The role of bacterial superantigens in the pathophysiology of the skin;Die rolle bakterieller superantigene in der pathophysiologie der haut

Hautarzt

Volumn 50, Issue 2, 1999, Pages 91-97

  Boehncke, Wolf Henning ^a,b   Zollner, Thomas Matthias ^a  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^b GOETHE UNIVERSITY   (Germany)

Author keywords

Atopic dermatitis; Psoriasis; Superantigen; Therapy

Indexed keywords

BACTERIAL ANTIGEN; SUPERANTIGEN;

ANTIGENICITY; ATOPIC DERMATITIS; HOST RESISTANCE; HUMAN; PATHOPHYSIOLOGY; PSORIASIS; REVIEW; T LYMPHOCYTE ACTIVATION;

DERMATITIS, ATOPIC; GRAM-POSITIVE BACTERIA; HUMANS; LYMPHOCYTE ACTIVATION; PSORIASIS; SKIN DISEASES; SUPERANTIGENS; T-LYMPHOCYTES;

EID: 0032971452     PISSN: 00178470     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001050050870     Document Type: Review

References (67)

1. Acha-Orbea H (1995) Superantigens and tolerance. In: Bell JI, Owen MJ, Simpson E (eds) T cell receptors. Oxford University Press, Oxford, pp 224-265
2. Aoki Y, Yoshikai Y (1997) Further clonal expansion of T cells upon rechallenge of superantigen staphylococcal enterotoxin A. Microbiol Immunol 41:337-343
3. Baker BS, Bokth S, Powles A, Garioch JJ, Lewis H, Valdimarsson H, Fry L (1993) Group A streptococcal antigen specific T lymphocytes in guttate psoriatic lesions. Br J Dermatol 128:493-499
4. Baker BS, Swain AF, Fry L, Valdimarsson H (1984) Epidermal T lymphocytes and HLA-DR expression in psoriasis. Br J Dermatol 110:555-564
5. Berg EL, Yoshin T, Ron LS, Robinson MK, Warnock RA, Kishimoto TK, Picker LJ, Butcher EC (1991) The cutaneous lymphocyte antigen is a skin lymphocyte homing receptor for the vaascular lectin endothelial cell-leukocyte adhesion molecule 1. J Exp Med 174:1461-1466
6. Boehmer H v (1994) Positive selection of lymphocytes. Cell 76:219-228
7. Boehncke W-H (1996) Psoriasis and bacterial superantigens - formal or causal correlation? Trends Microbiol 4:485-489
8. Boehncke W-H, Dressel D, Manfras B, Zollner TM, Wettstein A, Bohm BO, Sterry W (1995) T-cell-receptor repertoire in chronic plaquestage psoriasis is restricted and lacks enrichment of superantigen-associated Vß regions. J Invest Dermatol 104:725-728
9. Boehncke W-H, Dressel D, Zollner TM, Kaufmann R (1996) Pulling the trigger on psoriasis. Nature 379:777
10. Boon T, Cerottini JC, van den Eynde B, van der Bruggen P, van Pel A (1994) Tumor antigens recognized by T lymphocytes. Annu Rev Immunol 12:337-365
11. Brocke S, Gaur A, Piercy C, Gautam A, Fathman CG, Steinman L (1993) Induction of relapsing paralysis in experimental allergic encephalomyelitis by bacterial superantigen. Nature 365:642-644
12. Campbell DE, Kemp AS (1997) Proliferation and production of interferon-gamma (IFN-γ) and IL-4 in response to Staphylococcus aureus and staphylococcal superantigen in childhood atopic dermatitis. Clin Exp Immunol 107:392-397
13. Chang JC, Smith LR, Froning KJ, Schwabe BJ, Laxer JA, Caralli LL, Kurland HH, Karasek MA, Wilkinson DI, Carlo DJ (1994) CD8+ T cells in psoriatic lesions preferentially use T-cell receptor Vß3 and/or Vß13.1 genes. Proc Natl Acad Sci (USA) 91:9282-9286
14. Chen VL, France DS, Martinelli GP (1986) De novo synthesis of lysozyme by human epidermal cells. J Invest Dermatol 87:585-587
15. Conrad B, Weldmann E, Trucco G, Rudert WA, Behboo R, Ricordi C, Rodriquez-Rilo H, Finegold D, Trucco M (1994) Evidence for superantigen involvement in insulin-dependent diabetes mellitus aetiology. Nature 371:351-355
