Local recurrences and distant metastases after breast-conserving surgery and radiation therapy for early breast cancer

International Journal of Radiation Oncology Biology Physics

Volumn 43, Issue 1, 1999, Pages 25-38

  Touboul, Emmanuel ^a   Buffat, Laurent ^a   Belkacémi, Yazid ^a   Lefranc, Jean Pierre ^b   Uzan, Serge ^a   Lhuillier, Pierre ^c   Faivre, Corinne ^a   Huart, Judith ^a   Lotz, Jean Pierre ^a   Antoine, Martine ^a   Pène, Françoise ^a   Blondon, Jean ^b   Izrael, Victor ^a   Laugier, Alain ^a   Schlienger, Michel ^a   Housset, Martin ^a  

^a HÔPITAL TENON   (France)

^b PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^c Service d'Ophtalmologie   (France)

Author keywords

Conservative surgery; Early breast cancer; Local recurrence; Metastatic failure; Radiotherapy

Indexed keywords

ADULT; AGED; ARTICLE; BREAST CANCER; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER RISK; CANCER SURGERY; CANCER SURVIVAL; CONSERVATIVE TREATMENT; EARLY DIAGNOSIS; FEMALE; HUMAN; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROSPECTIVE STUDY;

ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; ANALYSIS OF VARIANCE; AXILLA; BREAST NEOPLASMS; CHEMOTHERAPY, ADJUVANT; COMBINED MODALITY THERAPY; FEMALE; FOLLOW-UP STUDIES; HUMANS; LYMPH NODE EXCISION; MASTECTOMY, SEGMENTAL; MENOPAUSE; MIDDLE AGED; NEOPLASM METASTASIS; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; RADIOTHERAPY DOSAGE;

EID: 0032935514     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0360-3016(98)00365-4     Document Type: Article

References (86)

