Inability of interleukin-12 to modulate T-helper 0 effectors to T- helper 1 effectors: A possible distinct subset of T cells

Immunology

Volumn 97, Issue 1, 1999, Pages 84-91

  Hu, C ^a   Salgame, P ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 12;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; HELPER CELL; HUMAN; HUMAN CELL; IMMUNOMODULATION; IMMUNOREACTIVITY; LYMPHOCYTE DIFFERENTIATION; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION;

BLOTTING, NORTHERN; CELL CULTURE TECHNIQUES; HUMANS; INTERFERON TYPE II; INTERLEUKIN-12; INTERLEUKIN-4; RNA, MESSENGER; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, HELPER-INDUCER; TH1 CELLS; TRANSCRIPTION, GENETIC; UP-REGULATION;

EID: 0032936036     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.1999.00745.x     Document Type: Article

References (37)

1. 1. Mosmann T.R. & Coffman R.L. (1989) TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 7, 145.
2. + T cell: specificity and function. Immunol Rev 101, 39.
3. 3. Bloom B.R., Salgame P. & Diamond B. (1992) Revisiting and revising T suppresser cells. Immunol Today 13, 131.
4. 4. Romagnani S. (1994) Lymphokine production by human T cells in disease states. Annu Rev Immunol 12, 227.
5. + T cell clones. J Immunol 136, 2348.
6. + T cells. Annu Rev Immunol 12, 635.
7. 7. Swain S.L., Weinberg A.D., English M. & Huston G. (1990) IL-4 directs the synthesis of Th2-like helper effectors. J Immunol 145, 3796.
8. 8. Bretscher P.A., Wie G., Menon J.N. & Bielefeldt O.H. (1992) Establishment of stable, cell-mediated immunity that makes 'susceptible' mice resistant to Leishmania major. Science 257, 539.
9. 9. Pfeiffer C., Murray J., Madri J. & Bottomly K. (1991) Selective activation of Th1- and Th2-like cell in vivo-response to human collagen IV. Immunol Rev 123, 65.
10. 10. Novak T.J. & Rothenberg E.V. (1990) cAMP inhibits induction of interleukin 2 but not of interleukin 4 in T cells. Proc Natl Acad Sci USA 87, 9353.
11. 11. Weaver C.T., Hawrylowicz C.M. & Unanue E.R. (1988) T helper cell subsets require the expression of distinct costimulatory signals by antigen-presenting cells. Proc Natl Acad Sci USA 85, 8181.
12. 12. Gajewski T.F., Schell S.R. & Fitch F.W. (1990) Evidence implicating utilization of different T cell receptor-associated signalling pathways by Th1 and Th2 clones. J Immunol 144, 4100.
13. + T cells through IL-12 produced by Listeria-induced macrophages. Science 260, 547.
14. 14. McKnight A.J., Zimmer G.J., Fogelman I., Wolf S.F. & Abbas A.K. (1994) Effects of 1L-12 on helper T cell dependent immune responses in vivo. J Immunol 152, 2172.
15. + T cells from T cell receptor transgenic mice. J Exp Med 176, 1091.
16. 16. Le Gros G., Ben-Sasson S.Z., Seder R., Finkelman F.D. & Paul W.E. (1990) Generation of interleukin-4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation or IL-4-producing cells. J Exp Med 172, 921.
17. 17. Heinzel F.P., Schoenhaut D.S., Rerko R.M., Rosser L.E. & Gately M.K. (1993) Recombinant interleukin 12 cures mice infected with Leishmania major. J Exp Med 177, 1505.
18. 18. Sypek J.P., Chung C.L., Mayor S.E.H. et al. (1993) Resolution of cutaneous leishmaniasis: interleukin 12 initiates a protective T helper type 1 immune response. J Exp Med 177, 1797.
19. 19. Salgame P.R., Modlin R.L. & Bloom B.R. (1989) On the mechanism of human T cell suppression. Int Immunol 1, 121.
20. 20. Gough N.M. (1988) Rapid and quantitative preparation of cytoplasmic RNA from small numbers of cells. Anal Chem 173, 93.
21. 21. Woodford T.A., Schlegel R. & Pardee A.B. (1988) Selective isolation of newly synthesized mammalian mRNA after in vivo labelling with 4-thiouridine or 6-thioguanosinc. Anal Biochem 171, 166.
22. 22. Kamogawa Y., Minasi L.E., Carding S.R., Bottomly K. & Flavell R.A. (1993) The relationship of IL-4 and IFNγ-producing T cells studied by lineage ablation of IL-4-producing cells. Cell 75, 985.
23. + T cells. J Immunol 158, 1085.
24. 24. Manetti R., Gerosa F., Giudizi M.G. et al. (1994) Interleukin-12 induces stable priming for interferon-γ production during differentiation of human T helper cells and transient IFN-γ production in established Th2 cell clones. J Exp Med 179, 1273.
25. 25. Germann T., Gately M.K., Schoenhaut D.S. et al. (1993) Interleukin-12/T cell stimulating factor, a cytokine with multiple effects on T helper type 1 (Th1) but not on Th2 cells. Eur J Immunol 23, 1762.
26. + T cells through an effect on antigen-presenting cells. J Immunol 154, 2578.
27. + T lymphocytes. J Immunol 155, 111.
28. 28. Szabo S.J., Dighe A.S., Gubler A. & Murphy K.M. (1997) Regulation of the interleukin (IL)-12R, B2 subunit expression in developing T helper 1 (Th1) and Th2 cells. J Exp Med 185, 817.
29. 29. Rogge B.L., Barberis-Maino L., Biffi M. et al. (1997) Selective expression of an interleukin-12 receptor component by human T helper 1 cells. J Exp Med 185, 825.
30. 30. Yssel H., Johnson K.E., Schneider P.V. et al. (1992) T cell activation inducing epitopes of the house dust mite allergen Der pi. Induction of a restricted cytokine production profile of Der pi-specific T cell clones upon antigen-specific activation. J Immunol 148, 738.
31. 31. Jacobson N.G., Szabo S.J., Weber-Nordt R.M. et al. (1995) Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat) 3 and Stat4. J Exp Med 181, 1755.
32. 32. Pang Y., Norihisa Y., Benjamin D., Kantor R.R.S. & Young H.A. (1990) Interferon-γ gene expression in human B-cell lines: induction by interleukin-2, protein kinase C activators, and possible effects of hypomethylation on gene regulation. Blood 80, 724.
33. 33. Finkelman F.D., Madden K.B., Cheever A.W. et al. (1994) Effects of interleukin-12 on immune responses and host protection in mice infected with intestinal nematode parasites. J Exp Med 179, 1563.
34. 34. Wynn T.A., Jankovic D., Hieny S. et al. (1995) IL-12 exacerbates rather than suppresses T helper 2-dependent pathology in the absence of endogenous IFN-γ. J Immunol 154, 3999.
35. 35. Bliss J., Van Cleave V., Murray K. et al. (1996) IL-12, as an adjuvant, promotes a T helper 1 cell, but does not suppress a T helper 2 recall response. J Immunol 156, 887.
36. + allergen-specific Th2 T cell clones. Int Immunol 6, 1091.
37. 37. Jeannin P., Deineste Y., Life P., Gauchat J.-F., Kaiserlian D. & Bonnefoy J.-Y. (1995) Interleukin-12 increases interleukin-4 production by established human Th0 and Th2-like T cell clones. Eur J Immunol 25, 2247.