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Volumn 11, Issue 1, 1999, Pages 27-32

Inflammatory bowel disease approaching the 3rd millennium: Pathogenesis and therapeutic implications?

Author keywords

Crohn's disease; Inflammatory bowel disease; Ulcerative colitis

Indexed keywords

CLONIDINE; CYTOKINE; LIDOCAINE; NICOTINE;

EID: 0032976217     PISSN: 0954691X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00042737-199901000-00006     Document Type: Review
Times cited : (30)

References (49)
  • 1
    • 0028911445 scopus 로고
    • Molecular defined HLA-DR2 alleles in ulcerative colitis and an antineutrophil cytoplasmic antibody-positive subgroup
    • Duerr R, Neigut D. Molecular defined HLA-DR2 alleles in ulcerative colitis and an antineutrophil cytoplasmic antibody-positive subgroup. Gastroenterology 1995; 108:423-427.
    • (1995) Gastroenterology , vol.108 , pp. 423-427
    • Duerr, R.1    Neigut, D.2
  • 2
    • 0030007093 scopus 로고    scopus 로고
    • Contribution of genes of the major histocompatibility complex to susceptibility and disease phenotype in inflammatory bowel disease
    • Satsangi J, Welsh K, Bunce M, Julier C, Farrant JM, Bell JI, et al. Contribution of genes of the major histocompatibility complex to susceptibility and disease phenotype in inflammatory bowel disease. Lancet 1996; 347:1212-1217.
    • (1996) Lancet , vol.347 , pp. 1212-1217
    • Satsangi, J.1    Welsh, K.2    Bunce, M.3    Julier, C.4    Farrant, J.M.5    Bell, J.I.6
  • 3
    • 0028123647 scopus 로고
    • Novel genetic association between ulcerative colitis and the antiinflammatory cytokine interleukin-1 receptor antagonist
    • Mansfield JC, Holden H, Tarlow JK, Di Giovane FS, McDowell IL, Wilson AG, et al. Novel genetic association between ulcerative colitis and the antiinflammatory cytokine interleukin-1 receptor antagonist. Gastroenterology 1994; 106:637-642.
    • (1994) Gastroenterology , vol.106 , pp. 637-642
    • Mansfield, J.C.1    Holden, H.2    Tarlow, J.K.3    Di Giovane, F.S.4    McDowell, I.L.5    Wilson, A.G.6
  • 4
    • 0000171738 scopus 로고
    • Association between ulcerative colitis and a polymorphism in intron 2 of the interleukin-1 receptor antagonist gene
    • Duerr R, Tran T. Association between ulcerative colitis and a polymorphism in intron 2 of the interleukin-1 receptor antagonist gene [Abstract]. Gastroenterology 1995; 108:A812.
    • (1995) Gastroenterology , vol.108
    • Duerr, R.1    Tran, T.2
  • 5
    • 0029935072 scopus 로고    scopus 로고
    • Tumor necrosis factor microsatellites define a Crohn's disease-associated haplotype on chromosome 6
    • Plevy S, Targan S, Yang H, Fernandez D, Rotter J, Toyoda H. Tumor necrosis factor microsatellites define a Crohn's disease-associated haplotype on chromosome 6. Gastroenterology 1996; 110:1053-1060.
    • (1996) Gastroenterology , vol.110 , pp. 1053-1060
    • Plevy, S.1    Targan, S.2    Yang, H.3    Fernandez, D.4    Rotter, J.5    Toyoda, H.6
  • 7
    • 16044373177 scopus 로고    scopus 로고
    • Two stage genome-wide search in inflammatory bowel disease provides evidence for susceptibility loci on chromosome 3, 7, and 12
    • Satsangi J, Parkes M, Louis E, Hashimoto L, Kato N, Weish K, et al. Two stage genome-wide search in inflammatory bowel disease provides evidence for susceptibility loci on chromosome 3, 7, and 12. Nature Genet 1996; 14:199-202.
    • (1996) Nature Genet , vol.14 , pp. 199-202
    • Satsangi, J.1    Parkes, M.2    Louis, E.3    Hashimoto, L.4    Kato, N.5    Weish, K.6
  • 8
    • 0026575548 scopus 로고
    • Somatic gene therapy in gastroenterology: Approaches and applications
    • Ledley FD. Somatic gene therapy in gastroenterology: approaches and applications. J Pediatr Gastroenterol Nutr 1992; 14:328-337.
    • (1992) J Pediatr Gastroenterol Nutr , vol.14 , pp. 328-337
    • Ledley, F.D.1
