Vascular endothelial growth factor levels in ovarian cyst fluid correlate with malignancy

Clinical Cancer Research

Volumn 5, Issue 4, 1999, Pages 823-829

  Hazelton, Darcie ^a   Nicosia, Roberto F ^a   Nicosia, Santo V ^b  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; VASCULOTROPIN;

ADULT; AGED; ANGIOGENESIS; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION FUNCTION; CYST FLUID; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; OVARY CANCER; OVARY CYST; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; TUMOR VASCULARIZATION;

ADULT; AGED; AGED, 80 AND OVER; CYST FLUID; CYSTADENOMA; ENDOTHELIAL GROWTH FACTORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FIBROBLAST GROWTH FACTOR 2; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHOKINES; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; OVARIAN CYSTS; OVARIAN NEOPLASMS; PREDICTIVE VALUE OF TESTS; TUMOR MARKERS, BIOLOGICAL; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0032951394     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Ovarian cancer. Screening, treatment and followup. NIH Consensus Statement, 12: 1-30, 1994.
2. Folkman, J. The role of angiogenesis in tumor growth. Semin. Cancer Biol., 3: 65-71, 1992.
3. Rak, J., Filmus, J., and Kerbel, R. S. Reciprocal paracrine interactions between tumor cells and endothelial cells: "the angiogenesis progression" hypothesis. Eur. J. Cancer, 32A: 2438-2450, 1996.
4. Nicosia, R. F., Tchao, R., and Leighton, J. Angiogenesis-dependent tumor spread in reinforced fibrin clot culture. Cancer Res., 43: 2159-2166, 1983.
5. Hollingsworth, H. C., Kohn, E. C., Steinberg, S. M., Rothenberg, M. L., and Merino, M. J. Tumor angiogenesis in advanced stage ovarian carcinoma. Am. J. Pathol., 147: 33-41, 1995.
6. Folkman, J. Fighting cancer by attacking its blood supply. Sci. Am., 275: 150-154, 1996.
7. Ferrara, N., and Davis-Smyth, T. The biology of vascular endothelial growth factor. Endocr. Rev., 18: 4-25, 1997.
8. Dvorak, H. F., Brown, L. F., Detmar, M., and Dvorak, A. M. Vascular permeability factor/vascular endothelial growth factor, microvascular permeability and angiogenesis. Am. J. Pathol., 146: 1029-1039, 1995.
9. Carmeliet, P., Ferreira, V., Breier, G., Pollefeyt, S., Kieckens, L., Gertsenstein, M., Fahrig, M., Vandenhoeck, A., Harpal, K., Eberhardt, C., Declercq, C., Pawling, J., Moons, L., Collen, D., Risau, W., and Nagy, A. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature (Lond.), 380: 435-439, 1996.
10. Ferrara, N., Carver-Moore, K., Chen, H., Dowd, M., Lu, L., O'Shea, K. S., Powell-Braxton, L., Hillan, K. J., and Moore, M. W. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature (Lond.), 380: 439-442, 1996.
11. Fong, G., Rossant, J., Gertsenstein, M., and Breitman, M. L. Role of the flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature (Lond.), 376: 66-70, 1995.
12. Shalaby, F., Rossant, J., Yamaguchi, T. P., Gertsenstein, M., Wu, X. F., Breitman, M. L., and Schuh, A. C. Failure of blood-island formation and vasculogenesis in flk-1 deficient mice. Nature (Lond.), 376: 62-66, 1995.
13. Borgstrom, P., Hillan, K. J., Sriramarao, P., and Ferrara, N. Complete inhibition of angiogenesis and growth of microtumors by antivascular endothelial growth factor neutralizing antibody: novel concepts of angiostatic therapy from intravital videomicroscopy. Cancer Res., 56: 4032-4039, 1996.
14. Presta, L. G., Chen, H., O'Connor, S. J., Chisholm, V., Meng, Y. G., Krummen, L., Winkler, M., and Ferrara, N. Humanization of an antivascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders. Cancer Res., 57: 4593-4599, 1997.
15. Nakanishi, Y., Kodama, J., Yoshinouchi, M., Tokumo, K., Kamimura, S., Okuda, H., and Kudo, T. The expression of vascular endothelial growth factor and transforming growth factor-β associates with angiogenesis in ovarian cancer. Int. J. Gynecol. Pathol., 16: 256-262, 1997.
16. Crickard, K., Gross, J. L., Crickard, U., Yoonessi, M., Lele, S., Herblin, W. F., and Eidsvoog, K. Basic fibroblast growth factor and receptor expression in human ovarian cancer. Gynecol. Oncol., 56: 277-284, 1994.
17. Di Blasio, A. M., Cremonesi, L., Vigano, P., Ferrari, M., Gospodarowicz, D., Vignali, M., and Jaffe R. B. Basic fibroblast growth factor and its receptor messenger ribonucleic acids are expressed in human ovarian epithelial neoplasms. Am. J. Obstet. Gynecol., 769: 1517-1523, 1993.
