Complement processing and immunoglobulin binding to Neisseria gonorrhoeae determined in vitro simulates in vivo effects

Journal of Infectious Diseases

Volumn 179, Issue 1, 1999, Pages 124-135

  McQuillen, Daniel P ^a   Gulati, Sunita ^b   Ram, Sanjay ^b   Turner, Adrian K ^b   Jani, Darshana B ^b   Heeren, Timothy C ^b   Rice, Peter A ^b  

^a BOSTON MEDICAL CENTER   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALTERNATIVE COMPLEMENT PATHWAY C3 C5 CONVERTASE; COMPLEMENT; COMPLEMENT COMPONENT C3B; COMPLEMENT COMPONENT C4; IMMUNOGLOBULIN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; METHYLAMINE; MONOCLONAL ANTIBODY; OLIGOSACCHARIDE; PORIN;

ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; GONORRHEA; HUMAN; NEISSERIA GONORRHOEAE; NONHUMAN; OPSONIZATION; PELVIC INFLAMMATORY DISEASE; PRIORITY JOURNAL; SERUM BACTERICIDAL ACTIVITY; SIALYLATION;

ANIMALS; ANTIBODIES, MONOCLONAL; BLOOD BACTERICIDAL ACTIVITY; COMPLEMENT C3B; COMPLEMENT FACTOR B; COMPLEMENT PATHWAY, ALTERNATIVE; COMPLEMENT PATHWAY, CLASSICAL; COMPLEMENT SYSTEM PROTEINS; FEMALE; GONORRHEA; HUMANS; IMMUNOGLOBULINS; KINETICS; LIPOPOLYSACCHARIDES; MICE; NEISSERIA GONORRHOEAE; SIALIC ACIDS;

EID: 0032952645     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/314545     Document Type: Article

References (63)