  • 9
    • 0030051756 scopus 로고    scopus 로고
    • Antisense-oligonucleotide therapy
    • Askari FK, McDonnell WM. Antisense-oligonucleotide therapy. N Engl J Med 1996; 334:316-318.
    • (1996) N Engl J Med , vol.334 , pp. 316-318
    • Askari, F.K.1    McDonnell, W.M.2
  • 10
    • 0031467628 scopus 로고    scopus 로고
    • Therapeutic effects of interleukin-4 gene transfer in experimental inflammatory bowel disease
    • Hogaboam CM, Vallance BA, Kumar A, Addison CL, Graham FL, Gauldie J, et al. Therapeutic effects of interleukin-4 gene transfer in experimental inflammatory bowel disease. J Clin Invest 1997; 100:2766-2776.
    • (1997) J Clin Invest , vol.100 , pp. 2766-2776
    • Hogaboam, C.M.1    Vallance, B.A.2    Kumar, A.3    Addison, C.L.4    Graham, F.L.5    Gauldie, J.6
  • 11
    • 0024353079 scopus 로고
    • Th1 and Th2 cells: Different patterns of lymphokine secretion lead to different functional properties
    • Mosman TR, Coffman RL. Th1 and Th2 cells: different patterns of lymphokine secretion lead to different functional properties. Ann Rev Immunol 1989; 7:145-173.
    • (1989) Ann Rev Immunol , vol.7 , pp. 145-173
    • Mosman, T.R.1    Coffman, R.L.2
  • 12
    • 0030209985 scopus 로고    scopus 로고
    • Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease: Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5
    • Fuss IJ, Neurath M, Boirivant M, Klein JS, Delamotte C, Strong SA, et al. Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease: Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5. J Immunol 1996; 157:1261-1270.
    • (1996) J Immunol , vol.157 , pp. 1261-1270
    • Fuss, I.J.1    Neurath, M.2    Boirivant, M.3    Klein, J.S.4    Delamotte, C.5    Strong, S.A.6
  • 13
    • 0002050773 scopus 로고    scopus 로고
    • Biological therapy for inflammatory bowel disease
    • Sands BE. Biological therapy for inflammatory bowel disease. Inflam Bowel Dis 1997; 3:95-113.
    • (1997) Inflam Bowel Dis , vol.3 , pp. 95-113
    • Sands, B.E.1
  • 15
    • 0030989417 scopus 로고    scopus 로고
    • CD4 antibody treatment in patients with active Crohn's disease: A phase i dose finding study
    • Stronkhorst A, Radema S, Yong SL, Bijl H, Ten Berg UM, Tytgat GNJ, et al. CD4 antibody treatment in patients with active Crohn's disease: a phase I dose finding study. Gut 1997; 40:320-327.
    • (1997) Gut , vol.40 , pp. 320-327
    • Stronkhorst, A.1    Radema, S.2    Yong, S.L.3    Bijl, H.4    Ten Berg, U.M.5    Tytgat, G.N.J.6
  • 16
    • 0025743242 scopus 로고
    • Treatment of inflammatory bowel disease with anti-CD4 monoclonal antibody
    • Emmrich J, Seyfarth M, Fleig WE, Emmrich F. Treatment of inflammatory bowel disease with anti-CD4 monoclonal antibody. Lancet 1991; 338:570-571.
    • (1991) Lancet , vol.338 , pp. 570-571
    • Emmrich, J.1    Seyfarth, M.2    Fleig, W.E.3    Emmrich, F.4
  • 17
    • 0000313865 scopus 로고
    • Anti-CD6 antibody treatment in inflammatory bowel disease without a long CD4+-cell depletion
    • Emmrich J, Seyfarth M, Liebe S, Emmrich F. Anti-CD6 antibody treatment in inflammatory bowel disease without a long CD4+-cell depletion [Abstract]. Gastroenterology 1995; 108:A815.
    • (1995) Gastroenterology , vol.108
    • Emmrich, J.1    Seyfarth, M.2    Liebe, S.3    Emmrich, F.4
  • 20
    • 0028907439 scopus 로고
    • Immunoregulatory role of interleukin 10 in patients with inflammatory bowel disease
    • Schreiber S, Heing T, Thiele HG, Raedler A. Immunoregulatory role of interleukin 10 in patients with inflammatory bowel disease. Gastroenterology 1995; 108:1434-1444.
    • (1995) Gastroenterology , vol.108 , pp. 1434-1444
    • Schreiber, S.1    Heing, T.2    Thiele, H.G.3    Raedler, A.4
  • 21
    • 0030835754 scopus 로고    scopus 로고
    • Multiple doses of intravenous interleukin 10 in steroid refractory Crohn's disease
