Characteristic epitope recognition pattern of autoantibodies against eukaryotic ribosomal protein L7 in systemic autoimmune diseases

Arthritis and Rheumatism

Volumn 40, Issue 4, 1997, Pages 661-671

  Neu, Elli ^a,e   Hemmerich, Peter H ^a   Peter, Hans Hartmut ^b   Krawinkel, Ulrich ^c   Von Mikecz, Anna H ^d  

^a FRITZ LIPMANN INSTITUTE   (Germany)

^b HEINRICH HEINE UNIVERSITY   (Germany)

^c UNIVERSITY OF KONSTANZ   (Germany)

^d UNIVERSITY OF FREIBURG   (Germany)

^e UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; EPITOPE; RIBOSOME PROTEIN;

ANTIBODY RESPONSE; ANTIBODY SPECIFICITY; ANTIGEN RECOGNITION; ARTICLE; AUTOIMMUNITY; B LYMPHOCYTE ACTIVATION; CONTROLLED STUDY; DIAGNOSIS; DISEASE ACTIVITY; ETIOLOGY; HUMAN; HUMORAL IMMUNITY; ISOELECTRIC FOCUSING; MAJOR CLINICAL STUDY; MIXED CONNECTIVE TISSUE DISEASE; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SYSTEMIC LUPUS ERYTHEMATOSUS; SYSTEMIC SCLEROSIS;

ADOLESCENT; ARTHRITIS, RHEUMATOID; AUTOANTIBODIES; AUTOIMMUNE DISEASES; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPE MAPPING; EPITOPES; FEMALE; HUMANS; ISOELECTRIC FOCUSING; LUPUS ERYTHEMATOSUS, SYSTEMIC; PEPTIDE FRAGMENTS; RIBOSOMAL PROTEINS; SCLERODERMA, SYSTEMIC; SENSITIVITY AND SPECIFICITY;

EID: 0030908393     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.1780400411     Document Type: Article

References (48)

