Up-regulated EGF receptors undergo to rapid internalization and ubiquitin-dependent degradation in human cancer cells exposed to 8-Cl-cAMP

FEBS Letters

Volumn 447, Issue 2-3, 1999, Pages 203-208

  Caraglia, M ^a   Di Gennaro, E ^b   Barbarulo, D ^b   Marra, M ^a   Tagliaferri, P ^a   Abbruzzese, A ^a   Budillon, A ^b  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

cAMP analogue; Endocytosis; Epidermal growth factor receptor; Mitogen activated protein kinase; Protein kinase A; Ubiquitin

Indexed keywords

8 CHLOROADENOSINE 3',5' PHOSPHATE; EPIDERMAL GROWTH FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; UBIQUITIN;

ARTICLE; CANCER CELL; CELL PROLIFERATION; CONTROLLED STUDY; DEGRADATION; ENDOCYTOSIS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RADIOIMMUNOASSAY; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; SQUAMOUS CELL CARCINOMA;

8-BROMO CYCLIC ADENOSINE MONOPHOSPHATE; ANTINEOPLASTIC AGENTS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELL DIVISION; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ENDOCYTOSIS; ENZYME INHIBITORS; EPIDERMAL GROWTH FACTOR; HUMANS; NEOPLASMS; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED; UBIQUITINS;

EID: 0032971478     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-5793(99)00292-6     Document Type: Article

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