    • van Deventer Sjhelson CO, Fedorak RN, for the Crohn's Disease Study Group. Multiple doses of intravenous interleukin 10 in steroid refractory Crohn's disease. Gastroenterology 1997; 113:383-389.
    • (1997) Gastroenterology , vol.113 , pp. 383-389
    • Van Deventer Sjhelson, C.O.1    Fedorak, R.N.2
  • 22
    • 85038200406 scopus 로고    scopus 로고
    • Safety, tolerance and efficacy of multiple doses of subcutaneous interleukin-10 in mild to moderate active Crohn's disease (Stamm-CD)
    • New Orleans, 17-20 May
    • Fedorak RN, Gangl A, Elson CO, Rutgeers P, Schreiber S, Wild G, et al. Safety, tolerance and efficacy of multiple doses of subcutaneous interleukin-10 in mild to moderate active Crohn's disease (Stamm-CD). Presented at Digestive Disease Week, New Orleans, 17-20 May 1998:A4408.
    • (1998) Digestive Disease Week
    • Fedorak, R.N.1    Gangl, A.2    Elson, C.O.3    Rutgeers, P.4    Schreiber, S.5    Wild, G.6
  • 23
    • 0028861975 scopus 로고
    • Antibodies to interleukin 12 abrogate established experimental colitis in mice
    • Neurath MF, Fuss I, Kelsall BL, Stuber E, Strober W. Antibodies to interleukin 12 abrogate established experimental colitis in mice. J Exp Med 1995; 182:1281-1290.
    • (1995) J Exp Med , vol.182 , pp. 1281-1290
    • Neurath, M.F.1    Fuss, I.2    Kelsall, B.L.3    Stuber, E.4    Strober, W.5
  • 24
    • 0029878287 scopus 로고    scopus 로고
    • Therapeutic potential for blockade of the CD40 ligand, gp39
    • Buhlmann JE, Noelle RJ. Therapeutic potential for blockade of the CD40 ligand, gp39. J Clin Immunol 1996; 16:83-89.
    • (1996) J Clin Immunol , vol.16 , pp. 83-89
    • Buhlmann, J.E.1    Noelle, R.J.2
  • 25
    • 0028069352 scopus 로고
    • Cytokines in intestinal inflammation: Pathophysiological and clinical considerations
    • Sartor RB. Cytokines in intestinal inflammation: pathophysiological and clinical considerations. Gastroenterology 1994; 106:533-539.
    • (1994) Gastroenterology , vol.106 , pp. 533-539
    • Sartor, R.B.1
  • 26
    • 0028038782 scopus 로고
    • Inflammatory granuloma formation is mediated by TNF-alpha-inducible intercellular adhesion molecule-1
    • Lukacs NW, Chensue SW, Strieter RM, Warmington K, Kunkel SL. Inflammatory granuloma formation is mediated by TNF-alpha-inducible intercellular adhesion molecule-1. J Immunol 1994; 152:5883-5889.
    • (1994) J Immunol , vol.152 , pp. 5883-5889
    • Lukacs, N.W.1    Chensue, S.W.2    Strieter, R.M.3    Warmington, K.4    Kunkel, S.L.5
  • 27
    • 0028222364 scopus 로고
    • Rabbit interleukin-1 receptor antagonist: Cloning, expression, functional characterization, and regulation during intestinal inflammation
    • Cominelli F, Bortolami M, Pizzarro TT. Rabbit interleukin-1 receptor antagonist: cloning, expression, functional characterization, and regulation during intestinal inflammation. J Biol Chem 1994; 269:6962-6971.
    • (1994) J Biol Chem , vol.269 , pp. 6962-6971
    • Cominelli, F.1    Bortolami, M.2    Pizzarro, T.T.3
  • 28
    • 0026697049 scopus 로고
    • Recombinant interleukin-1 receptor antagonist blocks the proinflammatory activity of endogenous interleukin-1 in rabbit immune colitis
    • Cominelli F, Nast CC, Duchini A, Lee M. Recombinant interleukin-1 receptor antagonist blocks the proinflammatory activity of endogenous interleukin-1 in rabbit immune colitis. Gastroenterology 1992; 103:65-71.
    • (1992) Gastroenterology , vol.103 , pp. 65-71
    • Cominelli, F.1    Nast, C.C.2    Duchini, A.3    Lee, M.4
  • 30
    • 0030954732 scopus 로고    scopus 로고
    • A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor a for Crohn's disease
    • Targan SR, Hanauer SB, Van Deventer SJH, Mayer L, Present DH, Braakman T, et al. A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor a for Crohn's disease. N Engl J Med 1997; 337:1029-1035.