1. Tan EM: Antinuclear antibodies: diagnostic markers for autoimmune disease and probes for cell biology. Adv Immunol 44:93-151, 1989
2. Tan EM: Autoantibodies in pathology and cell biology. Cell 61:841-842, 1991
3. Tan EM, Schur PH, Carr RI, Kunkel HG: Deoxyribonucleic acid (DNA) and antibodies to DNA in the serum of patients with systemic lupus erythematosus. J Clin Invest 45:1732-1740, 1966
4. Koffler D, Schur PH, Kunkel HG: Immunological studies concerning the nephritis of systemic lupus erythematosus. J Exp Med 126:607-624, 1967
5. Venables PJW: Epitope mapping of ribonucleoprotein antigens: answers without questions? Clin Exp Immunol 94:225-226, 1993
6. Van Venrooij WJ, van Gelder CVVG: B cell epitopes on nuclear autoantigens: what can they tell us? Arthritis Rheum 37:608-616, 1994
7. Bozic B, Pruijn GJM, Rozman B, van Venrooij WJ: Sera from patients with rheumatic diseases recognize different epitope regions on 52 kDa Ro/SS-A protein. Clin Exp Immunol 94:227-235, 1993
8. Bini P, Chu J-L, Okolo C, Elkon K: Analysis of autoantibodies to recombinant La (SS-B) peptide in systemic lupus erythematosus and primary Sjögren's syndrome. J Clin Invest 85:325-333, 1990
9. Boire G, Lopez-Longo F-J, Lapointe S, Ménard H-A: Sera from patients with autoimmune diseases recognize conformational determinants on the 60-kd Ro/SS-A protein. Arthritis Rheum 34: 722-730, 1991
10. Chou C-H, Reeves \VH: Recognition of multiple epitopes in the coiled-coil domain of lamin B by human autoantibodies. Mol Immunol 29:1055-1062, 1992
11. Kasturi KN, Hatakeyama A, Spiera H, Bona CA: Antifibrillarin autoantibodies present in systemic sclerosis and other connective tissue diseases interact with similar epitopes. J Exp Med 181:1027-1036, 1995
12. McNeilage LJ, Macmillan EM, Whittingham SF: Mapping of epitopes on the La(SS-B) autoantigen of primary Sjögren's syndrome: identification of a crossreactive epitope. J Immunol 145: 3829-3835, 1990
13. Verheijen R, van den Hoogen F, Beijer R, Richter A, Penner E, Habets WJ, van Venrooij WJ: A recombinant topoisomerase I used for autoantibody detection in sera from patients with systemic sclerosis. Clin Exp Immunol 80:38-43, 1990
14. James JA, Gross T, Scofield RH, Harley JB: Irhmunoglobulin epitope spreading and autoimmune disease after peptide immunization: Sm B/B'-derived PPPGMRPP and PPPGIRGP induce spliceosome autoimmunity. J Exp Med 181:453-461, 1995
15. Topfer F, Gordon T, McCluskey J: Intra- and intermolecular spreading of autoimmunity involving the nuclear self-antigen La (SS-B) and Ro (SS-A). Proc Natl Acad Sci U S A 92:875-879,1995
16. Elkon K, Bonfa E, Llovet R, Danho W, Weissbach C, Brot N: Properties of the ribosomal P2 autoantigen are similar to those of foreign protein antigens. Proc Natl Acad Sci U S A 85:5186-5189, 1988
17. Chan EKL, Tan EM: Epitopic targets for autoantibodies in systemic lupus efythematosus and Sjögren's syndrome. Curr Opin Rheumatol 1:376-381, 1989
18. Dohlman JG, Lupas A, Carson M: Long charge-rich alpha-helices in systemic autoantigens. Biochem Biophys Research Commun 195:686-694, 1993
19. Von Mikecz A, Hemmerich P, Peter H-H, Krawinkel U: Characterization of eukaryotic protein L7 as a novel autoantigen which frequently elicits an immune response in patients suffering from systemic autoimmune disease. Immunobiology 192:137-154, 1994
20. Neu E, von Mikecz AH, Hemmerich PH, Peter H-H, Fricke M, Deicher H, Genth E, Krawinkel U, Members of the SLE Study Group: Autoantibodies against eukaryotic protein L7 in patients suffering from systemic lupus erythematosus and progressive systemic sclerosis: frequency and correlation with clinical, serological and genetic parameters. Clin Exp Immunol 100:198-204, 1995
21. Von Mikecz AH, Hemmerich PH, Peter H-H, Krawinkel U: Autoantigenic epitopes on eukaryotic L7. Clin Exp Immunol 100:205-213, 1995
22. Tan EM, Cohen AS, Fries JF, Masi AT, McShane DJ, Rothfield NF, Schaller JG, Talal N, Winchester RJ: The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 25:1271-1277, 1982
23. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, Healey LA, Kaplan SR, Liang MH, Luthra HS, Medsger TA Jr, Mitchell DM, Neustadt DH, Pinals RS, Schaller JG, Sharp JT, Wilder RL, Hunder GG: The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 31:315-324, 1988
24. Subcommittee for Scleroderma Criteria of the American Rheumatism Association Diagnostic and Therapeutic Criteria Committee: Preliminary criteria for the classification of systemic sclerosis (scleroderma). Arthritis Rheum 23:581-590, 1980
25. Hemmerich P, von Mikecz A, Neumann F, Sözeri O, Wolff-Vorbeck G, Zoebelein R, Krawinkel U: Structural and functional properties of ribosomal protein L7 from humans and rodents. Nucleic Acids Res 21:223-231, 1993