18. Abu-Jawdeh, G. M., Faix, J. D., Niloff, J., Tognazzi, K., Manseau, E., Dvorak, H. F., and Brown, L. Strong expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in ovarian borderline and malignant neoplasms. Lab. Invest., 74: 1105-1115, 1996.
19. Paley, P. J., Staskus, K. A., Gebhard, K., Mohanraj, D., Twiggs, L. B., Carson, L. F., Ramakrishnan, S. Vascular endothelial growth factor expression in early stage ovarian carcinoma. Cancer (Phila.), 80: 98-106, 1997.
20. Gordon, J. D., Mesiano, S., Zaloudek, C. J., and Jaffe, R. B. Vascular endothelial growth factor localization in human ovary and fallopian tubes: possible role in reproductive function and ovarian cyst formation. J. Clin. Endocrinol. Metabol., 81: 353-359, 1996.
21. Yeo, K. T., Wang, H. H., Nagy, J. A., Sioussat, T. M., Ledbetter, S. R., Hoogewerf, A. J., Zhou, Y., Masse, E. M., Senger, D. R., Dvorak, H. F., and Yeo, T. K. Vascular permeability factor (vascular endothelial growth factor) in guinea pig and human tumor and inflammatory effusions. Cancer Res., 53: 2912-2918, 1993.
22. Boocock, C. A., Charnock-Jones, D. S., Sharkey, A. M., McLaren, J., Barker, P. J., Wright, K. A., Twentyman, P. R., and Smith, S. K. Expression of vascular endothelial growth factor and its receptors flt and KDR in ovarian carcinoma. J. Natl. Cancer Inst., 87: 506-516, 1995.
23. Pierro, E., Nicosia, S. V., Saunders, B., Fultz, C. B., Nicosia, R. F., and Mancuso, S. Influence of growth factors on proliferation and morphogenesis of rabbit ovarian mesothelial cells in vitro. Biol. Rep., 54: 660-669, 1996.
24. Mattern, J., Stammler, G., Koomagi, R., Wallwiener, D., Kaufmann, M., and Volm, M. Association of vascular endothelial growth factor expression with tumor cell proliferation in ovarian cancer. Anticancer Res., 17: 621-624, 1997.
25. Silva, E. G., Kurman, R. J., Russell, P., and Scully, R. E. Symposium: ovarian tumors of borderline pathology. Int. J. Gynecol. Pathol., 15: 281-302, 1996.
26. Hanahan, D., Christofori, G., Naik, P., and Arbeit, J. Transgenic mouse models of tumor angiogenesis: the angiogenic switch, its molecular controls, and prospects for preclinical therapeutic models. Eur. J. Cancer, 32A: 2386-2393, 1996.
27. Weidner, N. Intratumor microvessel density as a prognostic factor in cancer. Am. J. Pathol., 147: 9-19, 1995.
28. Hall, N. R., Fish, D. E., Hunt, N., Goldin, R. D., Guillou, P. J., and Monson J. R. T. Is the relationship between angiogenesis and metastasis in breast cancer real? Surg. Oncol., 1: 223-229, 1992.
29. Mignatti, P., and Rifkin, D. B. Release of basic fibroblast growth factor, an angiogenic factor devoid of secretory signal sequence: a trivial phenomenon or a novel secretion mechanism. J. Cell. Biochem., 47: 201-207, 1991.
30. Li, V. W., Folkerth, R. D., Watanabe, H., Yu, C., Rupnick, M., Barnes, P., Scott, R. M., Black, P., Sallan, S. E., and Folkman, J. Microvessel count and cerebrospinal fluid basic fibroblast growth factor in children with brain tumours. Lancet, 344: 82-86, 1994.
31. Fujimoto, K., Ichimori, Y., Kakizoe T., Okajima, E., Sakamoto, H., Sugimura, T., and Terada, M. Increased serum levels of basic fibroblast growth factor in patients with renal cell carcinoma. Biochem. Biophys. Res. Commun., 180: 386-392, 1991.
32. Nguyen, M., Watanabe, H., Budson, A. E., Richie, J. P., Hayes, D. F., and Folkman, J. Elevated levels of an angiogenic peptide, basic fibroblast growth factor, in the urine of patients with a wide spectrum of cancers. J. Natl. Cancer Inst., 86: 356-361, 1994.
33. Outwater, E. K., Huang, A. B., Dunton, C. J., Talerman, A., and Capuzzi, D. M. Papillary projections in ovarian neoplasms: appearance on MRI. J. Magn. Resonance Imaging, 7: 689-695, 1997.
34. Yamamoto, S., Konishi, I., Mandai, M., Kuroda, J., Komatsu, T., Nanbu, K., Sakahara, H., and Mori, T. Expression of vascular endothelial growth factor (VEGF) in epithelial ovarian neoplasms: correlation with clinicopathology and patient survival, and analysis of serum VEGF levels. Br. J. Cancer, 76: 1221-1227, 1997.
35. McLaren, J., Prentice A., Charnock-Jones, D. S., and Smith S. K. Vascular endothelial growth factor (VEGF) concentrations are elevated in peritoneal fluid of women with endometriosis. Hum. Reprod., 11: 220-223, 1996.
36. Kamat, B. R., Brown, L. F., Manseau, E. J., Senger, D. R., and Dvorak, H. F. Expression of vascular permeability factor/vascular endothelial growth factor by human granulosa and theca lutein cells, role in corpus luteum development. Am. J. Pathol., 146: 157-165, 1995.