1. Blichert-Toft M., Rose C., Anderson J.A., Overgaard M., Axelson R.H., Anderson K.W., Mouridsen H.D. Danish randomized trial comparing breast-preserving therapy with mastectomy Six years of life table analysis . J Natl Cancer Inst Monogr. 11:1992;19-25.
2. Fisher B., Redmond C., Poisson R., Margolese R., Wolmark N., Wickerham L., Fisher E.R., Deutsch M., Coplan H., Terz J., Sidorovich L. Eight year results of randomized clinical trial comparing total mastectomy and lumpectomy with or without irradiation in the treatment of breast cancer. N Engl J Med. 320:1989;822-823.
3. Jacobson J.A., Danforth D.N., Cowan K.H., d'Angello T., Steinberg S.M., Pierce L., Lippman M.E., Lichter A.S., Glastein E., Okunieff P. Ten-year results of a comparison of conservation with mastectomy in the treatment of stage I and II breast cancer. N Engl J Med. 332:1995;907-911.
4. Sarrazin D., Lê M.G., Arriagada R., Benhamou S., Benhamou E., Lasser P., Fontaine F., Spielman M., Rochard F., Le Chevalier T., Lacour J. Ten-year results of a randomized trial comparing a conservative treatment to mastectomy in early breast cancer. Radiother Oncol. 14:1989;177-184.
5. Van Dongen J.A., Bartelink H., Fentiman I.S., Leru T., Mignolet F., Olthuis G., Van Der Schueren E., Sylvester R., Winter J., Van Zÿl K. Randomized clinical trial to assess the value of breast cancer. E.O.R.T.C. 10801 trial. J Natl Cancer Inst Monogr. 11:1992;15-18.
6. Veronesi U., Banfi A., Salvadori B., Luini A., Saccozi R., Zucali R., Marulini E., Del Vecchio M., Borachi P., Marchini S., Merson M., Sacchini V., Riboldi G., Santoro G. Breast conservation is the treatment of choice in small breast cancer Long-term results of randomized trial . Eur J Cancer. 26:1990;668-670.
7. Clark R.M., Whelan T., Levine M., Robeerts R., Willan A., Mc Culloch P., Wilkinson R.H., Mahoney L.J. Randomized clinical trial of breast irradiation following lumpectomy and axillary dissection for node-negative breast cancer An update . J Natl Cancer Inst. 88:1996;165-174.
8. Fisher B., Anderson S., Redmond C.K., Wolmark N., Wickerham D.L., Cronin W.M. Reanalysis and results after 12 years of follow-up in a randomized clinical trial comparing total mastectomy with lumpectomy with or without irradiation in the treatment of breast cancer. N Engl J Med. 333:1995;1456-1461.
9. Randomized controlled trial of conservation therapy for breast cancer 6-year analysis of Scottish trial . Lancet. 348:1996;700-713.
10. Lilegren G., Holmberg L., Adami H.O., Westman G., Graffman S., Bergh J. Sector resection with or without postoperative radiotherapy for stage I breast cancer Five-year results of a randomized trial - Uppsala-Orebro Breast Cancer Study Group . J Natl Cancer Inst Monogr. 86:1994;717-722.
11. Veronesi U., Luini A., Del Vecchio M., Greco M., Galimberti V., Merson M., Rilke F., Sacchini R., Saccozi R., Savio T., Zucali R., Zurrida S., Salvadori B. Radiotherapy after breast-preserving surgery in women with localized cancer of the breast. N Engl J Med. 328:1993;1587-1591.
12. Fowble B.L., Solin L.J., Schultz D.J., Goodman R.L. Ten-year results of conservative surgery and irradiation for stage I and II breast cancer. Int J Radiat Oncol Biol Phys. 21:1991;269-277.
13. Gage I., Recht A., Gelman R., Nixon A.J., Silver B., Bornstein B.A., Harris J.R. Long-term outcome following breast-conserving surgery and radiation therapy. Int J Radiat Oncol Biol Phys. 33:1995;245-251.
14. Veronesi U., Marubini E., Del Vecchio M., Manzari A., Andreola S., Greco M., Luini A., Merson M., Saccozzi R., Rilke F., Salvadori B. Local recurrences and distant metastases after conservative breast cancer treatments Partly independent events . J Natl Cancer Inst. 87:1995;19-27.
15. Mac Millan R.D., Purushotham A.D., George W.D. Local recurrence after breast-conserving surgery for breast-cancer. Br J Surgery. 83:1996;149-155.
16. International Union Against Cancer: TNM classification of malignant tumors. 4th ed. (Hermaneck P, Sobin LM, eds). Berlin: Springer-Verlag; 1987.
