In vivo biodistribution, pharmacokinetic parameters, and brain uptake of 5-halo-6-methoxy(or ethoxy)-5,6-dihydro-3′-azido-3′-deoxythymidine diastereomers as potential prodrugs of 3′-Azido-3′-deoxythymidine

Journal of Medicinal Chemistry

Volumn 39, Issue 4, 1996, Pages 826-833

  Wang, Lili ^a   Morin, Kevin W ^a   Kumar, Rakesh ^a   Cheraghali, Majid ^a   Todd, Kathryn G ^a   Baker, Glen B ^a   Knaus, Edward E ^a   Wiebe, Leonard I ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

3' AZIDO 3' DEOXY 5,6 DIHYDRO 5 IODO 6 METHOXYTHYMIDINE; 3' AZIDO 5 BROMO 3' DEOXY 5,6 DIHYDRO 6 METHOXYTHYMIDINE; 3' AZIDO 5 BROMO 3' DEOXY 6 ETHOXY 5,6 DIHYDROTHYMIDINE; 3' AZIDO 5 CHLORO 3' DEOXY 5,6 DIHYDRO 6 METHOXYTHYMIDINE; NITROBENZYLTHIOINOSINE; PRODRUG; UNCLASSIFIED DRUG; ZIDOVUDINE; ZIDOVUDINE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BONE MARROW TOXICITY; DOSE RESPONSE; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG UPTAKE; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INTRAVENOUS DRUG ADMINISTRATION; MOUSE; NONHUMAN;

ACQUIRED IMMUNODEFICIENCY SYNDROME; ANIMALS; ANTIVIRAL AGENTS; BONE AND BONES; BRAIN; CARBON RADIOISOTOPES; DIDEOXYNUCLEOSIDES; ERYTHROCYTES; HUMANS; INDICATORS AND REAGENTS; MICE; MICE, INBRED BALB C; PRODRUGS; RADIOISOTOPE DILUTION TECHNIQUE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TISSUE DISTRIBUTION; ZIDOVUDINE;

EID: 0030029362     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9408326     Document Type: Article

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