Autoreactive human T cell lines recognizing ribosomal protein L7

International Immunology

Volumn 11, Issue 2, 1999, Pages 125-132

  Donauer, Johannes ^a,b   Wochner, Michael ^a   Witte, Esther ^a   Peter, Hans Hartmut ^b   Schlesier, Michael ^b   Krawinkel, Ulrich ^a  

^a UNIVERSITY OF KONSTANZ   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Autoreactivity; Human T cells; Ribosomal protein L7

Indexed keywords

AUTOANTIBODY; CD3 ANTIGEN; CD4 ANTIGEN; CD45 ANTIGEN; GAMMA INTERFERON; HLA DR ANTIGEN; IMMUNOGLOBULIN G; RIBOSOME PROTEIN; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN;

ARTICLE; AUTOIMMUNITY; CELL LINE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE;

AMINO ACID SEQUENCE; ANTIGEN-PRESENTING CELLS; AUTOANTIGENS; CELL LINE; CELLS, CULTURED; CYTOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENES, T-CELL RECEPTOR ALPHA; GENES, T-CELL RECEPTOR BETA; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; LUPUS ERYTHEMATOSUS, SYSTEMIC; LYMPHOCYTE ACTIVATION; MOLECULAR SEQUENCE DATA; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; RECOMBINANT PROTEINS; RIBOSOMAL PROTEINS; T-LYMPHOCYTES;

EID: 0032973236     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/11.2.125     Document Type: Article

References (39)

