The influence of stimulus temperature rise rate, adapting temperature, and stimulus duration on suprathreshold responses evoked by noxious heat in the glabrous skin of the limb. Comparison of neuronal discharge in the rat spinal dorsal horn with human sensations

Experimental Brain Research

Volumn 126, Issue 4, 1999, Pages 482-494

  Pertovaara, Antti ^a,b  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UNIVERSITY OF TURKU   (Finland)

Author keywords

Adapting temperature; Descending control; Human; Rat; Spinal dorsal horn neuron; Suprathreshold heat pain; Temporal parameters

Indexed keywords

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; FEMALE; GLABROUS SKIN; HEAT ACCLIMATIZATION; HUMAN; HUMAN EXPERIMENT; LATENT PERIOD; LIMB; MALE; NERVE FUNCTION; NOCICEPTIVE STIMULATION; NONHUMAN; NORMAL HUMAN; PAIN THRESHOLD; PERCEPTIVE THRESHOLD; PRIORITY JOURNAL; PSYCHOPHYSIOLOGY; RAT; SKIN STIMULATION; SPINAL CORD DORSAL HORN; TEMPERATURE; THERMAL STIMULATION;

ACCLIMATIZATION; ADULT; ANIMALS; BODY TEMPERATURE REGULATION; HAND; HEAT; HINDLIMB; HUMANS; MALE; MIDDLE AGED; NEURONS; PAIN; RATS; RATS, WISTAR; REACTION TIME; SENSATION; SKIN; SPINAL CORD;

EID: 0032974330     PISSN: 00144819     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002210050756     Document Type: Article

References (52)

