High sensitivity of the ultraviolet-induced p53 response in ultraviolet-sensitive syndrome, a photosensitive disorder with a putative defect in deoxyribonucleic acid repair of actively transcribed genes

Mutation Research - DNA Repair

Volumn 433, Issue 1, 1999, Pages 23-32

  Ohta, Mika ^a   Nitta, Makoto ^a   Yamaizumi, Masaru ^a  

^a KUMAMOTO UNIV SCHOOL OF MEDICINE   (Japan)

Author keywords

UV(s) syndrome; UV induced p53

Indexed keywords

ALPHA AMANITIN; NUCLEOTIDE; PROTEIN P53;

ARTICLE; CELL CYCLE; CELL NUCLEUS; COCKAYNE SYNDROME; CONTROLLED STUDY; DNA REPAIR; EXCISION REPAIR; FLUORESCENCE ACTIVATED CELL SORTER; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; PHOTOSENSITIVITY; PRIORITY JOURNAL; RNA SYNTHESIS; ULTRAVIOLET RADIATION; UNSCHEDULED DNA SYNTHESIS; WESTERN BLOTTING; XERODERMA PIGMENTOSUM;

AMANITINS; CELL CYCLE; COCKAYNE SYNDROME; DNA DAMAGE; DNA REPAIR; FIBROBLASTS; FLOW CYTOMETRY; HEAT; HUMANS; IMMUNOHISTOCHEMISTRY; NUCLEAR PROTEINS; PHOTOSENSITIVITY DISORDERS; RNA; TUMOR SUPPRESSOR PROTEIN P53; ULTRAVIOLET RAYS;

EID: 0032969728     PISSN: 09218777     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0921-8777(98)00058-5     Document Type: Article

References (21)

1. s syndrome, a new general category of photosensitive disorder with defective DNA repair, is distinct from xeroderma pigmentosum variant and rodent complementation group 1. Am. J. Hum. Genet. 56:1995;1267-1276.
2. Yamaizumi M., Sugano T. UV-induced nuclear accumulation of p53 is evoked through DNA damage of actively transcribed genes independent of the cell cycle. Oncogene. 9:1994;2775-2784.
3. Ko L.J., Prives C. p53: puzzle and paradigm. Genes Dev. 10:1996;1054-1072.
4. Ford J.M., Hanawalt P.C. Li-Fraumeni syndrome fibroblasts homozygous for p53 mutations are deficient in global DNA repair but exhibit normal transcription-coupled repair and enhanced UV resistance. Proc. Natl. Acad. Sci. U.S.A. 92:1995;8876-8880.
5. Weinberg R.A. Tumor suppressor genes. Science. 254:1991;1138-1146.
6. Levine A.J., Momand J., Finlay C.A. The p53 tumor suppressor gene. Nature. 351:1991;453-456.
7. Fritsche M., Haessler C., Brandner G. Induction of nuclear accumulation of the tumor suppressor protein p53 by DNA-damaging agents. Oncogene. 8:1993;307-318.
8. Hall P.A., McKee P.H., Menage H. du P., Dover R., Lane D.P. High levels of p53 protein in UV-irradiated normal human skin. Oncogene. 8:1993;203-207.
9. Ljungman M., Zhang F. Blockage of RNA polymerase as a possible trigger for UV light-induced apoptosis. Oncogene. 13:1996;823-831.
10. Itoh T., Ono T., Yamaizumi M. A new UV-sensitive syndrome not belonging to any complementation groups of xeroderma pigmentosum or Cockayne syndrome: siblings showing biochemical characteristics of Cockayne syndrome without typical clinical manifestations. Mutat. Res. 314:1994;233-248.
11. Nitta M., Okamura H., Aizawa S., Yamaizumi M. Heat shock induces transient p53-dependent cell cycle arrest at G1/S. Oncogene. 15:1997;561-568.
12. Sugano T., Nitta M., Ohmori H., Yamaizumi M. Nuclear accumulation of p53 in normal human fibroblasts is induced by various cellular stresses which evoke the heat shock response, independently of the cell cycle. Jpn. J. Cancer Res. 86:1995;415-418.
13. Lu X., Lane D.P. Differential induction of transcriptionally active p53 following UV or ionizing radiation: defects in chromosome instability syndromes? Cell. 75:1993;765-778.
14. Ellis N.A., Groden J., Ye T.-Z., Straughen J., Lennon D.J., Ciocci S., Proytcheva M., German J. The Bloom's syndrome gene product is homologous to RecQ helicases. Cell. 83:1995;655-666.
15. Khanna K.K., Lavin M.F. Ionizing radiation and UV induction of p53 protein by different pathways in ataxia-telangiectasia cells. Oncogene. 8:1993;3307-3312.
16. Kastan M.B., Zhan Q., El-Deiry W.S., Carrier F., Jacks T., Walsh W.V., Plunkett B.S., Vogelstein B., Fornace A.J. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell. 71:1992;587-597.
17. Savitsky K., Bar-Shira A., Gilad S., Rotman G., Ziv Y., Vanagaite L., Tagle D.A., Smith S., Uziel T., Sfez S., Ashkenazi M., Pecker I., Frydman M., Harnik R., Patanjali S.R., Simmons A., Clines G.A., Sartiel A., Gatti R.A., Chessa L., Sanal O., Lavin M.F., Jaspers N.G.J., Taylor A.M.R., Arlett C.F., Miki T., Weissman S.M., Lovett M., Collins F.S., Shiloh Y. A single ataxia-telangiectasia gene with a product similar to PI3 kinase. Science. 268:1995;1749-1753.
18. Xu Y., Baltimore D. Dual roles of ATM in the cellular response to radiation and in cell growth control. Genes Dev. 10:1996;2401-2410.
19. Mosner J., Mummenbrauer T., Bauer C., Sczakiel G., Grosse F., Deppert W. Negative feedback regulation of wild-type p53 biosynthesis. EMBO J. 14:1995;4442-4449.
20. Fu L., Minden M.D., Benchimol S. Translational regulation of human p53 gene expression. EMBO J. 15:1996;4392-4401.
21. Maltzman W., Czyzyk L. UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells. Mol. Cell. Biol. 4:1984;1689-1694.