17. Touboul E., Belkacémi Y., Lefranc J.P., Uzan S., Ozsahin M., Korbas D., Buffat L., Balosso J., Pène F., Blondon J., Schlienger M., Laugier A. Early breast cancer Influence of type of boost (electron vs iridium 192 implant) on local control and cosmesis after conservative surgery and radiation therapy . Radiother Oncol. 34:1995;105-113.
18. ICRU. Dose specification for reporting external beam therapy with photons and electrons. Washington, DC: ICRU Publications; 1978. ICRU Report No. 29.
19. Pierquin B., Owen R., Maylin C., Otmezguine Y., Raynal M., Mueller W., Hannoun B. Radical radiation therapy of breast cancer. Int J Radiat Oncol Phys. 6:1980;17-24.
20. Pierquin B., Dutreix A., Paine C.H., Chassagne D., Marinello G., Ash D. The Paris system in interstitial radiation therapy. Acta Radiol. 17:1978;33-48.
21. Kaplan E.L., Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc. 53:1958;457-481.
22. Mantel N., Haenszel W. Chi-square with one degree of freedom Extensions of the Mantel-Haenszel procedure . J Am Stat Assoc. 58:1963;690-700.
23. Cox D.R. Regression models and life table. JR Stat Soc. 34:1972;187-220.
24. Clayton D., Cuzick J. Multivariate generalization of the proportional hazards model. JR Stat Soc. 48:1985;82-117.
25. Fowble B., Solin L.J., Schultz D.J., Rubeinstein J., Goodman R.L. Breast recurrence following conservative surgery and radiation Patterns of failure, prognosis and pathologic findings from mastectomy specimens with implications for treatment . Int J Radiat Oncol Biol Phys. 19:1990;833-842.
26. De La Rochefordière A., Asselain B., Campana F., Scholl S.M., Fenton J., Vilcoq J.R., Durand J.C., Pouillard P., Magdelenat H., Fourquet A. Age as prognostic factor in premenopausal breast carcinoma. Lancet. 341:1993;1039-1043.
27. Local relapse and contralateral tumor rates in patients with breast cancer treated with conservative surgery and radiotherapy (Institut Gustave Roussy 1970-1982). Cancer. 76:1995;2260-2265.
28. Fourquet A., Campana F., Zafrani B., Mosseri V., Viehl P., Durand J., Vilcoq J.R. Prognostic factors in the conservative management for early breast cancer A 25-year follow-up at the Institut Curie . Int J Radiat Oncol Biol Phys. 17:1989;719-725.
29. Fowble B.L., Schultz D.J., Overmoyer B., Solin L.J., Fox K., Jardines L., Orel S., Glick J.H. The influence of young age on outcome in early stage breast cancer. Int J Radiat Oncol Biol Phys. 30:1994;23-33.
30. Kurtz J.M., Jacquemier J., Amalric R., Brandone H., Ayme Y., Hans D., Bressac C., Roth J., Spitalier J.M. Risk factors for breast recurrence in premenopausal and postmenopausal patients with ductal cancers treated by conservation therapy. Cancer. 65:1990;1867-1878.
31. Leborgne F., Leborgne J.H., Ortega B., Doldan R., Zubizarreta E. Breast conservation treatment of early stage breast cancer Patterns of failure . Int J Radiat Oncol Biol Phys. 31:1995;765-775.
32. Matthews R.H., Mc Neese M.D., Montague E.D., Oswald M.J. Prognostic implications of age in breast cancer patients treated with tumorectomy and irradiation or with mastectomy. Int J Radiat Oncol Biol Phys. 14:1988;659-663.
33. Recht A., Connolly J.L., Schnitt S.J., Silver B., Rose M.A., Love S., Harris J.R. The effect of young age on tumor recurrence in the treated breast after conservative surgery and radiotherapy. Int J Radiat Oncol Phys. 14:1988;3-10.
34. Bartelink H., Borger J.H., Van Dongen J.A., Peterse J.L. The impact of tumor size and histology on local control after breast-conserving therapy. Radiother Oncol. 11:1988;297-303.
35. Van Limbergen E., Van Der Bogaert W., Van Der Schueren E., Rijnders A. Tumor excision and radiotherapy as primary treatment of breast cancer Analysis of patients and treatment parameters and local control . Radiother Oncol. 8:1987;1-9.
36. Nixon A.J., Schnitt S.J., Gelman R., Gage I., Bornstein B., Hetelekidis S., Recht A., Silver B., Harris J.R., Connolly J.L. Relationship of tumor grade to other pathologic features and to treatment outcome of patients with early stage breast carcinoma treated with breast-conserving therapy. Cancer. 78:1996;1426-1431.
