Linkage of the Na,K-ATPase α2 and β1 genes with resting and exercise heart rate and blood pressure: Cross-sectional and longitudinal observations from the Quebec Family Study

Journal of Hypertension

Volumn 17, Issue 3, 1999, Pages 339-349

  Rankinen, Tuomo ^a   Pérusse, Louis ^a   Dériaz, Olivier ^b   Thériault, Germain ^a   Chagnon, Monique ^a   Nadeau, André ^b   Bouchard, Claude ^a  

^a UNIVERSITÉ LAVAL   (Canada)

^b LAVAL UNIVERSITY   (Canada)

Author keywords

Blood pressure; Exercise; Family study; Genetic polymorphism; Heart rate; Linkage analysis; Na,K ATPase

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ANTIHYPERTENSIVE AGENT; GLUCOSE; INSULIN;

ADULT; ALPHA CHAIN; ARTICLE; BETA CHAIN; CANADA; DIASTOLIC BLOOD PRESSURE; EXERCISE; FAMILY STUDY; FEMALE; GENETIC LINKAGE; GENETIC MARKER; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HEART RATE; HEMODYNAMICS; HUMAN; HUMAN CELL; INSULIN BLOOD LEVEL; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; OUTCOMES RESEARCH; PHENOTYPE; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SIBLING; SYSTOLIC BLOOD PRESSURE;

EID: 0032974376     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004872-199917030-00006     Document Type: Article

References (46)