1. O'Brien JP, Goldenberg DL, Rice PA. Disseminated gonococcal infection: a prospective analysis of 49 patients and a review of pathophysiology and immune mechanisms. Medicine 1983;62:395-406.
2. Rice PA, Goldenberg DL. Clinical manifestations of disseminated infection caused by Neisseria gonorrhoeae are linked to differences in bactericidal reactivity of infecting strains. Ann Intern Med 1981;95:175-8.
3. Rice PA, McCormack WM, Kasper DL. Natural serum bactericidal activity against Neisseria gonorrhoeae from disseminated, locally invasive, and uncomplicated disease. J Immunol 1980;124:2105-9.
4. Densen P, MacKeen LA, Clark RA. Dissemination of gonococcal infection is associated with delayed stimulation of complement-dependent neutrophil chemotaxis in vitro. Infect Immun 1982;38:563-72.
5. Ross SC, Densen P. Opsonophagocytosis of Neisseria gonorrhoeae: interaction of local and disseminated isolates with complement and neutrophils. J Infect Dis 1985;151:33-41.
6. Densen P. Interaction of complement with Neisseria meningitidis and Neisseria gonorrhoeae. Clin Microbiol Rev 1989;2S:S11-7.
7. Gordon DL, Rice J, Finlay-Jones JJ, McDonald PJ, Hostetter MK. Analysis of C3 deposition and degradation on bacterial surfaces after opsonization. J Infect Dis 1988;157:697-704.
8. Schweinle JE, Hitchcock PJ, Tenner AJ, Hammer CH, Frank MM, Joiner KA. Interaction of Neisseria gonorrhoeae with classical complement components, C1-inhibitor, and a monoclonal antibody directed against the neisserial H.8 antigen. J Clin Invest 1989;83:397-403.
9. Jarvis GA. Analysis of C3 deposition and degradation on Neisseria meningitidis and Neisseria gonorrhoeae. Infect Immun 1994;62:1755-60.
10. Apicella MA, Mandrell RE, Shero M, et al. Modification by sialic acid of Neisseria gonorrhoeae lipooligosaccharide epitope expression in human urethral exudates: an immunoelectron microscopic analysis. J Infect Dis 1990;162:506-12.
11. James W, Swanson J. Studies on gonococcus infection. XII. Occurrence of color/opacity colonial variants in clinical cultures. Infect Immun 1978;19:332-40.
12. McQuillen DP, Gulati S, Rice PA. Complement-mediated bacterial killing assays. Methods Enzymol 1994;236:137-47.
13. Ram S, McQuillen DP, Gulati S, Elkins C, Pangburn MK, Rice PA. Binding of complement factor H to loop 5 of porin protein IA: a molecular mechanism of serum resistance of non-sialylated Neisseria gonorrhoeae. J Exp Med 1998;188:671-80.
14. Densen P, Gulati S, Rice PA. Specificity of antibodies against Neisseria gonorrhoeae that stimulate neutrophil chemotaxis. J Clin Invest 1987;80:78-87.
15. Rice PA, Kasper DL. Characterization of gonococcal antigens responsible for induction of bactericidal antibody in disseminated infection: the role of gonococcal endotoxins. J Clin Invest 1977;60:1149-58.
16. Rice PA, Kasper DL. Characterization of serum resistance of Neisseria gonorrhoeae that disseminate: roles of blocking antibody and gonococcal outer membrane proteins. J Clin Invest 1982;70:157-67.
17. Apicella MA, Bennett KM, Hermerath CA, Roberts DE. Monoclonal antibody analysis of lipopolysaccharide from Neisseria gonorrhoeae and Neisseria meningitidis. Infect Immun 1981;34:751-6.
18. Mandrell R, Apicella A, Boslego J, Chung R, Rice P, Griffiss JM. Human immune response to monoclonal antibody-defined epitopes of Neisseria gonorrhoeae lipooligosaccharides. In: Poolman IT, Zanen H, Mayer T, et al, eds. Gonococci and meningococci. Dordrecht, the Netherlands: Kluwer Academic Publishers, 1988:569-74.
19. Parsons NJ, Patel PV, Tan EL, et al. Cytidine 5′-monophospho-N-acetyl neuraminic acid and a low molecular weight factor from human red blood cells induce lipopolysaccharide alteration in gonococci when conferring resistance to killing by human serum. Microb Pathog 1988;5:303-9.
20. Nairn CA, Cole JA, Patel PV, Parsons NJ, Fox JE, Smith H. Cytidine 5′-monophospho-N-acetyl neuraminic acid or a related compound is the low molecular weight factor from human red blood cells which induces gonococcal resistance to killing by human serum. J Gen Microbiol 1988;134:3295-306.
