Atovaquone and proguanil hydrochloride for treatment of malaria

Journal of Travel Medicine

Volumn 6, Issue SUPPL. 1, 1999, Pages

  Kremsner, Peter G ^a   Looareesuwan, Sornchai ^b   Chulay, Jeffrey D ^c  

^a ALBERT SCHWEITZER HOSPITAL   (Gabon)

^b MAHIDOL UNIVERSITY   (Thailand)

^c GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMODIAQUINE; ATOVAQUONE; ATOVAQUONE PLUS PROGUANIL; CHLOROQUINE; FANSIDAR; HALOFANTRINE; MEFLOQUINE; PRIMAQUINE; PROGUANIL; QUININE; TETRACYCLINE;

ANAPHYLAXIS; ANTIBIOTIC PROPHYLAXIS; ANTIMALARIAL ACTIVITY; ARTICLE; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; HUMAN; MALARIA; MALARIA FALCIPARUM; MEDICAL LITERATURE; VOMITING;

ANTIMALARIALS; ATOVAQUONE; CHEMOPREVENTION; DRUG COMBINATIONS; HUMANS; MALARIA, FALCIPARUM; PLASMODIUM FALCIPARUM; PROGUANIL; TRAVEL;

EID: 0032969250     PISSN: 11951982     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Looareesuwan S, Viravan C, Webster HK, et al. Clinical studies of atovaquone, alone or in combination with other antimalarial drugs, for treatment of acute uncomplicated malaria in Thailand. Am J Trop Med Hyg 1996; 54:62-66.
2. Looareesuwan S,. Chulay JD. Canfield CJ, Hutchinson DB.Malarone (atovaquone and proguanil hydrochloride): a review of its clinical development for treatment ot malaria. Am J Trop Med Hyg 1999; 60:533-541.
3. Radloff PD, Philipps J. Nkeyi M, et al. Atovaquone and proguanil for Plasmodium falciparum malaria. Lancet 1996; 347:1511 - 1514.
4. Radloff PD, Philipps J, Hutchinson D, Kremsner PG. Atovaquone plus proguanil is an effective treatment for Plasmodium ovale and P. malariae malaria. Trans R Soc Trop Med 1996; 90:682.
5. de Alencar FE, Cerutti C Jr, Durlacher RR, et al. Atovaquone and proguanil for the treatment of malaria in Brazil. J Infect Dis 1997; 175:1544-1547.
6. Sabchareon A. Attanath P, Phanuaksook P, et al. Efficacy and pharmacokinetics of atovaquone and proguanil in children with multidrugresistant Plasmodium falciparum malaria. Trans R Soc Trop Med Hyg 1998; 92:201-206.
7. Looareesuwan S, Wilairatana P, Chalermarut K, et al. Efficacy and safety of atovaquone/proguanil compared with mefloqiune for treatment of acute Plasmodium falciparum malaria in Thailand. Am J Trop Med Hyg 1999; 60:526-532.
8. Mulenga M, Canfield CJ, Hutchinson DBA. Atovaquone/proguanil versus pyrimethamine/sulfadoxine for treatment of acute falciparum malaria in Zambia. Clin Therap 1999 (in press).
9. Anabwani G, Canfield CJ, Hutchinson DBA. Combination ato vaquone and proguanil hydrochloride versus halofantrine for treatment of acute Plasmodium falciparum malaria in children. Pediatr Infect Dis J 1999; 18:456-461.
10. Bustos DG, Canfield CJ, Canete-Miguel E, Hutchinson DBA. Atovaquone/proguanil compared with chloroquine and chloroquine/sulfadoxine/pyrimehamine tor treatment of acute Plasmodium falciparum malaria in the Philippines. J Infect Dis 1999 (in press).
11. Glaxo Wellcome, data on file.
12. World Health Organization. Chemotherapy of malaria and resistance to antimalarials. WHO Tech Rep Ser 1973; 529: 30-32.
13. Lell B. Luckner D. Ndjave M, et al. Randomised placebo-controlled study of atovaquone plus proguanil for malaria prophylaxis in children. Lancet 1998; 351:709-713.
14. Shanks GD, Gordon DM, Klotz FW et al. Efficacy and safety of atovaquone/proguanil for suppressive prophylaxis against Plasmodium falciparum malaria. Clin Infect Dis 1998; 27: 494-499.
15. Sukwa TY, Mulenga M, Chisaka N, et al. A randomized, double-blind, placebo-controlled field trial to determine the efficacy and safety of Malarone (atovaquone/proguanil) for the prophylaxis of malaria in Zambia. Am J Trop Med Hyg 1999; 60:521-525.
16. Canfield CJ, Pudney M, Gutteridge WE. Interactions of atovaquone with other antimarial drugs against Plasmodium Falciparum in vitro. Exp Parasitol 1995; 80:373-381.
17. Blanchard TJ, Mabey DC, Hunt-Cooke A, et al. Multiresistant falciparum malaria cured using atovaquone and proguanil. Trans R Soc Trop Med 1994; 88:693.
18. Luxemburger C, Brockman A, Silamut K, et al. Two patients with falciparum malaria and poor in vivo response to artesunate. Trans R Soc Trop Med 1998; 92:668-669.