37. Chung M., Chang H.R., Bland K.I., Wanebo H.J. Younger women with breast carcinoma have a poorer prognosis than older women. Cancer. 77:1996;97-103.
38. Lee C.G., Mc Cormick B., Mazumbar M., Vetto J., Borgen P.I. Infiltrating breast carcinoma in patients age 30 years and younger Long term outcome for life, relapse, and second primary tumors . Int J Radiat Oncol Biol Phys. 23:1992;969-975.
39. Mansfield C.M., Kornarnicky L.T., Schwartz G.F., Rosemberg A.L., Kishnan L., Jewell W.R., Rosato F.E., Moses M.L., Haghbin M., Taylor J. Ten-year results in 1070 patients with stage I and II breast cancer treated by conservative surgery and radiation therapy. Cancer. 75:1995;2328-2336.
40. Fisher E.R., Sass R., Fisher B., Gregorio R., Brown R., Wickerham L. Pathologic findings from the National Surgical Adjuvant Breast Project (protocol 6) II. Relation of local breast recurrence to multicentricity. Cancer. 57:1986;1717-1724.
41. Locker A.P., Ellis I.O., Morgan D.A., Elston C.W., Mitchell A., Blamey R.W. Factors influencing local recurrence after excision and radiotherapy for primary breast cancer. Br J Surg. 7:1989;890-894.
42. Sastre-Garau X., Jouve M., Asselain B., Vincent-Salomon A., Beuzeboc P., Dorval T., Durand J.C., Fourquet A., Pouillart P. Infiltrating lobular carcinoma of the breast. Clinicopathologic analysis of 975 cases with reference to data on conservative therapy and metastatic patterns. Cancer. 77:1996;113-120.
43. Silverstein M.J., Lewinsky B.S., Waisman J.R., Gierson E.D., Colburn W.J., Senofsky G.N., Gamagami P. Infiltrating lobular carcinoma is it different from infiltrating duct carcinoma? Cancer. 73:1994;1673-1677.
44. Weiss M.C., Fowble B.L., Solin L.J., Yeh I.T., Schultz D.J. Outcome of conservative therapy for invasive breast cancer by histologic subtype. Int J Radiat Oncol Biol Phys. 23:1992;941-947.
45. White J.R., Gustafson G.S., Wimbish K., Ingold J.A., Lucas R.J., Levine A.J., Matter R.A., Martinez A., Vicini F.A. Conservative surgery and radiation therapy for infiltrating lobular carcinoma of the breast. The role of preoperative mammograms in guiding treatment. Cancer. 74:1994;640-647.
46. Kurtz J.M., Jacquemier J., Amalric R., Brandone H., Ayme Y., Hans D., Bressac C., Spitalier J.M. Breast conserving therapy for macroscopically multiple cancers. Ann Surg. 212:1991;38-44.
47. Leopold K.A., Recht A., Schnitt S.J., Connolly J.L., Rose M.A., Silver B., Harris J.R. Results of conservative surgery and radiation therapy for multiple synchronous cancers of one breast. Int J Radiat Oncol Biol Phys. 16:1989;11-16.
48. Wilson L.D., Bienfield M., Mc Khann C.F., Haffty B.G. Conservative surgery and radiation in the treatment of synchronous ipsilateral breast cancers. Cancer. 72:1993;137-142.
49. Hartsell W.F., Recine D.C., Griem K.L., Cobleigh M.A., Witt T.R., Murphy A.K. Should multicentric disease be an absolute contraindication to the use of breast-conserving therapy? Int J Radiat Oncol Biol Phys. 30:1994;49-53.
50. Borger J., Kemperman H., Hart A., Peterse H., Van Dongen J., Bartelink H. Risk factors in breast-conservation therapy. J Clin Oncol. 12:1994;653-660.
51. Lindley R., Burman A., Parsons P., Phillips R., Henry K., Ellis H. Histologic features predictive of an increase risk of early recurrence after treatment of breast cancer by local tumor excision and radical radiotherapy. Surgery. 105:1989;13-20.
52. Zafrani B., Viehl P., Fourquet A., Mosseri V., Durand J.C., Salmon R.J., Vilcoq J.R. Conservative treatment of early breast cancer Prognostic value of the ductal in situ component and other pathological variables on local control and survival . Eur J Cancer Clin Oncol. 11:1989;1645-1650.
53. Paterson D.A., Anderson T.J., Jack W.J.L., Kerr G.R., Rodger A., Chetty U. Pathological features predictive of local recurrence after management by conservation of invasive breast cancer Importance of non-invasive carcinoma . Radiother Oncol. 25:1992;176-180.