21. Schägger H, Von-Jagow G. Tricine-sodium dodecyl sulfate polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa. Anal Biochem 1987;166:368-79.
22. Hammer CH, Wirtz GH, Renfer L, Gresham HD, Tack BF. Large scale isolation of functionally active components of the human complement system. J Biol Chem 1981;256:3995-4006.
23. Iida K, Mitomo K, Fujita T, Tamura N. Characterization of three monoclonal antibodies against C3 with selective specificities. Immunology 1987;62:413-7.
24. Tamerius JD, Pangburn MK, Muller-Eberhard HJ. Detection of a neoantigen on human C3bi and C3d by monoclonal antibody. J Immunol 1985;135:2015-9.
25. Morse SA, Stein S, Hines J. Glucose metabolism in Neisseria gonorrhoeae. J Bacteriol 1974;129:702-14.
26. Vogel CW, Muller-Eberhard HJ. The cobra venom factor dependent C3 convertase of human complement. A kinetic and thermodynamic analysis of a protease acting on its natural high molecular weight substrate. J Biol Chem 1982;257:8292-9.
27. Ram S, Sharma AK, Simpson SD, et al. A novel sialic acid binding site on factor H mediates serum resistance of sialylated Neisseria gonorrhoeae. J Exp Med 1998;187:743-52.
28. Alberti S, Alvarez D, Merino S, et al. Analysis of complement C3 deposition and degradation on Klebsiella pneumoniae: Infect Immun 1996;64:4726-32.
29. Bellinger-Kawahara C, Horwitz MA. Complement component C3 fixes selectively to the major outer membrane protein (MOMP) of Legionella pneumophila and mediates phagocytosis of liposome-MOMP complexes by human monocytes. J Exp Med 1990;172:1201-10.
30. Rice PA, Vayo H, Tam M, Blake MS. Immunoglobulin G antibodies directed against protein III block killing of serum-resistant Neisseria gonorrhoeae by immune serum. J Exp Med 1986;164:1735-48.
31. Zollinger WD, Boslego JW. A general approach to standardization of the solid-phase radioimmunoassay for quantitation of class-specific antibodies. J Immunol Methods 1981;46:129-40.
32. Price RJ, Boettcher B. The presence of complement in human cervical mucus and its possible relevance to infertility in women with complement-dependent sperm-immobilizing antibodies. Fertil Steril 1979;32:61-6.
33. Blake MS, Johnston KH, Russell-Jones GJ, Gotschlich EC. A rapid, sensitive method for detection of alkaline phosphatase-conjugated anti-antibody on Western blots. Anal Biochem 1984;136:175-9.
34. Swanson J. Surface-exposed protein antigens of the gonococcal outer membrane. Infect Immun 1981;34:804-16.
35. Zar JH. Biostatistical analysis. 2nd ed. Englewood Cliffs, NJ: Prentice-Hall, 1984.
36. Gulati S, McQuillen DP, Mandrell RE, Jani DB, Rice PA. Immunogenicity of Neisseria gonorrhoeae lipooligosaccharide epitope 2C7, widely expressed in vivo with no immunochemical similarity to human glycosphingolipids [published erratum appears in J Infect Dis 1997;175:1027]. J Infect Dis 1996;174:1223-37.
37. SAS/STAT user's guide. Version 6. 4th ed. Cary, NC: SAS Institute, 1989.
38. Mandrell RE, Lesse AJ, Sugai JV, et al. In vitro and in vivo modification of Neisseria gonorrhoeae lipooligosaccharide epitope structure by sialylation. J Exp Med 1990;171:1649-64.
39. Henwick S, Hetherington SV, Hostetter MK. Specificity of three anti-complement factor 3 monoclonal antibodies. J Immunol Methods 1992;153:173-84.
40. Pangburn MK, Muller-Eberhard HJ. Relation of putative thioester bond in C3 to activation of the alternative pathway and the binding of C3b to biological targets of complement. J Exp Med 1980;152:1102-14.
41. Sim RB, Sim E. Autolytic fragmentation of complement components C3 and C4 and its relationship to covalent binding activity. Ann NY Acad Sci 1983;421:259-76.
42. Schiller NL, Hatch RA, Joiner KA. Complement activation and C3 binding by serum-sensitive and serum-resistant strains of Pseudomonas aeruginosa. Infect Immun 1989;57:1707-13.
43. Hostetter MK. Serotypic variations among virulent pneumococci in deposition and degradation of covalently bound C3b: implications for phagocytosis and antibody production. J Infect Dis 1986;153:682-93.
