메뉴 건너뛰기




Volumn 14, Issue 7, 1996, Pages 665-670

The formation of cocaethylene and clinical presentation of ED patients testing positive for the use of cocaine and ethanol

Author keywords

clinical presentation; Cocaethylene; cocaine; emergency department; ethanol; trauma

Indexed keywords

ALCOHOL; BENZOYLECGONINE; COCAINE; DRUG METABOLITE; HOMOCOCAINE;

EID: 0029820195     PISSN: 07356757     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0735-6757(96)90085-6     Document Type: Article
Times cited : (20)

References (43)
  • 1
    • 0025232852 scopus 로고
    • Concurrent and simultaneous use of alcohol with cocaine: Results of national survey
    • Grant BF, Harford TC: Concurrent and simultaneous use of alcohol with cocaine: results of national survey. Drug Alc Depend 1990;25:97-104
    • (1990) Drug Alc Depend , vol.25 , pp. 97-104
    • Grant, B.F.1    Harford, T.C.2
  • 2
    • 0024207127 scopus 로고
    • Psychopathology in cocaine users: Changing trends
    • Weiss RD, Mirin SM, Griffin ML, et al: Psychopathology in cocaine users: Changing trends. J Nerv Ment Dis 1988;176:719-725
    • (1988) J Nerv Ment Dis , vol.176 , pp. 719-725
    • Weiss, R.D.1    Mirin, S.M.2    Griffin, M.L.3
  • 3
    • 0021615266 scopus 로고
    • Alcoholism and polydrug use: The need for the "basics."
    • Kreek MJ, Stimmel B: Alcoholism and polydrug use: The need for the "basics." Adv Alc Subst Abuse 1984;3:1-6
    • (1984) Adv Alc Subst Abuse , vol.3 , pp. 1-6
    • Kreek, M.J.1    Stimmel, B.2
  • 4
    • 0026599031 scopus 로고
    • Cocaine, alcohol mix in body to form even longer lasting, more lethal drug
    • Randall T: Cocaine, alcohol mix in body to form even longer lasting, more lethal drug. JAMA 1992;267:1043-1044
    • (1992) JAMA , vol.267 , pp. 1043-1044
    • Randall, T.1
  • 5
    • 0027397422 scopus 로고
    • Management of cocaineinduced cardiovascular complications
    • Om A, Ellahham S, DiSciascio G: Management of cocaineinduced cardiovascular complications. Am Heart J 1993;125:469-475
    • (1993) Am Heart J , vol.125 , pp. 469-475
    • Om, A.1    Ellahham, S.2    DiSciascio, G.3
  • 6
    • 0024161797 scopus 로고
    • Ethanol and cocaine interactions in humans: Cardiovascular consequences
    • Foltin RW, Fischman MF: Ethanol and cocaine interactions in humans: cardiovascular consequences. Pharmacol Biochem Behav 1989;31:877-883
    • (1989) Pharmacol Biochem Behav , vol.31 , pp. 877-883
    • Foltin, R.W.1    Fischman, M.F.2
  • 7
    • 0027400391 scopus 로고
    • Enhancement of cocaine-induced hepatotoxicity by ethanol
    • Odeleye OE, Watson RR, Eskelson CD, et al: Enhancement of cocaine-induced hepatotoxicity by ethanol. Drug Alc Depend 1993;31: 253-263
    • (1993) Drug Alc Depend , vol.31 , pp. 253-263
    • Odeleye, O.E.1    Watson, R.R.2    Eskelson, C.D.3
  • 8
    • 0026032342 scopus 로고
    • Potentiation of cocaine hepatotoxicity by ethanol in human hepatocytes
    • Jover R, Ponsoda X, Gomez-Lechon MJ, et al: Potentiation of cocaine hepatotoxicity by ethanol in human hepatocytes. Toxicol Appl Pharmacol 1991;107:526-34
    • (1991) Toxicol Appl Pharmacol , vol.107 , pp. 526-534
    • Jover, R.1    Ponsoda, X.2    Gomez-Lechon, M.J.3
