Dissection of CR1, factor H, membrane cofactor protein, and factor B binding and functional sites in the third complement component

Journal of Immunology

Volumn 156, Issue 12, 1996, Pages 4821-4832

  Lambris, John D ^a   Lao, Zhege ^a   Oglesby, Teresa J ^b   Atkinson, John P ^b   Hack, C Erik ^c   Becherer, J David ^d  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c CENTRAL LABORATORY   (Netherlands)

^d GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALTERNATIVE COMPLEMENT PATHWAY C3 C5 CONVERTASE; COMPLEMENT COMPONENT C3A; COMPLEMENT COMPONENT C3B; COMPLEMENT COMPONENT C3C; COMPLEMENT FACTOR H; SNAKE VENOM;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; COMPLEMENT FIXATION; CONFORMATIONAL TRANSITION; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DETERMINATION; PROTEIN PROTEIN INTERACTION; SEQUENCE ANALYSIS; TROUT; XENOPUS;

AMINO ACID SEQUENCE; ANTIGENS, CD; ANTIGENS, CD46; BASE SEQUENCE; BINDING SITES; COBRA VENOMS; COMPLEMENT C3; COMPLEMENT FACTOR B; COMPLEMENT FACTOR H; COMPLEMENT FACTOR I; DNA PRIMERS; HEMOLYSIS; HUMANS; MEMBRANE GLYCOPROTEINS; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; RECEPTORS, COMPLEMENT; RECOMBINANT FUSION PROTEINS;

EID: 0030004710     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (60)