44. Apicella MA, Westerink MAJ, Morse SA, Schneider H, Rice PA, Griffiss JM. Bactericidal antibody response of normal human serum to the lipooligosaccharide of Neisseria gonorrhoeae. J Infect Dis 1986;153:520-6.
45. Glynn AA, Ward ME. Nature and heterogeneity of the antigens of Neisseria gonorrhoeae involved in the serum bactericidal reaction. Infect Immun 1970;2:162-8.
46. Densen P, McRill CM, Ross SC. Assembly of the membrane attack complex promotes decay of the alternative pathway C3 convertase on Neisseria gonorrhoeae. J Immunol 1988;141:3902-9.
47. Isenman DE, Kells DIC, Cooper NR, Muller-Eberhard HJ, Pangburn MK. Nucleophilic modification of human complement protein C3: correlation of conformational changes with acquisition of C3b-like functional properties. Biochemistry 1981;20:4458-67.
48. Pangburn MK, Schreiber RD, Muller-Eberhard HJ. C3b deposition during activation of the alternative complement pathway and the effect of deposition on the activating surface. J Immunol 1983;131:1930-5.
49. Tomlinson S, Pontes de Carvalho LC, Vandekerckhove F, Nussenzweig V. Role of sialic acid in the resistance of Trypanosoma cruzi trypomastigotes to complement. J Immunol 1994;153:3141-7.
50. Wetzler LM, Barry K, Blake MS, Gotschlich EC. Gonococcal lipooligosaccharide sialylation prevents complement-dependent killing by immune sera. Infect Immun 1992;60:39-43.
51. 2 mediate killing of E. coli O111:B4 by the alternative complement pathway without increasing C5b-9 deposition. J Immunol 1983;131:2563-9.
52. Gill MJ, McQuillen DP, van Putten JP, et al. Functional characterization of a sialyltransferase-deficient mutant of Neisseria gonorrhoeae. Infect Immun 1996;64:3374-8.
53. Lambris JD, Lao Z, Oglesby TJ, Atkinson JP, Hack CE, Becherer JD. Dissection of CR1, factor H, membrane cofactor protein, and factor B binding and functional sites in the third complement component. J Immunol 1996;156:4821-32.
54. Pangburn MK, Schreiber RD, Muller-Eberhard HJ. Human complement C3b inactivator: isolation, characterization, and demonstration of an absolute requirement for the serum protein beta1H for cleavage of C3b and C4b in solution. J Exp Med 1977;146:257-70.
55. Dale PA, McQuillen DP, Gulati S, Rice PA. Human vaccination with Escherichia coli J5 mutant induces cross-reactive bactericidal antibody against Neisseria gonorrhoeae lipooligosaccharide. J Infect Dis 1992;166:316-25.
56. Robbins JB, Schneerson R, Szu SC. Perspective: hypothesis: serum IgG antibody is sufficient to confer protection against infectious diseases by inactivating the inoculum. J Infect Dis 1995;171:1387-98.
57. Zaleski A, Densen P. Sialylation of LOS inhibits gonococcal killing primarily through an effect on classical pathway activation. In: Zollinger WD, Frasch CE, Deal CD, eds. Abstracts of the 10th International Pathogenic Neisseria Conference. Baltimore: National Institutes of Health, 1996:114.
58. Ollert MW, David K, Bredehorst R, Vogel CW. Classical complement pathway activation on nucleated cells. Role of factor H in the control of deposited C3b. J Immunol 1992;155:4955-62.
59. van Amerongen A, van Dijk H, Willers JM. Role of C4-binding protein in the defective lysis of sensitized sheep erythrocytes by mouse complement. Int Arch Allergy Appl Immunol 1982;69:209-13.
60. Sheehan M, Morris CA, Pussell BA, Charlesworth JA. Complement inhibition by human vitronectin involves non heparin binding domains. Clin Exp Immunol 1995;101:136-41.
61. Ringner M, Paulsson M, Wadstrom T. Vitronectin binding by Helicobacter pylori. FEMS Microbiol Immunol 1992;5:219-24.
62. Duensing TD, van Putten JP. Vitronectin mediates internalization of Neisseria gonorrhoeae by Chinese hamster ovary cells. Infect Immun 1997;65:964-70.
63. Gomez-Duarte OG, Dehio M, Guzman CA, Chatwal GS, Dehio C, Meyer TF. Binding of vitronectin to opa-expressing Neisseria gonorrhoeae mediates invasion of HeLa cells. Infect Immun 1997;65:3857-66.