Characteristics of temporal summation of second pain sensations elicited by brief contact of glabrous skin by a preheated thermode

Journal of Neurophysiology

Volumn 78, Issue 2, 1997, Pages 992-1002

  Vierck Jr , Charles J ^a   Cannon, Richard L ^a   Fry, Gentry ^a   Maixner, William ^b   Whitsel, Barry L ^c  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; GLABROUS SKIN; HUMAN; MONKEY; NONHUMAN; NORMAL HUMAN; PAIN; PRIORITY JOURNAL; SKIN TEMPERATURE; TEMPORAL SUMMATION; THERMAL STIMULATION;

EID: 1842336342     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.1997.78.2.992     Document Type: Article

References (48)

1. ARENDT-NIELSEN, L., PETERSON-FELIX, M. D., FISCHER, M., BAK, P., BJERRING, P., AND ZBINDEN, A. M. The effect of N-methyl-D-aspartate antagonist (ketamine) on single and repeated nociceptive stimuli: a placebo-controlled experimental human study. Anesth. Analg. 81: 63-68, 1995.
2. BACKONJA, M., ARNDT, G., GOMBAR, K. A., CHECK, B., AND ZIMMERMANN, M. Response of chronic neuropathic pain syndromes to ketamine: a preliminary study. Pain 56: 51-57, 1994.
3. CARLTON, S. M., HARGETT, G. L., AND COGGESHALL, R. E. Localization and activation of glutamate receptors in unmyelinated axons of rat glabrous skin. Neurosci. Lett. 197: 25-28, 1995.
4. CAUNA, N. Fine morphological characteristics and microtopography of the free nerve endings of the human digital skin. Anat. Rec. 198: 643-656, 1980.
5. CHUNG, J. M., LEE, K. H., HORI, Y., ENDO, K., AND WILLIS, W. D. Factors influencing peripheral nerve stimulation produced inhibition of primate spinothalamic tract cells. Pain 19: 277-293, 1984.
6. CHURCH, J., LODGE, D., AND BERRY, S. C. Differential effects of dextrorphan and levorphanol on the excitation of rat spinal neurons by amino acids. Ear. J. Pharmacol. 111: 185-190, 1985.
7. CODERRE, T. J., KATZ, J., VACCARINO, A. L., AND MELZACK, R. Contribution of central neuroplasticity to pathological pain: review of clinical and experimental evidence. Pain 52: 259-285, 1993.
8. COOPER, B. Y., VIERCK. C. J., JR., AND YEOMANS, D. C. Selective reduction of second pain sensations by systemic morphine in humans. Pain 24: 93-116, 1986.
9. DAVIES, S. N. AND LODGE, D. Evidence for involvement on N-methylaspartate receptors in "wind-up" of class 2 neurones in the dorsal horn of the rat. Brain Res. 424: 402-406, 1987.
10. DICKENSON, A. H. A cure for wind up: NMDA receptor antagonists as potential analgesics. Trends Pharmacol. Sci. 11: 307-309, 1990.
11. DICKENSON, A. H. AND SULLIVAN, A. F. Evidence for the role of the NMDA receptor in the frequency dependent potentiation of deep rat dorsal horn nociceptive neurones following C Fiber stimulation. Neuropharmacology 26: 1235-1238, 1987.
12. DYCK, P. J. Quantitative sensory testing. A consensus report from the Peripheral Neuropathy Association. Neurology 43: 1050-1052, 1993.
13. EIDE, P. K., STUBHAUG, A., OYE, I. H., AND BREIVIK, H. Continuous subcutaneous administration of the N-methy 1-D-aspartic acid (NMDA) receptor antagonist ketamine in the treatment of post-herpetic neuralgia. Pain 61: 221-228, 1995.
14. FELSBY, S., NIELSON, J., ARENDT-NIELSEN, L., AND JENSEN, T. S. NMDA receptor blockade in chronic neuropathic pain: a comparison of ketamine and magnesium chloride. Pain 64: 283-291, 1995.
