Rb inhibits the intrinsic kinase activity of TATA-binding protein- associated factor TAF(II)250

Molecular and Cellular Biology

Volumn 19, Issue 1, 1999, Pages 846-854

  Siegert, Jennifer L ^a   Robbins, Paul D ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN KINASE; RETINOBLASTOMA PROTEIN; TATA BINDING PROTEIN;

ARTICLE; AUTOPHOSPHORYLATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; HUMAN; NONHUMAN; PRIORITY JOURNAL;

EID: 0032953312     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.19.1.846     Document Type: Article

References (50)

1. Adnane, J., Z. Shao, and P. D. Robbins. 1995. The retinoblastoma susceptibility gene product represses transcription when directly bound to the promoter. J. Biol. Chem. 270:8837-8843.
2. II90 is required for cell cycle progression through G2/M but not for general transcription activation. Genes Dev. 10:2368-2380.
3. Brehm, A., E. A. Miska, D. J. McCance, J. L. Reid, A. J. Bannister, and T. Kouzarides. 1998. Retinoblastoma protein recruits histone deacetylase to repress transcription. Nature 391:597-601.
4. Bremner, R., B. L. Cohen, M. Spota, P. A. Hamel, C. J. Ingles, B. L. Gallie, and R. A. Phillips. 1995. Direct transcriptional repression by pRB and its reversal by specific cyclins. Mol. Cell. Biol. 15:3256-3265.
5. Chen, J.-L., L. D. Attardi, C. P. Verrijzer, K. Yokomori, and R. Tjian. 1994. Assembly of recombinant TFIID reveals differential coactivator requirements for distinct transcriptional activators. Cell 79:93-105.
6. Chow, K. N. B., and D. C. Dean. 1996. Domains A and B in the Rb pocket interact to form a transcriptional repressor motif. Mol. Cell. Biol. 16:4862-4868.
7. II250 is a bipartite protein kinase that phosphorylates the basal transcription factor RAP74. Cell 84: 781-790.
8. Dynlacht, B. D. 1997. Regulation of transcription by proteins that control the cell cycle. Nature 389:149-152.
9. Dynlacht, B. D., T. Hoey, and R. Tjian. 1991. Coactivators associated with the TATA-binding protein mediate transcriptional activation in Drosophila. Cell 66:563-576.
10. Field, S. J., F. Y. Tsai, F. Kuo, A. M. Zubiaga, W. G. Kaelin, Jr., D. M. Livingston, S. H. Orkin, and M. E. Greenberg. 1996. E2F-1 functions in mice to promote apoptosis and suppress proliferation. Cell 85:549-561.
11. Finkelstein, A., C. F. Kostrub, J. Li, D. P. Chavez, B. Q. Wang, S. M. Fang, J. Greenblatt, and Z. F. Burton. 1992. A cDNA encoding RAP74, a general initiation factor for transcription by RNA polymerase II. Nature 355:464-467.
12. Flemington, E. K., S. H. Speck, and W. G. Kaelin, Jr. 1993. E2F-1-mediated transactivation is inhibited by complex formation with the retinoblastoma susceptibility gene product. Proc. Natl. Acad. Sci. USA 90:6914-6918.
13. Harlow, E., and D. Lane. 1988. Antibodies: a laboratory manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
14. II250 gene is mutated in thermosensitive G1 mutants of the BHK21 cell line derived from golden hamster. Gene 141:267-270.
15. Helin, K., E. Harlow, and A. Fattaey. 1993. Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein. Mol. Cell. Biol. 13: 6501-6508.
16. Hisatake, K., S. Hasagawa, R. Takada, Y. Nakatani, M. Horikoshi, and R. G. Roeder. 1993. The p250 subunit of native TATA box-binding factor TFIID is the cell-cycle regulatory protein CCG1. Nature 362:179-181.
17. Horowitz, J. M., S.-H. Park, E. Bogenmann, J.-C. Cheng, D. W. Yandell, F. J. Kaye, J. D. Minna, T. P. Dryja, and R. A. Weinberg. 1990. Frequent inactivation of the retinobiastoma anti-oncogene is restricted to a subset of human tumor cells. Proc. Natl. Acad. Sci. USA 87:2775-2779.
18. Horowitz, J. M., D. W. Yandell, S.-H. Park, S. Canning, P. Whyte, K. Buchkovich, E. Harlow, R. A. Weinberg, and T. P. Dryja. 1989. Point mutational inactivation of the retinoblastoma antioncogene. Science 243:937-940.
19. Kaelin, W. G., Jr., W. Krek, W. R. Sellers, J. A. DeCaprio, F. Ajchenbaum, C. S. Fuchs, T. Chittenden, Y. Li, P. J. Farnham, M. A. Blanar, D. M. Livingston, and E. K. Flemington. 1992. Expression and cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties. Cell 70:351-364.
20. Kaelin, W. G., Jr., D. C. Pallas, J. A. Decaprio, F. J. Kaye, and D. M. Livingston. 1991. Identification of cellular proteins that can interact specifically with the T/E1A-binding region of the retinoblastoma gene product. Cell 64:521-532.
