Does ethanol enhance cocaine toxicity?

Journal of Clinical Forensic Medicine

Volumn 6, Issue 1, 1999, Pages 19-23

  Karch, S B ^a,c   Stephens, B G ^a,c   Tseng, A ^b  

^a Medical Examiner's Office   (United States)

^b UNIVERSITY OF NEVADA   (United States)

^c CITY AND COUNTY OF SAN FRANCISCO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; COCAINE; DRUG METABOLITE;

ACCIDENTAL DEATH; ADULT; ALCOHOL BLOOD LEVEL; ALCOHOL CONSUMPTION; ARTICLE; AUTOPSY; BODY MASS; BRAIN HEMORRHAGE; CAUSE OF DEATH; COCAINE DEPENDENCE; DRUG BLOOD LEVEL; DRUG FATALITY; FEMALE; HEART DISEASE; HEART WEIGHT; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; NONHUMAN; ORGAN WEIGHT; STATISTICAL ANALYSIS;

EID: 0032934797     PISSN: 13531131     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1353-1131(99)90171-2     Document Type: Article

References (30)

1. Grant B, Hartford T. Concurrent and simultaneous use of alcohol with cocaine: results of a national survey. Drug Alcohol Dep 1990; 25: 97-104
2. Cook MN, Ware DD, Boone EM et al. Ethanol modulates cocaine-induced behavioral change in inbred mice. Pharmacol Biochem Behav 1998; 59(3): 567-575
3. Uemura K, Li YJ, Ohbora Y, Fujimiya T, Komura S. Effects of repeated cocaine administration on alcohol consumption. J Stud Alcohol 1998; 59(1): 115-118
4. Farre M, de la Torre R, Llorente M et al. Alcohol and cocaine interactions in humans. J Pharmacol Exp Ther 1993; 266(3): 1364-1373
5. Rose S, Hearn L, Mash DC et al. Cocaine and cocaethylene cocentrations in human postmortem cerebral cortex. Neuroscience 1990; 16: 14
6. Escabedo L, Ruttenbur A, Anda R et al. Coronary artery disease, left ventricular hypertrophy, and the risk of cocaine overdose death. Coronary Art Dis 1992; 3: 853-857
7. Griesemer E, Liu Y, Budd R et al. The determination of cocaine and its major metabolite, benzoylecgonine by computerized gas chromatography/mass spectrometry. J Forensic Sci 1983; 28: 894-900
8. Weiss R, Mirin S, Griffin M, Michael J. Psychopathology in cocaine abusers - changing trends. J Nerv Ment Dis 1988; 176: 719-725
9. Rounsaville B, Anton S, Carroll K et al. Psychiatric diagnoses of treatment-seeking cocaine abusers. Arch Gen Psych 1991; 48: 43-51
10. Hime G, Hearn W, Rose S, Cofino J. Analysis of cocaine and cocaethylene in blood and tissues by GC-NPD and GC-ion trap mass spectrometry. J Analyt Toxicol 1991; 15: 241-245
11. Hedaya M, Wei-Jian P. Effect of alcohol coadministration on the plasma and brain concentrations of cocaine in rats. Drug Metabl Disp 1997; 25: 647-649
12. McCance-Katz E, Price L, McDougle C et al. Concurrent cocaine-ethanol ingestion in humans: pharmacology, physiology, behavior, and the role of cocaethylene. Psychopharmacology 1993; 111: 39-46
13. Hearn W, Rose S, Wagner J et al. Cocaethylene is more potent than cocaine in mediating lethality. Pharm Biochem Behav 1991; 39: 531-533
14. Hearn W, Flynn D, Hime G et al. Cocaethylene: a unique cocaine metabolite displays high affinity for the dopamine transporter. J Neurochem 1991; 56: 698-701
15. Andrews P. Cocaethylene toxicity. J Addict Dis 1997; 16: 75-84
16. Vanek V. Concurrent use of cocaine and alcohol by patients treated in the emergency department. Ann Emerg Med 1996; 28(5): 508-514
17. Signs S. The formation of cocaethylene and clinical presentation of ED patients testing positive for the use of cocaine and ethanol. Am J Emerg Med 1996; 14(7): 665-670
18. Goggins M, Roe SFA. Cocaine and benzoylecgonine concentrations in postmortem blood and liver. Clin Chem 1990; 36: 1023
19. Jenkins AJ, Goldberger BA. Identification of unique cocaine metabolites and smoking by-products in postmortem blood and urine specimens. J Forensic Sci 1997; 42(5): 824-827
20. Clauwaert K. Liquid chromatographic determination of cocaine, benzoylecgonine, and cocaethylene in whole blood and serum samples with diode-array detection. J Chromatogr Sci 1997; 35(7): 321-328
21. Brickner E, Willard J, Eichorn E et al. Left ventricular hypertrophy associated with chronic cocaine abuse. Circulation 1991; 84: 1130-1135
22. Karch SB, Green GS, Young S. Myocardial hypertrophy and coronary artery disease in male cocaine users. J Forensic Sci 1995; 40(4): 591-595
23. Karch S. The pathology of drug abuse, 2nd ed. Boca Raton, CRC Press, 1996
24. Samuels M. 'Voodo' death revisited: the modern lessons of neurocardiology. The Neurologist 1997; 3: 293-304
25. Henning RJ, Wilson LD, Glauser JM. Cocaine plus ethanol is more cardiotoxic than cocaine or ethanol alone. Crit Care Med 1994; 22(12): 1896-1906
26. Bai H, Otsu K, Islam MN et al. Direct cardiotoxic effects of cocaine and cocaethylene on isolated cardiomyocytes. Int J Cardiol 1996; 53(1): 15-23
27. Samanin R, Garattini S. Neurochemical mechanism of action of anorectic drugs. Clin Pharm Tox 1993; 73: 63-68
28. Staley JK, Hearn WL, Ruttenber AJ, Wetli CV, Mash DC. High affinity cocaine recognition sites on the dopamine transporter are elevated in fatal cocaine overdose victims. J Pharmacol Exp Ther 1994; 271(3): 1678-1685
29. Staley J, Mash DC. Adaptive increase in D3 dopamine receptors in the brain reward circuits of human cocaine fatalities. J Neurosci 1996; 16: 6100-6106
30. Substance Abuse and Mental Health Administration. Preliminary estimates from the 1996 Drug Abuse Warning Network. DHHS Publication No (SMA) 97-3144. Rockville, Maryland, July 1997