26. Smith DB, Johnson KS: Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione-S-transferase. Gene 67:31-40, 1988
27. Vitali C, Bencivelli W, Isenberg DA, Smolen JS, Snaith ML, Sciuto M, Neri R, Bombardieri S, the European Consensus Study Group for Disease Activity in SLE: Disease activity in systemic lupus erythematosus: report of the Consensus Study Group of the European Workshop for Rheumatology Research. II. Identification of the variables indicative of disease activity and their use in the development of an activity score. Clin Exp Rheumatol 10:541-547, 1992
28. Kreth HW, Williamson AR: The extent of diversity of anti-hapten antibodies in inbred mice: anti-NIP (4-hydroxy-5-iodo-3-nitro-phenacetyl) antibodies in CBA/H mice. Eur J Immunol 3:141-147, 1973
29. Askonas DA, Williamson AR, Wright BEG: Selection of a single antibody-forming cell clone and its propagation in syngeneic mice. Proc Natl Acad Sci U S A 67:1398-1403, 1970
30. Bonfa E, Chu J-L, Broth N, Elkon KB: Lupus anti-ribosomal P peptide antibodies show limited heterogeneity and are predominantly of the IgG1 and IgG2 subclasses. Clin Immunol Immunopathol 45:129-138, 1987
31. Barakat S, Meyer O, Torterotot F, Youinou P, Briand JP, Kahn MF, Muller S: IgG antibodies from patients with primary Sjögren's syndrome and systemic lupus erythematosus recognize different epitopes in 60-kD SS-A/Ro protein. Clin Exp Immunol 89:38-45, 1992
32. Brito J, Biamonti G, Caporali R, Montecucco C: Autoantibodies to human nuclear lamin B2 protein: epitope specificity in different autoimmune diseases. J Immunol 153:2268-2277, 1994.
33. Hemmerich P, Bosbach S, von Mikecz A, Krawinkel U: Human ribosomal protein L7 binds RNA within a-helical arginine- and lysine-rich domain. Eur J Biochem (in press)
34. Lapetina E, Reep B: Specific binding of (a-32P) GTP to cytosolic and membrane-bound proteins of human platelets correlates with the activation of phospholipase C. Proc Natl Acad Sci U S A 84:2261-2265, 1987
35. Goud B, Salminen A, WaKvorth MC, Novick PJ: A GTP-binding protein required for secretion rapidly associates with secretory vesicles and the plasma membrane in yeast. Cell 53:753-768, 1988
36. Butler MH, Solimena M, Dirkx R Jr, Hayday A, De Camilli P: Identification of a dominant epitope of glutamic acid decarboxylase (GAD-65) recognized by autoantibodies in Stiff-Man syndrome. J Exp Med 178:2097-2106, 1993
37. Neumann F, Hemmerich P, von Mikecz A, Peter H-H, Krawinkel U: Human ribosomal protein L7 inhibits cell-free translation in reticulocyte lysates and affects the expression of nuclear proteins upon stable transfection into Jurkat T-lymphoma cells. Nucleic Acids Res 23:195-202, 1995
38. Horsfall AC: Molecular mimicry and autoantigens in connective tissue diseases. Mol Biol Rep 16:139-147, 1992
39. Casciola-Rosen LA, Anhalt G, Rosen A: Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes. J Exp Med 179: 1317-1330, 1994
40. Neumann F, Krawinkel U: Constitutive expression of human ribosomal protein L7 arrests the cell cycle in G, and induces apoptosis in Jurkat T-lymphoma cells. Exp Cell Res (in press)
41. Kirn J, Namchuk M, Bugawan T, Fu Q, Jaffe M, Shi Y, Aanstoot H-J, Turck CW, Erlich H, Lennon V, Baekkeskov S: Higher autoantibody levels and recognition of a linear NH2-terminal epitope in the autoantigen GAD65, distinguish Stiff-Man syndrome from insulin-dependent diabetes mellitus. J Exp Med 180:595-606, 1994
42. Elson CJ, Barker RN, Thompson SJ, Williams NA: Immunologically ignorant autoreactive T cells, epitope spreading and repertoire limitation. Immunol Today 16:71-76, 1995
43. Vlase H, Nakashima M, Graves PN, Tomer Y, Morris JC, Davies TF: Defining the major antibody epitopes on the human thyrotropin receptor in immunized mice: evidence for intramolecular epitope spreading. Endocrinology 136:4415-4423, 1995
44. Lehmann PV, Forsthuber T, Miller A, Sercarz EE: Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen. Nature 358:155-157, 1992
45. Jansson L, Diener P, Engström A, Olsson T, Holmdahl R: Spreading of the immune response to different myelin basic protein peptide in chronic experimental autoimmune encephalomyelitis in B10.RHI mice. Eur J Immunol 25:2195-2200, 1995
46. Kaufman DL, Clare-Salzler M, Tian J, Forsthuber T, Ting GSP, Robinson P, Atkinson MA, Sercarz EE, Tobin AJ, Lehmann PV: Spontaneous joss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes. Nature 366:69-72, 1993
47. McRae BL, Vanderlugt CL, Dal Canto MC, Miller SD: Functional evidence for epitope spreading in the relapsing pathology of experimental autoimmune encephalomyelitis. J Exp Med 182:75-85, 1995
48. Hoet RM, Koornneef I, de Rooij DJ, van de Putte LB, van Veenrooij WJ: Changes in anti-Ul RNA antibody levels correlate with disease activity in patients with systemic lupus erythematosus overlap syndrome. Arthritis Rheum 35:1202-1210, 1992