Administration of an unconjugated bile acid increases duodenal tumors in a murine model of familial adenomatous polyposis

Carcinogenesis

Volumn 20, Issue 2, 1999, Pages 299-303

  Mahmoud, Najjia N ^a,b   Dannenberg, Andrew J ^a,b   Bilinski, Robyn T ^a   Mestre, Juan R ^b   Chadburn, Amy ^a   Churchill, Matthew ^a   Martucci, Charles ^b   Bertagnolli, Monica M ^a,b  

^a NEW YORK PRESBYTERIAN HOSPITAL   (United States)

^b STRANG CANCER PREVENTION CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BILE ACID; CHENODEOXYCHOLIC ACID; TUMOR PROMOTER;

ADENOMATOUS POLYP; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL TRANSFORMATION; CHEMICAL CARCINOGENESIS; CONTROLLED STUDY; DIET; DUODENUM TUMOR; FEMALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ADENOMATOUS POLYPOSIS COLI; ADENOMATOUS POLYPOSIS COLI PROTEIN; ANIMALS; BETA CATENIN; CARCINOGENICITY TESTS; CHENODEOXYCHOLIC ACID; CHOLAGOGUES AND CHOLERETICS; CYTOSKELETAL PROTEINS; DINOPROSTONE; DISEASE MODELS, ANIMAL; DUODENAL NEOPLASMS; DUODENUM; FEMALE; MICE; TRANS-ACTIVATORS;

EID: 0032958831     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/20.2.299     Document Type: Article

References (38)

