Monoclonal antibodies for prevention and treatment of respiratory syncytial virus infection

Drugs of the Future

Volumn 21, Issue 10, 1996, Pages 1047-1054

  Weltzin, Richard ^a  

^a Acambis   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN; MONOCLONAL ANTIBODY; VIRUS VACCINE;

HUMAN; INTRANASAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; REVIEW; VIRUS INFECTION;

EID: 0029848567     PISSN: 03778282     EISSN: None     Source Type: Journal    
DOI: 10.1358/dof.1996.021.10.385491     Document Type: Review

References (94)

1. Parrott, R.H., Kim, H.W., Arrobio, J.O. et al. Epidemiology of respiratory syncytial virus infection in Washington, D.C. II. Infection and disease with respect to age, immunologic status, race and sex. Amer J Epidemiol 1973, 98: 289-300.
2. Collins, P.L., McIntosh, K., Chanock, R.M. Respiratory syncytial virus. In: Virology. B.N. Fields, D.M. Knipe, P.M. Howley (Eds.). Lippincott-Raven Publishers: Philadelphia 1996, 1313-51.
3. Chanock, R.M., Roizman, B., Myers, R. Recovery from infants with respiratory illness of a virus related to chimpanzee coryza agent: I. Isolation, properties and characterization. Amer J Hygiene 1957, 66: 281-90.
4. Morris, J.A., Blount, R.E., Savage, R.E. Recovery of cytopathogenic agent from chimpanzees with coryza. Proc Soc Exp Biol Med 1956, 92: 544-50.
5. Glezen, W.P., Taber, L.H., Frank, A.L., Kasel, J.A. Risk of primary infection and reinfection with respiratory syncytial virus. Amer J Dis Child 1986, 140: 543-6.
6. Meissner, H.C. Economic impact of viral respiratory disease in children. J Pediatr 1994, 124: S17-21.
7. Agius, G., Dindinaud, G., Biggar, R.J. et al. An epidemic of respiratory syncytial virus in elderly people: Clinical and serological findings. J Med Virol 1990, 30: 117-27.
8. Englund, J.A., Sullivan, C.J., Jordan, M.C., Dehner, L.P., Vercellotti, G.M., Balfour, H.H. Respiratory syncytial virus infection in immunocompromised adults. Ann Intern Med 1988, 109: 203-8.
9. Hall, C.B., Douglas, R.G. Modes of transmission of respiratory syncytial virus. J Pediatr 1981, 99: 100-3.
10. Fenner, F. The classification and nomenclature of viruses. Summary of results of meetings of the International Committee on Taxonomy of Viruses in Madrid, September, 1975. Intervirology 1975, 71: 371-8.
11. Huang, Y.T., Wertz, G.W. The genome of respiratory syncytial virus is a negative-stranded RNA that codes for at least seven mRNA species. J Virol 1982, 43: 150-7.
12. Walsh, E.E., Schlesinger, J.J., Brandriss, M.W. Purification and characterization of GP90, one of the envelope glycoproteins of respiratory syncytial virus. J Gen Virol 1984, 65: 761-7.
13. Walsh, E.E., Brandriss, M.W., Schlesinger, J.J. Purification and characterization of the respiratory syncytial virus fusion protein. J Gen Virol 1985, 66: 409-15.
14. Walsh, E.E., Hruska, J. Monoclonal antibodies to respiratory syncytial virus proteins: Identification of the fusion protein. J Virol 1983, 47: 171-7.
15. Johnson, P.R., Spriggs, M.K., Olmsted, R.A., Collins, P.L. The G glycoprotein of human respiratory syncytial viruses of subgroups A and B: Extensive sequence divergence between antigenically related proteins. Proc Natl Acad Sci USA 1987, 84: 5625-9.
16. Johnson, P.R., Olmsted, R.A., Prince, G.A. et al. Antigenic relatedness between glycoproteins of human respiratory syncytial virus subgroups A and B: Evaluation of the contributions of F and G glycoproteins to immunity. J Virol 1987, 61: 3163-6.
17. Hall, C.B., Walsh, E.E., Long, C.E., Schnabel, K.C. Immunity to and frequency of reinfection with respiratory syncytial virus. J Infect Dis 1991, 163: 693-8.
18. Walsh, E. E., Schlesinger, J.J., Brandriss, M.W. Protection from respiratory syncytial virus infection in cotton rats by passive transfer of monoclonal antibodies. Infect Immun 1984, 43: 756-8.
19. Trudel, M., Nadon, F., Seguin, C., Dionne, G., Lacroix, M. Identification of a synthetic peptide as part of a major neutralization epitope of respiratory syncytial virus. J Gen Virol 1987, 68: 2273-80.
