Actions of roxindole at recombinant human dopamine D2, D3 and D4 and serotonin 5-HT(1A), 5-HT(1B) and 5-HT(1D) receptors

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 359, Issue 6, 1999, Pages 447-453

  Newman Tancredi, A ^a   Cussac, D ^a   Audinot, V ^a   Millan, M J ^a  

^a INSTITUT DE RECHERCHES INTERNATIONALES SERVIER   (France)

Author keywords

35S GTP S binding; Antidepressants; Dopamine D3 receptors; G proteins; Roxindole; Serotonin 5 HT(1A) receptors

Indexed keywords

ANTIDEPRESSANT AGENT; DOPAMINE 2 RECEPTOR; DOPAMINE 3 RECEPTOR; DOPAMINE 4 RECEPTOR; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; ROXINDOLE; SEROTONIN 1A ANTAGONIST; SEROTONIN 1A RECEPTOR; SEROTONIN 1B RECEPTOR; SEROTONIN 1D RECEPTOR;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING COMPETITION; CHINESE HAMSTER; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG RECEPTOR BINDING; FEMALE; NONHUMAN; PSYCHIATRIC TREATMENT;

ADENYLATE CYCLASE; ANIMALS; BINDING, COMPETITIVE; CELL MEMBRANE; CHO CELLS; CRICETINAE; DOPAMINE AGONISTS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HUMANS; INDOLES; PYRIDINES; QUINPIROLE; RECEPTOR, SEROTONIN, 5-HT1B; RECEPTOR, SEROTONIN, 5-HT1D; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D3; RECEPTORS, DOPAMINE D4; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; RECOMBINANT PROTEINS; SEROTONIN;

EID: 0032969297     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00005374     Document Type: Article

References (22)

1. 2 autoreceptor agonist. J Pharmacol Exp Ther 276: 41-48
2. De Lean A, Stadel JM, Lefkowitz RJ (1980) A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled β-adrenergic receptor. J Biol Chem 255: 7108-7117
3. Devoto P, Collu M, Muntoni L, Pistis M, Serra G, Gsa GL, Diana M (1995) Biochemical and electrophysiological effects of 7-OH-DPAT on the mesolimbic dopaminergic systems. Synapse 20: 153-155
4. 1A receptor agonists: recent developments and controversial issues. Psychopharmacology 121: 1-26
5. 1A receptor antagonist. Behav Brain Res 73: 337-353
6. 2 dopamine receptor family: differential coupling to Gi, Gz and Gs. Dopamine 98 Symposium, July 22-25, Strasbourg, P033
7. 3 (auto)receptors inhibit dopamine release in the frontal cortex of freely moving rats in vivo. J Neurochem 66: 2209-2212
8. Gründer G, Wetzel H, Hammes E, Benkert O (1993) Roxindole, a dopamine autoreceptor agonist, in the treatment of major depression. Psychopharmacology 111: 123-126
9. 3 receptor mutant mice. J Neurosci 18: 2231-2238
10. B from inhibition curves in functional experiments: alternatives to the Cheng-Prusoff equation. Trends Pharmacol Sci 14: 237-239
11. 3 dopamine receptor: neurobiology and potential clinical relevance. Pharmacol Rev 49: 231-252
12. Maj J, Kolodziejczyk K, Rogóz Z, Skuza G (1996) Roxindole, a potential antidepressant. I. Effect on the dopamine system. J Neural Transm 103: 627-641
13. Maj J, Kolodziejczyk K, Rogóz Z, Skuza G (1997) Roxindole, a dopamine autoreceptor agonist with a potential antidepressant activity. II. Effect on the 5-hydroxytryptamine system. Pharmacopsychiatry 30: 55-61
14. 2 receptor deficient mice. Neuroscience 79: 323-327
15. 1A receptors in vivo. J Pharmacol Exp Ther 273: 1418-1427
16. Missale C, Nash SR, Robinson SW, Jaber M, Caron MG (1998) Dopamine receptors: from structure to function. Physiol Rev 78: 189-225
17. 1A receptors. Eur J Pharmacol 307: 107-111
18. 4.4 receptors: actions of antiparkinsonian and antipsychotic agents. J Pharmacol Exp Ther 282: 181-191
19. 35S]-GTPγS binding study. Eur J Pharmacol 355: 245-256
20. 35S]thio)-triphosphate binding and antibody study. Mol Pharmacol 55: 564-574
21. 2 dopamine agonist with actions on serotonin systems. Eur J Pharmacol 160: 31-41
22. 3 receptors. Eur J Pharmacol 277: 151-158