Eotaxin levels and eosinophils in guinea pig broncho-alveolar lavage fluid are increased at the onset of a viral respiratory infection

Clinical and Experimental Allergy, Supplement

Volumn 29, Issue 2, 1999, Pages 74-77

  Scheerens, J ^a   Folkerts, G ^a   Van Der Linde, H ^a   Sterk, P J ^c   Conroy, D M ^b   Williams, T J ^b   Nijkamp, F P ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

^c NONE

Author keywords

Asthma; Eotaxin; Viral infections

Indexed keywords

CHEMOKINE; EOTAXIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; BRONCHUS HYPERREACTIVITY; CELL DIFFERENTIATION; CONFERENCE PAPER; CONTROLLED STUDY; EOSINOPHIL; EOSINOPHILIA; GUINEA PIG; LEUKOCYTE COUNT; LUNG LAVAGE; MALE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; VIRUS INFECTION;

ANIMALS; ASTHMA; BRONCHOALVEOLAR LAVAGE; BRONCHOALVEOLAR LAVAGE FLUID; CHEMOKINES, CC; CHEMOTACTIC FACTORS, EOSINOPHIL; CYTOKINES; EOSINOPHILS; GUINEA PIGS; LEUKOCYTE COUNT; LUNG; MALE; PARAINFLUENZA VIRUS 3, HUMAN; RESPIRATORY TRACT INFECTIONS; RESPIROVIRUS INFECTIONS;

EID: 0032974108     PISSN: 09602178     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (19)

1. Folkerts G, Busse WW, Nijkamp FP, Sorkness R, Gern JE. Virus-induced airway hyperresponsiveness and asthma. Am J Respir Crit Care Med 1998; 157:1708-20.
2. Johnston SL, Pattemore PK, Sanderson G et al. Community study of role of viral infections in exacerbations of asthma in 9-11 year old children. Br Med J 1995; 310:1225-8.
3. Fraenkel DJ, Bardin PG, Sanderson G et al. Lower airways inflammation during rhinovirus colds in normal and asthmatic subjects. Am Respir Crit Care Med 1995; 151:879-86.
4. Grünberg K, Smits HH, Timmers MC et al. Experimental rhinovirus 16 infection effects on cell differentials and soluble markers in sputum in asthmatic subjects. Am J Respir Crit Care Med 1997; 156:609-16.
5. Folkerts G, Verheyen AKCP, Geuens GMA, Folkerts HF, Nijkamp FP. Virus-induced changes in airway responsiveness, morphology, and histamine levels in guinea pigs. Am Rev Respir Dis 1993; 147:1569-77.
6. Folkerts G, Van der Linde HJ, Nijkamp FP. Virus-induced airway hyperresponsiveness in guinea pigs is related to a deficiency in nitric oxide. J Clin Invest 1995; 95:26-30.
7. Folkerts G, De Clerck F, Reijnart I, Span P, Nijkamp FP. Virus-induced airway hyperresponsiveness in the guinea pig: possible involvement of histamine and inflammatory cells. Br J Pharmacol 1993; 108:1083-93.
8. Baggiolini M, Dewald B, Moser B. Human chemokines an update. Annu Rev Immunol 1997; 15:675-705.
9. Jose PJ, Griffiths-Johnson DA, Collins PD et al. Eotaxin: a potent cosinophil chemoattractant cytokine detected in a guinea pig model of allergic airway inflammation. J Exp Med 1994; 179:881-7.
10. Griffiths-Johnson DA, Collins PD, Rossi AG, Jose PJ, Williams TJ. The chemokine, eotaxin, activates guinea pig eosinophils in vitro and causes their accumulation into the lung in vivo. Biochem Biophys Res Comm 1993; 197:1167-72.
11. Collins PD, Marleau S, Griffiths-Johnson DA, Jose PJ, Williams TJ. Cooperation between interleukin-5 and the chemokines eotaxin to induce eosinophil accumulation in vivo. J Exp Med 1995; 182:1169-74.
12. Ponath PD, Qin S, Post TW et al. Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils. J Exp Med 1996; 183:2437-48.
13. Uguccioni M, Mackay CR, Ochensherger B et al. High expression of the chemokine receptor CCR3 in human blood basophils. Role and activation by eotaxin, MCP-4 and other chemokines. J Clin Invest 1997; 100:1137-43.
14. Sallusto F, Mackay CR, Lanzavecchia A. Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells. Sci 1997; 227:2005-7.
15. Humbles AA, Conroy DM, Marleau S et al. Kinetics of eotaxin generation and its relationship to eosinophil accumulation in allergic airways disease: analysis in a guinea pig model in vivo. J Exp Med 1997; 183:601-12.
16. Amkhioued B, Renzi PM, Abi-Younes S et al. Increased expression of eotaxin in bronchoalveolar lavage and airways of asthmatics contributes to the chemotaxis of eosinophils to the site of inflammation. J Immunol 1997; 159:4593-601.
17. Folkerts G, Van Esch B, Janssen M, Nijkamp FP. Virus-induced airway hyperresponsiveness in guinea pigs in vivo: study of brocho-alveolar cell number and activity. Eur J Pharmacol 1992; 228:219-27.
18. Van Oosterhout AJM, Van Ark I, Folkerts G et al. Antibody to interleukin-5 inhibits virus-induced airway hyperresponsiveness to histamine in guinea pigs. Am J Respir Crit Care Med 1995; 151:177-83.
19. Okada S, Kita H, George TJ, Gleich GJ, Leiferman KM. Transmigration of eosinophils through basement membrane components in vitro: synergistic effects of platelet activating factor and eosinophil-active cytokines. Am J Respir Cell Mol Biol 1997; 16:455-63.