16. Dohlsten M, Lando PA, Hedlund G, Trowsdale J, Kalland T (1990) Targeting of human cytotoxic T lymphocytes to MHC class II expressing cells by staphylococcal enterotoxins. Immunology 71:96-100
17. Ezepchuk YV, Norris DA, Middleton MH, Leung DYM (1995) Keratinocytes as target cells for staphylococcal toxins. J Invest Dermatol 104:611 (A)
18. Fuhlbrigge RC, Kieffer JD, Armerding D, Kupper TS (1997) Cutaneous lymphocyte antigen is a specialized form of PSGL-1 expressed on skin-homing T cells. Nature 389: 978-981
19. Germain RN (1994) MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation. Cell 76:287-299
20. Giantonio BJ, Alpaugh RK, Schultz J, McAleer C, Newton DW, Shannon B, Guedez Y, Kotb M, Vitek L, Persson R, Gunnarsson P-O, Kalland T, Dohlsten M, Persson B, Weiner LM (1997) Superantigen-based immunotherapy: a phase I trial of PNU-214565, a monoclonal antibody-staphylococcal enterotoxin A recombinant fusion protein, in advanced pancreatic and colorectal cancer. J Clin Oncol 15:1994-2007
21. Gidlöf C, Dohlsten M, Lando P, Kalland T, Sundström C, Tötterman TH (1997) A superantigen-antibody fusion protein for T-cell immunotherapy of human B-lineage malignancies. Blood 89:2089-2097
22. 389 IL-2) suggests a primary immune, but not keratinocyte, pathogenic basis. Nature Med 1:442-447
23. Gottlieb AB, Lifshitz B, Fu SM, Staiano-Coico L, Wang CY, Carter DM (1986) Expression of HLA-DR molecules by keratinocytes, and presence of Langerhans cells in the dermal infiltrate of active psoriatic plaques. J Exp Med 164:1013-1028
24. Hamid Q, Boguniewicz M, Leung DYM (1994) Differential in situ cytokine gene expression in acute vs. chronic atopic dermatitis. J Clin Invest 94:870-876
25. Hansson J, Ohlsson L, Persson R, Andersson G, Ilbäck N-G, Litton MJ, Kalland T, Dohlsten M (1997) Genetically engineered superantigens as tolerable antitumor agents. Proc Natl Acad Sci (USA) 94:2489-2494
26. Herman A, Croteau G, Sekaly R-P, Kappler J, Marrack P (1990) HLA-DR alleles differ in their ability to present staphylococcal enterotoxins to T cells. J Exp Med 172:709-717
27. Herrmann T, Accolla RS, MacDonald HR (1989) Different staphylococcal enterotoxins bind preferentially to distinct major histocompatibility complex class II isotypes. Eur J Immunol 19:2171-2174
28. Hofer MF, Lester MR, Schlievert PM, Leung DYM (1995) Upregulation of IgE synthesis by staphylococcal toxic shock syndrome toxin-1 in peripheral blood mononuclear cells from patients with atopic dermatitis. Clin Exp Allergy 25:1218-1227
29. Jack AS, Boylston AW, Carrel S, Grigor I (1990) Cutaneous T-cell lymphoma cells employ a restricted range of T-cell antigen receptor variable region genes. Am J Pathol 136:17-21
30. Jackow CM, Cather JC, Hearne V, Asano AT, Musser JM, Duvic M (1997) Association of erythrodermic cutaneous T-cell lymphoma, superantigen-positive Staphylococcus aureus, and oligoclonal T-cell receptor V beta gene expansion. Blood 89:32-40
31. Jardetzky TS, Brown JH, Gorga JC, Stern LJ, Urban RG, Chi Y-I, Stauffacher C, Strominger JL, Wiley DC (1994) Three-dimensional structure of human class II histocompatibility molecule complexed with superantigen. Nature 368:711-718
32. Kawabe Y, Ochi A (1991) Programmed cell death and extrathymic reduction of Vbeta8+CD4+ T cells in mice tolerant to Staphylococcus aureus enterotoxin B. Nature 349:245-248
