Cytotoxic effect of paraquat on rat C6 glioma cells: Evidence for the possibility of non-oxidative damage to the cells

Japanese Journal of Pharmacology

Volumn 79, Issue 1, 1999, Pages 121-124

  Morita, Kyoji ^a   Tokunaga, Itsuo ^a   Kubo, Shin Ichi ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

Cytotoxicity; Paraquat; Rat C6 glioma cell

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; GLUTATHIONE; PARAQUAT;

ANIMAL CELL; ARTICLE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DOSE TIME EFFECT RELATION; GLIA CELL; NONHUMAN; RAT;

EID: 0032967720     PISSN: 00215198     EISSN: None     Source Type: Journal    
DOI: 10.1254/jjp.79.121     Document Type: Article

References (14)

1. Bus JS, Aust SD and Gibson JE: Superoxide-and singlet oxygen-catalyzed lipid peroxidation as a possible mechanism for paraquat (methylviologen) toxicity. Biochem Biophys Res Commun 58, 749-755 (1974)
2. Clejan L and Cederbaum AI: Synergistic interactions between NADPH-cytochrome P-450 reductase, paraquat and iron in the generation of active oxygen radicals. Biochem Pharmacol 38, 1779-1786 (1989)
3. Fukushima T, Yamada K, Isobe A, Shiwaku K and Yamane Y: Mechanism of cytotoxicity of paraquat: I. NADH oxidation and paraquat radical formation via complex I. Exp Toxic Pathol 45, 345-349 (1993)
4. Fukushima T, Yamada K, Hojo N, Isobe A, Shiwaku K and Yamane Y: Mechanism of cytotoxicity of paraquat: III. The effects of acute paraquat exposure on the electron transport system in rat mitochondria. Exp Toxic Pathol 46, 437-441 (1994)
5. Fukushima T, Tawara T, Isobe A, Hojo N, Shiwaku K and Yamane Y: Radical formation site of cerebral cortex complex I and Parkinson's disease. J Neurosci Res 42, 385-390 (1995)
6. Liou HH, Chen RC, Tsai YF, Chen WP, Chang YC and Tsai MC: Effects of paraquat on the substantia nigra of the Wistar rats: neurochemical, histochemical, and behavioral studies. Toxicol Appl Pharmacol 137, 34-41 (1996)
7. Bagetta G, Corasaniti MT, Iannone M, Nistico G and Stephenson JD: Production of limbic motor seizures and brain damage by systemic and intracerebral injections of paraquat in rats. Pharmacol Toxicol 71, 443-448 (1992)
8. Vornov JJ, Park J and Thomas AG: Regional vulnerability to endogenous and exogenous oxidative stress in organotypic hippocampal culture. Exp Neurol 149, 109-122 (1998)
9. Nagao M, Takatori T, Wu B, Terazawa K, Gotouda H, Akabane H, Inoue K and Shimizu M: Immunohistochemical localization of paraquat in lung and brain. Med Sci Law 31, 61-64 (1991)
10. Fautz R, Husein B and Hechenberger C: Application of the neutral red assay (NR assay) to monolayer cultures of primary hepatocytes: rapid colorimetric viability determination for the unscheduled DNA synthesis test (UDS). Mutat Res 253, 173-179 (1991)
11. Kasai H, Nishimura S, Kurokawa Y and Hayashi Y: Oral administration of the renal carcinogen, potassium bromate, specifically produces 8-hydroxydeoxyguanosine in rat target organ DNA. Carcinogenesis 8, 1959-1961 (1987)
12. Webster RP, Gawde MD and Bhattacharya RK: Protective effect of rutin, a flavonoid glycoside, on the carcinogen-induced DNA damage and repair enzymes in rats. Cancer Lett 109, 185-191 (1996)
13. Skaper SD, Fabris M, Ferrari V, Carbonare MD and Leon A: Quercetin protects cutaneous tissue-associated cell types including sensory neurons from oxidative stress induced by glutathione depletion: cooperative effects of ascorbic acid. Free Radic Biol Med 22, 669-678 (1997)
14. Metodiewa D, Kochman A and Karolczak S: Evidence for antiradical and antioxidant properties of four biologically active N,N-diethylaminoethyl esters of flavanone oximes: a comparison with natural polyphenolic flavonoid (rutin) action. Biochem Mol Biol Int 41, 1067-1075 (1997)