20. Beeler, J.A., van Wyke Coelingh, K. Neutralization epitopes of the F glycoprotein of respiratory syncytial virus: Effect of mutation upon fusion function. J Virol 1989, 63: 2941-50.
21. López, J.A., Peñas, C., García-Barreno, B., Melero, J.A., Portela, A. Location of a highly conserved neutralizing epitope in the F glycoprotein of human respiratory syncytial virus. J Virol 1990, 64: 927-30.
22. Paradiso, P.R., Hu, B.T., Arumugham, R., Hildreth, S. Mapping of a fusion related epitope of the respiratory syncytial virus fusion protein. Vaccine 1991, 9: 231-7.
23. Norrby, E., Mufson, M.A., Alexander, H., Houghten, R.A., Lerner, R.A. Site-directed serology with synthetic peptides representing the large glycoprotein G or respiratory syncytial virus. Proc Natl Acad Sci USA 1987, 84: 6572-6.
24. García-Barreno, B., Palomo, C., Peñas, C., Delgado, T., Pérez-Brena, P., Melero, J.A. Marked differences in the antigenic structure of human respiratory syncytial virus F and G glycoproteins. J Virol 1989, 63: 925-32.
25. Walsh, E.E., Hall, C.B., Schlesinger, J.J., Brandriss, M.W., Hildreth, S., Paradiso, P. Comparison of antigenic sites of subtype-specific respiratory syncytial virus attachment proteins. J Gen Virol 1989, 70: 2953-61.
26. Mills, J., Van Kirk, J.E., Wright, P.F., Chanock, R.M. Experimental respiratory syncytial virus infection of adults. Possible mechanisms of resistance to infection and illness. J Immunol 1971, 107: 123-30.
27. Watt, P.J., Robinson, B.S., Pringle, C.R., Tyrrell, D.A.J. Determinants of susceptibility to challenge and the antibody response of adult volunteers given experimental respiratory syncytial virus vaccines. Vaccine 1990, 8: 231-6.
28. McIntosh, K., Masters, H.B., Orr, I., Chao, R.K., Barkin, R.M. The immunologic response to infection with respiratory syncytial virus in infants. J Infect Dis 1978, 138: 24-32.
29. Scott, R., Gardner, P.S. Respiratory syncytial virus neutralizing activity in nasopharyngeal secretions. J Hygiene 1970, 68: 581-8.
30. Bruhn, F.W., Yeager, A.S. Respiratory syncytial virus in early infancy. Circulating antibody and the severity of infection. Amer J Dis Child 1977, 131: 145-8.
31. Kaul, T.N., Welliver, R.C., Wong, D.T., Udwadia, R.A., Riddlesberger, K., Ogra, P.L. Secretory antibody response to respiratory syncytial virus infection. Amer J Dis Child 1981, 135: 1013-6.
32. Reuman, P.D., Keely, S.P., Schiff, G.M. Rapid recovery in mice after combined nasal/oral immunization with killed respiratory syncytial virus. J Med Virol 1990, 32: 67-72.
33. Kanesaki, T., Murphy, B.R., Collins, P.L., Ogra, P.L. Effectiveness of enteric immunization in the development of secretory immunoglobulin A response and the outcome of infection with respiratory syncytial virus. J Virol 1991, 65: 657-63.
34. Carmack, M.A., Prober, C.G. Respiratory syncytial virus and ribavirin: Quo vadis? Infect Agents Dis 1992, 1: 99-107.
35. Kilharn, L., Ferrn, V.H. Congenital anomalies induced in hamster embryos with ribavirin. Science 1977, 195: 413-4.
36. Ubillas, R., Jolad, S.D., Bruening, R.C. et al. SP-303, an antiviral oligomeric proanthocyanidin from the latex of Croton lechleri (Sangre de Drago). Phytomedicine 1994, 1: 77-106.
37. Kapikian, A.Z., Mitchell, R.H., Chanock, R.M., Shvedoff, R.A., Stewart, C.E. An epidemiologic study of altered clinical reactivity to respiratory syncytial (RS) virus infection in children previously vaccinated with an inactivated RS virus vaccine. Amer J Epidemiol 1969, 89: 405-21.
38. Kim, H.W., Canchola, J.G., Brandt, C.D. et al. Respiratory syncytial virus disease in infants despite prior administration of antigenic inactivated vaccine. Amer J Epidemiol 1969, 89: 422-34.