15. KELLSTEIN, D. E., PRICE, D. D., HAYES, R. L., AND MAYER, D. J. Evidence that substance P selectively modulates C-fiber-evoked discharges of dorsal horn nociceptive neurons. Brain Res. 526: 291-298, 1990.
16. KRISTENSEN, J. D., SVENSSON, B., AND GORDH, T., JR, The Nmda-receptor antagonist Cpp abolishes neurogenic. "Wind-up pain" after intrathecal administration in humans. Pain 51: 249-253, 1992.
17. LAMOTTE, R. H. AND CAMPBELL, J. N. Comparison of responses of warm and nociceptive C-fiber afferents in monkey with human judgments of thermal pain. J. Neurophysiol. 41: 509-528, 1978.
18. LAMOTTE, R. H., LUNDBERG. L.E.R., AND TOREBJORK, H. E. Pain, hyperalgesia and activity in nociceptive C units in humans after intradermal injection of capsaicin. J. Physiol. Lond. 448: 749-764, 1992.
19. LIU, H., WANG, H., SHENG, M., JAN, L. Y., JAN, Y. N., AND BASBAUM, A. I. Evidence for presynaptic N-methyl-D-aspartate autoreceptors in the spinal cord dorsal horn. Proc. Natl. Acad. Sci. USA 91: 8383-8387, 1994.
20. LIU, X.-G. AND SANDKUHLER, J. Long-term potentiation of C-fiber-evoked potentials in the rat spinal dorsal horn is prevented by spinal N-methyl-D-aspartic acid receptor blockage. Neurosci. Lett. 191: 43-46, 1995.
21. MAO, J., PRICE, D. D., HAYES, R. L., LU, J., AND MAYER, D. J. Differential roles of NMDA and non-NMDA receptor activation in induction and maintenance of thermal hyperalgesia in rats with painful peripheral mononeuropathy. Brain Res. 598: 271-278, 1992.
22. MATHISEN, L. C., SKJELBRED, P., SKOGLUND, L. A., AND OYE, I. Effect of ketamine, an NMDA receptor inhibitor, in acute and chronic orofacial pain. Pain 61: 215-220, 1995.
23. MELLER, S. T., DYKSTRA, C., PECHMAN, P. S., MAVES, T. J., AND GEBHART, G. F. Ethanol dose-dependently attenuates NMDA-mediated thermal hyperalgesia in the rat. Neurosci. Lett. 154: 137-140, 1993.
24. MELZACK, R. AND WALL, P. D. Pain mechanism: a new theory. Pain Mechan. 150: 971-979, 1965.
25. MENDELL, L. M. Physiological properties of unmyelinated fiber projection to the spinal cord. Exp. Neurol. 16: 316-332, 1966.
26. NOORDENBOS, W. Pain. New York: Elsevier, 1959.
27. NOVOTNY, G.E.K. AND GOMMERT-NOVOTNY, E. Intraepidermal nerves in human digital skin. Cell Tissue Res. 254: 111-117, 1988.
28. PRICE, D. D. Characteristics of second pain and flexion reflexes indicative of prolonged central summation. Exp. Neurol. 37: 371-387, 1972.
29. PRICE, D. D. Characterizing central mechanisms of pathological pain states by sensory testing and neurophysiological analysis. Pain and Central Nervous System Disease: The Central Pain Syndromes, edited by K. L. Casey. New York: Raven, 8: 103-115, 1991.
30. PRICE, D. D., BENNETT, G. J., AND RAFII, A. Psychophysical observations on patients with neuropathic pain relieved by a sympathetic block. Pain 36: 273-288, 1989.
31. PRICE, D. D., HU, J. W., DUBNER, R., AND GRACELY, R. H. Peripheral suppression of first pain and central summation of second pain evoked by noxious heat pulses. Pain 3: 57-68, 1977.
32. PRICE, D. D., HULL. C. D., AND BUCHWALD, N. A. Intracellular responses of dorsal horn cells to cutaneous and sural nerve A and C fiber stimuli. Exp. Neurol. 33: 291-309, 1971.