1. Campbell, R. D., S. K. A. Law, K. B. M. Reid, and R. B. Sim. 1988. Structure, organization and regulation of the complement genes. Annu. Rev. Immunol. 6:1.
2. Holers, V. M., J. L. Cole, D. M. Lublin, T. Seya, and J. P. Atkinson. 1985. Human C3b- and C4b-regulatory proteins: a new multigene family. Immunol. Today 6:188.
3. Fearon, D. T., and J. M. Ahearn. 1990. Complement receptor type 1 (C3/C4b receptor, CD35) and complement receptor type 2 (C3d/Epstein-Barr virus receptor, CD21). Curr. Top. Microbiol. Immunol. 153:83.
4. Vik, D. P., P. Munoz-Canoves, D. D. Chaplin, and B. F. Tack. 1990. Factor H. Curr. Top. Microbiol. Immunol. 153:147.
5. Volanakis, J. E., Y. Yamauchi, and Y. Ishii. 1993. Structure, polymorphism, and regulation of expression of the C2 gene. Complement Today 1:5.
6. Alsenz, J., J. D. Becherer, B. Nilsson, and J. D. Lambris. 1989. Structural and functional analysis of C3 using monoclonal antibodies. Curr. Top. Microbiol. Immunol. 153:235.
7. Alsenz, J., D. Avila, H. P. Huemer, I. Esparza, J. D. Becherer, T. W. Kinoshita, Y. S. Oppermann, and J. D. Lambris. 1992. Phylogeny of the third component of complement, C3: analysis of the conservation of human CR1, CR2, H, and B binding sites, concanavalin A binding sites, and thiolester bond in the C3 from different species. Develop. Comp. Immunol. 16:63.
8. Esparza, I., J. D. Becherer, J. Alsenz, A. Delahera, Z. Lao, C. D. Tsoukas, and J. D. Lambris. 1991. Evidence for multiple sites of interaction in C3 for complement receptor type-2 (C3d/EBV receptor, CD21). Eur. J. Immunol. 21:2829.
9. Becherer, J. D., and J. D. Lambris. 1988. Identification of the C3b receptor-binding domain in third component of complement. J. Biol. Chem. 263:14586.
10. Ganu, V. S., and H. J. Müller-Eberhard. 1985. Inhibition of factor B and factor H binding to C3b by synthetic peptide corresponding to residues 749-789 of human C3. Complement 2:27 (Abstr.).
11. Fishelson, Z. 1991. Complement-C3: a molecular mosaic of binding sites. Mol. Immunol. 28:545.
12. Taniguchi-Sidle, A., and D. E. Isenman. 1994. Interactions of human complement component C3 with factor B and with complement receptors type 1 (CR1, CD35) and type 3 (CR3, CD11b/CD18) involve an acidic sequence at the N terminus of C3 α-chain. J. Immunol. 153:5285.
13. Hillenkamp, F., M. Karas, R. C. Beavis, and B. T. Chait. 1991. Matrix-assisted laser desorption/ionization mass spectrometry of biopolymers. Anal. Biochem. 63:1193.
14. Becherer, J. D., J. Alsenz, I. Esparza, C. E. Hack, and J. D. Lambris. 1992. Segment spanning residues 727-768 of the complement C3 sequence contains a neoantigenic site and accommodates the binding of CR1, factor H, and factor B. Biochemistry 31:1787.
15. Hack, C. E., J. Paardekooper, R. J. T. Smeenk, J. Abbink, A. J. M. Eerenberg, and J. H. Nuijens. 1988. Disruption of the internal thioester bond in the third component of complement (C3) results in the exposure of neodeterminants also present on activation products of C3: an analysis with monoclonal antibodies. J. Immunol. 141:1602.
16. Merrifield, R. B. 1963. Solid phase peptide synthesis. II. The synthesis of a tetrapeptide. J. Am. Chem. Soc. 85:2149.
17. Stewart, J. C., C. Pensa, G. Matsueda, and K. Harris. 1976. Some improvements in the solid phase synthesis of large peptides. In Peptides. A. Loffer, ed. Editions de l'Université de Bruxelles, Bruxelles, pp. 285-290.
18. Atherton, E., H. Fox, D. Harkiss, C. J. Logan, R. C. Sheppard, and B. J. Williams. 1978. A mild procedure for solid phase peptide synthesis: use of fluorenyl-methoxy-carbonylamino-acids. J. Chem. Soc. Chem. Comm. 537.
19. King, D. S., C. G. Fields, and G. B. Fields. 1990. A cleavage method which minimizes side reactions following Fmoc solid phase peptide synthesis. Int. J. Pept. Prot. Res. 36:255.
20. Lambris, J. D., and H. J. Müller-Eberhard. 1984. Isolation and characterization of a 33,000-dalton fragment of complement Factor B with catalytic and C3b binding activity. J. Biol. Chem. 259:12685.
21. Alsenz, J., T. F. Schulz, J. D. Lambris, R. B. Sim, and M. P. Dierich. 1985. Structural and functional analysis of the complement component factor H with the use of different enzymes and monoclonal antibodies to factor H. Biochem. J. 232:841.
22. Hsiung, L.-M., A. N. Barclay, M. R. Brandon, E. Sim, and R. R. Porter. 1982. Purification of human C3b inactivator by monoclonal-antibody affinity chromatography. Biochem. J. 203:293.
23. Adams, E. M., M. C. Brown, M. Nunge, M. Krych, and J. P. Atkinson. 1991. Contribution of the repeating domains of membrane cofactor protein (CD46) of the complement system to ligand binding and cofactor activity. J. Immunol. 147: 3005.
24. Lao, Z., Y. Wang, M. Mavroidis, I. Kostavasili, and J. D. Lambris. 1994. Overexpression, purification, and characterization of third component of complement. J. Immunol. 176:127.
25. Landt, O., H. P. Grunert, and U. Hahn. 1990. A general method for rapid site-directed mutagenesis using the polymerase chain reaction. Gene 96:125.
26. Susumu, O. 1993. Patterns in genome evolution. Curr. Opin. Genet. Dev. 3:911.
27. Lambris, J. D., J. Pappas, M. Mavroidis, Y. Wang, H. Manzone, H. Schwager, L. Du Pasquier, and R. Silibovsky. 1995. The third component of xenopus complement: cDNA cloning, structural and functional analysis, and evidence for an alternate C3 transcript. Eur. J. Immunol. 25:572.
28. Lambris, J. D., Z. Lao, J. Pang, and J. Alsenz. 1993. Third component of trout complement. cDNA cloning and conservation of functional sites. J. Immunol. 151:6123.
29. Summers, M. D., and G. E. Smith. 1987. A manual of methods for baculovirus vectors and insect cell culture procedures. Tex. Agric. Exp. Stn. Bull. 1555:1.