39. Graham, B.S., Henderson, G.S., Tang, Y.-W., Lu, X., Neuzil, K.M., Colley, D.G. Priming immunization determines T helper cytokine mRNA expression patterns in lungs of mice challenged with respiratory syncytial virus. J Immunol 1993, 151: 2032-40.
40. Alwan, W.H., Kozlowska, W.J., Openshaw, P.J. Distinct types of lung disease caused by functional subsets of antiviral T cells. J Exp Med 1994, 179: 81-9.
41. Suffin, S.C., Prince, G.A., Muck, K.B., Porter, D.D. Immunoprophylaxis of respiratory syncytial virus infection in the infant ferret. J Immunol 1979, 123: 10-4.
42. Prince, G.A., Horswood, R.L., Camargo, E., Koenig, D., Chanock, R.M. Mechanisms of immunity to respiratory syncytial virus in cotton rats. Infect Immun 1983, 42: 81-7.
43. Prince, G.A., Horswood, R.L., Chanock, R.M. Quantitative aspects of passive immunity to respiratory syncytial virus infection in infant cotton rats. J Virol 1985, 55: 517-20.
44. Prince, G.A., Hemming, V.G., Horswood, R.L., Chanock, R.M. Immunoprophylaxis and immunotherapy of respiratory syncytial virus infection in the cotton rat. Virus Res 1985, 3: 193-206.
45. Hemming, V.G., Prince, G.A., Horswood, R.L. et al. Studies of passive immunotherapy for infections of respiratory syncytial virus in the respiratory tract of a primate model. J Infect Dis 1985, 152: 1083-7.
46. Siber, G.R., Leombruno, D., Leszczynski, J. et al. Comparison of antibody concentrations and protective activity of respiratory syncytial virus immune globulin and conventional immune globulin. J Infect Dis 1994, 169: 1368-73.
47. Sami, I.R., Piazza, F.M., Johnson, S.A. et al. Systemic immunoprophylaxis of nasal respiratory syncytial virus infection in cotton rats. J Infect Dis 1995, 171: 440-3.
48. Hemming, V.G., Rodriguez, W., Kim, H.W. et al. Intravenous immunoglobulin treatment of respiratory syncytial virus infections in infants and young children. Antimicrob Agents Chemother 1987, 31: 1882-6.
49. Groothuis, J.R., Levin, M.J., Rodriguez, W. et al. Use of intravenous gamma globulin to passively immunize high-risk children against respiratory syncytial virus: Safety and pharmacokinetics. Antimicrob Agents Chemother 1991, 35: 1469-73.
50. Hemming, V.G., Prince, G.A., Groothuis, J.R., Siber, G.R. Hyperimmune globulins in prevention and treatment of respiratory syncytial virus infections. Clin Microbiol Rev 1995, 8: 22-33.
51. Meissner, H.C., Fulton, D.R., Groothuis, J.R. et al. Controlled trial to evaluate protection of high-risk infants against respiratory syncytial virus disease by using standard intravenous immune globulin. Antimicrob Agents Chemother 1993, 37: 1655-8.
52. Graham, B.S., Davis, T.H., Tang, Y.-W., Gruber, W.C. Immunoprophylaxis and immunotherapy of respiratory syncytial virus-infected mice with respiratory syncytial virus-specific immune serum. Pediatr Res 1993, 34: 167-72.
53. Groothuis, J.R., Simoes, E.A.F., Levin, M.J. et al. Prophylactic administration of respiratory syncytial virus immune globulin to high-risk infants and young children. New Engl J Med 1993, 329: 1524-30.
54. Groothuis, J.R., Simoes, E.A.F., Hemming, V.G. Respiratory syncytial virus (RSV) infection in preterm infants and the protective effects of RSV immune globulin (RSVIG). Pediatrics 1995, 95: 463-7.
55. Prince, G.A., Hemming, V.G., Horswood, R.L., Baron, P.A., Chanock, R.M. Effectiveness of topically administered neutralizing antibodies in experimental immunotherapy of respiratory syncytial virus infection in cotton rats. J Virol 1987, 61: 1851-4.
56. Prince, G.A., Hemming, V.G., Horswood, R.L., Baron, P.A., Murphy, B.R., Chanock, R.M. Mechanism of antibody-mediated viral clearance in immunotherapy of respiratory syncytial virus infection of cotton rats. J Virol 1990, 64: 3091-2
57. Piazza, F.M., Johnson, S.A., Ottolini, M.G. et al. Immunotherapy of respiratory syncytial virus infection in cotton rats (Sigmodon fulviventer) using IgG in a small-particle aerosol. J Infect Dis 1992, 166: 1422-4.
