Pathologic margin involvement and the risk of recurrence in patients treated with breast-conserving therapy

Cancer

Volumn 78, Issue 9, 1996, Pages 1921-1928

  Gage, Irene ^a,d   Schnitt, Stuart J ^a   Nixon, Asa J ^a   Silver, Barbara ^a,e   Recht, Abram ^a   Troyan, Susan L ^a   Eberlein, Timothy ^a   Love, Susan M ^c   Gelman, Rebecca ^b   Harris, Jay R ^a   Connolly, James L ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d JOHNS HOPKINS UNIVERSITY   (United States)

^e HARVARD RADIATION ONCOLOGY PROGRAM   (United States)

Author keywords

breast carcinoma; breast conserving therapy; extensive intraductal component; local recurrence; margins

Indexed keywords

ADULT; ARTICLE; BREAST CANCER; CALCULATION; CANCER CLASSIFICATION; CANCER RECURRENCE; CANCER RISK; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; PALLIATIVE THERAPY; PRIORITY JOURNAL; RISK ASSESSMENT;

EID: 10244252711     PISSN: 0008543X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1097-0142(19961101)78:9<1921::aid-cncr12>3.0.co;2-%23     Document Type: Article

References (26)

1. Fisher B, Redmond C, Poisson R, Margolese R, Wolmark N, Wickerham L, et al. Eight-year results of a randomized clinical trial comparing total mastectomy and lumpectomy with or without irradiation in the treatment of breast cancer. N Engl J Med 1989;320:822-8.
2. Jacobson JA, Danforth DN, Cowan JH, D'Angelo T, Steinberg SM, Pierce L, et al. Ten-year results of a comparison of conservation with mastectomy in the treatment of stage I and II breast cancer. N Engl J Med 1995;332:907-11.
3. van Dongen J, Bartelink H, Fentiman I, Lerut T, Mignolet F, Olthuis G, et al. Factors influencing local relapse and survival and results of salvage treatment after breast-conserving therapy in operable breast cancer: EORTC trial 10801, breast conservation compared with mastectomy in TNM stage I and II breast cancer. Eur J Cancer 1992;28A:801-5.
4. Recht A, Silen W, Schnitt SJ, Connolly JL, Gelman R, Rose MA, et al. Time course of local recurrence following conservative surgery and radiotherapy for early stage breast cancer. Int J Radiat Oncol Biol Phys 1988;15:255-61.
5. Vicini FA, Eberlein TJ, Connolly JL, Recht A, Abner A, Schnitt SJ, et al. The optimal extent of resection for patients with stages I or II breast cancer treated with conservative surgery and radiotherapy. Ann Surg 1991;214:200-4.
6. Schnitt SJ, Abner A, Gelman R, Connolly JL, Recht A, Duda RB, et al. The relationship between microscopic margins of resection and the risk of local recurrence in patients treated with conserving surgery and radiation therapy. Cancer 1994;74:1746-51.
7. Anscher MS, Jones P, Prosnitz LR, Blackstock W, Hebert M, Reddick R, et al. Local failure and margin status in early-stage breast carcinoma treated with conservation surgery and radiation therapy. Ann Surg 1993;218:22-8.
8. Borger J, Kemperman H, Hart A, Peterse H, van Dongen J, Bartelink H. Risk factors in breast-conservation therapy. J Clin Oncol 1994;12:653-60.
9. Clarke DH, Monique GL, Sarrazin D, Lacombe M-J, Fontaine F, Travagli J-P, et al. Analysis of local-regional relapses in patients with early breast cancers treated by excision and radiotherapy: experience of the Institut Gustave-Roussy. Int J Radiat Oncol Biol Phys 1985;11:137-45.
10. Kurtz JM, Jacquemier J, Amalric R, Brandone H, Ayme Y, Hans D, et al. Risk factors for breast recurrence in premeno-pausal and postmenopausal patients with ductal cancers treated by conservation therapy. Cancer 1990;65:1867-78.