30. Heuertz, R. M., D. Y. Xia, D. Samols, and R. O. Webster. 1994. Inhibition of C5a desArg-induced neutrophil alveolitis in transgenic mice expressing C-reactive protein. Am. J. Physiol. 266:L649.
31. Nilsson, B., K. Nilsson Ekdahl, D. Avila, U. R. Nilsson, and J. D. Lambris. 1990. Neoantigens in complement component C3 as detected by monoclonal antibodies: mapping of the recognized epitopes by synthetic peptides. Biochem. J. 268: 55.
32. Fraker, P. J., and J. C. Speck. 1978. Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6,-tetrachloro-3α,6α-diphenylglycoluril. Biochem. Biophys. Res. Commun. 80:849.
33. Ross, G. D., J. D. Lambris, J. A. Cain, and S. L. Newman. 1982. Generation of three different fragments of bound C3 with purified factor I or serum. I. Requirements for factor H vs CR1 cofactor activity. J. Immunol. 129:2051.
34. Ballard, L. L., N. S. Bora, G. H. Yu, and J. P. Atkinson. 1988. Biochemical characterization of membrane cofactor protein of the complement system. J. Immunol. 141:3923.
35. Hung, S. L., C. Peng, I. Kostavasili, H. M. Friedman, J. D. Lambris, R. J. Eisenberg, and G. H. Cohen. 1994. The interaction of glycoprotein C of herpes simplex virus types 1 and 2 with the alternative complement pathway. Virology 203:299.
36. Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 277:680.
37. Lambris, J. D. 1993. Chemistry, biology and phylogeny of C3. Complement Profiles 1:16.
38. Walsh, C. T. 1987. Biological and biochemical methods in protein modification. In Protein Engineering. D. L. Oxender and F. C. Fox, eds. Alan R. Liss, New York, pp. 47-49.
39. Lax, I., F. Bellot, R. Howk, A. Ullrich, D. Givol, and J. Schlessinger. 1989. Functional analysis of the ligand binding site of EGF-receptor utilizing chimeric chicken/human receptor molecules. EMBO J. 8:421.
40. Marullo, S., L. J. Emorine, D. A. Strosberg, and C. Delavier-Klutchko. 1990. Selective binding of ligands to β1,β2 or chimeric β1/β2-adrenergic receptors involves multiple subsites. EMBO J. 9:1471.
41. McKenzie, A. N. J., S. C. Barry, M. Strath, and C. J. Sanderson. 1991. Structure-function analysis of interleukin-5 utilizing mouse/human chimeric molecules. EMBO J. 10:1193.
42. Molina, H., C. Brenner, S. Jacobi, J, Gorka, J. C. Carel, T. Kinoshita, and V. M. Holers. 1991. Analysis of Epstein-Barr virus-binding sites on complement receptor 2 (CR2/CD21) using human-mouse chimeras and peptides: at least two distinct sites are necessary for ligand-receptor interaction. J. Biol. Chem. 266:12173.
43. DeFeo-Jones, D., K. Tatchell, and E. Scolnick. 1987. Biological function of modified Yeast and mammalian ras genes in their heterologous systems. In Protein Engineering. D. L. Oxender and F. C. Fox, eds. Alan R. Liss, New York, pp. 307-314.
44. Pompton, D., and A. Nicolas. 1989. Protein engineering by cDNA recombination in yeasts: shuffling of mammalian cytochrome P-450 functions. Gene 83:15.
45. Medof, M. E., K. Iida, C. Mold, and V. Nussenzweig. 1982. Unique role of the complement receptor CR1 in the degradation of C3b associated with immune complexes. J. Exp. Med. 156:1739.
46. Medicus, R. G., J. Melamed, and M. A. Arnaout. 1983. Role of human factor I and C3b receptor in the cleavage of surface-bound C3b. Eur. J. Immunol. 13:465.
47. Mitomo, K., T. Fujita, and K. Iida. 1987. Functional and antigenic properties of complement receptor type 2, CR2. J. Exp. Med. 165:1424.
48. Davis, A. E. I., and R. A. Harrison. 1982. Structural characterization of factor I mediated cleavage of the third component of complement. Biochemistry 21:5745.
49. Ekdahl, K. N., U. R. Nilsson, and B. Nilsson. 1990. Inhibition of factor I by diisopropylfluorophosphate: evidence of conformational changes in factor I induced by C3b and additional studies on the specificity of factor I. J. Immunol. 144:4269.
50. Press, E. M., and J. Gagnon. 1981. Human complement component C4. Biochem. J. 199:351.
51. Campbell, R. D., J. Gagnon, and R. R. Porter. 1981. Amino acid sequence around the thiol and reactive acyl groups of human complement component C4. Biochem. J. 199:359.
52. Wetsel, R. A., A. Lundwall, F. Davidson, T. Gibson, B. F. Tack, and G. H. Fey. 1984. Structure of murine complement component C3. II. Nucleotide sequence of cloned complementary DNA coding for the alpha chain. J. Biol. Chem. 259: 13857.
53. Kusano, M., N. H. Choi, M. Tomita, K. Yamamoto, S. Migita, T. Sekiya, and S. Nishimura. 1986. Nucleotide sequence of cDNA and derived amino acid sequence of rabbit complement component C3 alpha-chain. Immunol. Invest. 15: 365.
54. Misumi, Y., M. Sohda, and Y. Ikehara. 1990. Nucleotide and deduced amino acid sequence of rat complement C3. Nucleic Acids Res. 18:2178.
55. Tamerius, J. D., M. K. Pangburn, and H. J. Müller-Eberhard. 1982. Selective inhibition of functional sites of cell-bound C3b by hybridoma-derived antibodies. J. Immunol. 128:512.
56. Burger, R., U. Deubel, U. Hadding, and D. Bitter-Suermann. 1982. Identification of functionally relevant determinants on the complement component C3 with monoclonal antibodies. J. Immunol. 129:2042.
57. Wörner, I., R. Burger, and J. D. Lambris. 1989. Localization and functional characterization of epitopes on α and β chains of C3. Compl. Inflam. 6:416 (Abstr.).
58. Koistinen, V., S. Wessberg, and J. Leikola. 1989. A common binding region of complement factors B and H on C3b revealed by monoclonal anti-C3d. Compl. Inflam. 6:270.
59. Alsenz, J., and J. D. Lambris. 1988. Modulation of factor H (H) functional activities by monoclonal antibodies (MoAbs) to H. Complement 5:202 (Abstr.).
60. Klickstein, L. B., T. J. Bartow, V. Miletic, L. D. Rabson, J. A. Smith, and D. T. Fearon. 1988. Identification of distinct C3b and C4b recognition sites in the human C3b/C4b receptor (CR1, CD35) by deletion mutagenesis. J. Exp. Med. 168:1699.