54. Vicini F.A., Recht A., Abner A., Boyages J., Cady B., Connolly J.L., Gelman R., Osteen R.T., Schnitt S.J., Silen W., Harris J.R. Recurrence in the breast following conservative surgery and radiation therapy for early stage breast cancer. J Natl Cancer Inst. 11:1992;33-39.
55. Holland R., Veling S.H.J., Mravunac M., Hendriks J.H.C.L. Histologic multifocality of Tis, T-1-2 breast carcinomas. Implications for clinical trials of breast-conserving surgery. Cancer. 56:1985;979-990.
56. Gage I., Schnitt S.J., Nixon A.J., Silver B., Recht A., Troyan S.L., Eberlein T., Love S.M., Gelman R., Harris J.R., Connolly J.L. Pathologic margin involvement and the risk of recurrence in patients treated with breast-conserving therapy. Cancer. 78:1996;1921-1928.
57. Schnitt S.J., Abner A., Gelman R., Connolly J.L., Recht A., Duda R.D., Eberlein T.J., Mayzel K., Silver B., Harris J.R. The relationship between microscopic margins of resection and the risk of local recurrence in patients with breast-conserving surgery and radiation therapy. Cancer. 74:1994;1746-1751.
58. Veronesi U., Volterrani F., Luini A., Saccozi R., Zucali R., Marulini E., Del Vecchio M., Zucali R., Galimberti V., Rasponi A., Di Re F., Squicciarini P., Salvadori B. Quadrantectomy versus lumpectomy for small size breast cancer. Eur J Cancer. 6:1990;671-673.
59. Heimann R., Powers C., Halpern H.J., Michel A.G., Ewing C.A., Wyman B., Recant W., Weichselbaum R.R. Breast preservation in stage I and II carcinoma of the breast. The University of Chicago experience. Cancer. 78:1996;1722-1730.
60. Ryoo M.C., Kagan A.R., Wollin M., Tomé M.A., Tedeschi M.A., Rao A.R., Hintz B.L., Kuruvilla A.M., Nuesbaum H., Streeter O.E., Jabola B.R., Miller M.J. Prognostic factors for recurrence and cosmesis in 393 patients after radiation therapy for early mammary carcinoma. Radiology. 172:1989;555-559.
61. Smitt M.C., Nowels K.W., Zdeblick M.J., Jeffrey S., Carlson R.W., Stockdale F.E., Goffinet D.R. The importance of the lumpectomy surgical margin status in long term results of breast conservation. Cancer. 76:1995;259-261.
62. Solin L.J., Fowble B.L., Schultz D.J., Goodman R.L. The significance of the pathology margins of the tumor excision on the outcome of patients treated with definitive irradiation for early stage breast cancer. Int J Radiat Oncol Biol Phys. 21:1991;279-287.
63. Spivack B., Khanna M.M., Tafra L., Juillard G., Giulianno E.A. Margin status and local recurrence after breast-conserving surgery. Arch Surg. 129:1994;952-957.
64. Schmidt-Ullrich R., Wazer D.E., Tercialla O., Safaü H., Marchant D.J., Smith T.J., Homer M.A., Robert N.J. Tumor margin assessment as a guide to optimal conservation surgery and irradiation in early stage breast carcinoma. Int J Radiat Oncol Biol Phys. 17:1989;733-738.
65. Boyages J., Bosh C., Langlands A.O., Bilous A.M., Barraclough B., Gelski V.J. Breast conservation Long-term Australian data . Int J Radiat Oncol Biol Phys. 24:1992;253-260.
66. Van Tienhoven G., Van Bree N.A.M., Nijnheer B.J., Bartelink H. Quality assurance of the EORTC trial 22881/10882 "Assessment of the role of the booster dose in breast conserving therapy": The dummy run . Radiother Oncol. 22:1991;290-298.
67. Bataini J.P., Vilcoq J.R., Martin M., Calle R. Relation between time-dose and local control of operable breast cancer treated by tumorectomy and radiotherapy or by radical radiotherapy alone. Cancer. 42:1978;2059-2065.
68. Kurtz J.M., Amalric R., Brandone H., Ayme Y., Spitalier J. How important is adequate radiotherapy for the long term results of breast-conserving treatment? Radiother Oncol. 20:1991;84-90.
69. Machtay M., Lanciana R., Hoffman J., Hanks G.E. Inaccuracies in using the lumpectomy scar for planning electron boosts in primary breast carcinoma. Int J Radiat Oncol Biol Phys. 30:1994;43-48.
70. Magee B., Swindell R., Harris M., Banerjee S.S. Prognostic factors for breast recurrence after conservative breast surgery and radiotherapy Results from a randomized trial . Radiother Oncol. 39:1996;223-227.