1. Tan, E. M. 1989. Antinuclear antibodies: diagnostic markers for autoimmune diseases and probes for cell biology. Adv. Immunol. 44:93.
2. von Mikecz, A., Hemmerich, P., Peter, H. H. and Krawinkel, U. 1994. Characterization of eukaryotic protein L7 as a novel autoantigen which frequently elicits an immune response in patients suffering from systemic autoimmune diseases. Immunobiology 192:137.
3. Neu, E., von Mikecz, A., Hemmerich, P., Fricke, M., Peter, H. H. and Krawinkel, U. 1995. Autoantibodies against eukaryotic protein L7 in patients suffering from systemic lupus erythematosus and scleroderma: frequency and correlation with clinical, serological and genetic parameters. Clin. Exp. Immunol. 100:198.
4. Hemmerich, P., von Mikecz, A., Neumann, F., Sözeri, O., Wolff-Vorbeck, G., Zoebelein, R. and Krawinkel, U. 1993. Structural and functional properties of ribosomal protein L7 from humans and rodents. Nucleic Acids Res. 21:223.
5. Neumann, F., Hemmerich, P., von Mikecz, A., Peter, H. H. and Krawinkel, U. 1995. Human ribosomal protein L7 regulates cell-free translation and affects protein expression upon stable transfection into Jurkat T lymphoma cells. Nucleic Acids Res. 23:195.
6. Witte, S., Neumann, F., Krawinkel, U. and Przybylski, M. 1996 Mass spectometric identification of leucine zipper-like homodimer complexes of the autoantigen L7. J. Biol. Chem. 271:1817.
7. Hemmerich, P., Bosbach, S., von Mikecz, A. and Krawinkel, U. 1997 Human ribosomal protein L7 binds RNA with an α-helical arginine-rich and lysine-rich domain. Eur. J. Biochem. 245:549.
8. Witte, S. and Krawinkel, U. 1997 Specific interactions of the autoantigen L7 with multi-zinc finger protein ZNF7 and ribosomal protein S7. J. Biol. Chem. 272:22243.
9. Jackson, T. A., Richer, J. K., Bain, D. L., Takimoto, G. S., Tung, L. and Horwitz, K. B. 1997 The partial antagonist activity of antagonist-occupied steroid receptors is controlled by a novel hinge domain-binding coactivator L7/SPA and the corepressors N-CoR or SMRT. Mol. Endocrinol. 11:693.
10. 1-arrest of the cell cycle and apoptosis in Jurkat T-lymphoma cells. Exp. Cell Res. 230:252.
11. vov Mikecz, A., Hemmerich, P., Neu, E., Peter, H. H. and Krawinkel, U. 1995. Autoantigenic epitopes on eucaryotic L7. Clin. Exp. Immunol. 100:205.
12. Neu, E., Hemmerich, P. H., Peter, H. H., Krawinkel, U. and von Mikecz, A. H. 1997. Characteristic epitope recognition pattern of autoantibodies against eucaryotic ribosomal protein L7 in systemic autoimmune diseases. Arthritis Rheum. 40:661.
13. Fenning, S., Wolff-Vorbeck, G., Hackl, W., Krawinkel, U., Lührmann, R., Northemann, W., Peter, H. H. and Schlesier, M. 1995. T cell lines recognizing the 70 kD protein of U1 small nuclear ribonucleoprotein (U1snRNP). Clin. Exp. Immunol. 101:408.
14. Wolff-Vorbeck, G., Hackl, W., Fenning, S., Krawinkel, U., Lührmann, R., Peter, H. H. and Schlesier, M. 1994. Characterization of an HLA-DR4 restricted T cell clone recognizing a protein moiety of small nuclear ribonucleoproteins (UsnRNP). Clin. Exp. Immunol. 95:378.
15. Tan, E. M., Cohen, A. S., Tries, J. F., et al. 1982. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 25:1271.
16. Taguchi, T., McGhee, J. R., Coffman, R. L., Beagley, K. W., Eldridge, J. H., Takatsu, K. and Kiyono, H. 1990. Detection of individual mouse splenic T cells producing IFN-and IL-5 using the enzyme-linked immunospot (ELISPOT) assay. J. Immunol. Methods 128:65.
17. + reactive arthritis. Immunobiology 177:420.
18. Apte, A. N. and Siebert, P. D. 1993. Anchor ligated cDNA Libraries: a technique for generating a cDNA Library for the immediate cloning of the 5′ ends of mRNAs. BioTechniques 15:890.
19. Ausubel F. M., Brent R., Kingston R. E., Moore D. D., Seidman J. G., Smith J. A. and Struhl K. 1991. Current Protocols in Molecular Biology. Wiley Interscience, New York.
20. Sambrock, J., Fritsch, E. F. and Maniatis, T. 1989. Molecular Cloning. A Laboratory Manual, 2nd edn. Cold Spring Harbour Laboratory Press, Cold Spring Harbour, NY.
21. Effros, R. B. and Pawelec, G. 1997. Replicative senescence of T cells: does the Hayflick Limit lead to immune exhaustion? Immunol. Today 18:450.
22. Datta, S. K. and Kaliyaperuma, A. 1997. Nucleosome-driven autoimmune response in Lupus. Ann. NY Acad. Sci. 815:155.
23. h2 cells. Int. Immunol. 6:1003.
24. h2 effector cells. Immunology 88:110.
25. h2 and more. Immunol. Today 17:138.
26. Ohnishi, K., Ebling, F. M., Mitchell, B., Singh, R. R., Hahn, B. H. and Tsao, B. P. 1994. Comparision of pathogenic and nonpathogenic murine antibodies to DNA: antigen binding and structural characteristics. Int. Immunol. 6:817.
27. Singh, R. R., Kumar, V., Ebling, F. M., Southwood, S., Sette, A., Sercarz, E. E. and Hahn, B. H. 1995 T-cell determinants from autoantibodies to DNA can upregulate autoimmunity in murine systemic lupus erythematosus. J. Exp. Med. 181:2017.
28. Bradley, L. M., Yoshimoto, K. and Swaine, S. L. 1995. The cytokines IL-4, IFN-gamma, and IL-12 regulate the development of subsets of memory effector helper T cells in vitro. J. Immunol. 155:1713.
29. gag antigen. Cell 51:211.
30. Guldner, H. H., Netter, H. J., Szostecki, C., Jaeger, E. and Will, H. 1990. Human anti-P68 autoantibodies recognize a common epitope of U1 RNA containing small nuclear ribonucleoprotein and influenza B virus. J. Exp. Med. 171:819.
31. Netter, H. J., Will, H., Szostecki, C. and Guldner, H. H. 1991. Repetitive P68-autoantigen specific epitopes recognized by human anti-(U1) small nuclear ribonucleoprotein autoantibodies. J. Autoimmun. 4:651.
32. Sakurai, T., Ametani, A., Nakamura, Y., Shimizu, M., Idota, T. and Kaminogawa, S. 1993 Cryptic B cell determinant in a short peptide: T cells do not induce antibody response of B cells when their determinants entirely overlap each other. Int. Immunol. 5:793.
33. Harris, D. P., Vordermeier, H. M., Arya, A., Bogdan, K., Moreno, C. and Ivanyi, J. 1996. Immunogenicity of peptides for B cells is not impaired by overlapping T-cell epitope topology. Immunology 88:348.
34. Chan E. K. L. and Tan E. M. 1989. Epitopic targets for autoantibodies in systemic lupus erythematosus and Sjögren's syndrome. Curr. Opin. Rheumatol. 1:376.
35. + precursor stage. Nature 334:620.
36. Sha, W. C., Nelson, C. A., Newberry, R. D., Kranz, D. M., Russell, J. H. and Loh, D. 1988. Positive and negative selection of an antigen receptor on T cells in transgenic mice. Nature 336:73.
37. Blackman, M., Kappler, M. J. and Marrack, P. 1990. The role of the T cell receptor in positive and negative selection of developing T cells. Science 248:1335.
38. Pette, M., Fujita, K., Wilkinson, D., Altmann, D. M., Trowsdale, J., Giegerich, G., Hinkkanen, A., Epplen, J., Kappos, L. and Wekerle, H. 1990. Myelin autoreactivity in multiple sclerosis: recognition of myelin basic protein in the context of HLA-DR2 products by T lymphocytes of multiple sclerosis patients and healthy donors. Proc. Natl Acad. Sci. USA 87:7968.
39. Wekerle, H. 1993. T-cell autoimmunity in the central nervous system. Intervirology 22:753.