1. 1 Lifton RP. Molecular genetics of human blood pressure variation. Science 1996; 272:676-680.
2. 2 Bouchard C, Malina RM, Pérusse L. Genetics of fitness and physical performance. Champaign, Illinois: Human Kinetics; 1997. pp. 243-266.
3. 3 Rice T, Bouchard C, Borecki IB, Rao DC. Commingling and segregation analysis of blood pressure in a French-Canadian population. Am J Hum Genet 1990; 46:37-44.
4. 4 Pérusse L, Moll PP, Sing CF. Evidence that a single gene with gender-and age-dependent effects influences systolic blood pressure determination in a population-based sample. Am J Hum Genet 1991; 49:94-105.
5. 5 Shu-Chuan L, Carmelli D, Hunt SC, Williams RR. Evidence for a major gene influencing 7-year increases in diastolic blood pressure with age. Am J Hum Genet 1995; 57:1169-1177.
6. 6 Lingrel JB, Orlowski J, Shull MM, Price EM. Molecular genetics of Na,K-ATPase. Prog Nucleic Acid Res Mol Biol 1990; 38:37-89.
7. + -ATPase. Biochim Biophys Acta 1989; 988:185-220.
8. 8 DeLuise M, Flier JS. Evidence for coordinate genetic control of Na,K pump density in erythrocytes and lymphocytes. Metabolism 1985; 34:771-776.
9. 9 Beutler E, Kuhl W, Sacks P. Sodium-potassium-ATPase activity is influenced by ethnic origin and not by obesity. N Engl J Med 1983; 309:756-760.
10. 10 Hasstedt SJ, Wu LL, Kuida H, Williams RR. Recessive inheritance of a high number of sodium pump sites. Am J Med Genet 1989; 34:332-337.
11. 11 Hasstedt SJ, Hunt SC, Wu LL, Williams RR. Evidence for multiple genes determining sodium transport. Genet Epidemiol 1994; 11:553-568.
12. 12 Aviv A, Lasker N. Proposed defects in membrane transport and intracellular ions as pathogenic factors in essential hypertension. In: Laragh JH, Brenner BM (editors): Hypertension: pathophysiology, diagnosis and management. New York: Raven Press; 1990. pp. 923-937,
13. 13 Garner MH. Changes in Na,K-adenosine triphosphatase (ATPase) concentration and Na,K-ATPase-dependent adenosine triphosphate turnover in human erythrocytes in diabetes. Metabolism 1996; 45:927-934.
14. + -ATPase and blood pressure. Hypertension 1987; 10:259-266.
15. +-adenosine triphosphatase. J Clin Invest 1985; 75:1813-1820.
16. 16 Samani NJ, Gauguier D, Vincent M, Kaiser MA, Bihoreau MT, Lodwick D, et al. Analysis of quantitative trait loci for blood pressure on rat chromosomes 2 and 13: age-related differences in effect. Hypertension 1996; 28:1118-1122.
17. + -ATPase: mechanisms underlying rapid and sustained changes in pump activity. Am J Physiol 1995; 269:C295-C311.
18. 18 Tack CJJ, Lutterman JA, Vervoort G, Thien T, Smits P. Activation of the sodium-potassium pump contributes to insulin-induced vasodilation in humans. Hypertension 1996; 28:426-432.
19. + - ATPase gene expression by insulin in vascular smooth muscle cells. Am J Hypertens 1993; 6:626-629.
20. + /K -ATPase from intracellular compartments to the plasma membrane in mammalian skeletal muscle. J Biol Chem 1992; 267:5040-5043.
21. +)-ATPase. J Biol Chem 1985; 260:10075-10080.
22. 22 Bouchard C. Genetic epidemiology, association and sib-pair linkage: results from the Québec family study. In: Bray GA, Ryan DH (editors): Molecular and genetic aspects of obesity. Baton Rouge: Louisiana State University Press; 1996. pp. 470-481.
23. 23 Dériaz O, Dionne F, Pérusse L, Tremblay A, Vohl M-C, Ôte G, et al. DNA variation in the genes of the Na,K-adenosine triphosphatase and its relation with resting metabolic rate, respiratory quotient, and body fat. J Clin Invest 1994; 93:838-843.
24. 24 Pérusse L, Lortie G, Leblanc C, Tremblay A, Thériault G, Bouchard C. Genetic and environmental sources of variation in physical fitness. Ann Hum Biol 1987; 14:425-434.
25. 25 Oppert J-M, Nadeau A, Tremblay A, Després J-P, Thériault G, Dériaz O, et al. Plasma glucose, insulin, and glucagon before and after long-term overfeeding in identical twins. Metabolism 1995; 44:96-105.
26. 26 Richterich R, Dauwalder H. Zur Bestimmung der plasma-glukose-konzentration mit der hexokinase-glucose-6-phosphat-dehydrogenase methode. Schweiz Med Wochenschr 1971; 101:615-618.
27. 27 Desbuquois B, Aurbach GD. Use of polyethylene glycol to separate free and antibody-bound peptide hormones in radioimmunoassays. J Clin Endocrinol Metab 1971; 37:732-738.
28. 28 Terwillinger J, Ott J. Handbook of human genetic linkage. Baltimore, Maryland: Johns Hopkins University Press, 1994.
29. 29 Haseman JK, Elston RC. The investigation of linkage between a quantitative trait and a marker locus. Behav Genet 1972; 2:3-19.
30. 30 Amos CI, Elston RC, Wilson AF, Bailey-Wilson JE. A more powerful test of linkage for quantitative traits. Genet Epidemiol 1989; 6:435-439.
31. 31 SAGE. Statistical analysis for genetic epidemiology, release 3.0. Cleveland, Ohio: Department of Epidemiology and Biostatistics, Rammelkamp Center for Education and Research, MetroHealth Campus, Case Western Reserve University; 1997.
32. + -ATPase and heart excitability. Adv Exp Med Biol 1995; 382:23-30.
33. + -ATPase α-subunit gene expression in hypertension. Science 1988; 241:221-223.
34. 2 Na,K-ATPase gene expression in transgenic rats. Hypertension 1997; 29:606-612.
35. + -ATPase activity in the central nervous system and endogenous sodium-pump inhibitors in the neural regulation of arterial blood pressure. J Cardiovasc Pharmacol 1993; 22:S13-S15.
36. + -ATPase activity in the central nervous system of spontaneously hypertensive rats: relationship to the development of high blood pressure. Clin Exp Hypertens 1995; 15:751-767.
37. 37 Francis GS. Interaction of the sympathetic nervous system and electrolytes in congestive heart failure. Am J Cardiol 1990; 65:24E-27E.
38. 38 McDonough AA, Geering K, Farley RA. The sodium pump needs its β subunit. FASEB J 1990; 4:1598-1605.
39. 2 gene and identification of intragenic restriction fragment length polymorphisms. J Biol Chem 1989; 264:17532-17543.
40. + -ATPase alpha-2-subunit alter the cation regulation of pump current expressed in HeLa cells. J Physiol (Camb) 1996; 495:733-742.
41. 1 isoform of Na,K-ATPase. FEBS Lett 1996; 389:179-185.
42. 42 Feng J, Lingrel JB. Functional consequences of substitutions of the carboxyl residue glutamate 779 of the Na,K-ATPase. Cell Mol Biol Res 1995; 41:29-37.
43. + interaction. J Biol Chem 1995; 270:22764-22771.
44. 44 Burns EL, Price EM. Random mutagenesis of the sheep Na,K-ATPase alpha-1 subunit generates a novel T797N mutation that results in a ouabain-resistant enzyme. J Biol Chem 1993; 268:25632-25635.
45. 45 Palasis M, Kuntzweiler TA, Argüello JM, Lingrel JB. Ouabain interactions with the H5-H6 hairpin of the Na,K-ATPase reveal a possible inhibition mechanism via the cation binding domain. J Biol Chem 1996; 271:14176-14182.
46. + -adenosine triphosphatase alleles and essential hypertension. J Hypertens 1992; 10:1005-1010.