  • 9
    • 0026091130 scopus 로고
    • Analysis of cocaine and cocaethylene in blood and tissues by GC-NPD and GC-ion trap mass spectrometry
    • Hime GW, Hearn WL, Rose S, et al: Analysis of cocaine and cocaethylene in blood and tissues by GC-NPD and GC-ion trap mass spectrometry. J Anal Toxicol 1991;15:241-245
    • (1991) J Anal Toxicol , vol.15 , pp. 241-245
    • Hime, G.W.1    Hearn, W.L.2    Rose, S.3
  • 10
    • 0024802935 scopus 로고
    • Toxicology screening in urban trauma patients: Drug prevalence with its relationship to trauma severity and management
    • Sloan EP, Zalenski RJ, Smith RF, et al: Toxicology screening in urban trauma patients: drug prevalence with its relationship to trauma severity and management. J Trauma 1989;29:1647-1653
    • (1989) J Trauma , vol.29 , pp. 1647-1653
    • Sloan, E.P.1    Zalenski, R.J.2    Smith, R.F.3
  • 11
    • 0026481588 scopus 로고
    • Alcohol and cocaine: Clinical and pharmacological interactions
    • Galanter M (ed): New York, NY, Plenum
    • Gorelick DA: Alcohol and cocaine: Clinical and pharmacological interactions. In Galanter M (ed): Recent Developments in Alcoholism. New York, NY, Plenum, 1992, pp 37-56
    • (1992) Recent Developments in Alcoholism , pp. 37-56
    • Gorelick, D.A.1
  • 12
    • 0025955766 scopus 로고
    • Human liver cocaine esterases: Ethanol-mediated formation of ethylcocaine
    • Dean RA, Christian CD, Sample RHB, et al: Human liver cocaine esterases: ethanol-mediated formation of ethylcocaine. FASEB J 1991;5:2735-2739
    • (1991) FASEB J , vol.5 , pp. 2735-2739
    • Dean, R.A.1    Christian, C.D.2    Sample, R.H.B.3
  • 13
    • 0018774062 scopus 로고
    • Identification of cocaine and its metabolites in human urine in the presence of ethyl alcohol
    • Rafla FK, Epstein RL: Identification of cocaine and its metabolites in human urine in the presence of ethyl alcohol. J Anal Toxicol 1978;3:18-22
    • (1978) J Anal Toxicol , vol.3 , pp. 18-22
    • Rafla, F.K.1    Epstein, R.L.2
  • 14
    • 0027325438 scopus 로고
    • Cocaethylene toxicity in rat primary myocardial cell cultures
    • Welder AA, Dickson LJ, Melchert RB: Cocaethylene toxicity in rat primary myocardial cell cultures. Alcohol 1993;10:285-290
    • (1993) Alcohol , vol.10 , pp. 285-290
    • Welder, A.A.1    Dickson, L.J.2    Melchert, R.B.3
  • 15
    • 0028051609 scopus 로고
    • Cocaethylene, a metabolite of cocaine and ethanol, is a potent blocker of cardiac sodium channels
    • Xu Y-Q, Crumb WJ Jr, Clarkson CW: Cocaethylene, a metabolite of cocaine and ethanol, is a potent blocker of cardiac sodium channels. J Pharmacol Exp Ther 1994;271:319-325
    • (1994) J Pharmacol Exp Ther , vol.271 , pp. 319-325
    • Xu, Y.-Q.1    Crumb Jr., W.J.2    Clarkson, C.W.3
  • 16
    • 0028817424 scopus 로고
    • Cocaethylene-induced lethality in mice is potentiated by alcohol
    • Meehan SM, Schechter MD: Cocaethylene-induced lethality in mice is potentiated by alcohol. Alcohol 1995;26:99-106
    • (1995) Alcohol , vol.26 , pp. 99-106
    • Meehan, S.M.1    Schechter, M.D.2
  • 17
    • 0025745333 scopus 로고
    • Cocaethylene is more potent than cocaine in mediating lethality