21. Kaye, F. J., R. A. Kratzke, and J. M. Horowitz. 1990. A single amino acid substitution results in a retinoblastoma protein defective in phosphorylation and oncoprotein binding. Proc. Natl. Acad. Sci. USA 87:6922-6926.
22. Kim, S.-J., U. S. Onwuta, Y. I. Lee, R. Li, M. R. Botchan, and P. D. Robbins. 1992. The retinoblastoma gene product regulates Sp1-mediated transcription. Mol. Cell. Biol. 12:2455-2463.
23. Kim, S. J., H. D. Lee, P. D. Robbins, K. Busam, M. B. Sporn, and A. B. Roberts. 1991. Regulation of transforming growth factor β1 gene expression by the product of the retinoblastoma susceptibility gene. Proc. Natl. Acad. Sci. USA 88:3052-3056.
24. Lee, J.-O., A. A. Russo, and N. P. Pavletich. 1998. Structure of the retinoblastoma tumour-suppressor pocket domain bound to a peptide from HPV E7. Nature 391:859-865.
25. Lei, L., D. Ren, A. Finkelstein, and Z. F. Burton. 1998. Functions of the N-and C-terminal domains of human RAP74 in transcriptional initiation, elongation, and recycling of RNA polymerase II. Mol. Cell. Biol. 18:2130-2142.
26. Magnaghi-Jaulin, L., R. Groisman, I. Naguibneva, P. Robin, S. Lorain, J. P. Le Villain, F. Troalen, D. Trouche, and A. Harel-Bellan. 1998. Retinoblastoma protein represses transcription by recruiting a histone deacetylase. Nature 391:601-604.
27. II250 subunit of TFIID has histone acetyltransferase activity. Cell 87:1261-1270.
28. Moqtaderi, Z., Y. Bai, D. Poon, P. A. Weil, and K. Struhl. 1996. TBP-associated factors are not generally required for transcriptional activation in yeast. Nature 383:188-191.
29. II250 N-terminal kinase domain. Mol. Cell 1:905-911.
30. Robbins, P. D., J. M. Horowitz, and R. C. Mulligan. 1990. Negative regulation of c-fos expression by the retinoblastoma anti-oncogene. Nature 346: 668-671.
31. II250 interacts with RAP74: implications for RNA polymerase II initiation. Genes Dev. 9:2747-2755.
32. II250: a TBP-associated factor implicated in cell cycle regulation. Nature 362:175-179.
33. II250. Cell Growth Differ. 8:1099-1104.
34. II250 subunit of the TFIID basal transcription factor. Exp. Cell Res. 218:490-498.
35. Sellers, W. R., J. W. Rodgers, and W. G. Kaelin, Jr. 1995. A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites. Proc. Natl. Acad. Sci. USA 92:11544-11548.
36. Shan, B., X. Zhu, P.-L. Chen, T. Durfee, Y. Yang, D. Sharp, and W.-H. Lee. 1992. Molecular cloning of cellular genes encoding retinoblastoma-associated proteins: identification of a gene with properties of the transcription factor E2F. Mol. Cell. Biol. 12:5620-5631.
37. II250. Proc. Natl. Acad. Sci. USA 92:3115-3119.
38. II250/TFIID through multiple domains. Oncogene 15:385-392.
39. Siegert, J. L., and P. D. Robbins. Unpublished data.
40. Struhl, K. 1997. Selective roles for TATA-binding-protein-associated factors in vivo. Genes Funct. 1:5-9.
41. 1 at the nonpermissive temperature. Mol. Cell. Biol. 17:3284-3294.
42. Tanese, N., B. F. Pugh, and R. Tjian. 1991. Coactivators for a proline-rich activator purified from the multisubunit human TFIID complex. Genes Dev. 5:2212-2224.
43. Tansey, W. P., and W. Herr. 1997. TAFs: guilt by association? Cell 88:729-732.
44. Udvadia, A. J., K. T. Rogers, P. D. R. Higgins, Y. Murata, K. H. Martin, P. A. Humphrey, and J. M. Horowiti. 1993. Sp-1 binds promoter elements regulated by the RB protein and Sp-1-mediated transcription is stimulated by RB coexpression. Proc. Natl. Acad. Sci. USA 90:3265-3269.
45. IIS. Nature 383:185-188.
46. II145 required for transcription of G1/S cyclin genes and regulated by the cellular growth state. Cell 90:607-614.
47. Weinberg, R. A. 1991. Tumor suppressor genes. Science 254:1138-1146.
48. Weintraub, S. J., K. N. B. Chow, R. X. Luo, S. H. Zhang, S. He, and D. C. Dean. 1995. Mechanism of active transcriptional repression by the retinoblastoma protein. Nature 375:812-815.
49. Yamasaki, L., T. Jacks, R. Bronson, E. Goillot, E. Harlow, and N. J. Dyson. 1996. Tumor induction and tissue atrophy in mice lacking E2F-1. Cell 85: 537-548.
50. Zwicker, J., N. Liu, K. Engeland, F. Lucibello, and R. Muller. 1996. Cell cycle regulation of E2F site occupation in vivo. Science 271:1595-1597.