1. Adriaensen HJ, Gybels J, Handwerker HO, Van Hees J (1984) Suppression of C-fibre discharges upon repeated heat stimulation may explain characteristics of concomitant pain sensations. Brain Res 302:203-211
2. Arendt-Nielsen L, Bjerring P (1988) Sensory and pain threshold characteristics to laser stimuli. J Neurol Neurosurg Psychiatry 51:35-42
3. Basbaum AI, Fields HL (1984) Endogenous pain control systems: Brainstem spinal pathways and endorphin circuitry. Annu Rev Neurosci 7:309-338
4. Bessou P, Perl ER (1969) Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli. J Neurophysiol 32:1025-1043
5. Birren JE, Casperson RC, Botwinick J (1951) Pain measurement by the radiant heat method: individual differences in pain sensitivity, the effects of skin temperature, and stimulus duration. J Exp Psychol 41:419-424
6. Bouhassira D, Gall O, Chitour D, Le Bars D (1994) Dorsal horn convergent neurones: negative feedback triggered by spatial summation of nociceptive afferents. Pain 62:195-200
7. Campbell JN, La Motte RH (1983) Latency to detection of first pain. Brain Res 266:203-208
8. Campbell JN, Meyer RA (1983) Sensitization of unmyelinated nociceptive afferents in monkey varies with skin type. J Neurophysiol 49:98-110
9. Casey KL, Butler J, Lewis KG, Morrow TJ (1987) Evidence that the distribution of polymodal nociceptors does not determine both thermal and mechanical pain thresholds of human glabrous and hairy skin. Soc Neurosci Abstr 13:189
10. Coghill RC, Mayer DJ, Price DD (1993) Wide dynamic range but not nociceptive-specific neurons encode multidimensional features of prolonged repetitive heat pain. J Neurophysiol 69:703-716
11. Croze S, Duclaux R (1978) Thermal pain in humans: influence of the rate of stimulation. Brain Res 157:418-421
12. Croze S, Duclaux R, Kenshalo DR (1976) The thermal sensitivity of the polymodal nociceptors in the monkey. J Physiol (Lond) 263:539-562
13. Croze S, Duclaux R, Russek M (1977) Constancy of heat pain characteristics to changes in skin and body temperature. Brain Res 131:367-372
14. Douglass DK, Carstens E, Watkins LR (1992) Spatial summation in human thermal pain perception: comparison with and between dermatomes. Pain 50:197-202
15. Dubner R (1985) Specialization in nociceptive pathways: sensory discrimination, sensory modulation, and neural connectivity. Adv Pain Res Ther 9:111-137
16. Duggan AW, Griersmith BT, Headley PM, Maher JB (1978) The need to control skin temperature when using radiant heat in tests of analgesia. Exp Neurol 61:471-478
17. Eddy NB, Touchberry CF, Lieberman JE (1950) Synthetic analgesics. I. Methadone isomers and derivatives. J Pharmacol Exp Ther 98:121-137
18. Hardy JD, Wolff HG, Goodell H (1952) Pain sensations and reactions. Williams & Wilkins, Baltimore
19. Hensel H (1950) Die intracutane Temperaturbewegung bei Einwirkung äusserer Temperaturreize. Pflugers Arch 252:146-164
20. Hole K, Tjolsen A (1993) The tail-flick and formalin tests in rodents: changes in skin temperature as a confounding factor. Pain 53:247-254
21. Kanui TI (1988) Receptive field organization and electrophysiological responses of spinal cord thermoreactive neurones in the rat. Exp Brain Res 71:508-514
22. Kauppila T, Kontinen VK, Pertovaara A (1998) Influence of spinalization on spinal withdrawal reflex responses varies depending on the submodality of the test stimulus and the experimental pathophysiological condition. Brain Res 797:234-242
23. Kojo I, Pertovaara A (1986) Effect of tourniquet-induced ischemia on cutaneous thermal thresholds. Acta Neurol Scand 74:383-386
24. Kojo I, Pertovaara A (1987) The effects of stimulus area and adaptation temperature on warm and heat pain thresholds in man. Int J Neurosci 32:875-880
25. La Motte RH, Thalhammer JG, Torebjörk HE, Robinson CJ (1982) Peripheral neural mechanisms of cutaneous hyperalgesia following mild injury by heat. J Neurosci 2:765-781
26. Lima D (1998) The endogenous pain control system: facilitating and inhibitory pathways. In: Ayrapetyan SN, Apkarian AV (eds) Pain mechanisms and management. IOS Press, Amsterdam, pp 192-211
27. Luukko M, Konttinen Y, Kemppinen P, Pertovaara A (1994) Influence of various experimental parameters on the incidence of thermal and mechanical hyperalgesia induced by a constriction mononeuropathy of the sciatic nerve in lightly anesthetized rat. Exp Neurol 128:143-154
28. Lynn B (1979) The heat sensitization of polymodal nociceptors in the rabbit and its independence of the local blood flow. J Physiol (Lond) 287:493-507
29. Maier SF, Wiertelak EP, Watkins LR (1992) Endogenous pain facilitatory systems. Am Pain Soc J 1:191-198
30. Mendell LM (1966) Physiological properties of unmyelinated fibre projection to the spinal cord. Exp Neurol 16:315-332
31. Nielsen J, Arendt-Nielsen L (1997) Spatial summation of heat induced pain within and between dermatomes. Somatosens Mot Res 14:119-125
32. Nielsen J, Arendt-Nielsen L (1998a) The influence of rate of temperature change and peak stimulus duration on the pain intensity and quality. Somatosens Mot Res 15:220-229
33. Nielsen J, Arendt-Nielsen L (1998b) The importance of stimulus configuration for temporal summation of first and second pain to repeated heat stimuli. Eur J Pain 2:329-341
34. Pertovaara A (1998) A neuronal correlate of secondary hyperalgesia in the rat spinal dorsal horn is submodality selective and facilitated by supraspinal influence. Exp Neurol 149:193-202
35. Pertovaara A, Kojo I (1985) Influence of the rate of temperature change on thermal thresholds in man. Exp Neurol 87:439-445
36. Pertovaara A, Reinikainen K, Hari R (1984) The activation of unmyelinated or myelinated afferent fibers by brief infrared laser pulses varies with skin type. Brain Res 307:341-343
37. 2 laser pulses in humans: evidence on afferent mechanisms and the influence of varying stimulus conditions. Pain 34:261-269
38. Pertovaara A, Kauppila T, Hämäläinen MM (1996) Influence of skin temperature on heat pain thresholds in humans. Exp Brain Res 107:497-503
39. Plaghki L, Bragard D, Le Bars D, Willer JC, Godfraind JM (1998) Facilitation of nociceptive flexion reflex in man by nonnoxious radiant heat produced by laser. J Neurophysiol 79:2557-2567
40. Price DD, McHaffie JG, Larson MA (1989) Spatial summation of heat-induced pain: influence of stimulus area and spatial separation of stimuli on perceived sensation intensity and unpleasantness. J Neurophysiol 62:1270-1279
41. Sandkühler J, Liu XG (1998) Induction of long-term potentiation at spinal synapses by noxious stimulation or nerve injury. Eur J Neurosci 10:2476-2480
42. Tillman D, Treede RD, Meyer RA, Campbell JN (1995a) Response of C fibre nociceptors in the anaesthetized monkey to heat stimuli: estimates of receptors depth and threshold. J Physiol (Lond) 485:753-765
43. Tillman D, Treede RD, Meyer RA, Campbell JN (1995b) Response of C fibre nociceptors in the anaesthetized monkey to heat stimuli: correlation with pain thresholds in humans. J Physiol (Lond) 485:767-774
44. Treede RD, Meyer RA, Raja SN, Campbell JN (1992) Peripheral and central mechanisms of hyperalgesia. Prog Neurobiol 38:397-421
45. Treede RD, Meyer RA, Raja SN, Campbell JN (1995) Evidence for two different heat transduction mechanisms in nociceptive primary afferents innervating monkey skin. J Physiol (Lond) 483:747-758
46. Vierck CJ Jr, Cannon RL, Pry G, Maixner W, Whitsel BL (1997) Characteristics of temporal summation of second pain sensations elicited by brief contact of glabrous skin by a preheated thermode. J Neurophysiol 78:992-1002
47. Wilcox GL, Giesler GL (1984) An instrument using a multiple layer Peltier device to change skin temperature rapidly. Brain Res Bull 12:143-146
48. Willis WD, Coggeshall RE (1991) Sensory mechanisms of the spinal cord, 2nd edn. Plenum, New York
49. Yarnitsky D, Ochoa JL (1990) Studies of heat pain sensation in man: perception thresholds, rate of stimulus rise and reaction time. Pain 40:85-91
50. Yarnitsky D, Simone DA, Dotson RM, Cline MA, Ochoa JL (1992) Single C nociceptor responses and psychophysical parameters of evoked pain: effect of rate of rise of heat stimuli in humans. J Physiol (Lond) 450:581-592
51. Yeomans DC, Proudfit HK (1996) Nociceptive responses to high and low rates of noxious cutaneous heating are mediated by different nociceptors in the rat: electrophysiological evidence, Pain 68:141-150
52. Yeomans DC, Pirec V, Proudfit HK (1996) Nociceptive responses to high and low rates of cutaneous heating are mediated by different nociceptors in the rat: behavioral evidence. Pain 68:133-140