    • (1997) N Engl J Med , vol.337 , pp. 1029-1035
    • Targan, S.R.1    Hanauer, S.B.2    Van Deventer, S.J.H.3    Mayer, L.4    Present, D.H.5    Braakman, T.6
  • 31
    • 0031043778 scopus 로고    scopus 로고
    • Randomised controlled trial of CDP571 antibody to tumor necrosis factor-α in Crohn's disease
    • Stack WA, Mann SD, Roy AJ, Heath P, Sopwith M, Freeman J, et al. Randomised controlled trial of CDP571 antibody to tumor necrosis factor-α in Crohn's disease. Lancet 1997; 349:521-524.
    • (1997) Lancet , vol.349 , pp. 521-524
    • Stack, W.A.1    Mann, S.D.2    Roy, A.J.3    Heath, P.4    Sopwith, M.5    Freeman, J.6
  • 32
    • 0009407281 scopus 로고
    • The infectious track in inflammatory bowel disease: A controversial area
    • Geboes K, Ectors N. The infectious track in inflammatory bowel disease: a controversial area. Res Clin Forums 1995; 17:41-48.
    • (1995) Res Clin Forums , vol.17 , pp. 41-48
    • Geboes, K.1    Ectors, N.2
  • 43
    • 0030816854 scopus 로고    scopus 로고
    • Treatment of corticosteroid-resistant ulcerative colitis with heparin: A report of 16 cases
    • Evans RC, Shim Wong V, Morris AL, Rhodes JM. Treatment of corticosteroid-resistant ulcerative colitis with heparin: a report of 16 cases. Aliment Pharmacol Ther 1997; 11:1037-1040.
    • (1997) Aliment Pharmacol Ther , vol.11 , pp. 1037-1040
    • Evans, R.C.1    Shim Wong, V.2    Morris, A.L.3    Rhodes, J.M.4
  • 44
    • 0029837011 scopus 로고    scopus 로고
    • The immunomodulation of enteric neuromuscular function: Implication for motility and inflammatory disorders
    • Collins S. The immunomodulation of enteric neuromuscular function: implication for motility and inflammatory disorders. Gastroenterology 1996; 111:1683-1699.
    • (1996) Gastroenterology , vol.111 , pp. 1683-1699
    • Collins, S.1
  • 45
    • 0000101888 scopus 로고
    • Neural-immune interactions in the intestine: Implications for inflammatory bowel disease
    • Kirsner JB, Shorter RG (editors). Baltimore: Williams and Wilkins
    • Ottaway CA, Stanisz AM. Neural-immune interactions in the intestine: implications for inflammatory bowel disease. In: Inflammatory Bowel Disease, IVth Edn. Kirsner JB, Shorter RG (editors). Baltimore: Williams and Wilkins; 1995. pp. 281-300.
    • (1995) Inflammatory Bowel Disease, IVth Edn. , pp. 281-300
    • Ottaway, C.A.1    Stanisz, A.M.2
  • 46
    • 0026579287 scopus 로고
    • Treatment of the mucosa with local anaesthetics in ulcerative colitis
    • Bjork S, Dahlstrom A, Johansson L, Ahlman H. Treatment of the mucosa with local anaesthetics in ulcerative colitis. Agents Actions 1992; Special Conference Issue:C60-C75.
    • (1992) Agents Actions , vol.SPECIAL CONFERENCE ISSUE
    • Bjork, S.1    Dahlstrom, A.2    Johansson, L.3    Ahlman, H.4
  • 47
    • 0030067726 scopus 로고    scopus 로고
    • Ropivocaine gel in active distal ulcerative colitis and proctitis - A pharmacokinetic and exploratory clinical study
    • Arlander E, Ost A, Stahlberg D, Löfberg R. Ropivocaine gel in active distal ulcerative colitis and proctitis - a pharmacokinetic and exploratory clinical study. Aliment Pharmacol Ther 1996; 10:73-81.
    • (1996) Aliment Pharmacol Ther , vol.10 , pp. 73-81
    • Arlander, E.1    Ost, A.2    Stahlberg, D.3    Löfberg, R.4
  • 49
    • 85038202499 scopus 로고    scopus 로고
    • Efficacy of transdermal clonidine for mild to moderate active left-sided ulcerative colitis: A pilot study
    • in press
    • Ardizzone S, Bollani S, Manzionna G, Maconi G, Furlan R, Vago L, Bianchi Porro G. Efficacy of transdermal clonidine for mild to moderate active left-sided ulcerative colitis: a pilot study. Gut, in press.
    • Gut
    • Ardizzone, S.1    Bollani, S.2    Manzionna, G.3    Maconi, G.4    Furlan, R.5    Vago, L.6    Bianchi Porro, G.7


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