33. Kappler J, Kotzin B, Herron L, Gelfand EW, Bigler RD, Boylston A, Carrel S, Posnett DN, Choi Y, Marrack P (1989) Vß-specific stimulation of human T cells by staphylococcal toxins. Science 244:811-813
34. Lacour M, Hauser C (1993) The role of microorganisms in atopic dermatitis. Clin Rev Allergy 11:491-522
35. Lando P, Hedlund G, Dohlsten M, Kalland T (1991) Bacterial superantigens as anti-tumor agents: induction of tumor cytotoxicity in human lymphocytes by staphylococcal enterotoxin. Cancer Immunol Immunother 33:231-237
36. Leung DYM (1992) Immunopathology of atopic dermatitis. Springer Semin Immunopathol 13:427-440
37. Leung DYM, Harbeck R, Bina P, Hanifin JM, Reiser RF, Sampson HA (1993) Presence of IgE antibodies to staphylococcal exotoxins on the skin of patients with atopic dermatitis: evidence for a new group of allergens. J Clin Invest 92:1374-1380
38. Lewis HM, Baker BS, Bokth S, Powles AV, Garioch JJ, Valdimarsson H, Fry L (1993) Restricted T-cell receptor VR gene usage in the skin of patients with guttate and chronic plaque psoriasis. Br J Dermatol 129:514-520
39. Marrack P, Blackman M, Kushnir E, Kappler J (1990) The toxicity of staphylococcal enterotoxin B in mice is mediated by T cells. J Exp Med 171:455-464
40. McFadden JP, Noble WC, Camp RDR (1993) Superantigenic exotoxin-secreting potential of staphylococci isolated from atopic eczematous skin. Br J Dermatol 128:631-632
41. McFadden J, Valdimarsson H, Fry L (1991) Cross-reactivity between streptococcal M surface antigen and human skin. Br J Dermatol 125:443-447
42. Melish MF, Glasgow LA, Turner MD (1972) The staphylococcal scaled-skin syndrome: isolation and partial characterization of the exfoliative toxin. J Infect Dis 125:129-140
43. Miethke T, Wahl C, Heeg K, Wagner H (1995) Superantigens: the paradox of T-cell activation versus inactivation. Int Arch Allergy Immunol 106:3-7
44. Mel-14) in vivo. J Immunol 151:6777-6782
45. Moss P, Charmley P, Mulbihill E, Ziegler S, Raugi GJ, Kern D, Piepkorn M, Gelinas R (1997) The repertoire of T cell antigen receptor β-chain variable regions associated with psoriasis vulgaris. J Invest Dermatol 109:14-19
46. Neuber K, Steinrücke K, Ring J (1995) Staphylococcal enterotoxin B affects in vitro IgE synthesis, interferon-γ, interleukin-4 and Interleukin-5 production in atopic eczema. Int Arch Allergy Immunol 107:179-182
47. Nickoloff BJ, Mitra RS, Green J, Zheng X-G, Shimizu V, Thompson C, Turka LA (1993) Accessory cell function of keratinocytes for superantigens. J Immunol 150:2148-2159
48. Nossal GJV (1994) Negative selection of lymphocytes. Cell 76:229-239
49. Paliard X, West SG, Lafferty JA, Clements JR, Kappler JW, Marrack P, Kotzin BL (1991) Evidence for the effects of a superantigen in rheumatoid arthritis. Science 253:325-329
50. Platsoucas CD, Oleszak EL, Good RA (1986) Immunomodulation of human leukocytes by Staphylococcal enterotoxin A: augmentation of natural killer cells and induction of suppressor cells. Cell Immunol 97:371-385
51. Rosendahl A, Hansson J, Sundstedt A, Kalland T, Dohlsten M (1996) Immune response during tumor therapy with antibody-superantigen fusion proteins. Int J Cancer 68:109-113
52. Saloga J, Enk AH, Becker D, Mohamadzadeh M, Spieles S, Bellinghausen I, Leung DYM, Gelfand EW, Knop J (1995) Modulation of contact sensitivity responses by bacterial superantigen. J Invest Dermatol 105:220-224