71. Fisher B., Constantino J., Redmond C., Poisson R., Bowman D., Couture J., Dimitrov N.V., Wolmark N., Wickerham D.L., Fisher E.R., Margolese R., Robidoux A., Shibata H., Terz J., Paterson A.H.G., Feldman M.I., Farrar W., Evans J., Lickley H.L., Ketner M., et al. A randomized clinical trial evaluating tamoxifen in the treatment of patients with node-negative breast cancer who have estrogen-receptor positive tumors. N Engl J Med. 320:1989;479-484.
72. Fisher B., Redmond C., Dimitrov N.V., Bowman D., Legault-Poisson S., Wickerham D.L., Wolmark N., Fisher E., Margolese R., Sutherland C., Glass D.L., Foster R., Caplan R., et al. A randomized clinical trial evaluating sequantial methotrexate and fluorouracil in treatment of patients with node-negative breast cancer who have estrogen receptor negative tumors. N Engl J Med. 320:1989;473-478.
73. Timing of radiotherapy and chemotherapy following breast-conserving surgery for patients with node-positive breast cancer. Int J Radiat Oncol Biol Phys. 35:1996;649-659.
74. Recht A., Come S.E., Henderson I.C., Gelman R.S., Silver B., Hayes D.F., Shulman L.N., Harris J.R. The sequencing of chemotherapy and radiation therapy after conservative surgery for early-stage breast cancer. N Engl J Med. 334:1996;1356-1361.
75. Das I.J., Cheng C.W., Fein D.A., Fowble B. Patterns of dose variability in radiation prescription of breast cancer. Radiother Oncol. 44:1997;83-99.
76. Cajucom C.C., Tsangaris T.N., Nemoto T., Driscoll D., Penetrante R.B., Holyoke E.D. Results of salvage mastectomy for local recurrence after breast-conserving surgery without radiation therapy. Cancer. 71:1993;1774-1779.
77. Chauvet B., Reynaud-Bougnoux A., Calais G., Panel N., Lansac J., Bougnoux P., Le Floch O. Prognostic significance of breast relapse after conservative treatment in node-negative early breast cancer. Int J Radiat Oncol Biol Phys. 19:1990;1125-1130.
78. Chauvet B., Lemseffer A., Fetissof F., Body G., Le Pechoux C., Calais G., Reynaud-Bougnoux A., Bougnoux P., Lansac J., Le Floch O. Disappearance of the in situ component A criterion predictive of metastases in breast cancer local relapse . Radiother Oncol. 25:1992;181-185.
79. Haffty B.G., Fisher D., Bienfield M., Mc Khann C. Prognosis following local recurrence in the conservatively treated breast cancer patient. Int J Radiat Oncol Biol Phys. 21:1991;293-298.
80. Haffty B.G., Toth M., Flynn S., Fisher D., Carter D. Prognostic value of DNA flow cytometry in the locally recurrent conservatively treated breast cancer patient. J Clin Oncol. 10:1992;1839-1847.
81. Haffty B.G., Carter D., Flynn S.D., Fisher D.B., Brash D.E., Simons J., Ziegler A.M., Fisher J.J. Local recurrence versus new primary Clinical analysis of 82 breast relapses and potential applications for genetic fingerprinting . Int J Radiat Oncol Biol Phys. 27:1993;575-583.
82. Kurtz J.M., Spitalier J., Amalric R., Brandone H., Ayme Y., Jacquemier J., Hans D., Bressac C.C. The prognostic significance of late local recurrence after breast-conserving therapy. Int J Radiat Oncol Biol Phys. 18:1990;87-93.
83. Kurtz J.M., Amalric R., Brandone H., Ayme Y., Jacquemier J., Pietra J.C., Hans D., Pollet F.C., Bressac C., Spitalier C. Local recurrence after breast-conserving surgery and radiotherapy. Frequency, time course and prognosis. Cancer. 63:1989;1912-1917.
84. Fisher B., Anderson E.R., Redmond C., Wickerham D.L., Wolmark N., Namounas E.P., Deutsch M., Margolese R. Significance of ipsilateral breast tumor recurrence after lumpectomy. Lancet. 338:1991;327-331.
85. Whelan T., Clark R., Roberts R., Levine M., Foster G. Ipsilateral breast tumor recurrence postlumpectomy is predictive of subsequent mortality Results from a randomized trial . Int J Radiat Oncol Biol Phys. 1:1994;11-16.
86. Levitt S.H., Aeppli D.M., Nierengarten M.E. The impact of radiation on early breast carcinoma survival. A Bayesian analysis. Cancer. 78:1996;1035-1042.