    • Hearn WL, Rose S, Wagner J, et al: Cocaethylene is more potent than cocaine in mediating lethality. Pharmacol Biochem Behav 1991;39:531-533
    • (1991) Pharmacol Biochem Behav , vol.39 , pp. 531-533
    • Hearn, W.L.1    Rose, S.2    Wagner, J.3
  • 18
    • 0025959408 scopus 로고
    • Cocaethylene: A unique cocaine metabolite displays high affinity for the dopamine transporter
    • Hearn WL, Flynn DD, Hime GW, et al: Cocaethylene: A unique cocaine metabolite displays high affinity for the dopamine transporter. J Neurochem 1991;56:698-701
    • (1991) J Neurochem , vol.56 , pp. 698-701
    • Hearn, W.L.1    Flynn, D.D.2    Hime, G.W.3
  • 19
    • 0027469977 scopus 로고
    • Concurrent cocaine-ethanol ingestion in humans: Pharmacology, physiology, behavior, and the role of cocaethylene
    • McCance-Katz EF, Price LH, McDougle CJ, et al: Concurrent cocaine-ethanol ingestion in humans: pharmacology, physiology, behavior, and the role of cocaethylene. Psychopharmacol 1993;111: 39-46
    • (1993) Psychopharmacol , vol.111 , pp. 39-46
    • McCance-Katz, E.F.1    Price, L.H.2    McDougle, C.J.3
  • 20
    • 0028247365 scopus 로고
    • The order of drug discrimination: Its effect on the interaction between cocaine and ethanol
    • Perez-Reyes M: The order of drug discrimination: Its effect on the interaction between cocaine and ethanol. Life Sci 1994;55:541-550
    • (1994) Life Sci , vol.55 , pp. 541-550
    • Perez-Reyes, M.1
  • 21
    • 0026503358 scopus 로고
    • Alcohol-specific cocaine metabolites in serum and urine of hospitalized patients
    • Wu AHB, Onigbinde TA, Johnson KG, et al: Alcohol-specific cocaine metabolites in serum and urine of hospitalized patients. J Anal Toxicol 1992;16:132-136
    • (1992) J Anal Toxicol , vol.16 , pp. 132-136
    • Wu, A.H.B.1    Onigbinde, T.A.2    Johnson, K.G.3
  • 22
    • 0025911167 scopus 로고
    • Cocaine-related symptoms in patients presenting to an urban emergency department
    • Rich JA, Singer DE: Cocaine-related symptoms in patients presenting to an urban emergency department. Ann Emerg Med 1991;20:616-621
    • (1991) Ann Emerg Med , vol.20 , pp. 616-621
    • Rich, J.A.1    Singer, D.E.2
  • 23
    • 0023633707 scopus 로고
    • Acute neurologic and psychiatric complications associated with cocaine abuse
    • Lowenstein DH, Massa SM, Rowbotham MC, et al: Acute neurologic and psychiatric complications associated with cocaine abuse. Am J Med 1987;83:841-846
    • (1987) Am J Med , vol.83 , pp. 841-846
    • Lowenstein, D.H.1    Massa, S.M.2    Rowbotham, M.C.3
  • 24
    • 0025264441 scopus 로고
    • Cocaine-related medical problems: Consecutive series of 233 patients
    • Brody SL, Slovis CM, Wrenn KD: Cocaine-related medical problems: consecutive series of 233 patients. Am J Med 1990;88:325-331
    • (1990) Am J Med , vol.88 , pp. 325-331
    • Brody, S.L.1    Slovis, C.M.2    Wrenn, K.D.3
  • 25
    • 0026543435 scopus 로고
    • High prevalence of recent cocaine use and the unreliability of patient self-report in an inner-city walk-in clinic
    • McNagny SE, Parker RM: High prevalence of recent cocaine use and the unreliability of patient self-report in an inner-city walk-in clinic. JAMA 1992;267:1106-1108
    • (1992) JAMA , vol.267 , pp. 1106-1108
