R. A. AND TOKIMASA, T.: Inward rectification of resting and opiate-activated potassium currents in rat locus coeruleus neurones. J. Neurosci. 8: 4299-4306, 1988.