58. Hemming, V.G., Prince, G.A., London, W.T., Baron, P.A., Brown, R., Chanock, R.M. Topically administered immunoglobulin reduces pulmonary respiratory syncytial virus shedding in owl monkeys. Antimicrob Agents Chemother 1988, 32: 1269-70.
59. Graham, B.S., Tang, Y.-W., Gruber, W.C. Topical immunoprophylaxis of respiratory syncytial virus (RSV)-challenged mice with RSV-specific immune globulin. J Infect Dis 1995, 171: 1468-74.
60. Cote, P.J., Fernie, B.F., Ford, E.C., Shih, J.W., Gerin, J.L. Monoclonal antibodies to respiratory syncytial virus: Detection of virus neutralization and other antigen-antibody systems using infected human and murine cells. J Virol Methods 1981, 3: 137-47.
61. Fernie, B.F., Cote, P.J., Gerin, J.L. Classification of hybridomas to respiratory syncytial virus glycoproteins. Proc Soc Exp Biol Med 1982, 171: 266-71.
62. Taylor, G., Stott, E.J., Bew, M. et al. Monoclonal antibodies protect against respiratory syncytial virus infection in mice. Immunology 1984, 52: 137-42.
63. Anderson, L.J., Hierholzer, J.C., Tsou, C. et al. Antigenic characterization of respiratory syncytial virus strains with monoclonal antibodies. J Infect Dis 1985, 151: 626-33.
64. Routledge, E.G., McQuillin, J., Samson, A.C.R., Toms, G.L. The development of monoclonal antibodies to respiratory syncytial virus and their use in diagnosis by indirect immunofluorescence. J Med Virol 1985, 15: 305-20.
65. Anderson, L.J., Hierholzer, J.C., Stone, Y.O., Tsou, C., Fernie, B.F. Identification of epitopes on respiratory syncytial virus proteins by competitive binding immunoassay. J Clin Microbiol 1986, 23: 475-80.
66. Trudel, M., Nadon, F., Seguin, C., Ghoubril, S., Payment, P., Trepanier, P. Immunovirological studies on human respiratory syncytial virus structural proteins. Can J Microbiol 1986, 32: 15-21.
67. Walsh, E.E., Cote, P.J., Fernie, B.F., Schlesinger, J.J., Brandriss, M.W. Analysis of the respiratory syncytial virus fusion protein using monoclonal and polyclonal antibodies. J Gen Virol 1986, 67: 505-13.
68. Anderson, L.J., Bingham, P., Hierholzer, J.C. Neutralization of respiratory syncytial virus by individual and mixtures of F and G protein monoclonal antibodies. J Virol 1988, 62: 4232-8.
69. Weltzin, R., Hsu, S.A., Mittler, E.S., Georgakopoulos, K., Monath, T.P. Intranasal monoclonal immunoglobulin A against respiratory syncytial virus protects against upper and lower respiratory tract infections in mice. Antimicrob Agents Chemother 1994, 38: 2785-91.
70. Bansal, G.P., Hatfield, J., Young, J.F. et al. Efficacy of passively administered monoclonal antibodies against respiratory syncytial virus infection in cotton rats. In: Vaccines 91. R.M. Chanock, H.S. Ginsberg, F. Brown, R.A. Lerner (Eds.). Cold Spring Harbor Laboratory Press: Cold Spring Harbor 1991, 283-8.
71. Hemming, V.G., Prince, G.A. Respiratory syncytial virus: Babies and antibodies. Infect Agents Dis 1992, 1: 24-32.
72. Tempest, P.R., Bremner, P., Lambert, M. et al. Reshaping a human monoclonal antibody to inhibit human respiratory syncytial virus infection in vivo. Biotechnology 1991, 9: 266-71.
73. Taylor, G., Furze, J., Tempest, P.R., Bremner, P., Carr, F.J., Harris, W.J. Humanised monoclonal antibody to respiratory syncytial virus. Lancet 1991, 337: 1411-2.
74. Wyde, P.R., Moore, D.K., Hepburn, T. et al. Evaluation of the protective efficacy of reshaped human monoclonal antibody RSHZ19 against respiratory syncytial virus in cotton rats. Pediatr Res 1995, 38: 543-50.
75. Everitt, D., Thompson, K., DiCicco, R. et al. Safety, pharmacokinetics, antigenicity and fusion inhibition activity of SB 209763, a reshaped human monoclonal antibody to respiratory syncytial virus. Pediatr Res 1995, 37: 173A.
76. Tomasi, T.B., Tan, E.M., Solomon, A., Prendergast, R.A. Characteristics of an immune system common to certain external secretions. J Exp Med 1965, 121: 101-24.