    • McNagny, S.E.1    Parker, R.M.2
  • 26
    • 0026638360 scopus 로고
    • Enzymatic basis for the transesterification of cocaine in the presence of ethanol: Evidence for the participation of microsomal carboxylesterases
    • Boyer CS, Petersen DR: Enzymatic basis for the transesterification of cocaine in the presence of ethanol: Evidence for the participation of microsomal carboxylesterases. J Pharmacol Exp Ther 1992;260:939-946
    • (1992) J Pharmacol Exp Ther , vol.260 , pp. 939-946
    • Boyer, C.S.1    Petersen, D.R.2
  • 27
    • 0025344033 scopus 로고
    • Prolonged presence of metabolite in urine after compulsive cocaine use
    • Burke WM, Ravi NV, Dhopesh V, et al: Prolonged presence of metabolite in urine after compulsive cocaine use. J Clin Psychiatry 1990;51:145-148
    • (1990) J Clin Psychiatry , vol.51 , pp. 145-148
    • Burke, W.M.1    Ravi, N.V.2    Dhopesh, V.3
  • 28
    • 0024272084 scopus 로고
    • Protracted elimination of cocaine metabolites in long-term high-dose cocaine abusers
    • Weiss RD, Gawin FH: Protracted elimination of cocaine metabolites in long-term high-dose cocaine abusers. Am J Med 1988;85:879-80
    • (1988) Am J Med , vol.85 , pp. 879-880
    • Weiss, R.D.1    Gawin, F.H.2
  • 30
    • 0025763080 scopus 로고
    • Cocaethylene: A neuropharmacologically active metabolite associated with concurrent cocaine-ethanol ingestion
    • Jatlow PI, Elsworth JD, Bradberry CW, et al: Cocaethylene: A neuropharmacologically active metabolite associated with concurrent cocaine-ethanol ingestion. Life Sci 1991;48:1787-1794
    • (1991) Life Sci , vol.48 , pp. 1787-1794
    • Jatlow, P.I.1    Elsworth, J.D.2    Bradberry, C.W.3
  • 31
    • 0027531573 scopus 로고
    • Plasma cocaethylene concentrations in patients treated in the emergency room or trauma unit
    • Bailey DN: Plasma cocaethylene concentrations in patients treated in the emergency room or trauma unit. Am J Clin Pathol 1993;99:123-127
    • (1993) Am J Clin Pathol , vol.99 , pp. 123-127
    • Bailey, D.N.1
  • 32
    • 0029043581 scopus 로고
    • Cocaethylene: Pharmacology, physiology and behavioral effects in humans
    • McCance EF, Price LH, Kosten TR, et al: Cocaethylene: Pharmacology, physiology and behavioral effects in humans. J Pharmacol Exp Ther 1995;274:215-223
    • (1995) J Pharmacol Exp Ther , vol.274 , pp. 215-223
    • McCance, E.F.1    Price, L.H.2    Kosten, T.R.3
  • 33
    • 0028906689 scopus 로고
    • The effect of cocaine and amphetamines on vital signs in trauma patients
    • Richards CF, Clark RF, Holbrook R, et al: The effect of cocaine and amphetamines on vital signs in trauma patients. J Emerg Med 1995;13:59-63
    • (1995) J Emerg Med , vol.13 , pp. 59-63
    • Richards, C.F.1    Clark, R.F.2    Holbrook, R.3
  • 34
    • 0028477621 scopus 로고
    • Prospective multicenter evaluation of cocaine-associated chest pain
    • Hollander JE, Huffman RS, Gennis P, et al: Prospective multicenter evaluation of cocaine-associated chest pain. Acad Emerg Med 1994;1:330-339
    • (1994) Acad Emerg Med , vol.1 , pp. 330-339
    • Hollander, J.E.1    Huffman, R.S.2    Gennis, P.3
  • 35
    • 0025964334 scopus 로고