1. Hepner, G.W., Hofmann, A.F., Malagelada, J.R., Szczepanick, P.A. and Klein, P.D. (1974) Increased bacterial degradation of bile acids in cholecystectomized patients. Gastroenterology, 66, 556-564.
2. Giovanucci, E., Colditz, G.A. and Stampfer, M.J. (1993) A meta-analysis of cholecystectomy and risk of colorectal cancer. Gastroenterology, 105, 130-141.
3. Reddy, B.S. (1981) Diet and excretion of bile acids. Cancer Res., 41, 3766-3768.
4. Reddy, B.S. and Wynder, E.L. (1973) Large bowel carcinogenesis: fecal constituents of populations with diverse incidence rates of colon cancer. J. Natl Cancer Inst., 50, 1437-1442.
5. Bayerdorffer, E., Mannes, G.A., Richter, W.O., Ochsenkuhn, T., Wiebecke, B., Kopeke, W. and Paumgarter, G. (1993) Increased serum deoxycholic acid levels in men with colorectal adenomas. Gastroenterology, 104, 145-151.
6. Seraj, M.J., Umemoto, A., Kajikawa, A., Mimura, S., Kinouchi, T., Ohnishi, Y. and Monden, Y. (1997) Effects of dietary bile acids on formation of azoxymethane-induced aberrant crypt foci in F344 rats. Cancer Lett., 115, 97-103.
7. Sutherland, L.A.M. and Bird, R.P. (1994) The effect of chenodeoxycholic acid on the development of aberrant crypt foci in the rat colon. Cancer Lett., 76, 101-107.
8. Reddy, B.S., Narisawa, T., Weisburger, J.H. and Wynder, E.L. (1976) Promoting effect of sodium deoxycholate on colonic adenocarcinomas in germ free rats. J. Natl Cancer Inst., 56, 441-442.
9. McSherry, C.K., Cohen, B.I., Bokkenheuser, V.D., Mosbach, E.H., Winter, J., Mantoba, N. and Scholes, J. (1989) Effects of calcium and bile acid feeding on colon tumors in the rat. Cancer Res., 49, 6039-6043.
10. Pongrancz, J., Clark, P., Neoptolemos, J.P. and Lord, J.M. (1995) Expression of protein kinase C isoenzymes in colorectal cancer tissue and their differential activation by different bile acids. Int. J. Cancer, 61, 35-39.
11. Rigas, B., Tsioulias, G.J., Allan, C., Wali, R.K. and Brasitus, T.A. (1994) The effect of bile acids and piroxicam on MHC antigen expression in rat colonocytes during colon cancer development. Immunology, 83, 319-323.
12. Craven, R.A., Pfanstiel, J. and DeRubertis, F.R. (1987) Role of activation of protein kinase C in the stimulation of colonic epithelial proliferation and reactive oxygen formation by bile acids. J. Clin. Invest., 799, 532-541.
13. Fitzer, C.J., O'Brian, C.A., Guillem, J.G. and Weinstein, I.B. (1987) The regulation of protein kinase C by chenodeoxycholate, deoxycholate, and several structurally related bile acids. Carcinogenesis, 8, 217-220.
14. Kinzler, K.W. and Vogelstein, B. (1996) Lessons from hereditary colorectal cancer. Cell, 87, 159-170.
15. Jen, J., Powell, S., Papadopoulos, N., Smith, K.J., Hamilton, S.R., Vogelstein, B. and Kinzler, K. W. (1994) Molecular determinants of dysplasia in colorectal lesions. Cancer Res., 54, 5523-5526.
16. Moser, A.R., Pitot, H.C. and Dove, W.F. (1990) A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse. Science, 247, 322-324.
17. Mahmoud, N.N., Boolbol, S., Bilinski, R.T., Martucci, C., Chadburn, A. and Bertagnolli, M.M. (1997) Apc gene mutation is associated with a dominant-negative effect upon intestinal cell migration. Cancer Res., 57, 5045-5050.
18. Boolbol, S.K., Dannenberg, A.J., Chadburn, A. et al. (1996) Cyclooxygenase-2 overexpression and tumor formation are blocked by sulindac in a murine model of familial adenomatous polyposis. Cancer Res., 56, 2556-2560.
19. Mahmoud, N.N., Boolbol, S.K., Dannenberg, A.J., Mestre, J.R., Bilinski, R.T., Newmark, H.L., Chadburn, A. and Bertagnolli, M.M. (1998) The sulfide metabolite of sulindac prevents tumors and restores enterocyte apoptosis in a murine model of familial adenomatous polyposis. Carcinogenesis, 19, 87-91.
20. Subbaramaiah, K., Zakim, D., Weksler, B. and Dannenberg, A.J. (1997) Inhibition of cyclooxygenase: a novel approach to cancer prevention. Proc. Soc. Exp. Bio. Med., 216, 201-210.
21. del716 knockout mice by inhibition of cyclooxygenase 2. Cell, 87, 803-809.
22. 32P-postlabelling, in DNA treated in vitro with bile from patients with familial adenomatous polyposis and from unaffected controls. Carcinogenesis, 14, 1107-1110.
23. Hamada, K., Umemoto, A., Kajikawa, A., Seraj, M.J. and Monden, Y. (1994) In vitro formation of DNA adducts with bile acids. Carcinogenesis, 15, 1911-9115.
24. Scates, D.K., Spigelman, A.D. and Venitt, S. (1994) Bile acids do not form adducts when incubated with DNA in vitro. Carcinogenesis, 15, 2945-2948.
25. Spigelman, A.D., Owen, R.W., Hill, M.J. and Phillips, R.K.S. (1991) Biliary bile acid profiles in familial adenomatous polyposis. Br. J. Surg., 78, 321-325.
26. Reddy, B.S. (1975) Role of bile acids in colon carcinogenesis. Cancer, 36, 2401-2406.
27. Craven, P.A., Pfanstiel, J., Saito, R. and DeRubertis, F.R. (1986) Relationship between loss of rat colonic surface epithelium induced by deoxycholate and initiation of the subsequent proliferative response. Cancer Res., 46, 5754-5759.
28. Wargovich, M.J., Eng, V.W.S., Newmark, H.L. and Bruce, W.R. (1983) Calcium ameliorates the toxic effect of deoxycholic acid on colonic epithelium. Carcinogenesis, 4, 270-272.
29. DeRubertis, F., Craven, P. and Saito, R. (1984) Bile salt stimulation of colonic epithelial proliferation: evidence for involvement of lipoxygenase products. J. Clin. Invest., 74, 1614-1624.
30. Hirano, F., Tanaka, H., Makino, Y., Okamoto, K., Hiramoto, M., Handa, H. and Makino, I. (1996) Induction of the transcription factor AP-1 in cultured human colon adenocarcinoma cells following exposure to bile acids. Carcinogenesis, 17, 427-433.
31. Zhang, F., Subbaramaiah, K., Altorki, N. and Dannenberg, A. (1998) Dihydroxy bile acids activate the transcription of cyclooxygenase-2. J. Biol. Chem., 273, 2424-2428.
32. Goodwin, J.S. and Ceuppens, J. (1983) Regulation of the immune response by prostaglandins. J. Clin. Immunol., 3, 295-315.
33. Tsujii, M. and DuBois, R. (1995) Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2. Cell, 83, 493-501.
34. Tsujji, M., Kawano, S. and DuBois, R.N. (1997) Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential. Proc. Natl Acad. Sci. USA, 94, 3336-3340.
35. Waddell, W.R., Ganser, G.F., Cerise, E.J. and Loughry, R.W. (1989) Sulindac for polyposis of the colon. Am. J. Surg., 157, 175-179.
36. Giardiello, F.M., Hamilton, S.R., Krush, A.J., Piantadosi, S.M., Hylind, L.M., Celano, P., Booker, S.V., Robinson, C.R. and Offerhaus, G.J. (1993) Treatment of colonic and rectal adenomas with sulindac in familial adenomatous polyposis. N. Engl. J. Med., 328, 1313-1316.
37. Peifer, M. (1997) β-catenin as oncogene: the smoking gun. Science, 275, 1752-1753.
38. Peifer, M. (1996) Regulating cell proliferation: as easy as Apc. Science, 272, 974-975.