77. Bell, D.Y., Haseman, J.A., Spock, A., McLennan, G., Hook, G.E.R. Plasma proteins of the bronchoalveolar surface of the lungs of smokers and nonsmokers. Amer Rev Respir Dis 1981, 124: 72-9.
78. Weltzin, R., Lucia-Jandris, P., Michetti, P., Fields, B.N., Kraehenbuhl, J.P., Neutra, M.R. Binding and transepithelial transport of immunoglobulins by intestinal M cells: Demonstration using monoclonal IgA antibodies against enteric viral proteins. J Cell Biol 1989, 108: 1673-85.
79. Tomasi, T.B., Grey, H.M. Structure and function of immunoglobulin A. Prog Allergy 1972, 16: 81-213.
80. Mestecky, J., McGhee, J.R., Elson, C.O. Intestinal IgA system. Immnunol Allergy Clin N Amer 1988, 8: 349-68.
81. Renegar, K.B., Small, P.A. Passive transfer of local immunity to influenza virus infection by IgA antibody. J Immunol 1991, 146: 1972-8.
82. Burns, J.W., Siadat-Pajouh, M., Krishnaney, A.A., Greenberg, H.B. Protective effect of rotavirus VP6-specific IgA monoclonal antibodies that lack neutralizing activity. Science 1996, 272: 104-7.
83. Winner, L., Mack, J., Weltzin, R., Mekalanos, J.J., Kraehenbuhl, J.P., Neutra, M.R. New model for analysis of mucosal immunity: Intestinal secretion of specific monoclonal immunoglobulin A from hybridoma tumors protects against Vibrio cholerae infection. Infect Immun 1991, 59: 977-82.
84. Michetti, P., Mahan, M.J., Slauch, J.M., Mekalanos, J.J., Neutra, M.R. Monoclonal secretory immunoglobulin A protects mice against oral challenge with the invasive pathogen Salmonella typhimurium. Infect Immun 1992, 60: 1786-92.
85. Phalipon, A., Kaufmann, M., Michetti, P. et al. Monoclonal immunoglobulin A antibody directed against serotype-specific epitope of Shigella flexneri lipopolysaccharide protects against murine experimental shigellosis. J Exp Med 1995, 182: 769-78.
86. Mazanec, M.B., Kaetzel, C.S., Lamm, M.E., Fletcher, D., Nedrud, J.G. Intracellular neutralization of virus by immunoglobulin A antibodies. Proc Natl Acad Sci USA 1992, 89: 6901-5.
87. Weltzin, R., Traina-Dorge, V., Soike, K. et al. Intranasal monoclonal IgA antibody to respiratory syncytial virus protects rhesus monkeys against upper and lower respiratory tract infection. J Infect Dis 1996, 174: 256-61.
88. Schipper, N.G., Verhoef, J.C., Merkus, F.W. The nasal mucociliary clearance: Relevance to nasal drug delivery. Pharm Res 1991, 8: 807-14.
89. Chanock, R.M., Crowe, J.E., Murphy, B.R., Burton, D.R. Human monoclonal antibody Fab fragments cloned from combinatorial libraries: Potential usefulness in prevention and/or treatment of major human viral diseases. Infect Agents Dis 1993, 2: 118-31
90. Barbas, C.F., Crowe, J.E., Cabara, D. et al. Human monoclonal Fab fragments derived from a combinatorial library bind to respiratory syncytial virus F glycoprotein and neutralize infectivity. Proc Natl Acad Sci USA 1992, 89: 10164-8.
91. Crowe, J.E., Murphy, B.R., Chanock, R.M., Williamson, R.A., Barbas, C.F., Burton, D.R. Recombinant human respiratory syncytial virus (RSV) monoclonal antibody Fab is effective therapeutically when introduced directly into the lungs of RSV-infected mice. Proc Natl Acad Sci USA 1994, 91: 1386-90.
92. Moreno de Alborán, I., Martínez-Alonso, C., Barbas, C.F. III, Burton, D.R., Ditzel, H.J. Human monoclonal Fab fragments specific for viral antigens from combinatorial libraries. Immunotechnology 1995, 1: 21-8.
93. Berdoz, J., Monath, T.P., Kraehenbuhl, J.-P. Specific amplification by PCR of rearranged genomic variable regions of immunoglobulin genes from mouse hybridoma cells. PCR Methods Appl 1995, 4: 256-64.
94. Guirakhoo, R, Catalan, J., Monath, T., Weltzin, R. Cloning, expression and functional activities of a single chain antibody fragment directed to fusion protein of respiratory syncytial virus. Immunotechnology, in press.