    • Psychiatric diagnoses of treatment-seeking cocaine abusers
    • Rounsaville BJ, Anton SF, Carroll K, et al: Psychiatric diagnoses of treatment-seeking cocaine abusers. Arch Gen Psychiatry 1991;48:43-51
    • (1991) Arch Gen Psychiatry , vol.48 , pp. 43-51
    • Rounsaville, B.J.1    Anton, S.F.2    Carroll, K.3
  • 36
    • 0025223709 scopus 로고
    • Neurologic complications of cocaine abuse
    • Spivey WH, Euerle B: Neurologic complications of cocaine abuse. Ann Emerg Med 1990;19:1422-1428
    • (1990) Ann Emerg Med , vol.19 , pp. 1422-1428
    • Spivey, W.H.1    Euerle, B.2
  • 37
    • 0024548921 scopus 로고
    • Emergency department presentation of cocaine intoxication
    • Derlet RW, Albertson TE: Emergency department presentation of cocaine intoxication. Ann Emerg Med 1989;18:182-186
    • (1989) Ann Emerg Med , vol.18 , pp. 182-186
    • Derlet, R.W.1    Albertson, T.E.2
  • 38
    • 0023851651 scopus 로고
    • Drinking patterns and problems associated with injury status in emergency room admissions
    • Cherpitel CJ: Drinking patterns and problems associated with injury status in emergency room admissions. Alc Clin Exp Res 1988;12:105-110
    • (1988) Alc Clin Exp Res , vol.12 , pp. 105-110
    • Cherpitel, C.J.1
  • 40
    • 0029053962 scopus 로고
    • Fatal injuries after cocaine use as a leading cause of death among young adults in New York City
    • Marzuk PM, Tardiff K, Leon AC, et al: Fatal injuries after cocaine use as a leading cause of death among young adults in New York City. New Engl J Med 1995;332:1753-1757
    • (1995) New Engl J Med , vol.332 , pp. 1753-1757
    • Marzuk, P.M.1    Tardiff, K.2    Leon, A.C.3
  • 41
    • 16044369875 scopus 로고
    • Toxicology screens for cocaethylene in emergency department and trauma admissions associated with cocaine intoxication
    • Harris L (ed): Bethesda, MD, National Institute on Drug Abuse
    • Mash DC, Tanis DC, Schrank KS, et al: Toxicology screens for cocaethylene in emergency department and trauma admissions associated with cocaine intoxication. In Harris L (ed): Problems of Drug Dependence Research Monograph. Bethesda, MD, National Institute on Drug Abuse, 1992;119:489
    • (1992) Problems of Drug Dependence Research Monograph , vol.119 , pp. 489
    • Mash, D.C.1    Tanis, D.C.2    Schrank, K.S.3
  • 42
    • 0024789024 scopus 로고
    • Patterns of alcohol and drug abuse in an urban trauma center: The increasing role of cocaine abuse
    • Lindenbaum GA, Carroll SF, Daskal I, et al: Patterns of alcohol and drug abuse in an urban trauma center: The increasing role of cocaine abuse. J Trauma 1989;29:1654-1658
    • (1989) J Trauma , vol.29 , pp. 1654-1658
    • Lindenbaum, G.A.1    Carroll, S.F.2    Daskal, I.3
  • 43
    • 0027511292 scopus 로고
    • The underreporting of cocaine-related trauma: Drug abuse warning network reports vs hospital toxicology tests
    • Brookoff D, Campbell EA, Shaw LM: The underreporting of cocaine-related trauma: Drug abuse warning network reports vs hospital toxicology tests. Am J Public Health 1993;83:369-371
    • (1993) Am J Public Health , vol.83 , pp. 369-371
    • Brookoff, D.1    Campbell, E.A.2    Shaw, L.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.