33. PRICE, D. D., MAO, J., FRENK, H., AND MAYER, D. J. The N-methyl-D-aspartate receptor antagonist dextromethorphan selectively reduces temporal summation of second pain in man. Pain 59: 165-174, 1994.
34. REN, K., HYLDEN, J. L., RUDA, G. M., AND DUBNER, R. The effects of a non competitive NMDA receptor antagonist, MK-801, on behavioral hyperalgesia and dorsal horn neuronal activity in rats with unilateral inflammation. Pain 50: 331-344, 1985.
35. SIMONE, D. A., BAUMANN, T. K., AND LAMOTTE, R. H. Dose-dependent pain and mechanical hyperalgesia in humans after intradermal injection of capsaicin. Pain 38: 99-107, 1989.
36. SINCLAIR, D. C. AND STOKES, B. A. R. The production and characteristics of "second pain". Brain 87: 609-618, 1964.
37. SWERUP, C. Determination of conduction velocity in A-delta and C fibres in humans from thermal threshold. Acta Physiol. Scand. 153: 81-82, 1995.
38. TAL, M. AND BENNETT, G. J. Dextrorphan relieves neuropathic heat-evoked hyperalgesia in the rat. Neurosci. Lett. 151: 107-110, 1993.
39. TILLMAN, D.-B., TREEDE, R.-D., MEYER, R. A., AND CAMPBELL, J. N. Response of C-Fibre nociceptors in the anesthetized monkey to heat stimuli: estimates of receptor depth and threshold. J. Physiol. Lond. 485: 753-765, 1995.
40. TOMMERDAHL, M., DELEMOS, K. A., VIERCK, C. J., JR., FAVOROV, O., AND WHITSEL, B. L. Anterior parietal cortical response to tactile and shinheating stimuli applied to the same skin site. J. Neurophysiol. 75: 2662-2670, 1996a.
41. TOMMERDAHL, M., WHITSEL, B. L., VIERCK, C. J., JR., FAVORAOV, D. G., JULIANO, S., COOPER, B., METZ, C., AND NAKHLE, B. Effects of spinal dorsal column transection on the response of monkey anterior parietal cortex to repetitive skin stimulation. Cerebral Cortex 61: 131-155, 1996b.
42. TREEDE, R.-D., MEYER, R. A., RAJA, S. N., AND CAMPBELL, J. N. Evidence for two different heat transduction mechanisms in nociceptive primary afferents innervating monkey skin. J. Physiol. Lond. 483: 747-758, 1995.
43. URBAN, L. AND RANDIC, M. Slow excitatory transmission in rat dorsal horn: possible mediation by peptides. Brain Res. 290: 336-341, 1984.
44. WHITSEL, B. L., KELLY, D. G., FAVORAOV, D. G., AND TOMMERDAHL, M. Mechanism of dynamic peri-and intra-columnar interactions in somatosensory cortex: stimulus-specific contrast enhancement by NMDA receptor activation. In: Information Processing in the Somatosensory System, edited by O. Franzen and J. Westman. New York: Stockton, 1991, p. 353-369.
45. WILCOX, G. L. Spinal mediators of nociceptive neurotransmission and hyperalgesia: relationships among synaptic plasticity, analgesic tolerence, and blood flow. Am. J. Physiol. 2: 265-275, 1993.
46. WOOLF, C. J. AND THOMPSON, S.W.N. The induction and maintenance of central sensitization is dependent on N-methyl-D-aspartic acid receptor activation; implications for the treatment of post-injury pain hypersensitivity states. Pain 44: 293-299, 1991.
47. YAKSH, T. L. AND ABRAM, S. E. Preemptive analgesia: a popular misnomer, but a clinically relevant truth? APS J. 2: 116-121, 1993.
48. YEOMANS, D. C., COOPER, B. Y., AND VIERCK, C. J., JR. Effects of systemic morphine on responses to first or second pain sensations of primates. Pain 66: 253-263, 1996.