A cellular model for long QT syndrome. Trapping of heteromultimeric complexes consisting of truncated Kv1.1 potassium channel polypeptides and native Kv1.4 and Kv1.5 channels in the endoplasmic reticulum

Journal of Biological Chemistry

Volumn 272, Issue 42, 1997, Pages 26505-26510

  Folco, Eduardo ^a   Mathur, Rajesh ^a   Mori, Yasukiyo ^a   Buckett, Peter ^a   Koren, Gideon ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MEMBRANE PROTEIN; POTASSIUM CHANNEL;

ARTICLE; CELL FRACTIONATION; CELL LYSATE; CELL STRAIN GH3; CELLULAR DISTRIBUTION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; GENE EXPRESSION; IMMUNOFLUORESCENCE MICROSCOPY; IMMUNOPRECIPITATION; LONG QT SYNDROME; PRIORITY JOURNAL;

ANIMALS; CELL LINE; ENDOPLASMIC RETICULUM; LONG QT SYNDROME; MICE; MICE, TRANSGENIC; MODELS, BIOLOGICAL; PHENOTYPE; POTASSIUM CHANNELS; RECOMBINANT PROTEINS; SUBCELLULAR FRACTIONS; XENOPUS;

EID: 0030700480     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.42.26505     Document Type: Article

References (23)

1. Babila, T., Moscucci, A., Wang, H., Weaver, F. E. & Koren, G. (1994) Neuron 12, 615-626
2. London, B., Han, X., Folco, E. & Koren, G. (1996) Biophys. J. 70, A260 (abstr.)
3. MacKinnon, R. (1991) Nature 350, 232-235
4. Nagaya, N. & Papazian, D. M. (1996) J. Biol. Chem. 272, 3022-3027
5. Hurtley, S. M. & Helenius, A. (1989) Annu. Rev. Cell Biol. 5, 227-307
6. Shen, N. V., Chen, X., Boyer, M. M. & Pfaffinger, P. J. (1993) Neuron 11, 67-76
7. Li, M., Jan, Y. N. & Jan, L. Y. (1992) Science 257, 1225-1230
8. Tu, L., Santarelli, V., Sheng, Z., Skach, W., Pain, D. & Deutch, C. (1996) J. Biol. Chem. 271, 18904-18911
9. Tiwari-Woodruff, S. K., Schulteis, C. T., Mock, A. F. & Papazian, D. M. (1997) Biophys. J. 72, 1489-1500
10. Adelman, J. P., Bond, C. T., Pessia, M. & Maylie, J. (1995) Neuron 15, 1449-1454
11. Curran, M. E., Splawski, I., Timothy, K W., Vincent, G. M., Green, E. D. & Keating, M. T. (1995) Cell 80, 795-803
12. Sanguinetti, M. C., Curran, M. E., Zou, A., Shen, J., Spector, P. S., Atkinson, D. L. & Keating, M. T. (1996) Nature 384, 80-83
13. Sanguinetti, M. C., Curran, M. E., Spector, P. S. & Keating, M. T. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 2208-2212
14. Chung, S., Saal, D. B. & Kaczmarek, L. K. (1995) Proc. Natl. Acad. Sci. 92, 5955-5959
15. Takimoto, K., Fomina, A. F., Trimmer, J. S. & Levitan, E. D. (1993) Neuron 11, 359-369
16. Mori, Y., Folco, E. & Koren, G. (1995) J. Biol. Chem. 270, 27788-27796
17. Liman, E. R., Hess, P., Weaver, F. & Koren, G. (1991) Nature 353, 752-756
18. Li, X., Xu, J. & Li. M. (1997) J. Biol. Chem. 272, 705-708
19. Hartmann, E., Grolich, D., Kosta, S., Otto, A., Kraft, R., Knespel, S., Burger, E., Rapoport, T. A. & Prehn, S. (1993) Eur. J. Biochem. 214, 375-381
20. Shen, N. V. & Pfaffinger, P. J. (1995) Neuron 14, 625-633
21. Lemmon, M. A. & Engelman, D. M. (1994) Q. Rev. Biophys. 27, 157-218
22. MacKenzie, K. R., Prestegard, J. H. & Engelman, D. M. (1997) Science 276, 131-133
23. Peled-Zehavi, H., Arkin, I. T., Engelman, D. M. & Shai, Y. (1996) Biochemistry 35, 6828-6838