53. Stingl G, Katz SI, Clement L, Green I, Shevach EM (1978) Immunologic function of la-bearing epidermal Langerhans cells. J Immunol 121:2005-2013
54. Tefler NR, Chalmers RJG, Whale K, Colman G (1992) The role of streptococcal infection in the initiation of guttate psoriasis. Arch Dermatol 128:39-42
55. Thibodeau J, Dohlsten M, Cloutier I, Lavoie PM, Bjork R Michel F, Leveille C, Mourad W, Kalland T, Sekaly R-P (1997) Molecular characterization and role in T cell activation of Staphylococcal enterotoxin A binding to the HLA-DR α-chain. J Immunol 158:3698-3704
56. Tokura Y, Heald PW, Yan SL, Edelson RL (1992) Stimulation of cutaneous T-cell lymphoma cells with superantigenic Staphylococcal toxins. J Invest Dermatol 98:33-37
57. Tokura Y, Yagi J, O'Malley M, Lewis JM, Jakigawa M, Edelson RL, Tigelaar RE (1994) Superantigenic Staphylococcal exotoxins induce T-cell proliferation in the presence of Langerhans cells or class II-bearing keratinocytes and stimulate keratinoctes to produce T-cell-actrivating cytokines. J Invest Dermatol 102:31-38
58. Valdimarsson H, Sigmundsdottir H, Jonsdottir I (1997) Is psoriasis induced by streptococcal superantigens and maintained by M-protein-specific T cells that cross-react with keratin? Clin Exp Immunol 107 (S):21-24
59. Vath GM, Earhart CA, Rago JV, Kim MH, Bohach GA, Schlievert PM, Ohlendorf DH (1997) The structure of the superantigen exfoliative toxin A suggests a novel regulation as a serine protease. Biochemistry 36:1559-1566
60. Vekony MA, Holcer JE, Lee AJ, Horrocks C, Eperon IC, Camp RDR (1997) Selective amplification of T-cell receptor variable region species is demonstable but not essential in early lesions of psoriasis vulgaris: analysis by anchored polymerase chain reaction and hypervariable region size spectratyping. J Invest Dermatol 109:5-13
61. Wakita H, Tokura Y, Furukawa F, Takigawa M (1995) Staphylococcal enterotoxin B upregulates expression of ICAM-1 molecules on IFN-γ treated keratinocytes and keratinocyte cell lines. J Invest Dermatol 105:536-542
62. Walev I, Martin E, Jonas D, Mohamadzadeh M, Müller-Klieser W, Kunz L, Bhakdi S (1993) Staphylococcal alpha-toxin kills human keratinocytes by permeabilizing the plasma membrane for monovalent ions. Infect Immun 61:4972-4979
63. Wen R, Broussard DR, Surman S, Hogg TL, Blackman MA, Woodland DL (1997) Carboxyterminal residues of major histocompatibility complex class-II associated peptides control the presentation of the bacterial superantigen toxic shock syndrome toxin-1 to T cells. Eur J Immunol 27:772-781
64. Wrone-Smith T, Nickoloff BJ (1996) Dermal injection of immunocytes induces psoriasis. J Clin Invest 98:1878-1887
65. ZollnerTM, Munk ME, Keller T, Nuber V, Boehncke W-H, Kaufmann SHE, Duijvestijn AM, Sterry W, Kaufmann R (1996) The superantigen exfoliative toxin induces cutaneous lymphocyte-associated antigen expression in peripheral human T lymphocytes. Immunol Letters 49:111-116
66. ZollnerTM, Nuber V, Duijvestijn A-M, Boehncke W-H, Kaufmann R (1997) Superantigens but not mitogens are capable of inducing upregulation of E-selectin ligands on human lymphocytes. Exp Dermatol 6:161-166
67. Zollner TM, Wichelhaus T, Duijvestijn AM, Boehncke W-H, Brade V, Kaufmann R (1997) Production of superantigens by S. aureus is of clinical relevance in patients suffering from psoriasis and atopic eczema. J Invest Dermatol 109:445 (A)