11. Ryoo MC, Kagan AR, Wollin M, Tome MA, Tedeschi, MA, Rao AR, et al. Prognostic factors for recurrence and cosmesis in 393 patients after radiation therapy. Radiology 1989; 172:555-9.
12. Schmidt-Ullrich R, Wazer DE, Tercilla O, Safaii H, Marchant DJ, Smith TJ, et al. Tumor margin assessment as a guide to optimal conservation surgery and irradiation in early stage breast cancer. Int J Radiat Oncol Biol Phys 1989;17:733-8.
13. Smitt MC, Nowels JW, Zdeblich MJ, Jeffrey S, Carlson RW, Stockdale FE, et al. The importance of the lumpectomy surgical margin status in long term results of breast conservation. Cancer 1995;76:259-67.
14. Solin LJ, Fowble BL, Schultz DJ, Goodman RL. The significance of the pathology margins of the tumor excision on the outcome of patients treated with definitive irradiation for early stage breast cancer. Int J Radiat Oncol Biol Phys 1991;21:279-87.
15. Pittinger TP, Maronian NC, Poulter CA, Peacock JL. Importance of margin status in outcome of breast-conserving surgery for carcinoma. Surgery 1994;116:605-9.
16. Pezner RD, Terz J, Ben-Ezra J, Hill LR. Now there are two effective conservation approaches for patients with stage I and II breast cancer: how pathological assessment of inked resection margins can provide valuable information for the radiation oncologist. Am J Clin Oncol 1990;13:175-9.
17. Spivack R, Khanna MM, Tafra L, Juillard G, Giuliano AF., et al. Margin status and local recurrence after breast-conserving surgery. Arch Surg 1994;29:952-7.
18. Schnitt SJ, Connolly JC, Khettry U, Mazoujian G, Brenner M, Silver B, et al. Pathologic findings on reexcision of the primary site in breast cancer patients considered for treatment by primary radiation therapy. Cancer 1987;59:675-81.
19. Holland R, Connolly JL, Gelman R, Mravunac M, Hendriks JH, Verbeek AL, et al. The presence of an extensive intraductal component following a limited excision correlates with prominent residual disease in the remainder of the breast. J Clin Oncol 1990;8:113-8.
20. Ohtake T, Abe R, Kimijima I, Fukushima T, Tsuchiya A, Hoshi K, et al. Intraductal extension of primary invasive breast carcinoma treated by breast-conservative surgery. Cancer 1995;76:32-45.
21. Healey EA, Osteen RT, Schnitt SJ, Gelman R, Stomper PC, Connolly JL, et al. Can the clinical and mammographic findings at presentation predict the presence of an extensive intraductal component in early stage breast cancer? Int J Radiat Oncol Biol Phys 1989;17:1217-21.
22. Boyages J, Recht A, Connolly JL, Schnitt SJ, Gelman R, Kooy H, et al. Early breast cancer: predictors of breast recurrence for patients treated with conservative surgery and radiation therapy. Radiother Oncol 1990;19:29-41.
23. Bartelink H, Borger JH, van Dongen JA, Peterse JL. The impact of tumor size and histology on local control after breast-conserving therapy. Radiother Oncol 1988;11:297-303.
24. Fisher ER, Sass R, Fisher B, Gregorio R, Brown R, Wickerham L, et al. Pathologic findings from the National Surgical Adjuvant Breast Project (Protocol 6) II: Relation of local breast recurrence to multicentricity. Cancer 1986;57:1717-24.
25. Veronesi U, Luini A, Galimberti V, Zurrida S. Conservation approaches for the management of Stage I/II carcinoma of the breast: Milan Cancer Institute trials. World J Surg 1994;18:70-5.
26. Veronesi U, Volterrani F, Luini A, Saccozzi R, Del Vecchio M, Zucali R, et al. Quadrantectomy versus lumpectomy for small size breast cancer. Eur J Cancer 1990;26:671-3.